FMR LLC in group FMR LLC More: the full row for FMR LLC 4,482,609 $81.3M 0.01% +43,328 13F-HR Timeline Group RA CAPITAL MANAGEMENT, L.P. in group RA CAPITAL MANAGEMENT, L.P. More: the full row for RA CAPITAL MANAGEMENT, L.P. 2,866,733 $52M 0.87% +1,000,333 13F-HR Timeline Group Fairmount Funds Management LLC in group Fairmount Funds Management LLC More: the full row for Fairmount Funds Management LLC 2,700,691 $49M 7.6% 0 13F-HR Timeline Group Bain Capital Life Sciences Investors, L… in group Bain Capital Life Sciences In… More: the full row for Bain Capital Life Sciences Investors, LLC 2,689,707 $48.8M 7.22% 0 13F-HR Timeline Group Deep Track Capital, LP More: the full row for Deep Track Capital, LP 2,357,702 $42.8M 1.38% new 13F-HR Timeline Octagon Capital Advisors LP More: the full row for Octagon Capital Advisors LP 2,341,667 $42.5M 8.36% +231,500 13F-HR/A Timeline Venrock Adviser, LLC More: the full row for Venrock Adviser, LLC 1,744,373 $31.6M 2.69% 0 13F-HR Timeline Avidity Partners Management LP More: the full row for Avidity Partners Management LP 1,720,902 $31.2M 6.44% -1,152,098 13F-HR Timeline Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 1,700,069 $30.8M 2.2% +625,069 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 1,615,801 $29.3M <0.01% -35,081 13F-HR Timeline Group TCG Crossover Management, LLC More: the full row for TCG Crossover Management, LLC 1,501,624 $27.2M 3.72% 0 13F-HR Timeline Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 1,486,944 $27M 0.08% +1,293,344 13F-HR/A Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 1,108,875 $20.1M <0.01% -165,763 13F-HR Timeline Group 5AM Venture Management, LLC More: the full row for 5AM Venture Management, LLC 1,027,711 $18.6M 7.05% 0 13F-HR Timeline ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 1,025,622 $18.6M 0.01% -134,154 13F-HR Timeline Catalio Capital Management, LP More: the full row for Catalio Capital Management, LP 763,471 $13.8M 3.43% 0 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 759,679 $13.8M <0.01% -59,164 13F-HR Timeline Group JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 683,616 $13.7M 0.01% -402,032 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 517,018 $9.38M <0.01% +30,755 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 470,880 $8.54M 0.01% +48,842 13F-HR Timeline Group BRAIDWELL LP More: the full row for BRAIDWELL LP 375,355 $6.81M 0.24% -831,234 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 300,504 $5.45M 0.04% 0 13F-HR Timeline GREAT POINT PARTNERS LLC More: the full row for GREAT POINT PARTNERS LLC 275,000 $4.99M 2.71% 0 13F-HR Timeline TANG CAPITAL MANAGEMENT LLC in group TANG CAPITAL MANAGEMENT LLC More: the full row for TANG CAPITAL MANAGEMENT LLC 264,692 $4.8M 0.27% 0 13F-HR Timeline Group Candriam S.C.A. More: the full row for Candriam S.C.A. 248,610 $4.51M 0.03% new 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 235,533 $4.27M <0.01% -9,990 13F-HR Timeline Group Alphabet Inc. in group Alphabet Inc. More: the full row for Alphabet Inc. 208,697 $3.79M 0.24% 0 13F-HR Timeline Group SILVERARC CAPITAL MANAGEMENT, LLC in group SILVERARC CAPITAL MANAGEMENT,… More: the full row for SILVERARC CAPITAL MANAGEMENT, LLC 190,334 $3.45M 0.72% new 13F-HR Timeline Group ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 189,000 $3.43M 0.01% +9,000 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 168,102 $3.05M <0.01% +1,081 13F-HR/A Timeline Group Rhenman & Partners Asset Management AB More: the full row for Rhenman & Partners Asset Management AB 126,627 $2.3M 0.26% +12,627 13F-HR Timeline Sio Capital Management, LLC More: the full row for Sio Capital Management, LLC 116,997 $2.12M 0.64% new 13F-HR Timeline Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 106,931 $1.94M 0.02% +24,041 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 93,287 $1.69M <0.01% +15,114 13F-HR Timeline Group Ally Bridge Group (NY) LLC More: the full row for Ally Bridge Group (NY) LLC 80,584 $1.46M 1.32% -25,850 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 79,168 $1.44M <0.01% -36,881 13F-HR Timeline Group Hudson Bay Capital Management LP in group Hudson Bay Capital Management… More: the full row for Hudson Bay Capital Management LP 75,000 $1.36M 0.01% new 13F-HR Timeline Group Moody Aldrich Partners LLC More: the full row for Moody Aldrich Partners LLC 74,372 $1.35M 0.28% new 13F-HR Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 73,638 $1.34M <0.01% +748 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 73,430 $1.33M <0.01% -134,637 13F-HR/A Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 67,982 $1.23M <0.01% +7,645 13F-HR Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 64,381 $1.17M <0.01% 13F-HR Timeline Group AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 47,817 $867K <0.01% +3,821 13F-HR Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 47,429 $860K <0.01% -6,432 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 47,378 $859K <0.01% +30,856 13F-HR Timeline Group PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 37,100 $673K <0.01% 0 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 35,045 $636K <0.01% -888 13F-HR/A Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 34,820 $632K <0.01% +4,278 