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SILVERARC CAPITAL MANAGEMENT, LLC

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13F filer, CIK 1816307, BOSTON, MA

SILVERARC CAPITAL MANAGEMENT, LLC reported $979,812,415 across 73 holdings for the quarter ended 2026-03-31, in a 13F-HR filed 2026-05-14. Its ten largest share positions make up 48.96% of the portfolio.

Filed (acceptance time not in the bulk data set), ingested 13F-HR 0001420506-26-001011

Period
2026-03-31
Reported value
$980M
Holdings
73
Top 10 weight
48.96%
New
25
Sold out
20

Part of the filer group SILVERARC CAPITAL MANAGEMENT, LLC

How groups are built

Largest buys vs the previous quarter

SecurityShares changeApprox. value
ZBIOnew+1,135,935$22.2M
ASNDadded+75,430$17.3M
SRRKnew+339,613$16.7M
ALKSnew+460,314$16.3M
GLUEadded+972,974$16M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

SecurityShares changeApprox. value
ABVXreduced-119,663-$13.3M
CGONreduced-194,809-$13.2M
VRDNexited-348,569-$10.8M
PFEexited-419,134-$10.4M
AVTXexited-524,436-$9.52M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q1 2026

Share positions as resolved from 13F-HR 0001420506-26-001011, largest first. % of portfolio is the value over $848,646,466, the sum of the share positions whose value is usable for ratios (method).

