NEA Management Company, LLC More: the full row for NEA Management Company, LLC 24,471,264 $75.1M 4.24% 0 13F-HR Timeline Bain Capital Life Sciences Investors, L… in group Bain Capital Life Sciences In… More: the full row for Bain Capital Life Sciences Investors, LLC 14,565,457 $44.7M 5.26% 0 13F-HR Timeline Group TCG Crossover Management, LLC More: the full row for TCG Crossover Management, LLC 12,362,205 $38M 3.71% 0 13F-HR Timeline Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 10,775,000 $33.1M 1.96% +2,685,000 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 9,588,099 $29.4M <0.01% +189,012 13F-HR Timeline Group Frazier Life Sciences Management, L.P. More: the full row for Frazier Life Sciences Management, L.P. 8,660,379 $26.6M 1.1% +502,994 13F-HR Timeline VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 8,309,970 $25.5M <0.01% +365,959 13F-HR Timeline Group DEERFIELD MANAGEMENT COMPANY, L.P. in group DEERFIELD MANAGEMENT COMPANY,… More: the full row for DEERFIELD MANAGEMENT COMPANY, L.P. 7,964,000 $24.4M 0.47% +1,498,223 13F-HR Timeline Group Nantahala Capital Management, LLC in group Nantahala Capital Management,… More: the full row for Nantahala Capital Management, LLC 7,525,259 $23.1M 1.62% +2,344,308 13F-HR Timeline Group FARALLON CAPITAL MANAGEMENT, L.L.C. More: the full row for FARALLON CAPITAL MANAGEMENT, L.L.C. 6,835,000 $21M 0.11% +2,275,000 13F-HR Timeline WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 5,481,654 $16.8M <0.01% -3,142,358 13F-HR Timeline Group Sofinnova Investments, Inc. More: the full row for Sofinnova Investments, Inc. 5,471,299 $16.8M 1.23% -191,251 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 4,174,079 $12.8M <0.01% +35,803 13F-HR Timeline Group EMERALD ADVISERS, LLC group of 2 filers holding More: the full row for EMERALD ADVISERS, LLC 3,708,568 $11.4M new Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 2,784,037 $8.55M <0.01% +57,187 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 2,686,938 $8.25M 0.06% +381,743 13F-HR Timeline Rosalind Advisors, Inc. More: the full row for Rosalind Advisors, Inc. 2,654,944 $8.15M 4.39% new 13F-HR/A Timeline ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 2,115,771 $6.5M 0.01% -4,637,930 13F-HR Timeline Group Altium Capital Management LLC More: the full row for Altium Capital Management LLC 1,579,000 $4.85M 1.51% +4,000 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 1,423,139 $4.37M <0.01% +1,353,649 13F-HR Timeline Group SPHERA FUNDS MANAGEMENT LTD. in group SPHERA FUNDS MANAGEMENT LTD. More: the full row for SPHERA FUNDS MANAGEMENT LTD. 1,211,533 $3.72M 0.69% +648,426 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 1,176,192 $3.61M +228,428 Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 1,077,363 $3.31M <0.01% +89,573 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 1,053,508 $3.23M <0.01% -30,385 13F-HR Timeline Group AXA S.A. in group AXA S.A. More: the full row for AXA S.A. 1,049,775 $3.22M 0.01% -1,657 13F-HR Timeline Group ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 988,468 $3.03M 0.63% +245,834 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 963,821 $2.96M <0.01% +52,204 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 927,595 $2.85M <0.01% +53,054 13F-HR/A Timeline Group Connor, Clark & Lunn Investment Managem… More: the full row for Connor, Clark & Lunn Investment Management Ltd. 837,467 $2.57M 0.01% +146,858 13F-HR Timeline Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 700,987 $2.15M 0.01% new 13F-HR Timeline Group Exome Asset Management LLC More: the full row for Exome Asset Management LLC 699,698 $2.15M 1.62% new 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 666,482 $2.05M <0.01% -30,325 13F-HR Timeline Group READYSTATE ASSET MANAGEMENT LP More: the full row for READYSTATE ASSET MANAGEMENT LP 530,317 $1.63M 0.07% new 13F-HR Timeline SUPERSTRING CAPITAL MANAGEMENT LP More: the full row for SUPERSTRING CAPITAL MANAGEMENT LP 508,338 $1.56M 1.37% +308,338 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 482,263 $1.48M <0.01% +201,599 13F-HR Timeline Group Affinity Asset Advisors, LLC More: the full row for Affinity Asset Advisors, LLC 410,586 $1.26M 0.2% -289,414 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 395,958 $1.22M <0.01% -75,397 13F-HR/A Timeline Group Nuveen Asset Management, LLC in group TIAA More: the full row for Nuveen Asset Management, LLC 384,779 $1.18M <0.01% -30,766 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 361,229 $1.11M <0.01% new 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 2 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 294,975 $906K +257,466 Timeline UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 291,907 $896K -3,987 Timeline RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 259,798 $798K <0.01% 13F-HR/A Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 254,253 $781K <0.01% -28,989 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 253,630 $779K <0.01% +17,870 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 236,705 $727K <0.01% +5,700 13F-HR/A Timeline Group PRELUDE CAPITAL MANAGEMENT, LLC More: the full row for PRELUDE CAPITAL MANAGEMENT, LLC 214,625 $659K 0.06% new 13F-HR Timeline Swiss National Bank More: the full row for Swiss National Bank 178,000 $546K <0.01% -12,800 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 173,396 $532K <0.01% -142,793 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 159,461 $490K <0.01% +73,131 13F-HR Timeline Group Rafferty Asset Management, LLC More: the full row for Rafferty Asset Management, LLC 146,997 $451K <0.01% -21,128 13F-HR Timeline DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 143,661 $441K <0.01% +5,450 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 141,425 $434K <0.01% +9,041 13F-HR/A Timeline ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 138,771 $426K <0.01% +10,270 13F-HR Timeline Group ALGERT GLOBAL LLC More: the full row for ALGERT GLOBAL LLC 132,968 $408K 0.01% +9,000 13F-HR/A Timeline Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 122,635 $376K <0.01% +78,540 13F-HR Timeline Group EntryPoint Capital, LLC More: the full row for EntryPoint Capital, LLC 103,288 $317K 0.13% +62,325 13F-HR Timeline Cubist Systematic Strategies, LLC More: the full row for Cubist Systematic Strategies, LLC 103,099 $317K 0.01% +49,204 13F-HR Timeline ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 100,770 $309K <0.01% 0 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 99,959 $307K <0.01% +74,266 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 95,577 $293K <0.01% 0 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 86,465 $265K <0.01% -8,102 13F-HR/A Timeline VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 82,715 $254K <0.01% -736 13F-HR/A Timeline Group F/m Investments LLC More: the full row for F/m Investments LLC 81,343 $250K 0.01% new 13F-HR Timeline Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 77,863 $240K +2,122 Timeline D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 70,560 $217K <0.01% +53,547 13F-HR Timeline Group INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 67,572 $207K <0.01% +26,555 13F-HR Timeline Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 63,616 $195K <0.01% +19,608 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 59,277 $182K <0.01% +17,786 13F-HR Timeline Group MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 59,049 $181K <0.01% -7,858 13F-HR Timeline Group Corebridge Financial, Inc. in group Corebridge Financial, Inc. More: the full row for Corebridge Financial, Inc. 57,367 $176K <0.01% -4,330 13F-HR Timeline Group SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 51,589 $158K <0.01% +6,330 13F-HR Timeline Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 48,797 $150K <0.01% +1,839 13F-HR Timeline Group OCONNOR, A Distinct Business Unit of UB… More: the full row for OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 48,482 $149K <0.01% +10,000 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 44,734 $137K <0.01% -222 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 43,668 $135K <0.01% +5,236 13F-HR Timeline JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 42,400 $130K <0.01% -203,400 13F-HR Timeline Group ProShare Advisors LLC More: the full row for ProShare Advisors LLC 40,627 $125K <0.01% +9,096 13F-HR Timeline Sivia Capital Partners, LLC More: the full row for Sivia Capital Partners, LLC 38,000 $117K 0.06% -2,500 13F-HR Timeline LMR Partners LLP in group LMR Partners LLP More: the full row for LMR Partners LLP 36,800 $113K <0.01% 0 13F-HR Timeline Group China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 36,390 $112K 0.01% +4,732 13F-HR Timeline JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 35,046 $108K <0.01% -29,873 13F-HR Timeline Group PROFUND ADVISORS LLC More: the full row for PROFUND ADVISORS LLC 29,575 $90.8K <0.01% -4,640 13F-HR Timeline TEACHER RETIREMENT SYSTEM OF TEXAS More: the full row for TEACHER RETIREMENT SYSTEM OF TEXAS 27,118 $83K <0.01% +2,375 13F-HR Timeline ARIZONA STATE RETIREMENT SYSTEM More: the full row for ARIZONA STATE RETIREMENT SYSTEM 26,236 $80.5K <0.01% -2,170 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 26,223 $80.5K <0.01% 13F-HR Timeline Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 25,782 $79.2K <0.01% 0 13F-HR Timeline STATE BOARD OF ADMINISTRATION OF FLORID… More: the full row for STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 25,780 $79.1K <0.01% 0 13F-HR