Skip to content
Disclosery

SILVERARC CAPITAL MANAGEMENT, LLC

Follow

13F filer, CIK 1816307, BOSTON, MA

SILVERARC CAPITAL MANAGEMENT, LLC reported $720,050,731 across 68 holdings for the quarter ended 2025-12-31, in a 13F-HR filed 2026-02-12. Its ten largest share positions make up 51.78% of the portfolio.

Filed (acceptance time not in the bulk data set), ingested 13F-HR 0001420506-26-000321

Period
2025-12-31
Reported value
$720M
Holdings
68
Top 10 weight
51.78%
New
21
Sold out
35

Part of the filer group SILVERARC CAPITAL MANAGEMENT, LLC

How groups are built

Largest buys vs the previous quarter

SecurityShares changeApprox. value
CELCadded+286,446$28.6M
IMNMnew+1,126,210$24.2M
KALVadded+1,063,740$17.2M
COGTadded+430,179$15.3M
PFEnew+419,134$10.4M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

SecurityShares changeApprox. value
RNAMexited-844,633-$36.8M
AKROexited-643,636-$30.6M
RYTMreduced-234,046-$25.1M
INSMreduced-135,392-$23.6M
CDTXexited-220,902-$21.2M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q4 2025

Share positions as resolved from 13F-HR 0001420506-26-000321, largest first. % of portfolio is the value over $691,146,408, the sum of the share positions whose value is usable for ratios (method).

