FMR LLC in group FMR LLC More: the full row for FMR LLC 5,970,638 $235M 0.01% +1,426,450 13F-HR Timeline Group Fairmount Funds Management LLC in group Fairmount Funds Management LLC More: the full row for Fairmount Funds Management LLC 3,307,191 $130M 11.71% +600,000 13F-HR Timeline Group Avidity Partners Management LP More: the full row for Avidity Partners Management LP 3,204,184 $126M 28.7% +1,461,282 13F-HR Timeline RA CAPITAL MANAGEMENT, L.P. in group RA CAPITAL MANAGEMENT, L.P. More: the full row for RA CAPITAL MANAGEMENT, L.P. 2,866,733 $113M 1.39% 0 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 2,577,662 $101M 0.02% +2,503,311 13F-HR Timeline Group Octagon Capital Advisors LP More: the full row for Octagon Capital Advisors LP 2,416,667 $95.1M 14.84% +75,000 13F-HR Timeline Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 2,041,960 $80.4M 0.17% +649,443 13F-HR Timeline Group TCG Crossover Management, LLC More: the full row for TCG Crossover Management, LLC 1,676,624 $66M 3.25% +175,000 13F-HR Timeline VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 1,642,198 $64.6M <0.01% +196,117 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 1,340,091 $52.7M <0.01% -18,690 13F-HR Timeline Group Bain Capital Life Sciences Investors, L… in group Bain Capital Life Sciences In… More: the full row for Bain Capital Life Sciences Investors, LLC 1,315,892 $51.8M 3.44% -1,166,358 13F-HR Timeline Group Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 1,180,000 $46.4M 2.11% -2,020,000 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 1,013,501 $39.9M 0.03% +348,457 13F-HR Timeline Group Venrock Adviser, LLC More: the full row for Venrock Adviser, LLC 960,803 $37.8M 2.13% -39,197 13F-HR Timeline ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 852,384 $33.5M 0.01% -322,438 13F-HR Timeline BRAIDWELL LP More: the full row for BRAIDWELL LP 835,057 $32.9M 0.97% new 13F-HR Timeline BAKER BROS. ADVISORS LP in group BAKER BROS. ADVISORS LP More: the full row for BAKER BROS. ADVISORS LP 789,759 $31.1M 0.22% 0 13F-HR Timeline Group Polar Capital Holdings Plc in group Polar Capital Holdings Plc More: the full row for Polar Capital Holdings Plc 748,003 $29.4M 0.14% new 13F-HR Timeline Group SILVERARC CAPITAL MANAGEMENT, LLC in group SILVERARC CAPITAL MANAGEMENT,… More: the full row for SILVERARC CAPITAL MANAGEMENT, LLC 674,966 $26.6M 3.85% +579,160 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 671,048 $26.4M <0.01% -149,089 13F-HR Timeline Group Catalio Capital Management, LP More: the full row for Catalio Capital Management, LP 667,615 $26.3M 4.86% -78,912 13F-HR Timeline Sio Capital Management, LLC More: the full row for Sio Capital Management, LLC 577,750 $22.7M 5.75% +341,680 13F-HR Timeline MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 572,938 $22.5M 0.02% new 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 536,415 $21.1M <0.01% +51,515 13F-HR Timeline Group FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 450,311 $17.7M <0.01% new 13F-HR Timeline Group Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 443,703 $17.5M 0.04% new 13F-HR Timeline Group Nantahala Capital Management, LLC in group Nantahala Capital Management,… More: the full row for Nantahala Capital Management, LLC 375,000 $14.8M 0.91% new 13F-HR Timeline Group 5AM Venture Management, LLC More: the full row for 5AM Venture Management, LLC 365,053 $14.4M 5.26% -619,672 13F-HR Timeline Vivo Capital, LLC More: the full row for Vivo Capital, LLC 353,998 $13.9M 1.12% new 13F-HR Timeline Ikarian Capital, LLC in group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 346,001 $13.6M 2.75% new 13F-HR Timeline Group Candriam S.C.A. More: the full row for Candriam S.C.A. 301,428 $11.9M 0.06% +60,852 13F-HR Timeline GREAT POINT PARTNERS LLC More: the full row for GREAT POINT PARTNERS LLC 265,803 $10.5M 