Timeline NorthCoast Asset Management LLC More: the full row for NorthCoast Asset Management LLC 25,214 $77.4K <0.01% 0 13F-HR/A Timeline VIRTUS ADVISERS, LLC in group Virtus Investment Advisers, L… More: the full row for VIRTUS ADVISERS, LLC 21,222 $65.2K 0.03% -1,479 13F-HR Timeline Group BROWN ADVISORY INC in group BROWN ADVISORY INC More: the full row for BROWN ADVISORY INC 20,854 $64K <0.01% 0 13F-HR Timeline Group Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 20,755 $63.7K <0.01% new 13F-HR Timeline Group Creative Planning in group Creative Planning More: the full row for Creative Planning 15,864 $48.7K <0.01% new 13F-HR Timeline Group HSBC HOLDINGS PLC in group HSBC HOLDINGS PLC More: the full row for HSBC HOLDINGS PLC 15,627 $47.9K <0.01% new 13F-HR Timeline Group OPPENHEIMER & CO INC in group OPPENHEIMER ASSET MANAGEMENT … More: the full row for OPPENHEIMER & CO INC 15,600 $47.9K <0.01% -100,004 13F-HR Timeline Group CHOREO, LLC More: the full row for CHOREO, LLC 14,658 $45K <0.01% 0 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 13,855 $42.5K <0.01% 0 13F-HR/A Timeline KLP KAPITALFORVALTNING AS More: the full row for KLP KAPITALFORVALTNING AS 13,200 $40.5K <0.01% 13F-HR Timeline Point72 (DIFC) Ltd More: the full row for Point72 (DIFC) Ltd 12,179 $37.4K <0.01% new 13F-HR Timeline AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 12,139 $37.3K <0.01% new 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 11,689 $35.9K <0.01% 0 13F-HR Timeline Group VICTORY CAPITAL MANAGEMENT INC More: the full row for VICTORY CAPITAL MANAGEMENT INC 11,246 $34.5K <0.01% -128,764 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 11,136 $34.2K <0.01% new 13F-HR Timeline Group CIBC WORLD MARKETS CORP More: the full row for CIBC WORLD MARKETS CORP 10,798 $33.1K <0.01% new 13F-HR Timeline E Fund Management Co., Ltd. More: the full row for E Fund Management Co., Ltd. 10,399 $31.9K <0.01% -403 13F-HR Timeline CANADA LIFE ASSURANCE Co in group CANADA LIFE ASSURANCE Co More: the full row for CANADA LIFE ASSURANCE Co 7,047 $22K <0.01% 0 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 6,046 $18.6K <0.01% +2,765 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 4,775 $15K <0.01% -7,666 13F-HR Timeline Group Sio Capital Management, LLC More: the full row for Sio Capital Management, LLC 3,747 $11.5K <0.01% new 13F-HR Timeline GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 3,604 $11.1K <0.01% 13F-HR Timeline AMALGAMATED BANK More: the full row for AMALGAMATED BANK 3,087 $9K <0.01% 0 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 2,272 $6.97K <0.01% new 13F-HR/A Timeline Group R Squared Ltd More: the full row for R Squared Ltd 2,000 $6.14K 0.01% 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 2,046 $5.67K <0.01% 0 13F-HR Timeline Truvestments Capital LLC More: the full row for Truvestments Capital LLC 1,712 $5.26K <0.01% 0 13F-HR Timeline GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 1,499 $4.6K <0.01% -7,187 13F-HR/A Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 1,026 $3.15K <0.01% new 13F-HR Timeline Group JONES FINANCIAL COMPANIES LLLP in group JONES FINANCIAL COMPANIES LLLP More: the full row for JONES FINANCIAL COMPANIES LLLP 1,000 $3.07K <0.01% new 13F-HR Timeline Group Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 859 $2.64K <0.01% +718 13F-HR Timeline Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 553 $2K <0.01% 0 13F-HR Timeline Group RAFFA WEALTH MANAGEMENT, LLC More: the full row for RAFFA WEALTH MANAGEMENT, LLC 420 $1.29K <0.01% 0 13F-HR Timeline ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 350 $1.07K <0.01% +290 13F-HR Timeline Amundi in group Amundi More: the full row for Amundi 302 $918 <0.01% new 13F-HR Timeline Group US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 114 $350 <0.01% 0 13F-HR Timeline Group Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 81 $249 <0.01% 13F-HR/A Timeline NATIONAL BANK OF CANADA /FI/ in group NATIONAL BANK OF CANADA /FI/ More: the full row for NATIONAL BANK OF CANADA /FI/ 71 $218 <0.01% new 13F-HR Timeline Group IFP Advisors, Inc More: the full row for IFP Advisors, Inc 0 $150 <0.01% new 13F-HR Timeline Amount filed as zero, left out of ratios. NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 13 $40 <0.01% 0 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 5 $15 <0.01% 13F-HR Timeline MAI Capital Management More: the full row for MAI Capital Management 2 $7 <0.01% new 13F-HR Timeline Cornerstone Planning Group LLC More: the full row for Cornerstone Planning Group LLC 1 $3 <0.01% 0 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 44 $0 0% -11 13F-HR Timeline Group Value filed as zero, left out of ratios. CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.