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Disclosery

PTGX PROTAGONIST THERAPEUTICS INC

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COM (common), issuer CIK 1377121

311 managers (317 13F filers) reported a position in PTGX shares at 2025-12-31, 71,028,771 shares in all. 65 filers opened a position and 39 filers sold out during the quarter.

Managers
311
13F filers
317
New
65
Added
97
Reduced
103
Sold out
39
Shares held by filers
71,028,771

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q4 2025

Filers in the available 13F reports with a share position at 2025-12-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
BlackRock, Inc.in group BlackRock, Inc.9,715,999$849M0.01%+311,76713F-HRTimelineGroup
FARALLON CAPITAL MANAGEMENT, L.L.C.6,144,006$537M2.79%-52,00013F-HRTimelineThe filing omitted confidential holdings, a later amendment may add them.
VANGUARD GROUP INCgroup of 2 filers holding5,417,263$473M+1,156,736Timeline
RTW INVESTMENTS, LP5,059,053$442M4.43%-697,22413F-HRTimeline
STATE STREET CORPin group STATE STREET CORP3,199,729$279M0.01%+33,93413F-HRTimelineGroup
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…3,171,423$277M0.05%+1,262,97713F-HRTimelineGroup
UBS Group AGgroup of 2 filers holding2,874,549$251M+868,312Timeline
JANUS HENDERSON GROUP PLCin group Janus Henderson2,649,981$231M0.1%+1,549,16013F-HRTimelineGroup
JOHNSON & JOHNSONin group JOHNSON & JOHNSON2,449,183$214M38.54%013F-HR/ATimelineGroup
Invesco Ltd.in group Invesco Ltd.1,567,840$137M0.01%+564,13413F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC1,452,928$127M0.01%+36,28213F-HRTimelineGroup
Woodline Partners LP1,408,772$123M0.48%-29,47513F-HRTimeline
PRICE T ROWE ASSOCIATES INC /MD/1,400,738$122M0.01%+180,30213F-HRTimeline
PERCEPTIVE ADVISORS LLCin group PERCEPTIVE ADVISORS LLC1,350,425$118M2.16%+320,29113F-HRTimelineGroup
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC1,126,687$98.4M0.07%+888,80613F-HRTimelineGroup
Driehaus Capital Management LLC1,099,170$96M0.65%-40,68413F-HRTimeline
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC1,049,168$91.6M6.85%+59,98613F-HR/ATimelineGroup
MARSHALL WACE, LLPin group MARSHALL WACE, LLP1,024,925$89.5M0.09%-60,63913F-HRTimelineGroup
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC961,149$83.9M0.01%+179,43813F-HR/ATimelineGroup
MORGAN STANLEYin group MORGAN STANLEY879,024$76.8M<0.01%+110,66513F-HR/ATimelineGroup
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/867,580$75.8M0.01%+37,70313F-HRTimelineGroup
NORTHERN TRUST CORPin group NORTHERN TRUST CORP575,118$50.2M0.01%-28,10413F-HRTimelineGroup
Nationale-Nederlanden Powszechne Towarz…571,825$49.9M4.43%new13F-HRTimeline
Franklin Resourcesgroup of 2 filers holding566,284$49.5M+483,366Timeline
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co556,762$48.6M0.01%+3,88513F-HRTimelineGroup
FMR LLCin group FMR LLC539,878$47.2M<0.01%+19,21413F-HRTimelineGroup
AMERICAN CENTURY COMPANIES INCin group AMERICAN CENTURY COMPANIES INC535,423$46.8M0.02%-64,62413F-HRTimelineGroup
Pictet Asset Management Holding SAin group Pictet Asset Management Holdi…529,631$46.3M0.04%-292,58113F-HRTimelineGroup
Commodore Capital LPin group Commodore Capital LP450,000$39.3M2.62%-575,00013F-HRTimelineGroup