4.37% new 13F-HR Timeline TANG CAPITAL MANAGEMENT LLC in group TANG CAPITAL MANAGEMENT LLC More: the full row for TANG CAPITAL MANAGEMENT LLC 264,692 $10.4M 0.4% 0 13F-HR Timeline Group Affinity Asset Advisors, LLC More: the full row for Affinity Asset Advisors, LLC 262,100 $10.3M 0.96% new 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 218,771 $8.61M <0.01% -145,821 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 216,135 $8.51M <0.01% +205,443 13F-HR Timeline Alphabet Inc. in group Alphabet Inc. More: the full row for Alphabet Inc. 208,697 $8.21M 0.34% 0 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 204,369 $8.04M <0.01% +139,548 13F-HR/A Timeline Group Logos Global Management LP More: the full row for Logos Global Management LP 200,000 $7.87M 0.78% new 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 193,059 $7.6M <0.01% +28,746 13F-HR Timeline Group Tri Locum Partners LP More: the full row for Tri Locum Partners LP 182,867 $7.2M 1.65% new 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 180,025 $7.08M <0.01% +14,900 13F-HR/A Timeline Group Rhenman & Partners Asset Management AB More: the full row for Rhenman & Partners Asset Management AB 173,627 $6.83M 0.76% +47,000 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 157,531 $6.2M <0.01% -2,784 13F-HR Timeline Group Integral Health Asset Management, LLC More: the full row for Integral Health Asset Management, LLC 150,000 $5.9M 0.43% new 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 146,166 $5.75M <0.01% -49,191 13F-HR Timeline Group Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 141,129 $5.55M 0.05% +114,996 13F-HR Timeline Group BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 138,963 $5.47M 0.14% new 13F-HR Timeline Caption Management, LLC More: the full row for Caption Management, LLC 138,561 $5.45M 0.32% new 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 137,073 $5.39M <0.01% +5,592 13F-HR Timeline Group Ensign Peak Advisors, Inc More: the full row for Ensign Peak Advisors, Inc 134,416 $5.29M 0.01% 0 13F-HR/A Timeline Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 128,253 $5.05M 0.04% -43,786 13F-HR Timeline Patient Square Capital LP More: the full row for Patient Square Capital LP 125,000 $4.92M 1.32% new 13F-HR Timeline Artia Global Partners LP More: the full row for Artia Global Partners LP 108,723 $4.28M 0.75% new 13F-HR/A Timeline AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 103,755 $4.08M <0.01% +47,494 13F-HR Timeline Group Informed Momentum Co LLC More: the full row for Informed Momentum Co LLC 86,337 $3.34M 0.38% new 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 77,520 $3.05M <0.01% -60,329 13F-HR/A Timeline Group ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 77,000 $3.03M <0.01% -108,000 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 68,479 $2.69M <0.01% +56,809 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 68,124 $2.68M <0.01% +58,746 13F-HR/A Timeline Group PFM Health Sciences, LP More: the full row for PFM Health Sciences, LP 67,840 $2.67M 0.23% new 13F-HR Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 62,430 $2.46M <0.01% -4,282 13F-HR Timeline Group AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 62,321 $2.45M <0.01% +8,181 13F-HR Timeline Group Atom Investors LP More: the full row for Atom Investors LP 61,038 $2.4M 0.18% new 13F-HR Timeline HighVista Strategies LLC More: the full row for HighVista Strategies LLC 54,225 $2.13M 0.52% +38,364 13F-HR Timeline FRED ALGER MANAGEMENT, LLC in group FRED ALGER MANAGEMENT, LLC More: the full row for FRED ALGER MANAGEMENT, LLC 45,304 $1.78M 0.01% new 13F-HR Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 44,929 $1.77M <0.01% +23,989 13F-HR Timeline Group Moody Aldrich Partners LLC More: the full row for Moody Aldrich Partners LLC 43,291 $1.7M 0.32% -29,975 13F-HR