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Ikarian Capital, LLC

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13F filer, CIK 1778253, DALLAS, TX

Ikarian Capital, LLC reported $811,473,237 across 160 holdings for the quarter ended 2025-03-31, in a 13F-HR filed 2025-05-15. Its ten largest share positions make up 39.15% of the portfolio.

Filed (acceptance time not in the bulk data set), ingested 13F-HR 0001420506-25-001276

Period
2025-03-31
Reported value
$811M
Holdings
160
Top 10 weight
39.15%
New
59
Sold out
70

Part of the filer group Ikarian Capital, LLC

  • Neil Shahrestani
How groups are built

Stakes and trades reported after 2025-03-31

13D, 13G and Form 4 filings by this filer's group, dated after the 13F period, on securities the quarter does not hold as shares.

  • QNRX QUOIN PHARMACEUTICALS LTD: 13G/A 211,538 shares, 4.4% of the class, 13G/A filed 2026-10-07, 0001778253-26-000004Timeline
    Accepted , ingested

Largest buys vs the previous quarter

SecurityShares changeApprox. value
SPYnew+25,000$14M
AKROnew+245,000$9.92M
SRPTadded+135,000$8.62M
ALNYnew+31,594$8.53M
PCVXnew+200,000$7.55M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

SecurityShares changeApprox. value
SYREexited-282,159-$6.57M
TARSreduced-122,668-$6.3M
AVTXreduced-770,259-$6.17M
BLUEPRINT MEDICINES CORPreduced-55,470-$4.91M
BBIOreduced-124,876-$4.32M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q1 2025

Share positions as resolved from 13F-HR 0001420506-25-001276, largest first. % of portfolio is the value over $306,936,404, the sum of the share positions whose value is usable for ratios (method).