SecurityHistorySharesValue% of portfolioChangeLatest eventTimeline
ABVXABIVAX SAQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 461,660 shares; 2024Q4: 285,120 shares; 2025Q1: 210,901 shares; 2025Q2: not reported; 2025Q3: 539,704 shares; 2025Q4: 422,193 shares 422,193$56.9M8.24%-117,511Timeline
COGTCOGENT BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,221,362 shares; 2024Q4: 921,137 shares; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 815,075 shares; 2025Q4: 1,245,254 shares 1,245,254$44.2M6.4%+430,179Timeline
URGNUROGEN PHARMA LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 901,129 shares; 2024Q4: 1,120,473 shares; 2025Q1: 1,381,158 shares; 2025Q2: 2,022,482 shares; 2025Q3: 1,577,283 shares; 2025Q4: 1,738,821 shares 1,738,821$40.7M5.89%+161,538Timeline
KALVKALVISTA PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 574,558 shares; 2024Q4: 612,173 shares; 2025Q1: 1,698,984 shares; 2025Q2: 1,832,171 shares; 2025Q3: 1,363,378 shares; 2025Q4: 2,427,118 shares 2,427,118$39.2M5.67%+1,063,740Timeline
CELCCELCUITY INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 88,686 shares; 2025Q4: 375,132 shares 375,132$37.4M5.41%+286,446Timeline
NUVLNUVALENT INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 371,441 shares; 2024Q4: 400,014 shares; 2025Q1: 439,018 shares; 2025Q2: 235,583 shares; 2025Q3: 372,300 shares; 2025Q4: 311,430 shares 311,430$31.3M4.53%-60,870Timeline
DNTHDIANTHUS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 190,334 shares; 2025Q2: 95,806 shares; 2025Q3: 674,966 shares; 2025Q4: 750,136 shares 750,136$30.9M4.47%+75,170Timeline
KODKODIAK SCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 500,000 shares; 2024Q4: 1,000,000 shares; 2025Q1: 441,807 shares; 2025Q2: 401,540 shares; 2025Q3: 1,000,000 shares; 2025Q4: 1,023,122 shares 1,023,122$28.6M4.14%+23,122Timeline
PRAXPRAXIS PRECISION MEDICINES IQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 67,045 shares; 2024Q4: 72,516 shares; 2025Q1: 166,074 shares; 2025Q2: 10,000 shares; 2025Q3: 51,210 shares; 2025Q4: 82,465 shares 82,465$24.3M3.52%+31,255Timeline
IMNMIMMUNOME INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 1,126,210 shares 1,126,210$24.2M3.5%newTimeline
GUTSFRACTYL HEALTH INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 166,666 shares; 2024Q4: 176,922 shares; 2025Q1: 237,448 shares; 2025Q2: 202,590 shares; 2025Q3: 10,600,000 shares; 2025Q4: 9,840,041 shares 9,840,041$21.6M3.13%-759,959Timeline
GLUEMONTE ROSA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 694,942 shares; 2025Q4: 1,029,066 shares 1,029,066$16.1M2.33%+334,124Timeline
VCYTVERACYTE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 470,565 shares; 2024Q4: 503,281 shares; 2025Q1: 633,832 shares; 2025Q2: 448,495 shares; 2025Q3: 235,791 shares; 2025Q4: 357,558 shares 357,558$15.1M2.18%+121,767Timeline
CGONCG ONCOLOGY INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 541,034 shares; 2025Q3: 638,346 shares; 2025Q4: 361,158 shares 361,158$15M2.17%-277,188Timeline
RYTMRHYTHM PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 255,578 shares; 2024Q4: 273,896 shares; 2025Q1: 337,605 shares; 2025Q2: 400,772 shares; 2025Q3: 369,996 shares; 2025Q4: 135,950 shares 135,950$14.6M2.11%-234,046Timeline
SNDXSYNDAX PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 378,746 shares; 2024Q4: 1,230,400 shares; 2025Q1: 1,309,224 shares; 2025Q2: 402,964 shares; 2025Q3: 463,708 shares; 2025Q4: 642,899 shares 642,899$13.5M1.95%+179,191Timeline
BIIBBIOGEN INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 19,940 shares; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 80,419 shares; 2025Q4: 75,412 shares 75,412$13.3M1.92%-5,007Timeline
INSMINSMED INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 347,695 shares; 2024Q4: 372,230 shares; 2025Q1: 321,366 shares; 2025Q2: 249,060 shares; 2025Q3: 206,648 shares; 2025Q4: 71,256 shares 71,256$12.4M1.79%-135,392Timeline
CNTACENTESSA PHARMACEUTICALS PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 744,592 shares; 2024Q4: 598,952 shares; 2025Q1: 232,758 shares; 2025Q2: 5,000 shares; 2025Q3: 141,238 shares; 2025Q4: 458,203 shares 458,203$11.5M1.66%+316,965Timeline
VRDNVIRIDIAN THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 100,000 shares; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 259,509 shares; 2025Q4: 348,569 shares 348,569$10.8M1.57%+89,060Timeline
ASNDASCENDIS PHARMA A/SQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 5,000 shares; 2024Q4: 51,491 shares; 2025Q1: 75,751 shares; 2025Q2: 86,552 shares; 2025Q3: 53,554 shares; 2025Q4: 49,228 shares 49,228$10.5M1.52%-4,326Timeline
PFEPFIZER INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 344,338 shares; 2025Q3: not reported; 2025Q4: 419,134 shares 419,134$10.4M1.51%newTimeline
BNTCBENITEC BIOPHARMA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 250,000 shares; 2025Q2: 253,234 shares; 2025Q3: 276,267 shares; 2025Q4: 731,717 shares 731,717$9.86M1.43%+455,450Timeline
AVTXAVALO THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 720,922 shares; 2025Q4: 524,436 shares 524,436$9.52M1.38%-196,486Timeline
GHGUARDANT HEALTH INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 91,914 shares 91,914$9.39M1.36%newTimeline
ORICORIC PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,099,490 shares; 2024Q4: 1,178,300 shares; 2025Q1: 2,060,240 shares; 2025Q2: 1,800,829 shares; 2025Q3: 1,948,808 shares; 2025Q4: 1,116,604 shares 1,116,604$9.13M1.32%-832,204Timeline
PCVXVAXCYTE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 60,500 shares; 2024Q4: 40,788 shares; 2025Q1: not reported; 2025Q2: 287,796 shares; 2025Q3: 314,339 shares; 2025Q4: 148,787 shares 148,787$6.87M0.99%-165,552Timeline
TRVITREVI THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 482,575 shares; 2024Q4: 734,234 shares; 2025Q1: 530,000 shares; 2025Q2: 539,587 shares; 2025Q3: 588,789 shares; 2025Q4: 541,240 shares 541,240$6.78M0.98%-47,549Timeline
GOSSGOSSAMER BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 5,645,352 shares; 2024Q4: 6,171,847 shares; 2025Q1: 6,320,684 shares; 2025Q2: 5,146,782 shares; 2025Q3: 4,779,082 shares; 2025Q4: 2,135,722 shares 2,135,722$6.62M0.96%-2,643,360Timeline
