13F-HR filed by Ikarian Capital, LLC
Ikarian Capital, LLC filed this 13F-HR for the quarter ended 2025-03-31, filed 2025-05-15, with 160 holding rows worth $811,473,237.
- Accession
- 0001420506-25-001276
- Filer
- CIK 1778253
- Filed
- 2025-05-15
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q1 2025
A holdings report, 160 entries on the cover page, a total value of $811,473,237 stated on the cover page (in dollars after the unit check, H1), rows summing to $811,473,237 with VALUE read as dollars as filed, 13F file number 028-19721. The quarter's positions are built on this report. The resolved quarter.
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| SPY | 78462F103 | SHS | 320,000 | $179,004,800 | dollars as filed | put |
| Eli Lilly and Company | 532457108 | COM | 150,000 | $123,886,500 | dollars as filed | put |
| CORCEPT THERAPEUTICS INC | 218352102 | COM | 287,900 | $32,883,938 | dollars as filed | put |
| TARSUS PHARMACEUTICALS INC | 87650L103 | COMMON STOCK | 485,021 | $24,915,528 | dollars as filed | |
| BRIDGEBIO PHARMA INC | 10806X102 | COM | 655,400 | $22,657,178 | dollars as filed | call |
| CRINETICS PHARMACEUTICALS INC COM | 22663K107 | Stock | 523,431 | $17,555,875 | dollars as filed | |
| SOLENO THERAPEUTICS INC | 834203309 | COM | 243,000 | $17,362,350 | dollars as filed | call |
| SPY | 78462F103 | SHS | 25,000 | $13,984,750 | dollars as filed | |
| CORCEPT THERAPEUTICS INC | 218352102 | COM | 100,000 | $11,422,000 | dollars as filed | call |
| SAREPTA THERAPEUTICS INC | 803607100 | COM | 169,087 | $10,791,133 | dollars as filed | |
| BLUEPRINT MEDICINES CORP | 09627Y109 | COM | 113,904 | $10,081,644 | dollars as filed | |
| AKERO THERAPEUTICS INC | 00973Y108 | COM | 245,000 | $9,917,600 | dollars as filed | |
| AVIDITY BIOSCIENCES INC COM | 05370A108 | Stock | 300,000 | $8,856,000 | dollars as filed | put |
| ALNYLAM PHARMACEUTICALS INC COM | 02043Q107 | Stock | 31,594 | $8,531,012 | dollars as filed | |
| BIOHAVEN LTD | G1110E107 | COM | 348,200 | $8,370,728 | dollars as filed | call |
| TG THERAPEUTICS INC COM | 88322Q108 | Stock | 210,065 | $8,282,864 | dollars as filed | |
| VERONA PHARMA PLC | 925050106 | SPONSORED ADS | 130,000 | $8,253,700 | dollars as filed | |
| ULTRAGENYX PHARMACEUTICAL IN | 90400D108 | COM | 216,989 | $7,857,172 | dollars as filed | |
| SCHOLAR ROCK HLDG CORP | 80706P103 | COM | 244,179 | $7,850,355 | dollars as filed | |
| VAXCYTE INC COM | 92243G108 | Stock | 200,000 | $7,552,000 | dollars as filed | |
| TRUPANION INC | 898202106 | COM | 200,000 | $7,454,000 | dollars as filed | call |
| ARCELLX INC COMMON STOCK | 03940C100 | Stock | 111,600 | $7,320,960 | dollars as filed | put |
| SOLENO THERAPEUTICS INC | 834203309 | COM | 100,000 | $7,145,000 | dollars as filed | put |
| VIR BIOTECHNOLOGY INC | 92764N102 | COM | 1,068,062 | $6,921,041 | dollars as filed | |
| IMMUNOVANT INC | 45258J102 | COM | 400,000 | $6,836,000 | dollars as filed | put |
| VIRIDIAN THERAPEUTICS INC | 92790C104 | COM | 494,949 | $6,671,912 | dollars as filed | |
