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BAKER BROS. ADVISORS LP

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13F filer, CIK 1263508, NEW YORK, NY

BAKER BROS. ADVISORS LP reported $9,036,702,464 across 89 holdings for the quarter ended 2025-03-31, in a 13F-HR filed 2025-05-15. Its ten largest share positions make up 81.82% of the portfolio.

Filed (acceptance time not in the bulk data set), ingested 13F-HR 0001104659-25-049518

Period
2025-03-31
Reported value
$9.04B
Holdings
89
Top 10 weight
81.82%
New
4
Sold out
10

Part of the filer group BAKER BROS. ADVISORS LP

How groups are built

Largest buys vs the previous quarter

SecurityShares changeApprox. value
IMVTadded+3,750,000$64.1M
INSMadded+373,763$28.5M
IMCRadded+807,338$24M
PCVXadded+592,000$22.4M
CELCadded+1,579,182$16M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

SecurityShares changeApprox. value
ONCreduced-732,827-$199M
KRYSexited-169,934-$26.6M
RYTMreduced-479,766-$25.4M
CRSPreduced-653,912-$22.3M
AKROreduced-548,369-$22.2M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q1 2025

Share positions as resolved from 13F-HR 0001104659-25-049518, largest first. % of portfolio is the value over $9,036,702,464, the sum of the share positions whose value is usable for ratios (method).