SYRESPYRE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 187,737 shares 187,737$6.15M0.89%newTimeline
LXEOLEXEO THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 778,611 shares; 2025Q4: 617,608 shares 617,608$6.13M0.89%-161,003Timeline
AMLXAMYLYX PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 700,000 shares; 2025Q4: 506,242 shares 506,242$6.12M0.88%-193,758Timeline
CERSCERUS CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,495,329 shares; 2024Q4: 1,587,228 shares; 2025Q1: 2,456,537 shares; 2025Q2: 2,488,291 shares; 2025Q3: 2,715,786 shares; 2025Q4: 2,814,383 shares 2,814,383$5.8M0.84%+98,597Timeline
CMPXCOMPASS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 874,869 shares; 2025Q2: 1,249,781 shares; 2025Q3: 2,833,988 shares; 2025Q4: 1,051,343 shares 1,051,343$5.65M0.82%-1,782,645Timeline
SLNOSOLENO THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 166,417 shares; 2025Q2: 204,591 shares; 2025Q3: not reported; 2025Q4: 117,485 shares 117,485$5.44M0.79%newTimeline
CGENCOMPUGEN LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,501,113 shares; 2024Q4: 1,624,377 shares; 2025Q1: 2,895,430 shares; 2025Q2: 3,033,879 shares; 2025Q3: 3,311,165 shares; 2025Q4: 3,479,805 shares 3,479,805$5.32M0.77%+168,640Timeline
CLDXCELLDEX THERAPEUTICS INC NEWQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 145,000 shares; 2024Q4: 264,560 shares; 2025Q1: 205,962 shares; 2025Q2: 198,441 shares; 2025Q3: 348,922 shares; 2025Q4: 191,074 shares 191,074$5.19M0.75%-157,848Timeline
OLMAOLEMA PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 455,082 shares; 2024Q4: 233,281 shares; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 933,541 shares; 2025Q4: 206,280 shares 206,280$5.16M0.75%-727,261Timeline
ERASERASCA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 6,946,488 shares; 2024Q4: 7,543,901 shares; 2025Q1: 7,367,996 shares; 2025Q2: 2,569,591 shares; 2025Q3: 1,368,075 shares; 2025Q4: 1,317,584 shares 1,317,584$4.9M0.71%-50,491Timeline
FULCFULCRUM THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 394,650 shares 394,650$4.46M0.65%newTimeline
AARDAARDVARK THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 119,496 shares; 2025Q2: 286,807 shares; 2025Q3: 306,912 shares; 2025Q4: 303,939 shares 303,939$3.99M0.58%-2,973Timeline
CCCCC4 THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,147,891 shares; 2024Q4: 1,221,131 shares; 2025Q1: 882,300 shares; 2025Q2: not reported; 2025Q3: 1,897,383 shares; 2025Q4: 1,994,224 shares 1,994,224$3.81M0.55%+96,841Timeline
SRZNSURROZEN INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 157,323 shares 157,323$3.56M0.51%newTimeline
CTNMCONTINEUM THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 166,161 shares; 2025Q4: 307,540 shares 307,540$3.52M0.51%+141,379Timeline
MLYSMINERALYS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 338,354 shares; 2025Q2: 115,282 shares; 2025Q3: 80,000 shares; 2025Q4: 94,983 shares 94,983$3.45M0.5%+14,983Timeline
RLAYRELAY THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 419,242 shares; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 398,167 shares 398,167$3.37M0.49%newTimeline
ABEOABEONA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 917,898 shares; 2025Q3: 994,754 shares; 2025Q4: 627,738 shares 627,738$3.31M0.48%-367,016Timeline
TELATELA BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,124,928 shares; 2024Q4: 3,065,649 shares; 2025Q1: 2,771,288 shares; 2025Q2: 2,779,795 shares; 2025Q3: 2,782,923 shares; 2025Q4: 2,647,512 shares 2,647,512$3.12M0.45%-135,411Timeline
QUREUNIQURE NVQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 100,000 shares; 2025Q1: 203,400 shares; 2025Q2: 202,565 shares; 2025Q3: 455,000 shares; 2025Q4: 126,047 shares 126,047$3.02M0.44%-328,953Timeline
TARSTARSUS PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 40,000 shares; 2024Q4: 65,955 shares; 2025Q1: 81,331 shares; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 36,124 shares 36,124$2.96M0.43%newTimeline
KYMRKYMERA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 34,589 shares 34,589$2.69M0.39%newTimeline
NXTCNEXTCURE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 176,057 shares 176,057$2.5M0.36%newTimeline
ELUTELUTIA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,645,808 shares; 2024Q4: 1,782,271 shares; 2025Q1: 2,670,056 shares; 2025Q2: 2,761,684 shares; 2025Q3: 2,850,987 shares; 2025Q4: 2,751,314 shares 2,751,314$1.91M0.28%-99,673Timeline
SIONSIONNA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 114,138 shares; 2025Q2: 186,015 shares; 2025Q3: 108,801 shares; 2025Q4: 41,460 shares 41,460$1.71M0.25%-67,341Timeline
CTMXCYTOMX THERAPEUTICS INC.Quarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 385,974 shares 385,974$1.64M0.24%newTimeline
XFORX4 PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 357,387 shares 357,387$1.43M0.21%newTimeline
EWTXEDGEWISE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 42,052 shares 42,052$1.04M0.15%newTimeline
RADXRADIOPHARM THERANOSTICS LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 187,406 shares; 2025Q1: 187,406 shares; 2025Q2: 187,406 shares; 2025Q3: 187,406 shares; 2025Q4: 187,406 shares 187,406$978K0.14%0Timeline
FDMT4D MOLECULAR THERAPEUTICS INQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 100,000 shares 100,000$750K0.11%newTimeline
ADGMADAGIO MED HLDGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 515,384 shares 515,384$536K0.08%newTimeline
RAPPRAPPORT THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 203,946 shares; 2025Q4: 9,659 shares 9,659$293K0.04%-194,287Timeline
PALIPALISADE BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 102,108 shares 102,108$240K0.03%newTimeline
IBIOIBIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 106,000 shares 106,000$205K0.03%newTimeline
RCKTWROCKET PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 104,828 shares; 2024Q4: 104,828 shares; 2025Q1: 104,828 shares; 2025Q2: 104,828 shares; 2025Q3: 104,828 shares; 2025Q4: 104,828 shares 104,828$2.55K<0.01%0Timeline