Timeline Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 43,241 $1.7M <0.01% -4,452 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 42,698 $1.68M 0.01% -357,806 13F-HR Timeline STEMPOINT CAPITAL LP More: the full row for STEMPOINT CAPITAL LP 41,382 $1.63M 0.33% new 13F-HR Timeline PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 37,221 $1.46M <0.01% +121 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 34,593 $1.36M <0.01% -14,938 13F-HR Timeline Group D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 31,614 $1.24M <0.01% new 13F-HR Timeline Group TD Asset Management Inc More: the full row for TD Asset Management Inc 27,658 $1.09M <0.01% new 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 26,003 $1.02M <0.01% -5,498 13F-HR Timeline ACUTA CAPITAL PARTNERS, LLC More: the full row for ACUTA CAPITAL PARTNERS, LLC 25,000 $984K 1.02% new 13F-HR Timeline Longaeva Partners L.P. More: the full row for Longaeva Partners L.P. 25,000 $984K 0.21% new 13F-HR Timeline VOLORIDGE INVESTMENT MANAGEMENT, LLC More: the full row for VOLORIDGE INVESTMENT MANAGEMENT, LLC 21,868 $861K <0.01% new 13F-HR Timeline ArrowMark Colorado Holdings LLC More: the full row for ArrowMark Colorado Holdings LLC 20,788 $818K 0.02% 0 13F-HR Timeline Engineers Gate Manager LP More: the full row for Engineers Gate Manager LP 20,379 $802K 0.01% new 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 18,782 $739K <0.01% new 13F-HR Timeline Group Y-Intercept (Hong Kong) Ltd More: the full row for Y-Intercept (Hong Kong) Ltd 18,568 $731K 0.02% new 13F-HR Timeline Rafferty Asset Management, LLC More: the full row for Rafferty Asset Management, LLC 17,331 $682K <0.01% -11,191 13F-HR Timeline BESSEMER GROUP INC in group BESSEMER GROUP INC More: the full row for BESSEMER GROUP INC 16,134 $635K <0.01% +1,170 13F-HR Timeline Group BLAIR WILLIAM & CO/IL More: the full row for BLAIR WILLIAM & CO/IL 15,875 $625K <0.01% new 13F-HR Timeline Universal- Beteiligungs- und Serviceges… in group Universal- Beteiligungs- und … More: the full row for Universal- Beteiligungs- und Servicegesellschaft mbH 15,734 $619K <0.01% new 13F-HR Timeline Group ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 15,631 $615K <0.01% -1,735 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 14,488 $570K <0.01% 0 13F-HR Timeline Group SEI INVESTMENTS CO in group SEI INVESTMENTS CO More: the full row for SEI INVESTMENTS CO 14,275 $562K <0.01% new 13F-HR Timeline Group Quadrature Capital Ltd in group Quadrature Capital Ltd More: the full row for Quadrature Capital Ltd 13,939 $548K 0.01% new 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 12,383 $487K <0.01% +57 13F-HR Timeline Group OMERS ADMINISTRATION Corp More: the full row for OMERS ADMINISTRATION Corp 12,100 $476K <0.01% new 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 12,061 $475K <0.01% -18,006 13F-HR Timeline Group Brevan Howard Capital Management LP in group Brevan Howard Capital Managem… More: the full row for Brevan Howard Capital Management LP 11,930 $469K 0.01% new 13F-HR Timeline Group RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 11,245 $442K <0.01% +9,815 13F-HR Timeline Group Jain Global LLC More: the full row for Jain Global LLC 11,124 $438K 0.01% new 13F-HR Timeline MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 9,613 $378K <0.01% -4,480 13F-HR Timeline Group SCS Capital Management LLC More: the full row for SCS Capital Management LLC 9,375 $369K <0.01% new 13F-HR Timeline DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 8,689 $342K <0.01% new 13F-HR Timeline Group MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. in group Mirae Asset Global Investment… More: the full row for MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 8,405 $331K <0.01% -3,686 13F-HR Timeline Group STATE OF WISCONSIN INVESTMENT BOARD More: the full row for STATE