SecurityHistorySharesValue% of portfolioChangeLatest eventTimeline
TARSTARSUS PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,030,277 shares; 2024Q4: 607,689 shares; 2025Q1: 485,021 shares 485,021$24.9M8.12%-122,668Timeline
CRNXCRINETICS PHARMACEUTICALS INQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 426,913 shares; 2024Q4: 516,431 shares; 2025Q1: 523,431 shares 523,431$17.6M5.72%+7,000Timeline
SPYSTATE STR SPDR S&P 500 ETF TQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 25,000 shares 25,000$14M4.56%newTimeline
SRPTSAREPTA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 54,176 shares; 2024Q4: 34,087 shares; 2025Q1: 169,087 shares 169,087$10.8M3.52%+135,000Timeline
BLUEPRINT MEDICINES CORPBLUEPRINT MEDICINES CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 85,000 shares; 2024Q4: 169,374 shares; 2025Q1: 113,904 shares 113,904$10.1M3.28%-55,470
AKROAKERO THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 245,000 shares 245,000$9.92M3.23%newTimeline
ALNYALNYLAM PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 8,741 shares; 2024Q4: not reported; 2025Q1: 31,594 shares 31,594$8.53M2.78%newTimeline
TGTXTG THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 291,240 shares; 2025Q1: 210,065 shares 210,065$8.28M2.7%-81,175Timeline
VERONA PHARMA PLCVERONA PHARMA PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 80,000 shares; 2025Q1: 130,000 shares 130,000$8.25M2.69%+50,000
RAREULTRAGENYX PHARMACEUTICAL INQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 179,000 shares; 2024Q4: 178,989 shares; 2025Q1: 216,989 shares 216,989$7.86M2.56%+38,000Timeline
SRRKSCHOLAR ROCK HLDG CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 357,185 shares; 2025Q1: 244,179 shares 244,179$7.85M2.56%-113,006Timeline
PCVXVAXCYTE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 200,000 shares 200,000$7.55M2.46%newTimeline
VIRVIR BIOTECHNOLOGY INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 897,862 shares; 2025Q1: 1,068,062 shares 1,068,062$6.92M2.25%+170,200Timeline
VRDNVIRIDIAN THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 499,977 shares; 2024Q4: 469,949 shares; 2025Q1: 494,949 shares 494,949$6.67M2.17%+25,000Timeline
INSMINSMED INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 154,835 shares; 2024Q4: 119,800 shares; 2025Q1: 84,800 shares 84,800$6.47M2.11%-35,000Timeline
EWTXEDGEWISE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 280,000 shares 280,000$6.16M2.01%newTimeline
CPRXCATALYST PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 417,850 shares; 2024Q4: 349,649 shares; 2025Q1: 249,649 shares 249,649$6.05M1.97%-100,000Timeline
CYTKCYTOKINETICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 170,147 shares; 2024Q4: 149,982 shares; 2025Q1: 149,982 shares 149,982$6.03M1.96%0Timeline
ELVNENLIVEN THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 499,566 shares; 2024Q4: 394,538 shares; 2025Q1: 289,538 shares 289,538$5.7M1.86%-105,000Timeline
PRAXPRAXIS PRECISION MEDICINES IQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 145,502 shares 145,502$5.51M1.8%newTimeline
CDTXCIDARA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 53,940 shares; 2025Q1: 248,940 shares 248,940$5.36M1.75%+195,000Timeline
ACOGALPHA COGNITION INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 755,867 shares; 2025Q1: 967,867 shares 967,867$5.11M1.66%+212,000Timeline
TECXTECTONIC THERAPEUTIC INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 267,145 shares; 2024Q4: 142,328 shares; 2025Q1: 269,090 shares 269,090$4.77M1.55%+126,762Timeline
FBRXFORTE BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 609,225 shares; 2025Q1: 609,225 shares 609,225$4.73M1.54%0Timeline
GPCRSTRUCTURE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 115,200 shares; 2024Q4: 284,085 shares; 2025Q1: 264,085 shares 264,085$4.57M1.49%-20,000Timeline
MTSRMETSERA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 150,000 shares 150,000$4.08M1.33%newTimeline
STIMNEURONETICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 1,100,000 shares 1,100,000$4.05M1.32%newTimeline
DYNDYNE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 358,837 shares 358,837$3.75M1.22%newTimeline
TRVITREVI THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 325,000 shares; 2025Q1: 575,000 shares 575,000$3.62M1.18%+250,000Timeline