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP414,415$36.2M0.01%-24,10013F-HRTimelineGroup
683 Capital Management, LLCin group 683 Capital Management, LLC380,669$33.2M2.76%-26,83113F-HRTimelineGroup
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC366,165$32M0.03%+60,74613F-HRTimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp350,388$30.6M0.01%-12,87313F-HRTimelineGroup
PRINCIPAL FINANCIAL GROUP INCgroup of 2 filers holding347,932$30.4M+21,812Timeline
JENNISON ASSOCIATES LLC331,164$28.9M0.02%new13F-HRTimeline
BNP PARIBAS ASSET MANAGEMENT Holding S.…in group BNP PARIBAS ASSET MANAGEMENT …330,804$28.9M0.03%-120,96213F-HRTimelineGroup
ADAGE CAPITAL PARTNERS GP, L.L.C.in group ADAGE CAPITAL PARTNERS GP, L.…232,836$20.3M0.03%-485,36613F-HRTimelineGroup
NEXTBio Capital Management LP229,619$20.1M11.76%13F-HRTimeline
KENNEDY CAPITAL MANAGEMENT LLC221,444$19.3M0.41%+13,00713F-HRTimeline
Holocene Advisors, LP210,019$18.3M0.04%new13F-HRTimeline
Skandinaviska Enskilda Banken AB (publ)205,574$18M0.07%+126,77813F-HRTimeline
Public Sector Pension Investment Board203,426$17.8M0.06%-24,72013F-HRTimeline
Alyeska Investment Group, L.P.in group Alyeska Investment Group, L.P.199,523$17.4M0.05%new13F-HRTimelineGroup
MPM BIOIMPACT LLC199,471$17.4M1.99%new13F-HRTimeline
AIHC Capital Management Ltd189,823$16.6M15.54%13F-HRTimeline
BARCLAYS PLCin group BARCLAYS PLC187,642$16.4M0.01%+16,23613F-HRTimelineGroup
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC181,503$15.8M<0.01%-112,79313F-HRTimelineGroup
NAN FUNG TRINITY (HK) LTD180,670$15.8M1.25%+35,77813F-HRTimeline
Affinity Asset Advisors, LLC172,125$15M1.08%-48,47513F-HRTimeline
Boxer Capital Management, LLCin group Boxer Capital Management, LLC170,000$14.8M3.25%+60,00013F-HRTimelineGroup
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC169,518$14.8M<0.01%+16,32713F-HRTimelineGroup
Duquesne Family Office LLC159,700$13.9M0.33%013F-HRTimeline
TD Asset Management Inc158,730$13.9M0.01%+8,30213F-HRTimeline
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO155,300$13.6M<0.01%-97,10013F-HRTimelineGroup
RHUMBLINE ADVISERS154,950$13.5M0.01%-9,03013F-HRTimeline
Qube Research & Technologies Ltd153,876$13.4M0.02%new13F-HRTimeline
Legal & General Group Plcin group Legal & General Group Plc149,164$13M<0.01%-6,66513F-HRTimelineGroup
SEGALL BRYANT & HAMILL, LLC129,060$11.3M0.15%+5,93513F-HRTimeline
Nuveen, LLCin group TIAA125,861$11M<0.01%-2,52313F-HRTimelineGroup
PANAGORA ASSET MANAGEMENT INC125,384$11M0.04%-23,34513F-HRTimeline
Universal- Beteiligungs- und Serviceges…in group Universal- Beteiligungs- und …114,036$9.96M0.02%+23,71913F-HRTimelineGroup
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …113,340$9.89M0.01%-21,75613F-HRTimelineGroup
PRUDENTIAL FINANCIAL INCin group PRUDENTIAL FINANCIAL INC110,360$9.64M0.01%-16,04313F-HRTimelineGroup
Hudson Bay Capital Management LPin group Hudson Bay Capital Management…109,615$9.57M0.05%new13F-HRTimelineGroup
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\105,460$9.21M<0.01%-11,75213F-HRTimelineGroup
Opaleye Management Inc.105,000$9.17M1.21%013F-HR/ATimeline
SOROS FUND MANAGEMENT LLCin group SOROS FUND MANAGEMENT LLC100,000$8.73M0.12%new13F-HRTimelineGroup
NEUBERGER BERMAN GROUP LLCin group NEUBERGER BERMAN GROUP LLC98,473$8.6M0.01%-24,90413F-HRTimelineGroup