| INSMED INC COM PAR $.01 | 457669307 | Stock | 84,800 | $6,469,392 | dollars as filed | |
| EDGEWISE THERAPEUTICS INC | 28036F105 | COM | 280,000 | $6,160,000 | dollars as filed | |
| CATALYST PHARMACEUTICALS INC | 14888U101 | COM | 249,649 | $6,053,989 | dollars as filed | |
| CYTOKINETICS INC | 23282W605 | COM NEW | 149,982 | $6,027,776 | dollars as filed | |
| ENLIVEN THERAPEUTICS INC COM | 29337E102 | Stock | 289,538 | $5,698,108 | dollars as filed | |
| PRAXIS PRECISION MEDICINES I | 74006W207 | COM NEW | 145,502 | $5,510,161 | dollars as filed | |
| CIDARA THERAPEUTICS INC | 171757206 | COM NEW | 248,940 | $5,362,167 | dollars as filed | |
| ALPHA COGNITION INC | 02074J501 | COM NEW | 967,867 | $5,110,337 | dollars as filed | |
| KYMERA THERAPEUTICS INC | 501575104 | COM | 176,800 | $4,839,016 | dollars as filed | put |
| PROTAGONIST THERAPEUTICS | 74366E102 | COM | 100,000 | $4,836,000 | dollars as filed | put |
| PROTAGONIST THERAPEUTICS | 74366E102 | COM | 100,000 | $4,836,000 | dollars as filed | call |
| TECTONIC THERAPEUTIC INC | 878972108 | COMMON STOCK | 269,090 | $4,765,584 | dollars as filed | |
| FORTE BIOSCIENCES INC | 34962G208 | COMMON STOCK | 609,225 | $4,727,587 | dollars as filed | |
| STRUCTURE THERAPEUTICS INC COMP | 86366E106 | EQUITY | 264,085 | $4,571,311 | dollars as filed | |
| ULTRAGENYX PHARMACEUTICAL IN | 90400D108 | COM | 113,100 | $4,095,351 | dollars as filed | call |
| METSERA INC | 59267L107 | COM | 150,000 | $4,083,000 | dollars as filed | |
| NEURONETICS INC | 64131A105 | COM | 1,100,000 | $4,048,000 | dollars as filed | |
| CAPRICOR THERAPEUTICS INC | 14070B309 | COMMON STOCK | 400,000 | $3,796,000 | dollars as filed | call |
| DYNE THERAPEUTICS INC COM | 26818M108 | Stock | 358,837 | $3,753,434 | dollars as filed | |
| MOONLAKE IMMUNOTHERAPEUTICS CLASS A ORD | 61559X104 | Stock | 94,500 | $3,692,115 | dollars as filed | put |
| MOONLAKE IMMUNOTHERAPEUTICS CLASS A ORD | 61559X104 | Stock | 94,500 | $3,692,115 | dollars as filed | call |
| INCYTE CORP COM | 45337C102 | Stock | 60,400 | $3,657,220 | dollars as filed | call |
| VIKING THERAPEUTICS INC | 92686J106 | COM | 150,000 | $3,622,500 | dollars as filed | call |
| ULTRAGENYX PHARMACEUTICAL IN | 90400D108 | COM | 100,000 | $3,621,000 | dollars as filed | put |
| TREVI THERAPEUTICS INC COM | 89532M101 | Stock | 575,000 | $3,616,749 | dollars as filed | |
| MAZE THERAPEUTICS INC COM | 578784100 | Stock | 322,740 | $3,553,368 | dollars as filed | |
| JANUX THERAPEUTICS INC | 47103J105 | COM | 129,691 | $3,501,657 | dollars as filed | |
| ELEDON PHARMACEUTICALS INC | 28617k101 | COM | 1,025,221 | $3,475,499 | dollars as filed | |
| SCHOLAR ROCK HLDG CORP | 80706P103 | COM | 100,000 | $3,215,000 | dollars as filed | call |
| UNIQURE NV | N90064101 | SHS | 300,000 | $3,180,000 | dollars as filed | call |
| BRIDGEBIO PHARMA INC | 10806X102 | COM | 90,837 | $3,140,235 | dollars as filed | |
| CUMBERLAND PHARMACEUTICALS I | 230770109 | COM | 740,000 | $3,130,200 | dollars as filed | |
| TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS | 881624209 | ADR | 200,000 | $3,074,000 | dollars as filed | call |
