NEA Management Company, LLC More: the full row for NEA Management Company, LLC 24,471,264 $55.8M 4.2% 0 13F-HR Timeline Bain Capital Life Sciences Investors, L… in group Bain Capital Life Sciences In… More: the full row for Bain Capital Life Sciences Investors, LLC 17,600,621 $40.1M 5.02% 0 13F-HR Timeline Group TCG Crossover Management, LLC More: the full row for TCG Crossover Management, LLC 12,362,205 $28.2M 3.22% 0 13F-HR Timeline Frazier Life Sciences Management, L.P. More: the full row for Frazier Life Sciences Management, L.P. 11,462,301 $26.1M 1.05% 0 13F-HR Timeline Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 11,015,000 $25.1M 1.32% +15,000 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 9,775,573 $22.3M <0.01% -170,738 13F-HR Timeline Group Venrock Adviser, LLC More: the full row for Venrock Adviser, LLC 8,884,263 $20.3M 1.52% +5,626,624 13F-HR Timeline VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 8,453,980 $19.3M <0.01% +334,733 13F-HR Timeline Group Nantahala Capital Management, LLC in group Nantahala Capital Management,… More: the full row for Nantahala Capital Management, LLC 8,325,375 $19M 1.34% +250,000 13F-HR Timeline Group DEERFIELD MANAGEMENT COMPANY, L.P. in group DEERFIELD MANAGEMENT COMPANY,… More: the full row for DEERFIELD MANAGEMENT COMPANY, L.P. 7,964,000 $18.2M 0.33% 0 13F-HR Timeline Group FARALLON CAPITAL MANAGEMENT, L.L.C. More: the full row for FARALLON CAPITAL MANAGEMENT, L.L.C. 6,835,000 $15.6M 0.07% 0 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. EMERALD ADVISERS, LLC group of 2 filers holding More: the full row for EMERALD ADVISERS, LLC 5,720,772 $13M +616,103 Timeline ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 3,600,670 $8.21M 1.33% +2,240,379 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 3,350,272 $7.64M <0.01% -812,381 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 2,970,183 $6.77M <0.01% +147,946 13F-HR Timeline Group Rosalind Advisors, Inc. More: the full row for Rosalind Advisors, Inc. 2,654,944 $6.05M 2.93% 0 13F-HR Timeline Sofinnova Investments, Inc. More: the full row for Sofinnova Investments, Inc. 2,457,352 $5.6M 0.38% -3,024,314 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 2,456,941 $5.6M <0.01% +7,290 13F-HR Timeline Group SPHERA FUNDS MANAGEMENT LTD. in group SPHERA FUNDS MANAGEMENT LTD. More: the full row for SPHERA FUNDS MANAGEMENT LTD. 1,310,233 $2.99M 0.78% +26,082 13F-HR Timeline Group SUPERSTRING CAPITAL MANAGEMENT LP More: the full row for SUPERSTRING CAPITAL MANAGEMENT LP 1,115,379 $2.54M 3.17% +149,176 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 1,069,656 $2.44M <0.01% +13,478 13F-HR Timeline Group AXA S.A. in group AXA S.A. More: the full row for AXA S.A. 1,050,126 $2.39M 0.01% +1,685 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 995,511 $2.27M <0.01% +40,681 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 831,045 $1.89M <0.01% -84,972 13F-HR Timeline Group VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 797,118 $1.82M <0.01% +716,089 13F-HR Timeline Group Sio Capital Management, LLC More: the full row for Sio Capital Management, LLC 726,851 $1.66M 0.67% +7,197 13F-HR Timeline GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 708,463 $1.61M 0.11% +620,758 13F-HR Timeline DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 645,472 $1.47M <0.01% +356,798 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 530,078 $1.21M <0.01% +62,531 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 526,162 $1.2M <0.01% -271,165 13F-HR Timeline Group Affinity Asset Advisors, LLC More: the full row for Affinity Asset Advisors, LLC 500,000 $1.14M 0.17% new 13F-HR Timeline TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 482,079 $1.1M -187,240 Timeline UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 438,280 $999K +94,971 Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 382,613 $872K <0.01% +127,100 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 3 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 323,276 $737K -40,067 Timeline Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 320,273 $730K <0.01% -64,830 13F-HR Timeline Group F/m Investments LLC More: the full row for F/m Investments LLC 314,846 $718K 0.03% +91,830 13F-HR Timeline Connor, Clark & Lunn Investment