MAZEMAZE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 322,740 shares 322,740$3.55M1.16%newTimeline
JANXJANUX THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 74,691 shares; 2025Q1: 129,691 shares 129,691$3.5M1.14%+55,000Timeline
ELDNELEDON PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 1,126,637 shares; 2025Q1: 1,025,221 shares 1,025,221$3.48M1.13%-101,416Timeline
BBIOBRIDGEBIO PHARMA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 285,613 shares; 2024Q4: 215,713 shares; 2025Q1: 90,837 shares 90,837$3.14M1.02%-124,876Timeline
CPIXCUMBERLAND PHARMACEUTICALS IQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 740,000 shares 740,000$3.13M1.02%newTimeline
KROSKEROS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 274,009 shares 274,009$2.79M0.91%newTimeline
ABEOABEONA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 583,593 shares; 2024Q4: 533,581 shares; 2025Q1: 533,581 shares 533,581$2.54M0.83%0Timeline
HELPCYBIN INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 367,195 shares; 2024Q4: 397,175 shares; 2025Q1: 397,175 shares 397,175$2.52M0.82%0Timeline
IBIOIBIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 600,000 shares; 2024Q4: 599,913 shares; 2025Q1: 599,913 shares 599,913$2.41M0.79%0Timeline
DRUGBRIGHT MINDS BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 152,211 shares; 2025Q1: 65,431 shares 65,431$2.36M0.77%-86,780Timeline
EOLSEVOLUS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 258,279 shares; 2024Q4: 373,265 shares; 2025Q1: 193,265 shares 193,265$2.32M0.76%-180,000Timeline
RLAYRELAY THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 693,350 shares; 2024Q4: 693,308 shares; 2025Q1: 743,308 shares 743,308$1.95M0.63%+50,000Timeline
LXEOLEXEO THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 257,216 shares; 2024Q4: 499,301 shares; 2025Q1: 550,029 shares 550,029$1.91M0.62%+50,728Timeline
ARCTARCTURUS THERAPEUTICS HLDGSQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 200,000 shares; 2025Q1: 175,000 shares 175,000$1.85M0.6%-25,000Timeline
KODKODIAK SCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 476,586 shares; 2024Q4: 576,166 shares; 2025Q1: 649,534 shares 649,534$1.82M0.59%+73,368Timeline
ORKAORUKA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 175,000 shares 175,000$1.8M0.58%newTimeline
APLSAPELLIS PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 3,594 shares; 2025Q1: 75,000 shares 75,000$1.64M0.53%+71,406Timeline
VERVE THERAPEUTICS INCVERVE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 170,000 shares; 2024Q4: 169,991 shares; 2025Q1: 358,393 shares 358,393$1.64M0.53%+188,402
ARVNARVINAS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 229,900 shares 229,900$1.61M0.53%newTimeline
AVTXAVALO THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 970,359 shares; 2024Q4: 970,259 shares; 2025Q1: 200,000 shares 200,000$1.6M0.52%-770,259Timeline
VTGNVISTAGEN THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 77,616 shares; 2025Q1: 601,703 shares 601,703$1.5M0.49%+524,087Timeline
RCKTROCKET PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 197,096 shares; 2024Q4: 221,911 shares; 2025Q1: 221,911 shares 221,911$1.48M0.48%0Timeline
VTYXVENTYX BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 192,647 shares; 2024Q4: 1,092,590 shares; 2025Q1: 1,217,590 shares 1,217,590$1.4M0.46%+125,000Timeline
RCUSARCUS BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 744,000 shares; 2024Q4: 378,363 shares; 2025Q1: 163,363 shares 163,363$1.28M0.42%-215,000Timeline
DCTHDELCATH SYS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 100,370 shares; 2024Q4: 100,365 shares; 2025Q1: 100,365 shares 100,365$1.28M0.42%0Timeline
SGMOQSANGAMO THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 1,860,179 shares; 2025Q1: 1,860,179 shares 1,860,179$1.22M0.4%0Timeline
VKTXVIKING THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 50,000 shares 50,000$1.21M0.39%newTimeline
TDOCTELADOC HEALTH INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 150,000 shares 150,000$1.19M0.39%newTimeline
ALECALECTOR INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 950,000 shares; 2025Q1: 950,000 shares 950,000$1.17M0.38%0Timeline
OKURONKURE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 253,754 shares; 2025Q1: 253,754 shares 253,754$1.09M0.36%0Timeline