SecurityHistorySharesValue% of portfolioChangeLatest eventTimeline
KALVKALVISTA PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 574,558 shares; 2024Q4: 612,173 shares; 2025Q1: 1,698,984 shares; 2025Q2: 1,832,171 shares; 2025Q3: 1,363,378 shares; 2025Q4: 2,427,118 shares; 2026Q1: 2,876,407 shares 2,876,407$57.9M6.82%+449,289Timeline
DNTHDIANTHUS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 190,334 shares; 2025Q2: 95,806 shares; 2025Q3: 674,966 shares; 2025Q4: 750,136 shares; 2026Q1: 654,746 shares 654,746$54.9M6.47%-95,390Timeline
COGTCOGENT BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 1,221,362 shares; 2024Q4: 921,137 shares; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 815,075 shares; 2025Q4: 1,245,254 shares; 2026Q1: 1,314,189 shares 1,314,189$50.6M5.96%+68,935Timeline
CELCCELCUITY INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 88,686 shares; 2025Q4: 375,132 shares; 2026Q1: 357,903 shares 357,903$40.9M4.81%-17,229Timeline
IMNMIMMUNOME INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 1,126,210 shares; 2026Q1: 1,850,278 shares 1,850,278$40.5M4.77%+724,068Timeline
KODKODIAK SCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 500,000 shares; 2024Q4: 1,000,000 shares; 2025Q1: 441,807 shares; 2025Q2: 401,540 shares; 2025Q3: 1,000,000 shares; 2025Q4: 1,023,122 shares; 2026Q1: 991,930 shares 991,930$37.8M4.46%-31,192Timeline
NUVLNUVALENT INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 371,441 shares; 2024Q4: 400,014 shares; 2025Q1: 439,018 shares; 2025Q2: 235,583 shares; 2025Q3: 372,300 shares; 2025Q4: 311,430 shares; 2026Q1: 354,914 shares 354,914$36.4M4.28%+43,484Timeline
ABVXABIVAX SAQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 461,660 shares; 2024Q4: 285,120 shares; 2025Q1: 210,901 shares; 2025Q2: not reported; 2025Q3: 539,704 shares; 2025Q4: 422,193 shares; 2026Q1: 302,530 shares 302,530$33.7M3.97%-119,663Timeline
GLUEMONTE ROSA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 694,942 shares; 2025Q4: 1,029,066 shares; 2026Q1: 2,002,040 shares 2,002,040$32.9M3.88%+972,974Timeline
ERASERASCA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 6,946,488 shares; 2024Q4: 7,543,901 shares; 2025Q1: 7,367,996 shares; 2025Q2: 2,569,591 shares; 2025Q3: 1,368,075 shares; 2025Q4: 1,317,584 shares; 2026Q1: 1,851,812 shares 1,851,812$30M3.53%+534,228Timeline
ASNDASCENDIS PHARMA A/SQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 5,000 shares; 2024Q4: 51,491 shares; 2025Q1: 75,751 shares; 2025Q2: 86,552 shares; 2025Q3: 53,554 shares; 2025Q4: 49,228 shares; 2026Q1: 124,658 shares 124,658$28.5M3.36%+75,430Timeline
URGNUROGEN PHARMA LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 901,129 shares; 2024Q4: 1,120,473 shares; 2025Q1: 1,381,158 shares; 2025Q2: 2,022,482 shares; 2025Q3: 1,577,283 shares; 2025Q4: 1,738,821 shares; 2026Q1: 1,503,045 shares 1,503,045$27M3.18%-235,776Timeline
RYTMRHYTHM PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 255,578 shares; 2024Q4: 273,896 shares; 2025Q1: 337,605 shares; 2025Q2: 400,772 shares; 2025Q3: 369,996 shares; 2025Q4: 135,950 shares; 2026Q1: 306,000 shares 306,000$26.6M3.14%+170,050Timeline
PRAXPRAXIS PRECISION MEDICINES IQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 67,045 shares; 2024Q4: 72,516 shares; 2025Q1: 166,074 shares; 2025Q2: 10,000 shares; 2025Q3: 51,210 shares; 2025Q4: 82,465 shares; 2026Q1: 71,552 shares 71,552$23.1M2.72%-10,913Timeline
ZBIOZENAS BIOPHARMA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 1,135,935 shares 1,135,935$22.2M2.62%newTimeline
SNDXSYNDAX PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 378,746 shares; 2024Q4: 1,230,400 shares; 2025Q1: 1,309,224 shares; 2025Q2: 402,964 shares; 2025Q3: 463,708 shares; 2025Q4: 642,899 shares; 2026Q1: 888,987 shares 888,987$20.8M2.45%+246,088Timeline
CNTACENTESSA PHARMACEUTICALS PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 744,592 shares; 2024Q4: 598,952 shares; 2025Q1: 232,758 shares; 2025Q2: 5,000 shares; 2025Q3: 141,238 shares; 2025Q4: 458,203 shares; 2026Q1: 466,345 shares 466,345$18.5M2.18%+8,142Timeline
SRRKSCHOLAR ROCK HLDG CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 183,243 shares; 2025Q1: not reported; 2025Q2: 341,010 shares; 2025Q3: 233,920 shares; 2025Q4: not reported; 2026Q1: 339,613 shares 339,613$16.7M1.97%newTimeline
ALKSALKERMES PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 124,871 shares; 2025Q2: not reported; 2025Q3: 180,513 shares; 2025Q4: not reported; 2026Q1: 460,314 shares 460,314$16.3M1.92%newTimeline