OF WISCONSIN INVESTMENT BOARD 7,248 $285K <0.01% -10,761 13F-HR Timeline RBF Capital, LLC More: the full row for RBF Capital, LLC 7,000 $275K 0.01% new 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 6,900 $272K <0.01% +2,800 13F-HR Timeline STATE BOARD OF ADMINISTRATION OF FLORID… More: the full row for STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 6,900 $272K <0.01% new 13F-HR Timeline Palumbo Wealth Management LLC More: the full row for Palumbo Wealth Management LLC 6,650 $262K 0.08% new 13F-HR Timeline SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 6,313 $248K 0.01% +6,207 13F-HR Timeline Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 5,899 $232K 0.07% +1,024 13F-HR Timeline Group ENVESTNET ASSET MANAGEMENT INC in group ENVESTNET ASSET MANAGEMENT INC More: the full row for ENVESTNET ASSET MANAGEMENT INC 5,882 $231K <0.01% new 13F-HR Timeline Group Ethic Inc. More: the full row for Ethic Inc. 5,530 $218K <0.01% new 13F-HR Timeline Glenmede Investment Management, LP More: the full row for Glenmede Investment Management, LP 5,415 $213K <0.01% new 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 4,716 $186K <0.01% +486 13F-HR Timeline Point72 Asia (Singapore) Pte. Ltd. More: the full row for Point72 Asia (Singapore) Pte. Ltd. 3,004 $118K 0.02% +1,990 13F-HR Timeline Point72 (DIFC) Ltd More: the full row for Point72 (DIFC) Ltd 2,901 $114K 0.01% -6,012 13F-HR Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 1,618 $63.7K <0.01% new 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 1,470 $59K <0.01% -2,591 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 1,497 $58.9K <0.01% -332 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 1,443 $56.8K <0.01% -2,877 13F-HR Timeline Group US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 1,398 $55K <0.01% -43 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 1,373 $54K <0.01% -969 13F-HR Timeline Group AlphaQuest LLC More: the full row for AlphaQuest LLC 1,331 $52.4K <0.01% -3,697 13F-HR Timeline CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 1,220 $48K <0.01% +1 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 1,039 $40.9K <0.01% +553 13F-HR Timeline Parkside Financial Bank & Trust More: the full row for Parkside Financial Bank & Trust 950 $37.4K <0.01% +540 13F-HR Timeline AMALGAMATED BANK More: the full row for AMALGAMATED BANK 532 $21K <0.01% -295 13F-HR Timeline Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 490 $19.3K <0.01% new 13F-HR Timeline CROWLEY WEALTH MANAGEMENT, INC. More: the full row for CROWLEY WEALTH MANAGEMENT, INC. 221 $8.7K 0.01% 0 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 195 $7.67K <0.01% +69 13F-HR Timeline Optiver Holding B.V. in group Optiver Holding B.V. More: the full row for Optiver Holding B.V. 134 $5.27K <0.01% new 13F-HR Timeline Group Arax Advisory Partners More: the full row for Arax Advisory Partners 53 $2.09K <0.01% new 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 61 $2K <0.01% +46 13F-HR Timeline Group NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 50 $1.97K <0.01% 0 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 26 $1.02K <0.01% new 13F-HR Timeline Group OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 21 $717 <0.01% +14 13F-HR Timeline Group ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 15 $590 <0.01% 0 13F-HR Timeline PRINCIPAL SECURITIES, INC. in group PRINCIPAL FINANCIAL GROUP INC More: the full row for PRINCIPAL SECURITIES, INC. 11 $433 <0.01% 0 13F-HR Timeline Group MONTAG A & ASSOCIATES INC More: the full row for MONTAG A & ASSOCIATES INC 9 $355 <0.01% new 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 9 $355 <0.01% +1 13F-HR Timeline SIGNATUREFD, LLC More: the full row for SIGNATUREFD, LLC 8 $315 <0.01% 0 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 2 $79 <0.01% +1 13F-HR Timeline