NUVBNUVATION BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 83,282 shares; 2024Q4: 83,407 shares; 2025Q1: 619,258 shares 619,258$1.09M0.36%+535,851Timeline
NEKTAR THERAPEUTICSNEKTAR THERAPEUTICSQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,312,405 shares; 2024Q4: 2,029,028 shares; 2025Q1: 1,579,528 shares 1,579,528$1.07M0.35%-449,500
Tourmaline Bio IncTourmaline Bio IncQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 108,483 shares; 2024Q4: 67,927 shares; 2025Q1: 67,927 shares 67,927$1.03M0.34%0
IMUXIMMUNIC INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 493,496 shares; 2024Q4: 1,614,170 shares; 2025Q1: 914,170 shares 914,170$996K0.32%-700,000Timeline
TERNTERNS PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 308,497 shares; 2024Q4: 308,491 shares; 2025Q1: 308,491 shares 308,491$851K0.28%0Timeline
SLDBSOLID BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 230,000 shares 230,000$851K0.28%newTimeline
89BIO INC89BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 100,000 shares 100,000$727K0.24%new
OLMAOLEMA PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 92,000 shares; 2024Q4: 91,994 shares; 2025Q1: 191,994 shares 191,994$722K0.24%+100,000Timeline
Veru IncVeru IncQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 946,382 shares; 2024Q4: 945,239 shares; 2025Q1: 1,425,239 shares 1,425,239$699K0.23%+480,000
LXRXLEXICON PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 1,550,000 shares; 2025Q1: 1,417,952 shares 1,417,952$653K0.21%-132,048Timeline
GLUEMONTE ROSA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 311,593 shares; 2024Q4: 311,575 shares; 2025Q1: 136,575 shares 136,575$634K0.21%-175,000Timeline
CHANNEL THERAPEUTICS CORPORACHANNEL THERAPEUTICS CORPORAQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 440,849 shares 440,849$626K0.2%new
PYXSPYXIS ONCOLOGY INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 957,408 shares; 2024Q4: 613,253 shares; 2025Q1: 613,253 shares 613,253$601K0.2%0Timeline
INBXINHIBRX BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 42,123 shares; 2024Q4: 42,122 shares; 2025Q1: 42,122 shares 42,122$589K0.19%0Timeline
FULCFULCRUM THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 75,000 shares; 2024Q4: 200,096 shares; 2025Q1: 200,096 shares 200,096$576K0.19%0Timeline
SPRINGWORKS THERAPEUTICS INCSPRINGWORKS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 37,519 shares; 2025Q1: 12,519 shares 12,519$552K0.18%-25,000
KZRKEZAR LIFE SCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 106,901 shares; 2025Q1: 106,901 shares 106,901$522K0.17%0Timeline
BIOMX INCBIOMX INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 893,000 shares; 2024Q4: 892,976 shares; 2025Q1: 892,976 shares 892,976$496K0.16%0
LYELL IMMUNOPHARMA INCLYELL IMMUNOPHARMA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 526,066 shares; 2024Q4: 1,276,037 shares; 2025Q1: 876,037 shares 876,037$471K0.15%-400,000
ITEOS THERAPEUTICS INCITEOS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 78,574 shares; 2024Q4: 78,585 shares; 2025Q1: 78,585 shares 78,585$469K0.15%0
VIGIL NEUROSCIENCE INCVIGIL NEUROSCIENCE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 500,000 shares; 2025Q1: 250,000 shares 250,000$445K0.14%-250,000
Aethlon Medical Inc OLDAethlon Medical Inc OLDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 750,000 shares; 2025Q1: 1,229,285 shares 1,229,285$440K0.14%+479,285
ANROALTO NEUROSCIENCE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 350,000 shares; 2025Q1: 175,000 shares 175,000$378K0.12%-175,000Timeline
MIND MEDICINE MINDMED INCMIND MEDICINE MINDMED INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 62,481 shares; 2024Q4: 62,691 shares; 2025Q1: 62,691 shares 62,691$367K0.12%0
THRDTHIRD HARMONIC BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 100,000 shares; 2025Q1: 100,000 shares 100,000$347K0.11%0Timeline
DNAGINKGO BIOWORKS HOLDINGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 58,300 shares 58,300$332K0.11%newTimeline
TYRATYRA BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 60,000 shares; 2025Q1: 35,000 shares 35,000$326K0.11%-25,000Timeline
ABOSACUMEN PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 266,435 shares; 2024Q4: 265,769 shares; 2025Q1: 265,769 shares 265,769$292K0.1%0Timeline
