NEA Management Company, LLC More: the full row for NEA Management Company, LLC 24,471,264 $87.4M 4.79% 0 13F-HR Timeline Bain Capital Life Sciences Investors, L… in group Bain Capital Life Sciences In… More: the full row for Bain Capital Life Sciences Investors, LLC 17,600,621 $62.8M 4.17% 0 13F-HR Timeline Group Venrock Adviser, LLC More: the full row for Venrock Adviser, LLC 12,681,043 $45.3M 2.55% +3,796,780 13F-HR Timeline TCG Crossover Management, LLC More: the full row for TCG Crossover Management, LLC 12,362,205 $44.1M 2.17% 0 13F-HR Timeline Frazier Life Sciences Management, L.P. More: the full row for Frazier Life Sciences Management, L.P. 11,462,301 $40.9M 1.23% 0 13F-HR Timeline Nantahala Capital Management, LLC in group Nantahala Capital Management,… More: the full row for Nantahala Capital Management, LLC 8,775,375 $31.3M 1.93% +450,000 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 8,448,240 $30.2M <0.01% -1,327,333 13F-HR Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 8,313,194 $29.7M <0.01% -140,786 13F-HR Timeline Group DEERFIELD MANAGEMENT COMPANY, L.P. in group DEERFIELD MANAGEMENT COMPANY,… More: the full row for DEERFIELD MANAGEMENT COMPANY, L.P. 7,964,000 $28.4M 0.44% 0 13F-HR Timeline Group EMERALD ADVISERS, LLC group of 2 filers holding More: the full row for EMERALD ADVISERS, LLC 5,680,682 $20.3M -40,090 Timeline Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 4,015,000 $14.3M 0.65% -7,000,000 13F-HR Timeline Rosalind Advisors, Inc. More: the full row for Rosalind Advisors, Inc. 4,000,000 $14.3M 5.05% +1,345,056 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 2,795,661 $9.98M <0.01% -174,522 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 2,644,000 $9.44M <0.01% -706,272 13F-HR Timeline Group FARALLON CAPITAL MANAGEMENT, L.L.C. More: the full row for FARALLON CAPITAL MANAGEMENT, L.L.C. 2,500,000 $8.93M 0.05% -4,335,000 13F-HR/A Timeline Sofinnova Investments, Inc. More: the full row for Sofinnova Investments, Inc. 2,427,724 $8.67M 0.53% -29,628 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 2,359,858 $8.42M <0.01% -97,083 13F-HR Timeline Group ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 1,988,288 $7.1M 0.7% -1,612,382 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 1,917,827 $6.85M <0.01% +1,535,214 13F-HR/A Timeline Group Affinity Asset Advisors, LLC More: the full row for Affinity Asset Advisors, LLC 1,500,000 $5.36M 0.5% +1,000,000 13F-HR Timeline SPHERA FUNDS MANAGEMENT LTD. in group SPHERA FUNDS MANAGEMENT LTD. More: the full row for SPHERA FUNDS MANAGEMENT LTD. 1,350,333 $4.82M 1.14% +40,100 13F-HR Timeline Group SUPERSTRING CAPITAL MANAGEMENT LP More: the full row for SUPERSTRING CAPITAL MANAGEMENT LP 1,309,236 $4.67M 4.6% +193,857 13F-HR Timeline AXA Investment Managers S.A. More: the full row for AXA Investment Managers S.A. 1,053,261 $3.76M 0.01% 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 963,798 $3.44M <0.01% -31,713 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 946,732 $3.38M <0.01% -122,924 13F-HR Timeline Group VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 856,600 $3.06M <0.01% +59,482 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 850,978 $3.04M <0.01% +19,933 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 844,177 $3.01M <0.01% new 13F-HR Timeline Group Sio Capital Management, LLC More: the full row for Sio Capital Management, LLC 726,851 $2.59M 0.66% 0 13F-HR Timeline DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 700,646 $2.5M <0.01% +55,174 13F-HR Timeline Group UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 695,734 $2.48M +257,454 Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 668,106 $2.39M <0.01% +557,322 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 662,246 $2.36M <0.01% +132,168 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 654,395 $2.34M <0.01% +612,771 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 605,565 $2.16M <0.01% new 13F-HR Timeline Group Swedbank AB in group Swedbank AB More: the full row for Swedbank AB 550,000 $1.96M <0.01% new 13F-HR Timeline Group F/m Investments LLC More: the full row for F/m Investments LLC 433,713 $1.55M 0.06% +118,867 13F-HR Timeline Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 419,800 $1.5M <0.01% -106,362 13F-HR Timeline Group GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 372,449 $1.33M 0.11% -336,014 13F-HR Timeline D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 372,025 $1.33M <0.01% +292,312 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 273,356 $976K <0.01% +3,869 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 260,100 $929K <0.01% new 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 237,221 $847K <0.01% +81,361 13F-HR Timeline Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 236,835 $846K <0.01% -83,438 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 219,831 $785K -262,248 Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 176,516 $630K <0.01% -77,312 13F-HR/A Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 171,266 $611K <0.01% +50,375 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 157,567 $563K <0.01% -12,609 13F-HR Timeline ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 123,790 $442K 0.01% new 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 3 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 121,840 $435K -201,436 Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 119,989 $428K <0.01% +42,113 13F-HR/A Timeline Group ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 118,790 $424K <0.01% -18,300 13F-HR Timeline Universal- Beteiligungs- und Serviceges… in group Universal- Beteiligungs- und … More: the full row for Universal- Beteiligungs- und Servicegesellschaft mbH 110,000 $393K <0.01% 0 13F-HR Timeline Group Connor, Clark & Lunn Investment Managem… More: the full row for Connor, Clark & Lunn Investment Management Ltd. 93,867 $335K <0.01% -215,968 13F-HR Timeline Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 91,021 $325K <0.01% new 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 84,090 $300K <0.01% +6,199 13F-HR Timeline Group EntryPoint Capital, LLC More: the full row for EntryPoint Capital, LLC 81,648 $291K 0.11% -96,852 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 67,420 $241K <0.01% +11,753 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 63,835 $228K <0.01% -4,673 13F-HR/A Timeline Group Brooklyn Investment Group More: the full row for Brooklyn Investment Group 98,642 $218K 0.03% +20,731 13F-HR/A Timeline MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 60,306 $215K <0.01% -15,327 13F-HR Timeline Group Stonepine Capital Management, LLC More: the full row for Stonepine Capital Management, LLC 60,000 $214K 0.17% -25,000 13F-HR Timeline Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 59,877 $214K -16,645 Timeline Graham Capital Management, L.P. More: the full row for Graham Capital Management, L.P. 53,398 $191K 0.01% new 13F-HR Timeline Quadrature Capital Ltd in group Quadrature Capital Ltd More: the full row for Quadrature Capital Ltd 52,039 $185K <0.01% +33,580 13F-HR Timeline Group Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 50,349 $180K 0.05% +8,742 13F-HR Timeline Group Sivia Capital Partners, LLC More: the full row for Sivia Capital Partners, LLC 48,500 $173K 0.05% +7,000 13F-HR Timeline INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 46,303 $165K <0.01% -22,864 13F-HR Timeline Creative Planning in group Creative Planning More: the full row for Creative Planning 44,225 $158K <0.01% -11,776 13F-HR Timeline Group Jain Global LLC More: the full row for Jain Global LLC 39,505 $141K <0.01% new 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 38,667 $138K 0.01% -49,430 13F-HR Timeline Group MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 38,467 $137K <0.01% -13,463 13F-HR Timeline Group Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 33,925 $121K <0.01% +7,702 13F-HR Timeline Brevan Howard Capital Management LP in group Brevan Howard Capital Managem… More: the full row for Brevan Howard Capital Management LP 33,193 $118K <0.01% +18,613 13F-HR Timeline Group China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 30,296 $108K 0.01% -4,418 13F-HR Timeline Sanctuary Advisors, LLC More: the full row for Sanctuary Advisors, LLC 29,732 $106K <0.01% -6,464 13F-HR/A Timeline Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 29,176 $104K <0.01% -8,825 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 30,580 $101K <0.01% +20,660 13F-HR Timeline Group Y-Intercept (Hong Kong) Ltd More: the full row for Y-Intercept (Hong Kong) Ltd 26,798 $95.7K <0.01% new 13F-HR Timeline