FMR LLC in group FMR LLC More: the full row for FMR LLC 4,439,281 $96.8M 0.01% +36,133 13F-HR Timeline Group Avidity Partners Management LP More: the full row for Avidity Partners Management LP 2,873,000 $62.6M 6.24% -44,231 13F-HR Timeline Fairmount Funds Management LLC in group Fairmount Funds Management LLC More: the full row for Fairmount Funds Management LLC 2,700,691 $58.9M 5.85% 0 13F-HR Timeline Group Bain Capital Life Sciences Investors, L… in group Bain Capital Life Sciences In… More: the full row for Bain Capital Life Sciences Investors, LLC 2,689,707 $58.6M 6.9% -323,716 13F-HR Timeline Group Octagon Capital Advisors LP More: the full row for Octagon Capital Advisors LP 2,110,167 $46M 7.82% +363,500 13F-HR Timeline RA CAPITAL MANAGEMENT, L.P. in group RA CAPITAL MANAGEMENT, L.P. More: the full row for RA CAPITAL MANAGEMENT, L.P. 1,866,400 $40.7M 0.54% -466,600 13F-HR Timeline Group Venrock Adviser, LLC More: the full row for Venrock Adviser, LLC 1,744,373 $38M 2.61% 0 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 1,650,882 $36M <0.01% +6,063 13F-HR Timeline Group TCG Crossover Management, LLC More: the full row for TCG Crossover Management, LLC 1,501,624 $32.7M 3.2% new 13F-HR Timeline VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 1,274,638 $27.8M <0.01% -20,331 13F-HR Timeline Group BRAIDWELL LP More: the full row for BRAIDWELL LP 1,206,589 $26.3M 0.78% +712,902 13F-HR Timeline ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 1,159,776 $25.3M 0.01% +136,633 13F-HR Timeline JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 1,085,648 $23.6M 0.01% +136,314 13F-HR Timeline Group Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 1,075,000 $23.4M 1.39% +680,000 13F-HR Timeline 5AM Venture Management, LLC More: the full row for 5AM Venture Management, LLC 1,027,711 $22.4M 5.35% -203,908 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 818,843 $17.9M <0.01% -2,288 13F-HR Timeline Group Catalio Capital Management, LP More: the full row for Catalio Capital Management, LP 763,471 $16.6M 3.64% 13F-HR Timeline RTW INVESTMENTS, LP More: the full row for RTW INVESTMENTS, LP 666,667 $14.5M 0.22% 0 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 486,263 $10.6M <0.01% +1,142 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 422,038 $9.2M 0.01% +362,737 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 300,504 $6.55M 0.04% +50,000 13F-HR Timeline GREAT POINT PARTNERS LLC More: the full row for GREAT POINT PARTNERS LLC 275,000 $6M 2.83% 0 13F-HR Timeline TANG CAPITAL MANAGEMENT LLC in group TANG CAPITAL MANAGEMENT LLC More: the full row for TANG CAPITAL MANAGEMENT LLC 264,692 $5.77M 0.38% 0 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 245,523 $5.35M <0.01% +42,923 13F-HR Timeline Group Alphabet Inc. in group Alphabet Inc. More: the full row for Alphabet Inc. 208,697 $4.55M 0.26% 0 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 208,067 $4.54M <0.01% +127,461 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 193,600 $4.22M 0.01% -244,100 13F-HR Timeline Group ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 180,000 $3.92M 0.01% new 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 167,021 $3.64M <0.01% +1,092 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 116,049 $2.53M <0.01% +48,764 13F-HR/A Timeline Group Rhenman & Partners Asset Management AB More: the full row for Rhenman & Partners Asset Management AB 114,000 $2.49M 0.26% -36,000 13F-HR Timeline Ally Bridge Group (NY) LLC More: the full row for Ally Bridge Group (NY) LLC 106,434 $2.32M 1.99% new 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 90,436 $1.97M <0.01% +55,682 13F-HR Timeline Group Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 82,890 $1.81M 0.02% +52,890 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 78,173 $1.7M <0.01% -9,858 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 72,890 $1.59M <0.01% -125 13F-HR Timeline Group Nuveen Asset Management, LLC in group TIAA More: the full row for Nuveen Asset Management, LLC 65,851 $1.44M <0.01% 0 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 60,337 $1.32M <0.01% +6,552 13F-HR Timeline Group Cubist Systematic Strategies, LLC More: the full row for Cubist Systematic Strategies, LLC 54,766 $1.19M 0.02% +4,518 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 53,861 $1.17M <0.01% +25,433 13F-HR Timeline Group AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 43,996 $959K <0.01% +1,629 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 42,766 $932K <0.01% +1,082 13F-HR/A Timeline Group PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 37,100 $809K <0.01% 0 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 35,933 $783K <0.01% +1,316 13F-HR/A Timeline HighVista Strategies LLC More: the full row for HighVista Strategies LLC 31,387 $684K 0.25% +11,579 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 30,542 $666K <0.01% +13,148 13F-HR Timeline Group Rafferty Asset Management, LLC More: the full row for Rafferty Asset Management, LLC 