Swiss National Bank98,200$8.58M0.01%+2,10013F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS97,764$8.54M0.01%+84,62713F-HRTimelineGroup
CITIGROUP INCin group CITIGROUP INC94,909$8.29M0.01%-57,67113F-HRTimelineGroup
AXIOM INVESTORS LLC /DE89,468$7.81M0.07%+9,35513F-HRTimeline
Atika Capital Management LLCin group Atika Capital Management LLC86,000$7.51M1.05%+3,00013F-HRTimelineGroup
Moody Aldrich Partners LLC80,623$7.04M1.31%-62,43713F-HRTimeline
VICTORY CAPITAL MANAGEMENT INC80,571$7.04M<0.01%-4,92313F-HRTimeline
Informed Momentum Co LLC78,498$6.86M0.76%-1,56913F-HRTimeline
GREAT LAKES ADVISORS, LLC73,966$6.46M0.05%-15,20513F-HRTimeline
HighVista Strategies LLC73,545$6.42M1.65%-48,13713F-HRTimeline
ALLIANCEBERNSTEIN L.P.73,222$6.4M<0.01%-187,63213F-HRTimeline
Knott David M Jr73,000$6.38M2.95%-10,00013F-HRTimeline
EFG International AGin group EFG International AG72,623$6.34M0.12%13F-HRTimelineGroup
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN71,645$6.26M<0.01%+23,85113F-HRTimelineGroup
Fisher Asset Management, LLC65,114$5.69M<0.01%new13F-HRTimeline
Rafferty Asset Management, LLC63,661$5.56M0.02%-11,16613F-HRTimeline
STEMPOINT CAPITAL LP59,430$5.19M0.89%+11,47613F-HRTimeline
Eagle Health Investments LP57,300$5M1.1%new13F-HRTimeline
Quinn Opportunity Partners LLC55,259$4.83M0.21%new13F-HRTimeline
Birchview Capital, LP55,000$4.8M2.81%+7,00013F-HRTimeline
BESSEMER GROUP INCin group BESSEMER GROUP INC54,162$4.73M0.01%+49,88713F-HRTimelineGroup
SILVERCREST ASSET MANAGEMENT GROUP LLC53,217$4.65M0.03%013F-HRTimeline
KVP Capital Advisors, LP53,000$4.63M4.78%13F-HRTimeline
Eversept Partners, LP52,961$4.63M0.26%new13F-HRTimeline
Pentwater Capital Management LP50,000$4.37M0.03%new13F-HRTimeline
CANADA LIFE ASSURANCE Coin group CANADA LIFE ASSURANCE Co49,640$4.33M0.01%+1,23313F-HRTimelineGroup
NEW YORK STATE TEACHERS RETIREMENT SYST…49,350$4.31M0.01%-20013F-HRTimeline
NORTHWESTERN MUTUAL WEALTH MANAGEMENT COin group NORTHWESTERN MUTUAL INVESTMEN…48,894$4.27M<0.01%-10,00013F-HR/ATimelineGroup
CALIFORNIA STATE TEACHERS RETIREMENT SY…48,033$4.2M<0.01%+59613F-HRTimeline
FIRST TRUST ADVISORS LPin group FIRST TRUST ADVISORS LP46,454$4.06M<0.01%-16,27013F-HRTimelineGroup
J. Goldman & Co LP46,325$4.05M0.16%+28,25713F-HRTimeline
SummitTX Capital, L.P.42,266$3.69M0.11%+10,77613F-HRTimeline
Creative Planningin group Creative Planning41,254$3.6M<0.01%+5,04013F-HRTimelineGroup
Thrivent Financial for Lutheransin group Thrivent Financial for Luther…40,380$3.53M0.01%-1,80813F-HRTimelineGroup
LMR Partners LLPin group LMR Partners LLP40,000$3.49M0.03%new13F-HRTimelineGroup
State of Alaska, Department of Revenue38,099$3.33M0.04%+8,67413F-HRTimeline
Elmind Capital, LP38,000$3.32M0.98%13F-HRTimeline
SEI INVESTMENTS COin group SEI INVESTMENTS CO37,346$3.26M<0.01%-6,66513F-HRTimelineGroup
Aquatic Capital Management LLC36,615$3.2M0.09%new13F-HRTimeline
EXCHANGE TRADED CONCEPTS, LLC35,039$3.06M0.03%+1,48713F-HRTimeline
STATE OF WISCONSIN INVESTMENT BOARD34,786$3.04M0.01%-6,12013F-HRTimeline
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC34,307$3M<0.01%-10,03213F-HRTimelineGroup
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding33,827$2.95M+551Timeline
Deeter Investments LLP300,000$2.87M0.62%13F-HRTimeline
MetLife Investment Management, LLCin group MetLife Investment Management…32,440$2.83M0.01%-1,40613F-HRTimelineGroup
