TCG Crossover Management, LLC More: the full row for TCG Crossover Management, LLC 2,582,408 $87.5M 2.89% +946,133 13F-HR Timeline FCPM III SERVICES B.V. in group FCPM III SERVICES B.V. More: the full row for FCPM III SERVICES B.V. 1,833,333 $62.1M 8.14% +1,489,096 13F-HR Timeline Group ORBIMED ADVISORS LLC in group ORBIMED ADVISORS LLC More: the full row for ORBIMED ADVISORS LLC 1,642,891 $55.6M 1.14% +556,273 13F-HR Timeline Group RTW INVESTMENTS, LP More: the full row for RTW INVESTMENTS, LP 1,637,165 $55.5M 0.56% +166,666 13F-HR Timeline Foresite Capital Management VI LLC in group Foresite Capital Management V… More: the full row for Foresite Capital Management VI LLC 1,562,500 $52.9M 16% 0 13F-HR Timeline Group Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 1,375,000 $46.6M 1.39% +794,534 13F-HR Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 1,186,791 $40.2M <0.01% +490,603 13F-HR Timeline Group Frazier Life Sciences Management, L.P. More: the full row for Frazier Life Sciences Management, L.P. 983,333 $33.3M 0.89% new 13F-HR Timeline BRAIDWELL LP More: the full row for BRAIDWELL LP 929,694 $31.5M 1.01% new 13F-HR Timeline Redmile Group, LLC in group Redmile Group, LLC More: the full row for Redmile Group, LLC 885,927 $30M 2.21% +333,333 13F-HR Timeline Group PERCEPTIVE ADVISORS LLC in group PERCEPTIVE ADVISORS LLC More: the full row for PERCEPTIVE ADVISORS LLC 825,890 $28M 0.51% +642,000 13F-HR Timeline Group Soleus Capital Management, L.P. More: the full row for Soleus Capital Management, L.P. 764,000 $25.9M 1.1% +226,097 13F-HR Timeline Nantahala Capital Management, LLC in group Nantahala Capital Management,… More: the full row for Nantahala Capital Management, LLC 754,153 $25.5M 1.52% +130,871 13F-HR Timeline Group Ikarian Capital, LLC in group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 665,271 $22.5M 2.92% +50,271 13F-HR Timeline Group Caligan Partners LP More: the full row for Caligan Partners LP 644,400 $21.8M 2% new 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 639,804 $21.7M <0.01% +602,421 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 591,802 $20M 0.01% +576,272 13F-HR Timeline Group GREAT POINT PARTNERS LLC More: the full row for GREAT POINT PARTNERS LLC 581,187 $19.7M 6.38% new 13F-HR Timeline Octagon Capital Advisors LP More: the full row for Octagon Capital Advisors LP 574,000 $19.4M 2.43% new 13F-HR Timeline ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 509,679 $17.3M 1.29% +1,908 13F-HR/A Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 486,153 $16.5M <0.01% +396,650 13F-HR Timeline Group BOONE CAPITAL MANAGEMENT LLC More: the full row for BOONE CAPITAL MANAGEMENT LLC 470,456 $15.9M 5% -312,005 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 424,862 $14.4M 0.02% +379,480 13F-HR Timeline Group MPM BIOIMPACT LLC More: the full row for MPM BIOIMPACT LLC 397,906 $13.5M 1.54% new 13F-HR Timeline BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 390,747 $13.2M 0.34% +166,887 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 275,758 $9.34M <0.01% +27,380 13F-HR Timeline Group ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 275,000 $9.31M 0.01% new 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 254,053 $8.6M <0.01% +192,477 13F-HR/A Timeline Group Commodore Capital LP in group Commodore Capital LP More: the full row for Commodore Capital LP 250,000 $8.47M 0.56% new 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 239,790 $8.13M <0.01% +118,326 13F-HR Timeline Group Rock Springs Capital Management LP More: the full row for Rock Springs Capital Management LP 213,731 $7.24M 0.37% new 13F-HR Timeline Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 167,030 $5.66M <0.01% +26,486 13F-HR Timeline Group AWM Investment Company, Inc. More: the full row for AWM Investment Company, Inc. 162,560 $5.51M 0.53% new 13F-HR Timeline Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 158,292 $5.36M 0.01% new 13F-HR Timeline Tetragon Partners GP Ltd in group Tetragon Partners GP Ltd More: the full row for Tetragon Partners GP Ltd 131,770 $4.46M 0.94% new 13F-HR Timeline Group Deep Track Capital, LP More: the full row for Deep Track Capital, LP 110,448 $3.74M 0.09% -640,974 13F-HR Timeline Velan Capital Investment Management LP More: the full row for Velan Capital Investment Management LP 108,000 $3.66M 2.13% +28,023 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 106,671 $3.61M <0.01% +67,393 13F-HR Timeline Group Atika Capital Management LLC in group Atika Capital Management LLC More: the full row for Atika Capital Management LLC 94,245 $3.19M 0.44% new 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 91,173 $3.09M <0.01% +56,862 13F-HR Timeline JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 84,778 $2.87M <0.01% new 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 84,596 $2.87M <0.01% +67,751 13F-HR Timeline Group Euclidean Capital LLC More: the full row for Euclidean Capital LLC 82,234 $2.79M 0.75% 0 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 76,659 $2.6M <0.01% +76,564 13F-HR Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 66,225 $2.24M <0.01% +37,417 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 58,330 $1.98M <0.01% +54,359 13F-HR Timeline Group Quadrature Capital Ltd in group Quadrature Capital Ltd More: the full row for Quadrature Capital Ltd 57,590 $1.95M 0.02% new 13F-HR Timeline Group Trexquant Investment LP More: the full row for Trexquant Investment LP 54,016 $1.83M 0.02% new 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 