ORICORIC PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 1,099,490 shares; 2024Q4: 1,178,300 shares; 2025Q1: 2,060,240 shares; 2025Q2: 1,800,829 shares; 2025Q3: 1,948,808 shares; 2025Q4: 1,116,604 shares; 2026Q1: 1,100,010 shares 1,100,010$13.9M1.64%-16,594Timeline
IRONDISC MEDICINE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 103,862 shares; 2024Q4: 110,381 shares; 2025Q1: 236,471 shares; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 196,028 shares 196,028$12.5M1.48%newTimeline
HLXCHELIX ACQUISITION CORP IIIQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 1,208,986 shares 1,208,986$12.3M1.45%newTimeline
XENEXENON PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 10,121 shares; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 197,759 shares 197,759$11.5M1.36%newTimeline
CGONCG ONCOLOGY INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 541,034 shares; 2025Q3: 638,346 shares; 2025Q4: 361,158 shares; 2026Q1: 166,349 shares 166,349$11.3M1.33%-194,809Timeline
IMVTIMMUNOVANT INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 50,000 shares; 2025Q4: not reported; 2026Q1: 414,236 shares 414,236$10.3M1.21%newTimeline
SYRESPYRE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 187,737 shares; 2026Q1: 186,618 shares 186,618$9.41M1.11%-1,119Timeline
BIIBBIOGEN INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 19,940 shares; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 80,419 shares; 2025Q4: 75,412 shares; 2026Q1: 50,967 shares 50,967$9.34M1.1%-24,445Timeline
GHGUARDANT HEALTH INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 91,914 shares; 2026Q1: 98,514 shares 98,514$9.1M1.07%+6,600Timeline
PCVXVAXCYTE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 60,500 shares; 2024Q4: 40,788 shares; 2025Q1: not reported; 2025Q2: 287,796 shares; 2025Q3: 314,339 shares; 2025Q4: 148,787 shares; 2026Q1: 144,981 shares 144,981$8.42M0.99%-3,806Timeline
SVRASAVARA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 1,430,982 shares 1,430,982$7.81M0.92%newTimeline
BNTCBENITEC BIOPHARMA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 250,000 shares; 2025Q2: 253,234 shares; 2025Q3: 276,267 shares; 2025Q4: 731,717 shares; 2026Q1: 717,725 shares 717,725$7.64M0.9%-13,992Timeline
ORKAORUKA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 165,389 shares; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 150,908 shares 150,908$7.4M0.87%newTimeline
CGENCOMPUGEN LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 1,501,113 shares; 2024Q4: 1,624,377 shares; 2025Q1: 2,895,430 shares; 2025Q2: 3,033,879 shares; 2025Q3: 3,311,165 shares; 2025Q4: 3,479,805 shares; 2026Q1: 3,315,845 shares 3,315,845$7.06M0.83%-163,960Timeline
TRVITREVI THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 482,575 shares; 2024Q4: 734,234 shares; 2025Q1: 530,000 shares; 2025Q2: 539,587 shares; 2025Q3: 588,789 shares; 2025Q4: 541,240 shares; 2026Q1: 511,127 shares 511,127$6.1M0.72%-30,113Timeline
INSMINSMED INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 347,695 shares; 2024Q4: 372,230 shares; 2025Q1: 321,366 shares; 2025Q2: 249,060 shares; 2025Q3: 206,648 shares; 2025Q4: 71,256 shares; 2026Q1: 35,850 shares 35,850$5.86M0.69%-35,406Timeline
VCYTVERACYTE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 470,565 shares; 2024Q4: 503,281 shares; 2025Q1: 633,832 shares; 2025Q2: 448,495 shares; 2025Q3: 235,791 shares; 2025Q4: 357,558 shares; 2026Q1: 179,700 shares 179,700$5.79M0.68%-177,858Timeline
CERSCERUS CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 1,495,329 shares; 2024Q4: 1,587,228 shares; 2025Q1: 2,456,537 shares; 2025Q2: 2,488,291 shares; 2025Q3: 2,715,786 shares; 2025Q4: 2,814,383 shares; 2026Q1: 3,176,547 shares 3,176,547$5.78M0.68%+362,164Timeline
CLDXCELLDEX THERAPEUTICS INC NEWQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 145,000 shares; 2024Q4: 264,560 shares; 2025Q1: 205,962 shares; 2025Q2: 198,441 shares; 2025Q3: 348,922 shares; 2025Q4: 191,074 shares; 2026Q1: 178,378 shares 178,378$5.66M0.67%-12,696Timeline
CCCCC4 THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 1,147,891 shares; 2024Q4: 1,221,131 shares; 2025Q1: 882,300 shares; 2025Q2: not reported; 2025Q3: 1,897,383 shares; 2025Q4: 1,994,224 shares; 2026Q1: 1,911,785 shares 1,911,785$5.03M0.59%-82,439Timeline
CYTKCYTOKINETICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 211,000 shares; 2025Q4: not reported; 2026Q1: 71,203 shares 71,203$4.69M0.55%newTimeline
