FMR LLC in group FMR LLC More: the full row for FMR LLC 9,506,701 $241M 0.01% +424,701 13F-HR Timeline Group SR One Capital Management, LP More: the full row for SR One Capital Management, LP 5,037,854 $128M 12.31% 0 13F-HR Timeline NEA Management Company, LLC More: the full row for NEA Management Company, LLC 4,023,219 $102M 6.43% 0 13F-HR Timeline ENAVATE SCIENCES GP, LLC More: the full row for ENAVATE SCIENCES GP, LLC 3,919,159 $99.5M 28.8% 0 13F-HR Timeline FEDERATED HERMES, INC. in group FEDERATED HERMES, INC. More: the full row for FEDERATED HERMES, INC. 3,116,805 $79.1M 0.11% -10,226 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 2,686,225 $68.2M <0.01% +648,677 13F-HR Timeline Group Capital International Investors in group Capital International Investo… More: the full row for Capital International Investors 2,502,912 $63.5M 0.01% +68,912 13F-HR Timeline Group Polar Capital Holdings Plc in group Polar Capital Holdings Plc More: the full row for Polar Capital Holdings Plc 2,412,772 $61.2M 0.17% -135,672 13F-HR Timeline Group Royalty Pharma Sub-Manager, LLC in group Royalty Pharma Sub-Manager, L… More: the full row for Royalty Pharma Sub-Manager, LLC 2,388,150 $60.6M 25.05% 0 13F-HR/A Timeline Group Fairmount Funds Management LLC More: the full row for Fairmount Funds Management LLC 2,359,025 $59.9M 3.96% 0 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 2,055,100 $52.2M <0.01% +584,177 13F-HR Timeline Group VANGUARD GROUP INC group of 6 filers holding More: the full row for VANGUARD GROUP INC 1,954,511 $49.6M +242,641 Timeline VANGUARD CAPITAL MANAGEMENT LLC : 1,354,864 (<0.01%) 13F-HR VANGUARD PORTFOLIO MANAGEMENT LLC : 304,870 (<0.01%) 13F-HR VANGUARD FIDUCIARY TRUST CO : 254,623 (<0.01%) 13F-HR VANGUARD ASSET MANAGEMENT, Ltd : 20,623 (<0.01%) 13F-HR Vanguard Global Advisers, LLC : 15,332 (<0.01%) 13F-HR Vanguard Investments Australia, L… : 4,199 (<0.01%) 13F-HR NVP ASSOCIATES, LLC More: the full row for NVP ASSOCIATES, LLC 1,838,482 $46.7M 14.22% 0 13F-HR Timeline WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 1,593,819 $40.5M 0.01% +347,766 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 1,231,159 $31.2M <0.01% +842,812 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 1,226,928 $31.1M <0.01% +869,662 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 882,654 $22.4M <0.01% +226,869 13F-HR Timeline Group ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 1,103,388 $21.6M 0.01% +206,067 13F-HR Timeline TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 815,150 $20.7M 0.02% +540,094 13F-HR Timeline Group EcoR1 Capital, LLC More: the full row for EcoR1 Capital, LLC 789,500 $20M 0.99% 0 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 660,470 $16.8M 0.01% +183,652 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 590,539 $15M 0.05% +14 13F-HR Timeline Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 576,717 $14.6M 0.03% -90,353 13F-HR Timeline Group ArrowMark Colorado Holdings LLC More: the full row for ArrowMark Colorado Holdings LLC 573,318 $14.6M 0.61% -85,591 13F-HR Timeline SILVERARC CAPITAL MANAGEMENT, LLC in group SILVERARC CAPITAL MANAGEMENT,… More: the full row for SILVERARC CAPITAL MANAGEMENT, LLC 509,789 $12.9M 1.44% -626,146 13F-HR Timeline Group Rock Springs Capital Management LP More: the full row for Rock Springs Capital Management LP 502,077 $12.7M 0.62% 0 13F-HR Timeline Pivotal bioVenture Partners Investment … in group Pivotal bioVenture Partners I… More: the full row for Pivotal bioVenture Partners Investment Advisor LLC 490,766 $12.5M 4.05% -101,225 13F-HR Timeline Group NEXTBio Capital Management LP More: the full row for NEXTBio Capital Management LP 426,736 $10.8M 4.98% 0 13F-HR Timeline Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 365,000 $9.26M 0.22% +165,000 13F-HR Timeline MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 323,442 $8.21M 0.01% -178,486 13F-HR Timeline Group JENNISON ASSOCIATES LLC More: the full row for JENNISON ASSOCIATES LLC 314,049 $7.97M <0.01% +64,049 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 302,085 $7.67M <0.01% +77,683 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 281,140 $7.14M <0.01% +86,500 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 271,163 $6.88M <0.01% -110,298 13F-HR Timeline Group SPHERA FUNDS MANAGEMENT LTD. in group SPHERA FUNDS MANAGEMENT LTD. More: the full row for SPHERA FUNDS MANAGEMENT LTD. 230,834 $5.86M 0.84% +16,500 13F-HR Timeline Group UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 215,879 $5.48M -167,049 Timeline iA Global Asset Management Inc. More: the full row for iA Global Asset Management Inc. 215,130 $5.46M 0.06% -700 13F-HR Timeline Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 209,050 $5.31M 0.03% +83,818 13F-HR Timeline Group Sio Capital Management, LLC More: the full row for Sio Capital Management, LLC 208,557 $5.29M 0.91% -123,173 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 195,780 $4.97M <0.01% +128,910 13F-HR Timeline Group Voleon Capital Management LP More: the full row for Voleon Capital Management LP 167,145 $4.24M 0.08% +137,533 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 151,086 $3.83M <0.01% +141,087 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 134,979 $3.43M <0.01% +41,583 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 125,185 $3.18M 0.01% +82,311 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 115,965 $2.94M <0.01% +86,355 13F-HR Timeline Group SEVEN GRAND MANAGERS, LLC More: the full row for SEVEN GRAND MANAGERS, LLC 100,000 $2.54M 0.1% 0 13F-HR Timeline Birchview Capital, LP More: the full row for Birchview Capital, LP 93,601 $2.38M 1.11% +23,601 13F-HR Timeline Verition Fund Management LLC More: the full row for Verition Fund Management LLC 72,988 $1.85M 0.01% new 13F-HR/A Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 70,477 $1.79M <0.01% +9,613 13F-HR Timeline Group J. Goldman & Co LP More: the full row for J. Goldman & Co LP 68,232 $1.73M 0.06% +31,435 13F-HR Timeline CSM Advisors, LLC More: the full row for CSM Advisors, LLC 67,622 $1.72M 0.04% new 13F-HR Timeline Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 66,638 $1.69M <0.01% -1,132 13F-HR Timeline Group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 63,675 $1.62M 0.01% +19,981 13F-HR Timeline Swiss National Bank More: the full row for Swiss National Bank 53,200 $1.35M <0.01% +21,600 13F-HR Timeline Exome Asset Management LLC More: the full row for Exome Asset Management LLC 52,443 $1.33M 0.82% -28,287 13F-HR Timeline Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 51,022 $1.29M 0.01% -8,979 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 49,521 $1.26M <0.01% +39,633 13F-HR Timeline Group LOS ANGELES CAPITAL MANAGEMENT LLC More: the full row for LOS ANGELES CAPITAL MANAGEMENT LLC 48,465 $1.23M <0.01% new 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 40,034 $1.02M 0.01% +20,723 13F-HR Timeline Group Burkehill Global Management, LP More: the full row for Burkehill Global Management, LP 40,000 $1.02M 0.04% 0 13F-HR Timeline Rafferty Asset Management, LLC More: the full row for Rafferty Asset Management, LLC 37,509 $952K <0.01% -10,660 13F-HR Timeline Atom Investors LP More: the full row for Atom Investors LP 37,149 $943K 0.08% -69,867 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 34,245 $869K <0.01% +7,432 13F-HR Timeline BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 33,280 $845K 0.02% new 13F-HR Timeline AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 31,100 $789K <0.01% -19,871 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 29,471 $748K <0.01% +13,652 