| KEROS THERAPEUTICS INC COM | 492327101 | Stock | 274,009 | $2,792,152 | dollars as filed | |
| KYMERA THERAPEUTICS INC | 501575104 | COM | 100,000 | $2,737,000 | dollars as filed | call |
| APOGEE THERAPEUTICS INC COM | 03770N101 | Stock | 70,700 | $2,641,352 | dollars as filed | put |
| ABEONA THERAPEUTICS INC | 00289Y206 | COM NEW | 533,581 | $2,539,846 | dollars as filed | |
| CYBIN INC | 23256X407 | COM NEW | 397,175 | $2,518,090 | dollars as filed | |
| IBIO INC | 451033708 | CMN | 599,913 | $2,411,650 | dollars as filed | |
| BRIGHT MINDS BIOSCIENCES INC | 10919W405 | COMMON STOCK | 65,431 | $2,360,097 | dollars as filed | |
| EVOLUS INC | 30052C107 | COM | 193,265 | $2,324,979 | dollars as filed | |
| DYNE THERAPEUTICS INC COM | 26818M108 | Stock | 187,000 | $1,956,020 | dollars as filed | call |
| RELAY THERAPEUTICS INC COM | 75943R102 | Stock | 743,308 | $1,947,467 | dollars as filed | |
| LEXEO THERAPEUTICS INC | 52886X107 | COMMON STOCK | 550,029 | $1,908,601 | dollars as filed | |
| ARCTURUS THERAPEUTICS HLDGS | 03969T109 | COM | 175,000 | $1,853,249 | dollars as filed | |
| KODIAK SCIENCES INC | 50015M109 | COM | 649,534 | $1,821,942 | dollars as filed | |
| ORUKA THERAPEUTICS INC COM | 687604108 | Stock | 175,000 | $1,795,499 | dollars as filed | |
| APELLIS PHARMACEUTICALS INC | 03753U106 | COM | 75,000 | $1,640,250 | dollars as filed | |
| VERVE THERAPEUTICS INC | 92539P101 | COM | 358,393 | $1,637,857 | dollars as filed | |
| ARVINAS INC | 04335A105 | COM | 229,900 | $1,613,898 | dollars as filed | |
| AVALO THERAPEUTICS INC | 05338F306 | COMMON STOCK | 200,000 | $1,602,000 | dollars as filed | |
| ARCTURUS THERAPEUTICS HLDGS | 03969T109 | COM | 150,000 | $1,588,500 | dollars as filed | call |
| HARROW INC | 415858109 | COM | 58,300 | $1,550,780 | dollars as filed | call |
| VISTAGEN THERAPEUTICS INC | 92840H400 | COM | 601,703 | $1,504,259 | dollars as filed | |
| TRUPANION INC | 898202106 | COM | 40,000 | $1,490,800 | dollars as filed | put |
| ROCKET PHARMACEUTICALS INC | 77313F106 | COM | 221,911 | $1,480,146 | dollars as filed | |
| Ventyx Biosciences Inc | 92332V107 | Common Stock | 1,217,590 | $1,400,229 | dollars as filed | |
| ARCUS BIOSCIENCES INC | 03969F109 | COM | 163,363 | $1,282,400 | dollars as filed | |
| DELCATH SYSTEMS INC | 24661P807 | COMMON STOCK | 100,365 | $1,277,647 | dollars as filed | |
| COMPASS THERAPEUTICS INC | 20454B104 | COM | 662,200 | $1,258,180 | dollars as filed | put |
| COMPASS THERAPEUTICS INC | 20454B104 | COM | 662,200 | $1,258,180 | dollars as filed | call |
| PROTHENA CORP PLC SHS | G72800108 | Stock | 100,000 | $1,237,502 | dollars as filed | call |
| SANGAMO THERAPEUTICS INC | 800677106 | COM | 1,860,179 | $1,219,905 | dollars as filed | |
| VIKING THERAPEUTICS INC | 92686J106 | COM | 50,000 | $1,207,501 | dollars as filed | |
| ALTIMMUNE INC | 02155H200 | COM NEW | 240,000 | $1,200,000 | dollars as filed | put |
| TELADOC HEALTH INC | 87918A105 | COM | 150,000 | $1,194,000 | dollars as filed | |
| ALECTOR INC | 014442107 | COMMON STOCK | 950,000 | $1,168,500 | dollars as filed | |