RNACCARTESIAN THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 52,193 shares; 2024Q4: 52,166 shares; 2025Q1: 22,166 shares 22,166$292K0.1%-30,000Timeline
SPRUCE BIOSCIENCES INCSPRUCE BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 1,000,000 shares; 2025Q1: 1,000,000 shares 1,000,000$290K0.09%0
ALLAKOS INCALLAKOS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 972,675 shares; 2024Q4: 971,950 shares; 2025Q1: 1,171,950 shares 1,171,950$267K0.09%+200,000
GERNGERON CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 150,000 shares 150,000$238K0.08%newTimeline
CHEMOMAB THERAPEUTICS LTDCHEMOMAB THERAPEUTICS LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 213,392 shares; 2024Q4: 213,052 shares; 2025Q1: 213,052 shares 213,052$232K0.08%0
ACRSACLARIS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 350,000 shares; 2025Q1: 150,900 shares 150,900$231K0.08%-199,100Timeline
MNPRMONOPAR THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 5,908 shares; 2025Q1: 5,908 shares 5,908$215K0.07%0Timeline
CLYMCLIMB BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 175,100 shares; 2024Q4: 175,088 shares; 2025Q1: 175,088 shares 175,088$214K0.07%0Timeline
PEPGPEPGEN INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 150,000 shares 150,000$211K0.07%newTimeline
ANEBANEBULO PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 157,862 shares; 2024Q4: 157,720 shares; 2025Q1: 157,720 shares 157,720$205K0.07%0Timeline
VYGRVOYAGER THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 55,857 shares; 2024Q4: 55,766 shares; 2025Q1: 55,766 shares 55,766$188K0.06%0Timeline
ELEVATION ONCOLOGY INC COMELEVATION ONCOLOGY INC COMQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 690,089 shares; 2024Q4: 690,050 shares; 2025Q1: 690,050 shares 690,050$179K0.06%0
SENSEI BIOTHERAPEUTICS INCSENSEI BIOTHERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 650,000 shares; 2024Q4: 649,963 shares; 2025Q1: 449,963 shares 449,963$177K0.06%-200,000
EVAXEVAXION ASQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 80,000 shares 80,000$148K0.05%newTimeline
RZLTREZOLUTE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 887,230 shares; 2024Q4: 857,230 shares; 2025Q1: 50,058 shares 50,058$145K0.05%-807,172Timeline
LYRA THERAPEUTICS INCLYRA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,056,829 shares; 2024Q4: 1,058,148 shares; 2025Q1: 1,058,148 shares 1,058,148$134K0.04%0
TOVXTHERIVA BIOLOGICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 120,031 shares 120,031$132K0.04%newTimeline
LRMRLARIMAR THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 58,528 shares; 2024Q4: 58,526 shares; 2025Q1: 58,526 shares 58,526$126K0.04%0Timeline
JSPRJASPER THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 55,175 shares; 2024Q4: 55,107 shares; 2025Q1: 25,107 shares 25,107$108K0.04%-30,000Timeline
KPTIKARYOPHARM THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 27,257 shares 27,257$102K0.03%newTimeline
MGNXMACROGENICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 80,079 shares; 2024Q4: 80,071 shares; 2025Q1: 80,071 shares 80,071$102K0.03%0Timeline
TKNOALPHA TEKNOVA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 14,008 shares 14,008$72.7K0.02%newTimeline
TRAWTRAWS PHARMA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 98,493 shares; 2025Q1: 28,493 shares 28,493$65.5K0.02%-70,000Timeline
HOOKHOOKIPA PHARMA INC COM NEWQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 53,076 shares; 2024Q4: 52,996 shares; 2025Q1: 52,996 shares 52,996$57.2K0.02%0Timeline
SGMTSAGIMET BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 387,565 shares; 2024Q4: 11,984 shares; 2025Q1: 11,984 shares 11,984$39.1K0.01%0Timeline
AMIXAUTONOMIX MED INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 20,000 shares; 2025Q1: 20,000 shares 20,000$35K0.01%0Timeline
SYBXSYNLOGIC INC COM NEWQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 20,448 shares; 2024Q4: 20,422 shares; 2025Q1: 20,422 shares 20,422$25.3K0.01%0Timeline
NMRANEUMORA THERAPEUTICS INC.Quarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 15,457 shares 15,457$15.5K0.01%newTimeline
RLMDRELMADA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 40,369 shares; 2024Q4: 40,270 shares; 2025Q1: 40,270 shares 40,270$10.9K<0.01%0Timeline