13F-HR/A Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 28,881 $733K <0.01% +9,615 13F-HR Timeline Group DCF Advisers, LLC More: the full row for DCF Advisers, LLC 28,184 $715K 0.19% new 13F-HR Timeline STATE OF WISCONSIN INVESTMENT BOARD More: the full row for STATE OF WISCONSIN INVESTMENT BOARD 26,922 $683K <0.01% +6,108 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 24,445 $661K <0.01% -664 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 25,995 $660K <0.01% +17,110 13F-HR Timeline Group Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 20,247 $515K +3,061 Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 20,023 $508K <0.01% +9,591 13F-HR Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 18,954 $481K <0.01% -94,525 13F-HR Timeline Group China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 18,848 $478K 0.03% +5,322 13F-HR Timeline PROFUND ADVISORS LLC More: the full row for PROFUND ADVISORS LLC 18,838 $478K 0.01% -2,578 13F-HR Timeline ALLSTATE CORP in group ALLSTATE CORP More: the full row for ALLSTATE CORP 18,241 $463K <0.01% +18 13F-HR Timeline Group Y-Intercept (Hong Kong) Ltd More: the full row for Y-Intercept (Hong Kong) Ltd 17,332 $440K 0.01% new 13F-HR Timeline MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 17,041 $433K <0.01% +4,132 13F-HR Timeline Group Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 16,525 $419K 0.1% +9,808 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 16,136 $410K <0.01% new 13F-HR Timeline Group NORDEA INVESTMENT MANAGEMENT AB in group NORDEA INVESTMENT MANAGEMENT … More: the full row for NORDEA INVESTMENT MANAGEMENT AB 15,050 $383K <0.01% new 13F-HR Timeline Group Brevan Howard Capital Management LP in group Brevan Howard Capital Managem… More: the full row for Brevan Howard Capital Management LP 14,674 $372K 0.01% new 13F-HR Timeline Group Engineers Gate Manager LP More: the full row for Engineers Gate Manager LP 12,980 $329K <0.01% new 13F-HR Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 12,740 $323K <0.01% +10,019 13F-HR Timeline Group Creative Planning in group Creative Planning More: the full row for Creative Planning 11,723 $298K <0.01% -935 13F-HR Timeline Group VARCOV Co. More: the full row for VARCOV Co. 10,505 $267K 0.1% new 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 10,300 $261K <0.01% +4,100 13F-HR Timeline MASSACHUSETTS FINANCIAL SERVICES CO /MA/ in group MASSACHUSETTS FINANCIAL SERVI… More: the full row for MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 9,053 $230K <0.01% new 13F-HR Timeline Group Scientech Research LLC More: the full row for Scientech Research LLC 9,028 $229K 0.19% -3,924 13F-HR Timeline DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 8,874 $225K <0.01% new 13F-HR Timeline Group HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 8,879 $225K <0.01% -16,870 13F-HR Timeline Quantinno Capital Management LP More: the full row for Quantinno Capital Management LP 8,581 $218K <0.01% -12,545 13F-HR Timeline State of New Jersey Common Pension Fund… in group State of New Jersey Common Pe… More: the full row for State of New Jersey Common Pension Fund D 8,571 $218K <0.01% new 13F-HR Timeline Group SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 8,442 $214K <0.01% new 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 8,418 $214K <0.01% +2,055 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 8,032 $204K <0.01% new 13F-HR Timeline Group Jupiter Topco LLC in group Janus Henderson More: the full row for Jupiter Topco LLC 7,900 $201K <0.01% 13F-HR Timeline Group Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 7,563 $192K <0.01% +786 13F-HR Timeline KLP KAPITALFORVALTNING AS More: the full row for KLP KAPITALFORVALTNING AS 6,100 $155K <0.01% +2,700 13F-HR Timeline PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 4,739 $120K <0.01% -28 13F-HR