CLYMCLIMB BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 684,908 shares 684,908$4.69M0.55%newTimeline
CMPXCOMPASS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 874,869 shares; 2025Q2: 1,249,781 shares; 2025Q3: 2,833,988 shares; 2025Q4: 1,051,343 shares; 2026Q1: 859,049 shares 859,049$4.54M0.54%-192,294Timeline
SRZNSURROZEN INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 157,323 shares; 2026Q1: 144,255 shares 144,255$4.2M0.5%-13,068Timeline
CTNMCONTINEUM THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 166,161 shares; 2025Q4: 307,540 shares; 2026Q1: 301,729 shares 301,729$3.94M0.46%-5,811Timeline
ZURAZURA BIO LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 720,452 shares; 2025Q4: not reported; 2026Q1: 560,651 shares 560,651$3.34M0.39%newTimeline
FULCFULCRUM THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 394,650 shares; 2026Q1: 419,949 shares 419,949$3.22M0.38%+25,299Timeline
ABEOABEONA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 917,898 shares; 2025Q3: 994,754 shares; 2025Q4: 627,738 shares; 2026Q1: 648,942 shares 648,942$2.91M0.34%+21,204Timeline
CAMPCAMP4 THERAPEUTICS CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 653,594 shares; 2025Q4: not reported; 2026Q1: 653,594 shares 653,594$2.88M0.34%newTimeline
ANNXANNEXON INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 496,461 shares 496,461$2.75M0.32%newTimeline
ELUTELUTIA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 1,645,808 shares; 2024Q4: 1,782,271 shares; 2025Q1: 2,670,056 shares; 2025Q2: 2,761,684 shares; 2025Q3: 2,850,987 shares; 2025Q4: 2,751,314 shares; 2026Q1: 2,498,020 shares 2,498,020$2.62M0.31%-253,294Timeline
CBIOCRESCENT BIOPHARMA INC.Quarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 130,500 shares 130,500$2.4M0.28%newTimeline
MNPRMONOPAR THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 43,488 shares 43,488$2.38M0.28%newTimeline
OVIDOVID THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 1,000,000 shares 1,000,000$2.22M0.26%newTimeline
NXTCNEXTCURE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 176,057 shares; 2026Q1: 176,057 shares 176,057$1.88M0.22%0Timeline
CMPSCOMPASS PATHWAYS PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 300,000 shares 300,000$1.66M0.2%newTimeline
NMRANEUMORA THERAPEUTICS INC.Quarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 818,156 shares 818,156$1.6M0.19%newTimeline
SIONSIONNA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 114,138 shares; 2025Q2: 186,015 shares; 2025Q3: 108,801 shares; 2025Q4: 41,460 shares; 2026Q1: 39,417 shares 39,417$1.58M0.19%-2,043Timeline
TELATELA BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 1,124,928 shares; 2024Q4: 3,065,649 shares; 2025Q1: 2,771,288 shares; 2025Q2: 2,779,795 shares; 2025Q3: 2,782,923 shares; 2025Q4: 2,647,512 shares; 2026Q1: 2,259,312 shares 2,259,312$1.4M0.17%-388,200Timeline
EWTXEDGEWISE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 42,052 shares; 2026Q1: 42,615 shares 42,615$1.34M0.16%+563Timeline
REPLREPLIMUNE GROUP INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 171,936 shares 171,936$1.32M0.15%newTimeline
GENBGENERATE BIOMEDICINES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 100,000 shares 100,000$1.25M0.15%newTimeline
RADXRADIOPHARM THERANOSTICS LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 187,406 shares; 2025Q1: 187,406 shares; 2025Q2: 187,406 shares; 2025Q3: 187,406 shares; 2025Q4: 187,406 shares; 2026Q1: 187,406 shares 187,406$806K0.09%0Timeline
GUTSFRACTYL HEALTH INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 166,666 shares; 2024Q4: 176,922 shares; 2025Q1: 237,448 shares; 2025Q2: 202,590 shares; 2025Q3: 10,600,000 shares; 2025Q4: 9,840,041 shares; 2026Q1: 1,701,625 shares 1,701,625$779K0.09%-8,138,416Timeline
IBIOIBIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 106,000 shares; 2026Q1: 226,000 shares 226,000$429K0.05%+120,000Timeline
ADGMADAGIO MED HLDGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 515,384 shares; 2026Q1: 251,972 shares 251,972$290K0.03%-263,412Timeline
AARDAARDVARK THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 119,496 shares; 2025Q2: 286,807 shares; 2025Q3: 306,912 shares; 2025Q4: 303,939 shares; 2026Q1: 33,684 shares 33,684$127K0.01%-270,255Timeline
RCKTWROCKET PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 104,828 shares; 2024Q4: 104,828 shares; 2025Q1: 104,828 shares; 2025Q2: 104,828 shares; 2025Q3: 104,828 shares; 2025Q4: 104,828 shares; 2026Q1: 104,828 shares 104,828$2.16K<0.01%0Timeline