| ONKURE THERAPEUTICS INC | 68277Q105 | COM CL A | 253,754 | $1,091,143 | dollars as filed | |
| NUVATION BIO INC COM CL A | 67080N101 | Stock | 619,258 | $1,089,894 | dollars as filed | |
| CORVUS PHARMACEUTICALS INC | 221015100 | COM | 338,100 | $1,075,158 | dollars as filed | call |
| NEKTAR THERAPEUTICS | 640268108 | COM | 1,579,528 | $1,074,079 | dollars as filed | |
| Tourmaline Bio Inc | 89157D105 | Common Stock | 67,927 | $1,033,171 | dollars as filed | |
| IMMUNIC INC | 4525EP101 | COM | 914,170 | $996,445 | dollars as filed | |
| TERNS PHARMACEUTICALS INC COM | 880881107 | Stock | 308,491 | $851,435 | dollars as filed | |
| SOLID BIOSCIENCES INC | 83422E204 | COMMON STOCK | 230,000 | $851,001 | dollars as filed | |
| 89BIO INC | 282559103 | COM | 100,000 | $727,001 | dollars as filed | |
| OLEMA PHARMACEUTICALS INC | 68062P106 | COM | 191,994 | $721,897 | dollars as filed | |
| Veru Inc | 92536C103 | Common Stock | 1,425,239 | $698,509 | dollars as filed | |
| IMMUNIC INC | 4525EP101 | COM | 635,800 | $693,022 | dollars as filed | call |
| LEXICON PHARMACEUTICALS INC | 528872302 | COMMON STOCK | 1,417,952 | $653,393 | dollars as filed | |
| MONTE ROSA THERAPEUTICS INC | 61225M102 | COM | 136,575 | $633,709 | dollars as filed | |
| CHANNEL THERAPEUTICS CORPORA | 171126105 | COM | 440,849 | $626,004 | dollars as filed | |
| PYXIS ONCOLOGY INC COMMON STOCK | 747324101 | Stock | 613,253 | $600,927 | dollars as filed | |
| DISC MEDICINE INC COM | 254604101 | Stock | 11,900 | $590,716 | dollars as filed | call |
| INHIBRX BIOSCIENCES INC | 45720N103 | COM | 42,122 | $589,287 | dollars as filed | |
| FULCRUM THERAPEUTICS INC | 359616109 | COMMON STOCK | 200,096 | $576,276 | dollars as filed | |
| SPRINGWORKS THERAPEUTICS INC | 85205L107 | COM | 12,519 | $552,464 | dollars as filed | |
| MINERALYS THERAPEUTICS INC | 603170101 | COM | 34,300 | $544,684 | dollars as filed | call |
| KEZAR LIFE SCIENCES INC | 49372L209 | COM NEW | 106,901 | $521,677 | dollars as filed | |
| BIOMX INC | 09090D301 | COM | 892,976 | $496,226 | dollars as filed | |
| LYELL IMMUNOPHARMA INC | 55083R104 | COM | 876,037 | $471,307 | dollars as filed | |
| ITEOS THERAPEUTICS INC | 46565G104 | COM | 78,585 | $469,152 | dollars as filed | |
| VIGIL NEUROSCIENCE INC | 92673K108 | COM | 250,000 | $445,001 | dollars as filed | |
| Aethlon Medical Inc OLD | 00808Y406 | COM NEW | 1,229,285 | $440,084 | dollars as filed | |
| CELCUITY INC | 15102K100 | COM | 39,900 | $403,389 | dollars as filed | put |
| ALTO NEUROSCIENCE INC COM SHS | 02157Q109 | Stock | 175,000 | $378,001 | dollars as filed | |
| MIND MEDICINE MINDMED INC | 60255C885 | COM NEW | 62,691 | $366,742 | dollars as filed | |
| THIRD HARMONIC BIO INC | 88427A107 | COM | 100,000 | $347,001 | dollars as filed | |
| GINKGO BIOWORKS HOLDINGS INC | 37611X209 | COMMON STOCK | 58,300 | $332,310 | dollars as filed | |
| TYRA BIOSCIENCES INC | 90240B106 | COMMON STOCK | 35,000 | $325,500 | dollars as filed | |
| CELLDEX THERAPEUTICS INC NEW | 15117B202 | COM NEW | 17,800 | $323,070 | dollars as filed | put |