Options

Puts and calls, as filed. The amount and value describe the underlying shares, not the option premium, so they stay out of % of portfolio (H5).

SecurityTypeAmountValueChange
UNIQURE NVUNIQURE NV CALLcall720,800$17.2Mnew
KALVISTA PHARMACEUTICALS INCKALVISTA PHARMACEUTICALS INC CALLcall290,600$4.69Mnew
FULCRUM THERAPEUTICS INCFULCRUM THERAPEUTICS INC COMcall391,900$4.43Mnew
ULTRAGENYX PHARMACEUTICAL INULTRAGENYX PHARMACEUTICAL IN CALLcall110,000$2.53M-418,200

Sold out in Q4 2025

Positions in the previous quarter's report that this quarter's report no longer lists.

SecurityShares beforeValue beforeType
RNAMAVIDITY BIOSCIENCES INC844,633$36.8Mshares
AKROAKERO THERAPEUTICS INC643,636$30.6Mshares
UNITED THERAPEUTICS CORP DELUNITED THERAPEUTICS CORP DEL59,900$25.1Mput
CDTXCIDARA THERAPEUTICS INC220,902$21.2Mshares
CYTKCYTOKINETICS INC211,000$11.6Mshares
VSTMVERASTEM INC1,042,757$9.21Mshares
SRRKSCHOLAR ROCK HLDG CORP233,920$8.71Mshares
ALKSALKERMES PLC180,513$5.42Mshares
BBOTBRIDGEBIO ONCOLOGY THERAPEUT457,414$5.3Mshares
COGENT BIOSCIENCES INCCOGENT BIOSCIENCES INC360,000$5.17Mcall
PHVSPHARVARIS N V183,903$4.59Mshares
BCAXBICARA THERAPEUTICS INC250,606$3.96Mshares
KNSAKINIKSA PHARMACEUTICALS INTL88,910$3.45Mshares
EYPTEYEPOINT INC230,837$3.29Mshares
ZURAZURA BIO LTD720,452$3.12Mshares
DCTHDELCATH SYS INC203,386$2.19Mshares
CRNXCRINETICS PHARMACEUTICALS IN50,000$2.08Mshares
CAMPCAMP4 THERAPEUTICS CORP653,594$1.96Mshares
DYNDYNE THERAPEUTICS INC100,000$1.26Mshares
LBRXLB PHARMACEUTICALS INC70,000$1.11Mshares
CAPRICOR THERAPEUTICS INCCAPRICOR THERAPEUTICS INC144,700$1.04Mput
MERSANA THERAPEUTICS INCMERSANA THERAPEUTICS INC133,636$1.04Mshares
ATYR PHARMA INCATYR PHARMA INC1,250,000$901Kput
IMVTIMMUNOVANT INC50,000$806Kshares
ARCTURUS THERAPEUTICS HLDGSARCTURUS THERAPEUTICS HLDGS42,000$774Kput
SYNDAX PHARMACEUTICALS INCSYNDAX PHARMACEUTICALS INC50,000$770Kcall
ULTRAGENYX PHARMACEUTICAL INULTRAGENYX PHARMACEUTICAL IN25,000$752Kput
MOONLAKE IMMUNOTHERAPEUTICSMOONLAKE IMMUNOTHERAPEUTICS65,000$466Kcall
MODDMODULAR MED INC COM NEW639,531$448Kshares
BDSXBIODESIX INC49,607$375Kshares
MBXMBX BIOSCIENCES INC15,000$262Kshares
ELVNENLIVEN THERAPEUTICS INC10,675$219Kshares
MLTXMOONLAKE IMMUNOTHERAPEUTICS30,000$215Kshares
ARCTARCTURUS THERAPEUTICS HLDGS3,445$63.5Kshares
NKTRNEKTAR THERAPEUTICS365$20.8Kshares

How Q4 2025 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

FilingRoleAmendmentFiledAcceptedIngested
13F-HR 0001420506-26-000321 base2026-02-12acceptance time not in the bulk data set