SecurityHistorySharesValue% of portfolioChangeLatest eventTimeline
ONCBEONE MEDICINES LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 10,568,897 shares; 2024Q4: 9,531,880 shares; 2025Q1: 8,799,053 shares 8,799,053$2.39B26.5%-732,827Timeline
INCYINCYTE CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 30,739,020 shares; 2024Q4: 30,739,466 shares; 2025Q1: 30,739,953 shares 30,739,953$1.86B20.6%+487Timeline
ACADACADIA PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 42,877,916 shares; 2024Q4: 42,877,916 shares; 2025Q1: 42,877,916 shares 42,877,916$712M7.88%0Timeline
MDGLMADRIGAL PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,974,590 shares; 2024Q4: 1,974,590 shares; 2025Q1: 1,974,590 shares 1,974,590$654M7.24%0Timeline
SMMTSUMMIT THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 24,424,865 shares; 2024Q4: 24,424,865 shares; 2025Q1: 24,424,865 shares 24,424,865$471M5.21%0Timeline
INSMINSMED INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 4,415,918 shares; 2024Q4: 5,006,863 shares; 2025Q1: 5,380,626 shares 5,380,626$410M4.54%+373,763Timeline
RYTMRHYTHM PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 6,398,366 shares; 2024Q4: 6,084,249 shares; 2025Q1: 5,604,483 shares 5,604,483$297M3.29%-479,766Timeline
RVMDREVOLUTION MEDICINES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 7,569,090 shares; 2024Q4: 7,936,972 shares; 2025Q1: 7,936,972 shares 7,936,972$281M3.11%0Timeline
KYMRKYMERA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 5,995,929 shares; 2024Q4: 5,995,929 shares; 2025Q1: 5,995,929 shares 5,995,929$164M1.82%0Timeline
ALKSALKERMES PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 4,181,751 shares; 2024Q4: 4,181,751 shares; 2025Q1: 4,483,285 shares 4,483,285$148M1.64%+301,534Timeline
EWTXEDGEWISE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 5,840,059 shares; 2024Q4: 6,155,940 shares; 2025Q1: 6,155,940 shares 6,155,940$135M1.5%0Timeline
REPLREPLIMUNE GROUP INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 11,045,336 shares; 2024Q4: 11,045,336 shares; 2025Q1: 11,045,336 shares 11,045,336$108M1.19%0Timeline
IMVTIMMUNOVANT INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,225,410 shares; 2024Q4: 1,707,881 shares; 2025Q1: 5,457,881 shares 5,457,881$93.3M1.03%+3,750,000Timeline
BCYCBICYCLE THERAPEUTICS PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 9,399,960 shares; 2024Q4: 10,885,357 shares; 2025Q1: 10,885,357 shares 10,885,357$92.4M1.02%0Timeline
IMCRIMMUNOCORE HLDGS PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,515,318 shares; 2024Q4: 1,515,318 shares; 2025Q1: 2,322,656 shares 2,322,656$68.9M0.76%+807,338Timeline
KNSAKINIKSA PHARMACEUTICALS INTLQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,818,323 shares; 2024Q4: 2,818,323 shares; 2025Q1: 2,818,323 shares 2,818,323$62.6M0.69%0Timeline
ABCLABCELLERA BIOLOGICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 27,525,640 shares; 2024Q4: 27,525,640 shares; 2025Q1: 27,525,640 shares 27,525,640$61.4M0.68%0Timeline
RAREULTRAGENYX PHARMACEUTICAL INQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,576,114 shares; 2024Q4: 1,576,114 shares; 2025Q1: 1,576,114 shares 1,576,114$57.1M0.63%0Timeline
DNLIDENALI THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 3,731,695 shares; 2024Q4: 3,731,695 shares; 2025Q1: 3,731,695 shares 3,731,695$50.7M0.56%0Timeline
KODKODIAK SCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 17,310,490 shares; 2024Q4: 17,310,490 shares; 2025Q1: 17,310,490 shares 17,310,490$48.6M0.54%02026-09-28, 13D/A: 22,049,297 shares, 35% of the class, 13D/A filed 2026-09-30 Timeline
NRIXNURIX THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 3,882,125 shares; 2024Q4: 3,882,125 shares; 2025Q1: 3,882,125 shares 3,882,125$46.1M0.51%0Timeline
ARGXARGENX SEQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 111,904 shares; 2024Q4: 111,904 shares; 2025Q1: 77,760 shares 77,760$46M0.51%-34,144Timeline
TRDAENTRADA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 4,865,819 shares; 2024Q4: 4,865,819 shares; 2025Q1: 4,865,819 shares 4,865,819$44M0.49%0Timeline
CELCCELCUITY INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,874,978 shares; 2024Q4: 2,678,553 shares; 2025Q1: 4,257,735 shares 4,257,735$43M0.48%+1,579,182Timeline
GRALGRAIL INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 1,630,125 shares; 2025Q1: 1,630,125 shares 1,630,125$41.6M0.46%0Timeline
ROIVROIVANT SCIENCES LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,798,716 shares; 2024Q4: 3,767,773 shares; 2025Q1: 3,767,773 shares 3,767,773$38M0.42%0Timeline
IMTXIMMATICS N.VQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 6,443,398 shares; 2024Q4: 7,275,830 shares; 2025Q1: 7,275,830 shares 7,275,830$32.8M0.36%0Timeline
STOKSTOKE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 4,368,443 shares; 2024Q4: 4,633,838 shares; 2025Q1: 4,633,838 shares 4,633,838$30.8M0.34%0Timeline
CERSCERUS CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 19,477,339 shares; 2024Q4: 19,477,339 shares; 2025Q1: 19,351,087 shares 19,351,087$26.9M0.3%-126,252Timeline
PCVXVAXCYTE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 48,885 shares; 2024Q4: 48,885 shares; 2025Q1: 640,885 shares 640,885$24.2M0.27%+592,000Timeline
GLUEMONTE ROSA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 4,916,095 shares; 2024Q4: 4,916,095 shares; 2025Q1: 4,916,095 shares 4,916,095$22.8M0.25%0Timeline
CRSPCRISPR THERAPEUTICS AGQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 843,075 shares; 2024Q4: 1,308,011 shares; 2025Q1: 654,099 shares 654,099$22.3M0.25%-653,912Timeline
AKROAKERO THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,097,082 shares; 2024Q4: 1,097,082 shares; 2025Q1: 548,713 shares 548,713$22.2M0.25%-548,369Timeline
SERASERA PROGNOSTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 5,434,399 shares; 2024Q4: 5,434,399 shares; 2025Q1: 5,498,170 shares 5,498,170$20.2M0.22%+63,771Timeline
CNTACENTESSA PHARMACEUTICALS PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,227,178 shares; 2024Q4: 1,227,178 shares; 2025Q1: 1,227,178 shares 1,227,178$17.6M0.2%0Timeline
NGNENEUROGENE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 456,015 shares; 2024Q4: 674,450 shares; 2025Q1: 1,486,200 shares 1,486,200$17.4M0.19%+811,750Timeline
IDYAIDEAYA BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,062,123 shares; 2024Q4: 1,062,123 shares; 2025Q1: 1,062,123 shares 1,062,123$17.4M0.19%0Timeline
VERONA PHARMA PLCVERONA PHARMA PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 223,843 shares 223,843$14.2M0.16%new
CADLCANDEL THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 2,981,983 shares; 2025Q1: 2,437,189 shares 2,437,189$13.8M0.15%-544,794Timeline
PRAXPRAXIS PRECISION MEDICINES IQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 323,105 shares; 2024Q4: 331,533 shares; 2025Q1: 331,533 shares 331,533$12.6M0.14%0Timeline
2SEVENTY BIO INC COMMON STO…2SEVENTY BIO INC COMMON STOCKQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,497,526 shares; 2024Q4: 2,497,526 shares; 2025Q1: 2,497,526 shares 2,497,526$12.3M0.14%0
XENEXENON PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 993,679 shares; 2024Q4: 993,679 shares; 2025Q1: 347,408 shares 347,408$11.7M0.13%-646,271Timeline