Options

Puts and calls, as filed. The amount and value describe the underlying shares, not the option premium, so they stay out of % of portfolio (H5).

SecurityTypeAmountValueChange
SPDR SERIES TRUSTSPDR SERIES TRUST PUTput825,000$105Mnew
UNIQURE NVUNIQURE NV CALLcall500,000$8.18M-220,800
SYNDAX PHARMACEUTICALS INCSYNDAX PHARMACEUTICALS INC COMcall320,000$7.48Mnew
CELCUITY INCCELCUITY INC CALLcall54,500$6.22Mnew
FULCRUM THERAPEUTICS INCFULCRUM THERAPEUTICS INC COMcall391,900$3.01M0
COMPASS THERAPEUTICS INCCOMPASS THERAPEUTICS INC COMcall172,400$912Knew

Sold out in Q1 2026

Positions in the previous quarter's report that this quarter's report no longer lists.

SecurityShares beforeValue beforeType
VRDNVIRIDIAN THERAPEUTICS INC348,569$10.8Mshares
PFEPFIZER INC419,134$10.4Mshares
AVTXAVALO THERAPEUTICS INC524,436$9.52Mshares
GOSSGOSSAMER BIO INC2,135,722$6.62Mshares
LXEOLEXEO THERAPEUTICS INC617,608$6.13Mshares
AMLXAMYLYX PHARMACEUTICALS INC506,242$6.12Mshares
SLNOSOLENO THERAPEUTICS INC117,485$5.44Mshares
OLMAOLEMA PHARMACEUTICALS INC206,280$5.16Mshares
KALVISTA PHARMACEUTICALS INCKALVISTA PHARMACEUTICALS INC290,600$4.69Mcall
MLYSMINERALYS THERAPEUTICS INC94,983$3.45Mshares
RLAYRELAY THERAPEUTICS INC398,167$3.37Mshares
QUREUNIQURE NV126,047$3.02Mshares
TARSTARSUS PHARMACEUTICALS INC36,124$2.96Mshares
KYMRKYMERA THERAPEUTICS INC34,589$2.69Mshares
ULTRAGENYX PHARMACEUTICAL INULTRAGENYX PHARMACEUTICAL IN110,000$2.53Mcall
CTMXCYTOMX THERAPEUTICS INC.385,974$1.64Mshares
XFORX4 PHARMACEUTICALS INC357,387$1.43Mshares
FDMT4D MOLECULAR THERAPEUTICS IN100,000$750Kshares
RAPPRAPPORT THERAPEUTICS INC9,659$293Kshares
PALIPALISADE BIO INC102,108$240Kshares

How Q1 2026 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

FilingRoleAmendmentFiledAcceptedIngested
13F-HR 0001420506-26-001011 base2026-05-14acceptance time not in the bulk data set