FMR LLC in group FMR LLC More: the full row for FMR LLC 4,993,906 $65.2M <0.01% +1,157,076 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 4,281,425 $55.9M <0.01% +962,046 13F-HR Timeline Group Foresite Capital Management VI LLC group of 2 filers holding More: the full row for Foresite Capital Management VI LLC 3,262,665 $42.6M 0 Timeline Merck & Co., Inc. in group Merck & Co., Inc. More: the full row for Merck & Co., Inc. 1,666,666 $21.7M 4.13% 0 13F-HR Timeline Group T. Rowe Price Investment Management, In… More: the full row for T. Rowe Price Investment Management, Inc. 1,595,274 $20.8M 0.01% +372,787 13F-HR Timeline VANGUARD GROUP INC group of 4 filers holding More: the full row for VANGUARD GROUP INC 1,228,496 $16M +99,751 Timeline Capital World Investors More: the full row for Capital World Investors 1,175,944 $15.3M <0.01% +32,307 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 1,005,035 $13.1M <0.01% +29,201 13F-HR Timeline EcoR1 Capital, LLC More: the full row for EcoR1 Capital, LLC 732,606 $9.56M 0.47% 0 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 556,955 $7.27M <0.01% +283,024 13F-HR Timeline Group BAKER BROS. ADVISORS LP in group BAKER BROS. ADVISORS LP More: the full row for BAKER BROS. ADVISORS LP 555,555 $7.25M 0.04% 0 13F-HR Timeline Group ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 641,888 $6.79M <0.01% -380,300 13F-HR Timeline SOROS CAPITAL MANAGEMENT LLC in group SOROS FUND MANAGEMENT LLC More: the full row for SOROS CAPITAL MANAGEMENT LLC 484,672 $6.32M 1.13% 0 13F-HR Timeline Group StepStone Group LP More: the full row for StepStone Group LP 395,340 $5.16M 0.24% 0 13F-HR Timeline CANADA PENSION PLAN INVESTMENT BOARD More: the full row for CANADA PENSION PLAN INVESTMENT BOARD 379,024 $4.95M <0.01% 0 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 354,093 $4.62M <0.01% +313,943 13F-HR Timeline Group FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 350,000 $4.57M <0.01% 0 13F-HR Timeline Group General Catalyst Group Management, LLC More: the full row for General Catalyst Group Management, LLC 305,233 $3.98M 2.11% 0 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 263,932 $3.44M <0.01% +164,524 13F-HR Timeline Group Parkman Healthcare Partners LLC More: the full row for Parkman Healthcare Partners LLC 256,053 $3.34M 0.34% new 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 182,105 $2.38M <0.01% +51,026 13F-HR Timeline Group Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 179,775 $2.35M 0.01% new 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 175,927 $2.3M <0.01% +130,396 13F-HR Timeline Group Ensign Peak Advisors, Inc More: the full row for Ensign Peak Advisors, Inc 170,490 $2.22M <0.01% -29,510 13F-HR Timeline BNP PARIBAS ASSET MANAGEMENT Holding S.… in group BNP PARIBAS ASSET MANAGEMENT … More: the full row for BNP PARIBAS ASSET MANAGEMENT Holding S.A. 134,498 $1.76M <0.01% -5,846 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 133,020 $1.74M <0.01% -42,607 13F-HR Timeline Group Comprehensive Financial Management LLC More: the full row for Comprehensive Financial Management LLC 116,276 $1.52M 0.05% 0 13F-HR Timeline Burkehill Global Management, LP More: the full row for Burkehill Global Management, LP 115,000 $1.5M 0.05% 0 13F-HR Timeline Affinity Asset Advisors, LLC More: the full row for Affinity Asset Advisors, LLC 98,001 $1.28M 0.06% new 13F-HR Timeline TD Asset Management Inc More: the full row for TD Asset Management Inc 57,074 $745K <0.01% 0 13F-HR Timeline ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 54,948 $717K <0.01% new 13F-HR Timeline Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 50,900 $664K <0.01% new 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 47,788 $624K <0.01% new 13F-HR Timeline Group TCG Crossover Management, LLC More: the full row for TCG Crossover Management, LLC 37,902 $495K 0.01% new 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 37,575 $490K <0.01% -48,559 13F-HR Timeline Group POLEN CAPITAL MANAGEMENT LLC More: the full row for POLEN CAPITAL MANAGEMENT LLC 35,742 $466K <0.01% new 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 35,357 $461K <0.01% +6,734 13F-HR Timeline Group ProShare Advisors LLC More: the full row for ProShare Advisors LLC 29,685 $387K <0.01% new 13F-HR Timeline Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 28,988 $378K <0.01% new 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 27,455 $358K <0.01% +1,399 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 26,797 $350K <0.01% new 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 24,483 $319K <0.01% new 13F-HR Timeline Integrated Wealth Concepts LLC More: the full row for Integrated Wealth Concepts LLC 21,800 $284K <0.01% new 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 21,522 $281K <0.01% new 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 19,348 $252K <0.01% new 13F-HR Timeline Group Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 18,069 $236K <0.01% new 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 16,779 $219K <0.01% new 13F-HR Timeline Group TUDOR INVESTMENT CORP ET AL More: the full row for TUDOR INVESTMENT CORP ET AL 15,000 $196K <0.01% 0 13F-HR Timeline MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 13,755 $180K <0.01% new 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 13,023 $170K <0.01% -296,977 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 12,032 $157K <0.01% -3,241 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 10,324 $132K <0.01% +9,024 13F-HR Timeline Group MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. in group Mirae Asset Global Investment… More: the full row for MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 9,981 $130K <0.01% new 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 8,509 $111K <0.01% new 13F-HR Timeline Group Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 6,420 $83.8K <0.01% new 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 6,200 $80.9K <0.01% new 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 4,635 $60.5K <0.01% +4,317 13F-HR Timeline Group STRS OHIO More: the full row for STRS OHIO 4,300 $56.1K <0.01% new 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 3,635 $47.4K <0.01% +2,496 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 2,784 $36K <0.01% new 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 2,118 $27.6K <0.01% new 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 1,975 $25.8K <0.01% new 13F-HR Timeline Group Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 1,740 $22.7K <0.01% new 13F-HR Timeline Group IFP Advisors, Inc More: the full row for IFP Advisors, Inc 918 $12K <0.01% new 13F-HR Timeline State of Wyoming More: the full row for State of Wyoming 549 $7.16K <0.01% new 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 535 $6.98K <0.01% new 13F-HR Timeline Group Allworth Financial LP More: the full row for Allworth Financial LP 500 $6.53K <0.01% new 13F-HR Timeline CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 300 $3.92K <0.01% new 13F-HR/A Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 190 $2.48K <0.01% new 13F-HR Timeline Aspect Partners, LLC More: the full row for Aspect Partners, LLC 126 $1.64K <0.01% new 13F-HR Timeline Fortitude Family Office, LLC More: the full row for Fortitude Family Office, LLC 121 $1.58K <0.01% new 13F-HR Timeline Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 4 $52 <0.01% new 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 2 $26 <0.01% new 13F-HR Timeline