BCAXBICARA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 833,333 shares; 2024Q4: 833,333 shares; 2025Q1: 833,333 shares 833,333$10.9M0.12%0Timeline
IONSIONIS PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 223,470 shares; 2024Q4: 357,915 shares; 2025Q1: 357,915 shares 357,915$10.8M0.12%0Timeline
DBVTDBV TECHNOLOGIES S AQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 1,461,425 shares; 2025Q1: 1,461,425 shares 1,461,425$9.97M0.11%0Timeline
ALMSALUMIS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,562,500 shares; 2024Q4: 1,562,500 shares; 2025Q1: 1,562,500 shares 1,562,500$9.59M0.11%0Timeline
MERUS N VMERUS N VQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 300,000 shares; 2024Q4: 450,000 shares; 2025Q1: 223,500 shares 223,500$9.41M0.1%-226,500
PRLDPRELUDE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 10,123,824 shares; 2024Q4: 10,123,824 shares; 2025Q1: 10,123,824 shares 10,123,824$7.78M0.09%0Timeline
VERVE THERAPEUTICS INCVERVE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,691,530 shares; 2024Q4: 1,691,530 shares; 2025Q1: 1,691,530 shares 1,691,530$7.73M0.09%0
RCKTROCKET PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 97,079 shares; 2025Q1: 1,097,079 shares 1,097,079$7.32M0.08%+1,000,000Timeline
XNCRXENCOR INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 670,431 shares; 2024Q4: 670,431 shares; 2025Q1: 670,431 shares 670,431$7.13M0.08%0Timeline
DYNDYNE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 672,096 shares; 2024Q4: 672,096 shares; 2025Q1: 672,096 shares 672,096$7.03M0.08%0Timeline
KALAKALA BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 891,335 shares; 2024Q4: 1,201,894 shares; 2025Q1: 1,201,894 shares 1,201,894$6.89M0.08%0Timeline
DSGNDESIGN THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,743,725 shares; 2024Q4: 1,743,725 shares; 2025Q1: 1,743,725 shares 1,743,725$6.73M0.07%0Timeline
GPCRSTRUCTURE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 85,500 shares; 2024Q4: 361,565 shares; 2025Q1: 361,565 shares 361,565$6.26M0.07%0Timeline
TSHATAYSHA GENE THERAPIES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 4,004,756 shares; 2024Q4: 4,004,756 shares; 2025Q1: 4,004,756 shares 4,004,756$5.57M0.06%0Timeline
REGULUS THERAPEUTICS INCREGULUS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 2,694,044 shares 2,694,044$4.71M0.05%new
IGM BIOSCIENCES INCIGM BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 4,092,310 shares; 2024Q4: 4,094,304 shares; 2025Q1: 4,095,257 shares 4,095,257$4.71M0.05%+953
NTLAINTELLIA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 644,116 shares; 2025Q1: 644,116 shares 644,116$4.58M0.05%0Timeline
CLDXCELLDEX THERAPEUTICS INC NEWQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 247,644 shares; 2024Q4: 247,644 shares; 2025Q1: 247,644 shares 247,644$4.49M0.05%0Timeline
SIONSIONNA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 400,000 shares 400,000$4.18M0.05%newTimeline
BNTXBIONTECH SEQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 45,031 shares; 2025Q1: 45,031 shares 45,031$4.1M0.05%0Timeline
TCRXTSCAN THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,784,792 shares; 2024Q4: 2,784,792 shares; 2025Q1: 2,784,792 shares 2,784,792$3.84M0.04%0Timeline
IRONDISC MEDICINE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 77,050 shares; 2025Q1: 77,050 shares 77,050$3.82M0.04%0Timeline
VIRVIR BIOTECHNOLOGY INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 1,084,539 shares; 2025Q1: 542,539 shares 542,539$3.52M0.04%-542,000Timeline
SANASANA BIOTECHNOLOGY INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,380,949 shares; 2024Q4: 2,380,949 shares; 2025Q1: 2,030,949 shares 2,030,949$3.41M0.04%-350,000Timeline
SGMTSAGIMET BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,381,898 shares; 2024Q4: 952,996 shares; 2025Q1: 952,996 shares 952,996$3.11M0.03%0Timeline
RLAYRELAY THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,160,117 shares; 2024Q4: 1,160,117 shares; 2025Q1: 1,160,117 shares 1,160,117$3.04M0.03%0Timeline
WVEWAVE LIFE SCIENCES LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 344,063 shares; 2024Q4: 344,063 shares; 2025Q1: 344,063 shares 344,063$2.78M0.03%0Timeline
FATEFATE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,997,772 shares; 2024Q4: 3,258,402 shares; 2025Q1: 3,258,402 shares 3,258,402$2.57M0.03%0Timeline
SKYESKYE BIOSCIENCE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,434,634 shares; 2024Q4: 1,450,638 shares; 2025Q1: 1,450,638 shares 1,450,638$2.31M0.03%0Timeline
TARAPROTARA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 536,832 shares; 2024Q4: 536,832 shares; 2025Q1: 536,832 shares 536,832$2.29M0.03%0Timeline
ELVNENLIVEN THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 114,833 shares; 2024Q4: 114,833 shares; 2025Q1: 114,833 shares 114,833$2.26M0.03%0Timeline
CTNMCONTINEUM THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 312,500 shares; 2024Q4: 312,500 shares; 2025Q1: 312,500 shares 312,500$2.18M0.02%0Timeline
PRMEPRIME MEDICINE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,028,466 shares; 2024Q4: 1,028,466 shares; 2025Q1: 1,028,466 shares 1,028,466$2.05M0.02%0Timeline
TECXTECTONIC THERAPEUTIC INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 100,000 shares 100,000$1.77M0.02%newTimeline
VTVTVTV THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 97,314 shares; 2024Q4: 97,314 shares; 2025Q1: 97,314 shares 97,314$1.69M0.02%0Timeline
CMPXCOMPASS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,557,630 shares; 2024Q4: 1,557,630 shares; 2025Q1: 547,498 shares 547,498$1.04M0.01%-1,010,132Timeline
NMRANEUMORA THERAPEUTICS INC.Quarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,034,600 shares; 2024Q4: 1,034,600 shares; 2025Q1: 1,034,600 shares 1,034,600$1.03M0.01%0Timeline
HOOKHOOKIPA PHARMA INC COM NEWQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 812,814 shares; 2024Q4: 812,814 shares; 2025Q1: 812,814 shares 812,814$878K0.01%0Timeline
GENERATION BIO COGENERATION BIO COQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,944,945 shares; 2024Q4: 1,944,945 shares; 2025Q1: 1,944,945 shares 1,944,945$788K0.01%0
ALGSALIGOS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 83,055 shares; 2024Q4: 83,055 shares; 2025Q1: 83,055 shares 83,055$685K0.01%0Timeline
CYPHCYPHERPUNK TECHNOLOGIES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,172,175 shares; 2024Q4: 1,172,175 shares; 2025Q1: 404,744 shares 404,744$123K<0.01%-767,431Timeline
IPSCCENTURY THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 797,460 shares; 2024Q4: 797,460 shares; 2025Q1: 241,684 shares 241,684$115K<0.01%-555,776Timeline
TYRATYRA BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 10,607 shares; 2024Q4: 10,607 shares; 2025Q1: 10,607 shares 10,607$98.6K<0.01%0Timeline
ACRVACRIVON THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 52,885 shares; 2024Q4: 52,885 shares; 2025Q1: 22,809 shares 22,809$46.3K<0.01%-30,076Timeline
SRZNWSURROZEN INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 833,333 shares; 2024Q4: 833,333 shares; 2025Q1: 833,333 shares 833,333$25K<0.01%0Timeline
OPTEYOPTHEA LTD SPONSORED ADR NEW (Quarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,173,622 shares; 2024Q4: 2,173,622 shares; 2025Q1: 2,087,320 shares 2,087,320$00%-86,302Value filed as zero, left out of ratios.Timeline