Options

Puts and calls, as filed. The amount and value describe the underlying shares, not the option premium, so they stay out of % of portfolio (H5).

SecurityTypeAmountValueChange
SPYSTATE STR SPDR S&P 500 ETF T SHSput320,000$179Mnew
LLYELI LILLY & CO COMput150,000$124Mnew
CORTCORCEPT THERAPEUTICS INC COMput287,900$32.9Mnew
BBIOBRIDGEBIO PHARMA INC COMcall655,400$22.7M-44,600
SLNOSOLENO THERAPEUTICS INC COMcall243,000$17.4Mnew
CORTCORCEPT THERAPEUTICS INC COMcall100,000$11.4Mnew
RNAMAVIDITY BIOSCIENCES INC Stockput300,000$8.86M-100,000
BHVNBIOHAVEN LTD COMcall348,200$8.37Mnew
TRUPTRUPANION INC COMcall200,000$7.45Mnew
ACLXARCELLX INC Stockput111,600$7.32Mnew
SLNOSOLENO THERAPEUTICS INC COMput100,000$7.14M+25,000
IMVTIMMUNOVANT INC COMput400,000$6.84Mnew
KYMRKYMERA THERAPEUTICS INC COMput176,800$4.84Mnew
PTGXPROTAGONIST THERAPEUTICS INC COMput100,000$4.84Mnew
PTGXPROTAGONIST THERAPEUTICS INC COMcall100,000$4.84Mnew
RAREULTRAGENYX PHARMACEUTICAL IN COMcall113,100$4.1Mnew
CAPRCAPRICOR THERAPEUTICS INC COMMON STOCKcall400,000$3.8M+38,900
MLTXMOONLAKE IMMUNOTHERAPEUTICS Stockput94,500$3.69Mnew
MLTXMOONLAKE IMMUNOTHERAPEUTICS Stockcall94,500$3.69Mnew
INCYINCYTE CORP Stockcall60,400$3.66Mnew
VKTXVIKING THERAPEUTICS INC COMcall150,000$3.62Mnew
RAREULTRAGENYX PHARMACEUTICAL IN COMput100,000$3.62Mnew
SRRKSCHOLAR ROCK HLDG CORP COMcall100,000$3.21M-2,100
QUREUNIQURE NV SHScall300,000$3.18Mnew
TEVATEVA PHARMACEUTICAL INDS LTD ADRcall200,000$3.07M+100,000
KYMRKYMERA THERAPEUTICS INC COMcall100,000$2.74Mnew
APGEAPOGEE THERAPEUTICS INC Stockput70,700$2.64Mnew
DYNDYNE THERAPEUTICS INC Stockcall187,000$1.96Mnew
ARCTARCTURUS THERAPEUTICS HLDGS COMcall150,000$1.59Mnew
HROWHARROW INC COMcall58,300$1.55M0
TRUPTRUPANION INC COMput40,000$1.49Mnew
CMPXCOMPASS THERAPEUTICS INC COMput662,200$1.26Mnew
CMPXCOMPASS THERAPEUTICS INC COMcall662,200$1.26Mnew
PRTAPROTHENA CORP PLC Stockcall100,000$1.24Mnew
ALTALTIMMUNE INC COM NEWput240,000$1.2M+74,300
CRVSCORVUS PHARMACEUTICALS INC COMcall338,100$1.08M-416,300
IMUXIMMUNIC INC COMcall635,800$693K0
IRONDISC MEDICINE INC Stockcall11,900$591Knew
MLYSMINERALYS THERAPEUTICS INC COMcall34,300$545Knew
CELCCELCUITY INC COMput39,900$403Knew
CLDXCELLDEX THERAPEUTICS INC NEW COM NEWput17,800$323K-187,700
CLDXCELLDEX THERAPEUTICS INC NEW COM NEWcall17,800$323Knew
CRVSCORVUS PHARMACEUTICALS INC COMput50,000$159K-450,000
CELCCELCUITY INC COMcall14,900$151Knew

Sold out in Q1 2025

Positions in the previous quarter's report that this quarter's report no longer lists.