Managem… More: the full row for Connor, Clark & Lunn Investment Management Ltd. 309,835 $706K <0.01% -469,119 13F-HR Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 269,487 $614K <0.01% +6,552 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 253,828 $579K <0.01% +92,345 13F-HR/A Timeline Group Driehaus Capital Management LLC More: the full row for Driehaus Capital Management LLC 182,296 $416K <0.01% new 13F-HR Timeline EntryPoint Capital, LLC More: the full row for EntryPoint Capital, LLC 178,500 $407K 0.2% -3,155 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 170,176 $388K <0.01% +16,634 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 155,860 $355K <0.01% -96,052 13F-HR Timeline Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 149,427 $341K <0.01% +89,084 13F-HR Timeline Swiss National Bank More: the full row for Swiss National Bank 148,400 $338K <0.01% -29,600 13F-HR Timeline ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 137,090 $313K <0.01% +36,320 13F-HR Timeline Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 120,891 $276K <0.01% +31,633 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 110,784 $253K <0.01% -393,227 13F-HR Timeline Group Universal- Beteiligungs- und Serviceges… in group Universal- Beteiligungs- und … More: the full row for Universal- Beteiligungs- und Servicegesellschaft mbH 110,000 $251K <0.01% -27,694 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 88,097 $201K 0.01% new 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 86,465 $197K <0.01% 0 13F-HR Timeline Stonepine Capital Management, LLC More: the full row for Stonepine Capital Management, LLC 85,000 $194K 0.19% +55,921 13F-HR Timeline ALGERT GLOBAL LLC More: the full row for ALGERT GLOBAL LLC 79,948 $182K <0.01% -53,020 13F-HR/A Timeline D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 79,713 $182K <0.01% +23,453 13F-HR Timeline Group Brooklyn Investment Group More: the full row for Brooklyn Investment Group 77,911 $178K 0.02% +54,300 13F-HR/A Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 77,891 $178K <0.01% +11,928 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 77,876 $178K <0.01% -10,736 13F-HR Timeline Group Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 76,522 $174K -445 Timeline MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 75,633 $172K <0.01% +23,531 13F-HR Timeline Group INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 69,167 $158K <0.01% -8,522 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 68,508 $156K <0.01% -2,115,152 13F-HR Timeline Group Creative Planning in group Creative Planning More: the full row for Creative Planning 56,001 $128K <0.01% -37,888 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 55,667 $127K <0.01% +3,545 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 54,697 $125K <0.01% -42,119 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 53,178 $121K <0.01% -39,904 13F-HR Timeline Group MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 51,930 $118K <0.01% +6,449 13F-HR Timeline Group JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 42,400 $96.5K <0.01% 0 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 41,624 $95K <0.01% +41,467 13F-HR/A Timeline Group Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 41,607 $94.9K 0.03% -7,399 13F-HR Timeline Group Sivia Capital Partners, LLC More: the full row for Sivia Capital Partners, LLC 41,500 $94.6K 0.03% +3,459 13F-HR/A Timeline Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 38,001 $86.6K <0.01% +5,687 13F-HR Timeline Sanctuary Advisors, LLC More: the full row for Sanctuary Advisors, LLC 36,196 $82.5K <0.01% +24,942 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 34,714 $79.1K 0.01% +290 13F-HR Timeline ProShare Advisors LLC More: the full row for ProShare Advisors LLC 32,398 $73.9K <0.01% -1,417 13F-HR Timeline LOS ANGELES CAPITAL MANAGEMENT LLC More: the full row for LOS ANGELES CAPITAL MANAGEMENT LLC 30,395 $69.3K <0.01% new 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 26,223 $59.8K <0.01% 0 13F-HR Timeline STATE BOARD OF ADMINISTRATION OF FLORID… More: the full row for STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 25,780 $58.8K <0.01% 0 13F-HR Timeline NorthCoast Asset Management LLC More: the full row for NorthCoast Asset Management