13F-HR Timeline Group HighVista Strategies LLC More: the full row for HighVista Strategies LLC 31,387 $569K 0.22% 0 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 31,141 $565K <0.01% -11,625 13F-HR/A Timeline Group Rafferty Asset Management, LLC More: the full row for Rafferty Asset Management, LLC 23,872 $433K <0.01% -4,587 13F-HR Timeline ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 23,684 $430K <0.01% -248 13F-HR Timeline Group Cubist Systematic Strategies, LLC More: the full row for Cubist Systematic Strategies, LLC 21,818 $396K 0.01% -32,948 13F-HR Timeline ArrowMark Colorado Holdings LLC More: the full row for ArrowMark Colorado Holdings LLC 20,788 $377K 0.01% 0 13F-HR Timeline ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 18,285 $332K 0.06% +602 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 17,896 $325K <0.01% -2,115 13F-HR Timeline Group Point72 (DIFC) Ltd More: the full row for Point72 (DIFC) Ltd 16,748 $304K 0.03% +2,735 13F-HR Timeline Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 15,978 $290K <0.01% +4,457 13F-HR Timeline Group MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. in group Mirae Asset Global Investment… More: the full row for MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 15,334 $280K <0.01% +618 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 15,379 $279K <0.01% +1,561 13F-HR Timeline Group BESSEMER GROUP INC in group BESSEMER GROUP INC More: the full row for BESSEMER GROUP INC 14,829 $269K <0.01% 0 13F-HR Timeline Group MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 14,093 $256K <0.01% -279 13F-HR Timeline Group INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 12,969 $235K <0.01% +3,726 13F-HR Timeline STATE OF WISCONSIN INVESTMENT BOARD More: the full row for STATE OF WISCONSIN INVESTMENT BOARD 12,680 $230K <0.01% -346 13F-HR Timeline Corebridge Financial, Inc. in group Corebridge Financial, Inc. More: the full row for Corebridge Financial, Inc. 11,709 $212K <0.01% -174 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 11,683 $212K <0.01% -446 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 10,985 $199K <0.01% -96 13F-HR/A Timeline Group HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 10,997 $199K <0.01% new 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 10,491 $191K <0.01% +1,023 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 9,700 $176K <0.01% 0 13F-HR/A Timeline SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 7,101 $129K <0.01% -2,552 13F-HR Timeline Virtus Investment Advisers, LLC group of 2 filers holding More: the full row for Virtus Investment Advisers, LLC 6,986 $127K +3,961 Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 5,765 $105K <0.01% 0 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 4,784 $86K <0.01% -5,252 13F-HR/A Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 3,891 $70.6K <0.01% -8,428 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 2,342 $42.5K <0.01% 0 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 1,732 $31.4K <0.01% -6,323 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 1,585 $28.8K <0.01% +1,510 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 1,358 $24.6K <0.01% -1,337 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 1,003 $18.2K <0.01% -376 13F-HR Timeline Group AMALGAMATED BANK More: the full row for AMALGAMATED BANK 827 $15K <0.01% 0 13F-HR Timeline PICTON MAHONEY ASSET MANAGEMENT More: the full row for PICTON MAHONEY ASSET MANAGEMENT 455 $8K <0.01% new 13F-HR Timeline Parkside Financial Bank & Trust More: the full row for Parkside Financial Bank & Trust 385 $6.98K <0.01% 0 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 384 $6.97K <0.01% -327 13F-HR Timeline CROWLEY WEALTH MANAGEMENT, INC. More: the full row for CROWLEY WEALTH MANAGEMENT, INC. 221 $4.01K <0.01% 0 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 214 $3.88K <0.01% +90 13F-HR/A Timeline SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 111 $2K <0.01% new 13F-HR Timeline NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 90 $1.63K <0.01% +72 13F-HR Timeline ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 45 $816 <0.01% +35 13F-HR Timeline Arax Advisory Partners More: the full row for Arax Advisory Partners 32 $581 <0.01% 0 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 27 $574 <0.01% new 13F-HR Timeline TD PRIVATE CLIENT WEALTH LLC More: the full row for TD PRIVATE CLIENT WEALTH LLC 17 $308 <0.01% new 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 13 $236 <0.01% new 13F-HR Timeline Group IFP Advisors, Inc More: the full row for IFP Advisors, Inc 0 $218 <0.01% 0 13F-HR Timeline Amount filed as zero, left out of ratios. CoreCap Advisors, LLC More: the full row for CoreCap Advisors, LLC 11 $200 <0.01% new 13F-HR Timeline CREATIVE FINANCIAL DESIGNS INC /ADV More: the full row for CREATIVE FINANCIAL DESIGNS INC /ADV 10 $181 <0.01% new 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 7 $126 <0.01% 0 13F-HR Timeline Group SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 1 $18 <0.01% -6 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 17 $0 0% +8 13F-HR Timeline Group Value filed as zero, left out of ratios. CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.