SecurityShares beforeValue beforeType
XBISPDR SERIES TRUST750,000$67.5Mput
XBISPDR SERIES TRUST700,000$63Mcall
TSNTYSON FOODS INC630,000$36.2Mput
AMGNAMGEN INC74,000$19.3Mcall
PPCPILGRIMS PRIDE CORP300,000$13.6Mput
INSMINSMED INC150,000$10.4Mcall
SRPTSAREPTA THERAPEUTICS INC81,000$9.85Mcall
NMRANEUMORA THERAPEUTICS INC.900,000$9.54Mcall
AXSMAXSOME THERAPEUTICS INC.100,000$8.46Mcall
CALMCAL MAINE FOODS INC75,000$7.72Mput
DNAGINKGO BIOWORKS HOLDINGS INC769,700$7.56Mcall
IMVTIMMUNOVANT INC300,000$7.43Mcall
DYNDYNE THERAPEUTICS INC280,800$6.62Mput
SYRESPYRE THERAPEUTICS INC282,159$6.57Mshares
AKROAKERO THERAPEUTICS INC199,000$5.54Mput
ONCBEONE MEDICINES LTD29,800$5.5Mcall
VIRVIR BIOTECHNOLOGY INC720,300$5.29Mcall
LENZLENZ THERAPEUTICS INC149,502$4.32Mshares
MRNAMODERNA INC100,000$4.16Mput
CAPRCAPRICOR THERAPEUTICS INC300,000$4.14Mput
ANABANAPTYSBIO INC310,800$4.11Mput
MLYSMINERALYS THERAPEUTICS INC332,390$4.09Mshares
NUVLNUVALENT INC52,216$4.09Mshares
NMRANEUMORA THERAPEUTICS INC.350,000$3.71Mput
VRDNVIRIDIAN THERAPEUTICS INC175,100$3.36Mcall
ANABANAPTYSBIO INC250,000$3.31Mcall
RNAMAVIDITY BIOSCIENCES INC100,000$2.91Mcall
PTGXPROTAGONIST THERAPEUTICS INC70,000$2.7Mshares
ALGSALIGOS THERAPEUTICS INC64,300$2.56Mshares
ZVRAZEVRA THERAPEUTICS INC292,772$2.44Mshares
XENEXENON PHARMACEUTICALS INC62,052$2.43Mshares
NVAXNOVAVAX INC300,000$2.41Mcall
ACELYRIN INCACELYRIN INC676,608$2.12Mshares
RCUSARCUS BIOSCIENCES INC141,000$2.1Mcall
CRDFCARDIFF ONCOLOGY INC450,000$1.95Mshares
TARAPROTARA THERAPEUTICS INC350,489$1.85Mshares
BMEABIOMEA FUSION INC431,100$1.67Mput
ACHILLES THERAPEUTICS PL-ADRACHILLES THERAPEUTICS PL-ADR1,441,141$1.64Mshares
GALTGALECTIN THERAPEUTICS INC1,200,000$1.55Mput
GALTGALECTIN THERAPEUTICS INC1,200,000$1.55Mcall
SLDBSOLID BIOSCIENCES INC300,000$1.2Mcall
ALTALTIMMUNE INC165,700$1.19Mcall
MISTMILESTONE PHARMACEUTICALS IN466,030$1.1Mshares
SANASANA BIOTECHNOLOGY INC650,000$1.06Mcall
SANASANA BIOTECHNOLOGY INC500,000$815Kput
CMPSCOMPASS PATHWAYS PLC202,894$767Kshares
AMLXAMYLYX PHARMACEUTICALS INC201,187$760Kshares
NRIXNURIX THERAPEUTICS INC34,985$659Kshares
CRBPCORBUS PHARMACEUTICALS HLDGS51,431$607Kshares
SANASANA BIOTECHNOLOGY INC365,000$595Kshares
TVTXTRAVERE THERAPEUTICS INC22,600$394Kshares
ABEOABEONA THERAPEUTICS INC65,000$362Kcall
CATXPERSPECTIVE THERAPEUTICS INC108,300$345Kshares
CATXPERSPECTIVE THERAPEUTICS INC107,200$342Kput
ATXIAVENUE THERAPEUTICS INC COM PA140,000$280Kshares
KARYOPHARM THERAPEUTICS INCKARYOPHARM THERAPEUTICS INC408,899$277Kshares
QUOIN PHARMACEUTICALS ADRQUOIN PHARMACEUTICALS ADR275,000$179Kshares
AEON BIOPHARMA INCAEON BIOPHARMA INC257,563$139Kshares
Tempest Therapeutics, Inc.Tempest Therapeutics, Inc.105,285$87.9Kshares
STOKSTOKE THERAPEUTICS INC6,798$75Kshares
CADLCANDEL THERAPEUTICS INC3,600$31.2Kput
CADLCANDEL THERAPEUTICS INC3,600$31.2Kcall
IMVTIMMUNOVANT INC600$14.9Kshares
BCLIBRAINSTORM CELL THERAPEUTICS I6,016$13.7Kshares
CADLCANDEL THERAPEUTICS INC1,400$12.2Kshares
CTMXCYTOMX THERAPEUTICS INC.8,924$9.19Kshares
EWTXEDGEWISE THERAPEUTICS INC200$5.34Kput
GLYCOMIMETICS INCGLYCOMIMETICS INC6,501$1.62Kshares
FDMT4D MOLECULAR THERAPEUTICS IN40$223shares
GALTGALECTIN THERAPEUTICS INC100$129shares

How Q1 2025 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

FilingRoleAmendmentFiledAcceptedIngested
13F-HR 0001420506-25-001276 base2025-05-15acceptance time not in the bulk data set