ProShare Advisors LLC More: the full row for ProShare Advisors LLC 25,736 $91.9K <0.01% -6,662 13F-HR Timeline NorthCoast Asset Management LLC More: the full row for NorthCoast Asset Management LLC 25,214 $90K <0.01% 0 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 25,154 $89.8K <0.01% +11,681 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 25,136 $89.7K <0.01% new 13F-HR Timeline Group Cubist Systematic Strategies, LLC More: the full row for Cubist Systematic Strategies, LLC 24,087 $86K <0.01% new 13F-HR Timeline BROWN ADVISORY INC in group BROWN ADVISORY INC More: the full row for BROWN ADVISORY INC 20,854 $74.4K <0.01% 0 13F-HR Timeline Group Point72 Asia (Singapore) Pte. Ltd. More: the full row for Point72 Asia (Singapore) Pte. Ltd. 16,897 $60.3K 0.01% new 13F-HR Timeline OPPENHEIMER & CO INC in group OPPENHEIMER ASSET MANAGEMENT … More: the full row for OPPENHEIMER & CO INC 15,500 $55.3K <0.01% 0 13F-HR Timeline Group Point72 (DIFC) Ltd More: the full row for Point72 (DIFC) Ltd 14,743 $52.6K <0.01% new 13F-HR Timeline CHOREO, LLC More: the full row for CHOREO, LLC 14,658 $52.3K <0.01% 0 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 13,855 $49.5K <0.01% 0 13F-HR Timeline PRUDENTIAL FINANCIAL INC in group PRUDENTIAL FINANCIAL INC More: the full row for PRUDENTIAL FINANCIAL INC 13,145 $46.9K <0.01% +150 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 12,944 $46.2K <0.01% -40,234 13F-HR Timeline Group HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 12,849 $45K <0.01% new 13F-HR Timeline CIBC Bancorp USA Inc. in group CIBC Bancorp USA Inc. More: the full row for CIBC Bancorp USA Inc. 12,206 $43.6K <0.01% 13F-HR/A Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 12,102 $43.2K <0.01% -42,595 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 11,689 $41.7K <0.01% 0 13F-HR Timeline Group Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 10,480 $37.4K <0.01% +9,463 13F-HR Timeline Group SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 10,302 $36K <0.01% -1,531 13F-HR Timeline Mariner, LLC in group Mariner, LLC More: the full row for Mariner, LLC 10,000 $35.7K <0.01% new 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 8,457 $30.2K <0.01% -78,008 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 7,202 $25.7K <0.01% +1,551 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 6,531 $23.3K <0.01% -2,155 13F-HR Timeline Group AMALGAMATED BANK More: the full row for AMALGAMATED BANK 3,982 $14K <0.01% 0 13F-HR Timeline GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 3,667 $13.1K <0.01% -728 13F-HR Timeline Cornerstone Planning Group LLC More: the full row for Cornerstone Planning Group LLC 47 $8.98K <0.01% +46 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 2,279 $8.14K <0.01% +279 13F-HR Timeline COMERICA BANK More: the full row for COMERICA BANK 2,105 $7.51K <0.01% +1,433 13F-HR Timeline Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 1,995 $7.12K <0.01% new 13F-HR Timeline PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 1,838 $6.56K <0.01% +1,143 13F-HR Timeline Group Optiver Holding B.V. in group Optiver Holding B.V. More: the full row for Optiver Holding B.V. 1,524 $5.44K <0.01% new 13F-HR Timeline Group Larson Financial Group LLC More: the full row for Larson Financial Group LLC 639 $2.28K <0.01% new 13F-HR Timeline Point72 Europe (London) LLP More: the full row for Point72 Europe (London) LLP 617 $2.2K <0.01% new 13F-HR Timeline Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 553 $2K <0.01% 0 13F-HR Timeline Group CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 432 $2K <0.01% +114 13F-HR Timeline Group RAFFA WEALTH MANAGEMENT, LLC More: the full row for RAFFA WEALTH MANAGEMENT, LLC 420 $1.5K <0.01% 0 13F-HR Timeline Arax Advisory Partners More: the full row for Arax Advisory Partners 363 $1.3K <0.01% new 13F-HR Timeline Private Wealth Management Group, LLC More: the full row for Private Wealth Management Group, LLC 294 $1.05K <0.01% new 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 277 $989 <0.01% -29 13F-HR Timeline Sunbelt Securities, Inc. More: the full row for Sunbelt Securities, Inc. 25 $89 <0.01% new 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 4 $14 <0.01% -5 13F-HR Timeline MAI Capital Management More: the full row for MAI Capital Management 2 $8 <0.01% 0 13F-HR Timeline