Illinois Municipal Retirement Fund31,244$2.73M0.03%-1,93913F-HRTimeline
GUGGENHEIM CAPITAL LLCin group GUGGENHEIM CAPITAL LLC31,096$2.72M0.02%+12,51313F-HRTimelineGroup
Louisiana State Employees Retirement Sy…26,900$2.35M0.04%013F-HRTimeline
Verition Fund Management LLC26,792$2.34M0.01%new13F-HRTimeline
TEACHERS RETIREMENT SYSTEM OF THE STATE…26,528$2.32M0.02%+9,23213F-HRTimeline
KEYSTONE INVESTORS PTE LTD26,390$2.3M0.21%new13F-HRTimeline
Parkman Healthcare Partners LLC25,973$2.27M0.22%-35,87613F-HRTimeline
PROFUND ADVISORS LLC25,574$2.23M0.07%+7,41713F-HRTimeline
VIRGINIA RETIREMENT SYSTEMS ET Al25,400$2.22M0.01%+9,80013F-HRTimeline
Artia Global Partners LP22,951$2M0.32%013F-HRTimeline
DIADEMA PARTNERS LP22,700$1.98M1.18%-28,48513F-HRTimeline
INTECH INVESTMENT MANAGEMENT LLC22,485$1.96M0.02%+84213F-HRTimeline
State of Tennessee, Department of Treas…23,526$1.92M0.01%-2,96413F-HRTimeline
ORBIMED ADVISORS LLCin group ORBIMED ADVISORS LLC21,700$1.9M0.04%new13F-HRTimelineGroup
Gotham Asset Management, LLC21,595$1.89M0.01%-60313F-HRTimeline
Campbell & CO Investment Adviser LLC21,054$1.84M0.09%new13F-HRTimeline
NATIXIS ADVISORS, LLCin group Natixis Investment Managers20,495$1.79M<0.01%+3,64013F-HRTimelineGroup
POLEN CAPITAL MANAGEMENT LLC20,349$1.78M0.01%+2413F-HRTimeline
SG Americas Securities, LLC19,997$1.75M<0.01%-21,24913F-HRTimeline
Handelsbanken Fonder AB19,900$1.74M0.01%+1,00013F-HRTimeline
NEW YORK STATE COMMON RETIREMENT FUND18,382$1.61M<0.01%-1,20013F-HRTimeline
NOMURA ASSET MANAGEMENT CO LTDgroup of 2 filers holding17,521$1.53M+17,521Timeline
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC17,391$1.52M<0.01%-110,16913F-HRTimelineGroup
Headlands Technologies LLC17,079$1.49M0.12%new13F-HRTimeline
AMALGAMATED BANK17,063$1.49M0.01%+23713F-HRTimeline
ROYCE & ASSOCIATES LP16,989$1.48M0.02%013F-HRTimeline
State of New Jersey Common Pension Fund…in group State of New Jersey Common Pe…16,987$1.48M0.01%-20,96913F-HRTimelineGroup
Bellevue Group AGin group Bellevue Group AG16,543$1.44M0.03%-4,03813F-HRTimelineGroup
Pathstone Holdings, LLCin group Pathstone Holdings, LLC16,441$1.44M0.01%+3,07913F-HRTimelineGroup
STATE BOARD OF ADMINISTRATION OF FLORID…16,303$1.42M<0.01%013F-HRTimeline
STRS OHIO15,900$1.39M0.01%-1,90013F-HRTimeline
Police & Firemen's Retirement System of…15,834$1.38M0.01%-28513F-HRTimeline
YOUSIF CAPITAL MANAGEMENT, LLC16,281$1.36M0.01%-2,14513F-HRTimeline
ENVESTNET ASSET MANAGEMENT INCin group ENVESTNET ASSET MANAGEMENT INC14,673$1.28M<0.01%-9,58513F-HRTimelineGroup
COMMONWEALTH OF PENNSYLVANIA PUBLIC SCH…14,548$1.27M0.01%-34513F-HRTimeline
ProShare Advisors LLC14,084$1.23M<0.01%+89713F-HRTimeline
ARIZONA STATE RETIREMENT SYSTEM14,025$1.22M0.01%-64413F-HRTimeline
China Universal Asset Management Co., L…13,787$1.2M0.09%-2,11813F-HRTimeline
Erste Asset Management GmbHin group Erste Asset Management GmbH13,500$1.19M0.01%013F-HRTimelineGroup
OREGON PUBLIC EMPLOYEES RETIREMENT FUND13,393$1.17M0.01%+19313F-HRTimeline
Connor, Clark & Lunn Investment Managem…13,270$1.16M<0.01%new13F-HRTimeline
COMERICA BANK13,005$1.14M<0.01%-3,39013F-HRTimeline
Allianz Asset Management GmbHin group Allianz SE13,000$1.14M<0.01%-6,67813F-HRTimelineGroup
Jain Global LLC12,850$1.12M0.01%-2,00013F-HRTimeline