LLC 25,214 $57.5K <0.01% 0 13F-HR Timeline ARIZONA STATE RETIREMENT SYSTEM More: the full row for ARIZONA STATE RETIREMENT SYSTEM 22,626 $51.6K <0.01% -4,449 13F-HR Timeline TEACHER RETIREMENT SYSTEM OF TEXAS More: the full row for TEACHER RETIREMENT SYSTEM OF TEXAS 21,351 $48.7K <0.01% -4,019 13F-HR Timeline BROWN ADVISORY INC in group BROWN ADVISORY INC More: the full row for BROWN ADVISORY INC 20,854 $47.5K <0.01% 0 13F-HR Timeline Group Quadrature Capital Ltd in group Quadrature Capital Ltd More: the full row for Quadrature Capital Ltd 18,459 $42K <0.01% new 13F-HR Timeline Group Quarry LP More: the full row for Quarry LP 17,000 $38.8K 0.01% +10,000 13F-HR Timeline CIBC WORLD MARKETS CORP More: the full row for CIBC WORLD MARKETS CORP 15,589 $35.5K <0.01% -11,135 13F-HR Timeline OPPENHEIMER & CO INC in group OPPENHEIMER ASSET MANAGEMENT … More: the full row for OPPENHEIMER & CO INC 15,500 $35.3K <0.01% -100 13F-HR Timeline Group CHOREO, LLC More: the full row for CHOREO, LLC 14,658 $33.4K <0.01% 0 13F-HR Timeline Brevan Howard Capital Management LP in group Brevan Howard Capital Managem… More: the full row for Brevan Howard Capital Management LP 14,580 $33.2K <0.01% new 13F-HR Timeline Group May Hill Capital, LLC More: the full row for May Hill Capital, LLC 14,097 $32.1K 0.01% new 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 13,855 $31.6K <0.01% 0 13F-HR/A Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 13,473 $30.7K <0.01% +4,626 13F-HR Timeline Group KLP KAPITALFORVALTNING AS More: the full row for KLP KAPITALFORVALTNING AS 13,200 $30.1K <0.01% 0 13F-HR Timeline PRUDENTIAL FINANCIAL INC in group PRUDENTIAL FINANCIAL INC More: the full row for PRUDENTIAL FINANCIAL INC 12,995 $29.6K <0.01% new 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 11,689 $26.7K <0.01% 0 13F-HR Timeline Group SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 11,833 $26K <0.01% new 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 9,920 $22.6K <0.01% +9,890 13F-HR/A Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 8,686 $19.8K <0.01% +6,023 13F-HR Timeline Group RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 7,379 $16.8K <0.01% new 13F-HR Timeline Group CANADA LIFE ASSURANCE Co in group CANADA LIFE ASSURANCE Co More: the full row for CANADA LIFE ASSURANCE Co 7,047 $16K <0.01% 0 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 5,651 $12.9K <0.01% -7,431 13F-HR Timeline Group GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 4,395 $10K <0.01% 0 13F-HR Timeline AMALGAMATED BANK More: the full row for AMALGAMATED BANK 3,982 $9K <0.01% 0 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 2,000 $4.56K <0.01% -182 13F-HR Timeline Truvestments Capital LLC More: the full row for Truvestments Capital LLC 1,712 $3.9K <0.01% 0 13F-HR Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 1,017 $2.32K <0.01% new 13F-HR Timeline Group JONES FINANCIAL COMPANIES LLLP in group JONES FINANCIAL COMPANIES LLLP More: the full row for JONES FINANCIAL COMPANIES LLLP 1,000 $2.21K <0.01% 0 13F-HR Timeline Group PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 695 $1.58K <0.01% new 13F-HR Timeline Group COMERICA BANK More: the full row for COMERICA BANK 672 $1.53K <0.01% -1,735 13F-HR Timeline Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 553 $1K <0.01% 0 13F-HR Timeline Group CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 318 $1K <0.01% -332 13F-HR Timeline Group RAFFA WEALTH MANAGEMENT, LLC More: the full row for RAFFA WEALTH MANAGEMENT, LLC 420 $958 <0.01% 0 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 306 $698 <0.01% -234 13F-HR/A Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 20 $46 <0.01% -54 13F-HR Timeline Group True Wealth Design, LLC More: the full row for True Wealth Design, LLC 15 $35 <0.01% -26 13F-HR Timeline IFP Advisors, Inc More: the full row for IFP Advisors, Inc 0 $23 <0.01% 0 13F-HR Timeline Amount filed as zero, left out of ratios. SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 9 $21 <0.01% +5 13F-HR Timeline MAI Capital Management More: the full row for MAI Capital Management 2 $5 <0.01% 0 13F-HR Timeline Cornerstone Planning Group LLC More: the full row for Cornerstone Planning Group LLC 1 $3 <0.01% 0 13F-HR Timeline CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.