Timeline Group Ameritas Investment Partners, Inc. group of 2 filers holding More: the full row for Ameritas Investment Partners, Inc. 2,628 $66.7K +698 Timeline TOUNJIAN ADVISORY PARTNERS, LLC More: the full row for TOUNJIAN ADVISORY PARTNERS, LLC 2,500 $63.5K 0.03% new 13F-HR Timeline Quantbot Technologies LP More: the full row for Quantbot Technologies LP 1,928 $48.9K <0.01% +1,672 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 1,286 $32.6K <0.01% -5,949 13F-HR Timeline Group GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 1,138 $28.9K <0.01% -67 13F-HR Timeline SIGNATUREFD, LLC More: the full row for SIGNATUREFD, LLC 1,134 $28.8K <0.01% +764 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 847 $21K <0.01% new 13F-HR Timeline Group NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 651 $16.5K <0.01% -1,764 13F-HR Timeline Pacer Advisors, Inc. More: the full row for Pacer Advisors, Inc. 626 $16K <0.01% new 13F-HR Timeline BNP PARIBAS ASSET MANAGEMENT Holding S.… in group BNP PARIBAS ASSET MANAGEMENT … More: the full row for BNP PARIBAS ASSET MANAGEMENT Holding S.A. 539 $13.7K <0.01% new 13F-HR Timeline Group Silver Grove Financial Group, Inc. More: the full row for Silver Grove Financial Group, Inc. 538 $13.7K 0.01% new 13F-HR Timeline Larson Financial Group LLC More: the full row for Larson Financial Group LLC 454 $11.5K <0.01% +161 13F-HR Timeline Global Retirement Partners, LLC More: the full row for Global Retirement Partners, LLC 420 $10.7K <0.01% 13F-HR Timeline HARBOUR INVESTMENTS, INC. More: the full row for HARBOUR INVESTMENTS, INC. 370 $9.39K <0.01% -1,000 13F-HR Timeline GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 345 $8.76K <0.01% +45 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 304 $7.72K <0.01% -690 13F-HR Timeline Group OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 295 $7.49K <0.01% -382 13F-HR Timeline Group J.Safra Asset Management Corp More: the full row for J.Safra Asset Management Corp 224 $5.68K <0.01% -46 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 195 $4.95K <0.01% -50 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 162 $4.11K <0.01% +64 13F-HR Timeline Group Integrated Wealth Concepts LLC More: the full row for Integrated Wealth Concepts LLC 138 $3.5K <0.01% new 13F-HR Timeline Arax Advisory Partners More: the full row for Arax Advisory Partners 104 $2.64K <0.01% new 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 100 $2.54K <0.01% -679 13F-HR Timeline Bare Financial Services, Inc More: the full row for Bare Financial Services, Inc 95 $2.41K <0.01% +81 13F-HR Timeline Torren Management, LLC More: the full row for Torren Management, LLC 95 $2.41K <0.01% 0 13F-HR Timeline Physician Wealth Advisors, Inc. More: the full row for Physician Wealth Advisors, Inc. 67 $1.7K <0.01% -25 13F-HR Timeline Covestor Ltd More: the full row for Covestor Ltd 22 $1K <0.01% +16 13F-HR Timeline Fortitude Family Office, LLC More: the full row for Fortitude Family Office, LLC 29 $736 <0.01% new 13F-HR Timeline Cornerstone Financial Management LLC More: the full row for Cornerstone Financial Management LLC 26 $660 <0.01% 0 13F-HR/A Timeline ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 20 $508 <0.01% -1 13F-HR Timeline CoreCap Advisors, LLC More: the full row for CoreCap Advisors, LLC 12 $305 <0.01% new 13F-HR Timeline Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 2 $51 <0.01% -58 13F-HR Timeline Essential Partners LLC More: the full row for Essential Partners LLC 2 $51 <0.01% 0 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 1 $26 <0.01% -25 13F-HR Timeline Freestone Grove Partners LP More: the full row for Freestone Grove Partners LP 1 $25 <0.01% new 13F-HR Timeline Hughes Financial Services, LLC More: the full row for Hughes Financial Services, LLC 1 $25 <0.01% new 13F-HR Timeline