GLENMEDE TRUST CO NAin group GLENMEDE TRUST CO NA12,755$1.11M0.01%13F-HRTimelineGroup
HUSSMAN STRATEGIC ADVISORS, INC.12,600$1.1M0.27%-8,40013F-HRTimeline
SUSQUEHANNA INTERNATIONAL GROUP, LLPin group SUSQUEHANNA INTERNATIONAL GRO…11,762$1.03M<0.01%-51,42613F-HRTimelineGroup
WINTON GROUP Ltdin group WINTON GROUP Ltd11,471$1M0.03%-7,09013F-HRTimelineGroup
FRANKLIN STREET ADVISORS INC /NC11,300$987K0.06%013F-HRTimeline
KLP KAPITALFORVALTNING AS10,600$926K<0.01%+20013F-HRTimeline
Cache Advisors, LLC10,143$886K0.11%013F-HRTimeline
Zurcher Kantonalbank (Zurich Cantonalba…10,073$880K<0.01%013F-HRTimeline
DYMON ASIA CAPITAL (SINGAPORE) PTE. LTD.in group DYMON ASIA CAPITAL (SINGAPORE…10,000$873K0.19%new13F-HRTimelineGroup
Cerity Partners LLCin group Cerity Partners LLC9,049$790K<0.01%+43113F-HRTimelineGroup
FORA Capital, LLC9,130$788K0.1%+5,44513F-HRTimeline
Maryland State Retirement & Pension Sys…8,603$751K0.02%+19613F-HRTimeline
AlphaCentric Advisors LLC8,549$747K0.74%13F-HRTimeline
BAMCO INC /NY/in group Baron Capital8,300$725K<0.01%new13F-HRTimelineGroup
RENAISSANCE TECHNOLOGIES LLC8,167$713K<0.01%new13F-HRTimeline
Seven Fleet Capital Management LP8,000$699K0.47%13F-HR/ATimeline
Persistent Asset Partners Ltd7,908$691K0.33%-3,87213F-HRTimeline
TUDOR INVESTMENT CORP ET AL7,718$674K<0.01%new13F-HRTimeline
Mariner, LLCin group Mariner, LLC7,620$666K<0.01%-5,93113F-HRTimelineGroup
Horizon Investments, LLC7,461$652K0.01%new13F-HRTimeline
TEACHER RETIREMENT SYSTEM OF TEXAS7,350$642K<0.01%-4,75613F-HRTimeline
HighTower Advisors, LLC7,127$622K<0.01%-1,48613F-HRTimeline
Cambria Investment Management, L.P.6,960$608K0.04%-3,98413F-HRTimeline
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC6,954$607K<0.01%-1,61613F-HRTimelineGroup
MUTUAL OF AMERICA CAPITAL MANAGEMENT LLCin group MUTUAL OF AMERICA CAPITAL MAN…6,716$587K0.01%+16513F-HRTimelineGroup
FOX RUN MANAGEMENT, L.L.C.6,654$581K0.09%+3,55113F-HRTimeline
Palumbo Wealth Management LLC6,340$554K0.14%+1,07213F-HRTimeline
PSP Research LLC6,121$535K0.47%13F-HRTimeline
PUBLIC EMPLOYEES RETIREMENT ASSOCIATION…6,001$524K<0.01%013F-HRTimeline
Caprock Group, LLC5,991$523K0.01%+18913F-HRTimeline
Fieldview Capital Management, LLC5,841$510K0.09%new13F-HRTimeline
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…5,723$500K<0.01%-20113F-HRTimelineGroup
AVIVA PLCin group AVIVA PLC5,609$490K<0.01%-2,18313F-HRTimelineGroup
DekaBank Deutsche Girozentrale15,800$489K<0.01%013F-HRTimeline
Kestra Advisory Services, LLCin group Kestra Advisory Services, LLC5,142$449K<0.01%-8113F-HRTimelineGroup
ALGERT GLOBAL LLC5,090$445K0.01%new13F-HR/ATimeline
ARROWSTREET CAPITAL, LIMITED PARTNERSHIPin group ARROWSTREET CAPITAL, LIMITED …5,076$443K<0.01%new13F-HRTimelineGroup
Jefferies Financial Group Inc.in group Jefferies Financial Group Inc.5,000$437K<0.01%-816,50313F-HRTimelineGroup
Taconic Capital Advisors LPin group Taconic Capital Advisors LP5,000$437K0.16%new13F-HRTimelineGroupThe filing omitted confidential holdings, a later amendment may add them.
Quantinno Capital Management LP4,948$432K<0.01%+90113F-HRTimeline
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…4,725$413K0.01%-13813F-HRTimelineGroup
Advisors Asset Management, Inc.4,704$411K0.01%-213F-HR/ATimeline
Cornerstone Investment Partners, LLC4,634$405K0.02%+213F-HRTimeline