| CELLDEX THERAPEUTICS INC NEW | 15117B202 | COM NEW | 17,800 | $323,070 | dollars as filed | call |
| ACUMEN PHARMACEUTICALS INC | 00509G209 | CMN | 265,769 | $292,345 | dollars as filed | |
| CARTESIAN THERAPEUTICS INC | 816212302 | COMMON STOCK | 22,166 | $292,149 | dollars as filed | |
| SPRUCE BIOSCIENCES INC | 85209E109 | COM | 1,000,000 | $290,100 | dollars as filed | |
| ALLAKOS INC | 01671P100 | COM | 1,171,950 | $266,736 | dollars as filed | |
| GERON CORP | 374163103 | COM | 150,000 | $238,500 | dollars as filed | |
| CHEMOMAB THERAPEUTICS LTD | 16385C104 | SPONSORED ADS | 213,052 | $232,226 | dollars as filed | |
| ACLARIS THERAPEUTICS INC COM | 00461U105 | Stock | 150,900 | $230,877 | dollars as filed | |
| MONOPAR THERAPEUTICS INC | 61023L207 | COMMON STOCK | 5,908 | $215,111 | dollars as filed | |
| CLIMB BIO INC | 28658R106 | COMMON STOCK | 175,088 | $213,608 | dollars as filed | |
| PEPGEN INC COM | 713317105 | Stock | 150,000 | $210,750 | dollars as filed | |
| ANEBULO PHARMACEUTICALS INC | 034569103 | COM | 157,720 | $205,036 | dollars as filed | |
| VOYAGER THERAPEUTICS INC | 92915B106 | COMMON STOCK | 55,766 | $188,489 | dollars as filed | |
| ELEVATION ONCOLOGY INC COM | 28623U101 | Stock | 690,050 | $178,792 | dollars as filed | |
| SENSEI BIOTHERAPEUTICS INC | 81728A108 | COM | 449,963 | $177,285 | dollars as filed | |
| CORVUS PHARMACEUTICALS INC | 221015100 | COM | 50,000 | $159,000 | dollars as filed | put |
| CELCUITY INC | 15102K100 | COM | 14,900 | $150,639 | dollars as filed | call |
| EVAXION AS | 29970R303 | SPONSORED ADS | 80,000 | $148,000 | dollars as filed | |
| REZOLUTE INC | 76200L309 | COMMON STOCK | 50,058 | $145,168 | dollars as filed | |
| LYRA THERAPEUTICS INC | 55234L105 | COM | 1,058,148 | $133,645 | dollars as filed | |
| THERIVA BIOLOGICS INC | 87164U508 | COM NEW | 120,031 | $132,034 | dollars as filed | |
| LARIMAR THERAPEUTICS INC | 517125100 | COM | 58,526 | $125,830 | dollars as filed | |
| JASPER THERAPEUTICS INC | 471871202 | COM NEW | 25,107 | $107,959 | dollars as filed | |
| KARYOPHARM THERAPEUTICS INC | 48576U205 | COMMON STOCK | 27,257 | $101,941 | dollars as filed | |
| MACROGENICS INC | 556099109 | COM | 80,071 | $101,691 | dollars as filed | |
| ALPHA TEKNOVA INC | 02080L102 | COMMON STOCK | 14,008 | $72,701 | dollars as filed | |
| TRAWS PHARMA INC | 68232V884 | COM NEW | 28,493 | $65,534 | dollars as filed | |
| HOOKIPA PHARMA INC | 43906K209 | COM NEW | 52,996 | $57,236 | dollars as filed | |
| SAGIMET BIOSCIENCES INC A | 786700104 | COMMON STOCK | 11,984 | $39,067 | dollars as filed | |
| AUTONOMIX MED INC | 05330T205 | COM NEW | 20,000 | $35,001 | dollars as filed | |
| SYNLOGIC INC | 87166L209 | COM | 20,422 | $25,323 | dollars as filed | |
| NEUMORA THERAPEUTICS INC. | 640979100 | COM | 15,457 | $15,457 | dollars as filed | |
| RELMADA THERAPEUTICS INC | 75955J402 | COMMON STOCK | 40,270 | $10,873 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001420506-25-001276 | this filing | 2025-05-15 | acceptance time not in the bulk data set |