28,459 $620K <0.01% -2,188 13F-HR Timeline Allostery Investments LP More: the full row for Allostery Investments LP 25,000 $545K 1.07% 13F-HR Timeline ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 23,932 $522K <0.01% +1,635 13F-HR Timeline Group ArrowMark Colorado Holdings LLC More: the full row for ArrowMark Colorado Holdings LLC 20,788 $453K 0.01% 0 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 20,011 $436K <0.01% +7,179 13F-HR/A Timeline Group ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 17,683 $385K 0.08% -101,055 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 16,522 $360K <0.01% new 13F-HR Timeline Group BESSEMER GROUP INC in group BESSEMER GROUP INC More: the full row for BESSEMER GROUP INC 14,829 $323K <0.01% 0 13F-HR Timeline Group MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. in group Mirae Asset Global Investment… More: the full row for MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 14,716 $320K <0.01% +352 13F-HR Timeline Group Swiss National Bank More: the full row for Swiss National Bank 14,400 $314K <0.01% -2,900 13F-HR Timeline MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 14,372 $313K <0.01% +433 13F-HR Timeline Group Point72 (DIFC) Ltd More: the full row for Point72 (DIFC) Ltd 14,013 $305K 0.03% +1,539 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 13,818 $301K <0.01% -8,271 13F-HR Timeline Group STATE OF WISCONSIN INVESTMENT BOARD More: the full row for STATE OF WISCONSIN INVESTMENT BOARD 13,026 $284K <0.01% +4,370 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 12,319 $269K <0.01% +2,363 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 12,129 $264K <0.01% +1,490 13F-HR Timeline Group Corebridge Financial, Inc. in group Corebridge Financial, Inc. More: the full row for Corebridge Financial, Inc. 11,883 $259K <0.01% -897 13F-HR Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 11,521 $251K <0.01% +790 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 11,081 $242K <0.01% -4,082 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 10,601 $231K <0.01% -588 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 10,036 $220K <0.01% -18,895 13F-HR Timeline Group NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 9,700 $211K <0.01% 0 13F-HR/A Timeline SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 9,653 $210K <0.01% +814 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 9,468 $207K <0.01% +1,647 13F-HR Timeline INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 9,243 $201K <0.01% new 13F-HR Timeline CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 8,055 $176K <0.01% -1,352 13F-HR/A Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 5,765 $126K <0.01% 13F-HR Timeline AlphaQuest LLC More: the full row for AlphaQuest LLC 4,197 $91.5K 0.01% +3,072 13F-HR Timeline VIRTUS ADVISERS, LLC in group Virtus Investment Advisers, L… More: the full row for VIRTUS ADVISERS, LLC 3,025 $65.9K 0.03% -397 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 2,695 $58.8K <0.01% new 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 2,342 $51.1K <0.01% 0 13F-HR Timeline Group KBC Group NV in group KBC Group NV More: the full row for KBC Group NV 1,593 $35K <0.01% new 13F-HR Timeline Group KLP KAPITALFORVALTNING AS More: the full row for KLP KAPITALFORVALTNING AS 1,500 $32.7K <0.01% 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 1,379 $30.1K <0.01% -944 13F-HR Timeline Group R Squared Ltd More: the full row for R Squared Ltd 1,200 $26.2K 0.03% 13F-HR Timeline AMALGAMATED BANK More: the full row for AMALGAMATED BANK 827 $18K <0.01% 0 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 711 $15.5K <0.01% +633 13F-HR Timeline Parkside Financial Bank & Trust More: the full row for Parkside Financial Bank & Trust 385 $8.39K <0.01% 0 13F-HR Timeline CROWLEY WEALTH MANAGEMENT, INC. More: the full row for CROWLEY WEALTH MANAGEMENT, INC. 221 $4.82K <0.01% 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 124 $2.7K <0.01% +118 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 75 $1.64K <0.01% +10 13F-HR Timeline Group Arax Advisory Partners More: the full row for Arax Advisory Partners 32 $698 <0.01% new 13F-HR Timeline Lindbrook Capital, LLC More: the full row for Lindbrook Capital, LLC 21 $458 <0.01% +4 13F-HR Timeline NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 18 $392 <0.01% -55 13F-HR Timeline Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 13 $283 <0.01% 13F-HR/A Timeline IFP Advisors, Inc More: the full row for IFP Advisors, Inc 0 $262 <0.01% new 13F-HR Timeline Amount filed as zero, left out of ratios. ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 10 $218 <0.01% -10 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 7 $153 <0.01% 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 7 $152 <0.01% -3,105 13F-HR/A Timeline Group CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 9 $0 0% +4 13F-HR Timeline Group Value filed as zero, left out of ratios. CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.