51,324 $1.74M <0.01% +29,228 13F-HR/A Timeline Group Burkehill Global Management, LP More: the full row for Burkehill Global Management, LP 50,000 $1.69M 0.11% new 13F-HR Timeline TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 49,576 $1.68M +14,758 Timeline Connor, Clark & Lunn Investment Managem… More: the full row for Connor, Clark & Lunn Investment Management Ltd. 49,021 $1.66M <0.01% new 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 40,504 $1.37M <0.01% +23,484 13F-HR Timeline Group Rafferty Asset Management, LLC More: the full row for Rafferty Asset Management, LLC 32,984 $1.12M <0.01% new 13F-HR Timeline Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 25,185 $853K <0.01% +12,807 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 24,572 $832K <0.01% new 13F-HR Timeline Group GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 22,944 $777K 0.07% +12,386 13F-HR Timeline LANDSCAPE CAPITAL MANAGEMENT, L.L.C. in group LANDSCAPE CAPITAL MANAGEMENT,… More: the full row for LANDSCAPE CAPITAL MANAGEMENT, L.L.C. 22,859 $774K 0.05% new 13F-HR Timeline Group Sigma Planning Corp More: the full row for Sigma Planning Corp 19,000 $644K 0.02% new 13F-HR Timeline Man Group plc in group Man Group plc More: the full row for Man Group plc 18,802 $637K <0.01% new 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 18,195 $616K 0.02% new 13F-HR Timeline Group ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 16,788 $568K <0.01% 0 13F-HR Timeline Group Birchview Capital, LP More: the full row for Birchview Capital, LP 15,000 $508K 0.3% new 13F-HR Timeline BRIDGEWAY CAPITAL MANAGEMENT, LLC More: the full row for BRIDGEWAY CAPITAL MANAGEMENT, LLC 14,375 $487K 0.01% -6,250 13F-HR Timeline Exome Asset Management LLC More: the full row for Exome Asset Management LLC 14,194 $481K 0.24% new 13F-HR Timeline HighTower Advisors, LLC More: the full row for HighTower Advisors, LLC 12,525 $424K <0.01% -100 13F-HR Timeline PROFUND ADVISORS LLC More: the full row for PROFUND ADVISORS LLC 11,892 $403K 0.01% new 13F-HR Timeline OMERS ADMINISTRATION Corp More: the full row for OMERS ADMINISTRATION Corp 11,600 $393K <0.01% new 13F-HR Timeline Y-Intercept (Hong Kong) Ltd More: the full row for Y-Intercept (Hong Kong) Ltd 11,237 $381K 0.01% new 13F-HR Timeline AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 10,218 $346K <0.01% new 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 10,000 $339K <0.01% 0 13F-HR Timeline Group Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 9,845 $333K <0.01% new 13F-HR Timeline Group Engineers Gate Manager LP More: the full row for Engineers Gate Manager LP 9,784 $331K <0.01% new 13F-HR Timeline DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 8,934 $302K <0.01% 0 13F-HR Timeline Group Hudson Bay Capital Management LP in group Hudson Bay Capital Management… More: the full row for Hudson Bay Capital Management LP 8,900 $301K <0.01% new 13F-HR Timeline Group CANADA PENSION PLAN INVESTMENT BOARD More: the full row for CANADA PENSION PLAN INVESTMENT BOARD 8,800 $298K <0.01% new 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 8,566 $290K <0.01% +8,542 13F-HR Timeline Group Jain Global LLC More: the full row for Jain Global LLC 7,420 $251K <0.01% new 13F-HR Timeline Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 7,229 $245K 0.07% new 13F-HR Timeline Group VOLORIDGE INVESTMENT MANAGEMENT, LLC More: the full row for VOLORIDGE INVESTMENT MANAGEMENT, LLC 6,893 $233K <0.01% new 13F-HR Timeline BANK OF NOVA SCOTIA in group BANK OF NOVA SCOTIA More: the full row for BANK OF NOVA SCOTIA 6,700 $227K <0.01% new 13F-HR Timeline Group Opaleye Management Inc. More: the full row for Opaleye Management Inc. 150,000 $213K 0.03% new 13F-HR/A Timeline GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 5,282 $179K 0.01% +2,583 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 4,515 $153K 0.01% new 13F-HR Timeline Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 3,271 $110K new Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 3,085 $104K <0.01% new 13F-HR Timeline Group SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 2,846 $96.4K <0.01% new 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 1,668 $56.5K <0.01% +1,345 13F-HR Timeline Group GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 544 $18.4K <0.01% new 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 498 $16.9K <0.01% +419 13F-HR Timeline Group PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 497 $16.8K <0.01% 0 13F-HR Timeline Group Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 92 $3K <0.01% new 13F-HR Timeline Group NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 79 $2.68K <0.01% 0 13F-HR Timeline Basecamp Wealth Advisors LLC More: the full row for Basecamp Wealth Advisors LLC 68 $2.3K <0.01% 13F-HR Timeline Fortitude Family Office, LLC More: the full row for Fortitude Family Office, LLC 63 $2.13K <0.01% 0 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 35 $1K <0.01% -14,419 13F-HR Timeline Group CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 32 $1K <0.01% -81 13F-HR Timeline Group EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 20 $678 <0.01% -38 13F-HR Timeline Group Aster Capital Management (DIFC) Ltd More: the full row for Aster Capital Management (DIFC) Ltd 1 $34 <0.01% new 13F-HR Timeline BESSEMER GROUP INC in group BESSEMER GROUP INC More: the full row for BESSEMER GROUP INC 11 $0 0% 0 13F-HR Timeline Group Value filed as zero, left out of ratios.