Principal amounts

Notes and convertibles filed as a face amount (PRN). A face amount is never added to a share count (H6).

SecurityTypeAmountValueChange
INSMED INCINSMED INC NOTE 0.750% 6/0principal42,850,000$102M0

Sold out in Q1 2025

Positions in the previous quarter's report that this quarter's report no longer lists.

SecurityShares beforeValue beforeType
IONIS PHARMACEUTICALS INCIONIS PHARMACEUTICALS INC30,000,000$29.5Mprincipal
KRYSKRYSTAL BIOTECH INC169,934$26.6Mshares
MIRMMIRUM PHARMACEUTICALS INC190,476$7.88Mshares
ARVNARVINAS INC405,576$7.77Mshares
BMEABIOMEA FUSION INC1,451,990$5.63Mshares
ARCTARCTURUS THERAPEUTICS HLDGS151,329$2.57Mshares
Mersana Therapeutics IncMersana Therapeutics Inc1,086,115$1.55Mshares
PTCTPTC THERAPEUTICS INC20,400$921Kshares
PMVPPMV PHARMACEUTICALS INC322,024$486Kshares
FHTXFOGHORN THERAPEUTICS INC45,027$213Kshares

How Q1 2025 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

FilingRoleAmendmentFiledAcceptedIngested
13F-HR 0001104659-25-049518 base2025-05-15acceptance time not in the bulk data set