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Disclosery

SION SIONNA THERAPEUTICS INC

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COMMON STOCK (common), issuer CIK 2036042

100 managers (101 13F filers) reported a position in SION shares at 2025-12-31, 43,950,895 shares in all. 27 filers opened a position and 7 filers sold out during the quarter.

Managers
100
13F filers
101
New
27
Added
39
Reduced
20
Sold out
7
Shares held by filers
43,950,895

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q4 2025

Filers in the available 13F reports with a share position at 2025-12-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
RA CAPITAL MANAGEMENT, L.P.in group RA CAPITAL MANAGEMENT, L.P.9,905,045$407M4.17%-540,27713F-HRTimelineGroup
TPG GP A, LLCin group TPG GP A, LLC6,744,962$277M10.33%013F-HRTimelineGroup
ORBIMED ADVISORS LLCin group ORBIMED ADVISORS LLC3,561,655$147M3%-143,30413F-HRTimelineGroup
VIKING GLOBAL INVESTORS LPin group VIKING GLOBAL INVESTORS LP3,195,181$131M0.35%013F-HRTimelineGroup
Atlas Venture Life Science Advisors, LLC2,995,602$123M14.24%-619,92513F-HRTimeline
ENAVATE SCIENCES GP, LLC2,478,030$102M20.12%013F-HRTimeline
BlackRock, Inc.in group BlackRock, Inc.1,291,599$53.1M<0.01%+446,99413F-HRTimelineGroup
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO1,231,819$50.7M<0.01%-746,80713F-HRTimelineGroup
VANGUARD GROUP INCin group VANGUARD GROUP INC1,184,951$48.7M<0.01%+41,79713F-HRTimelineGroup
PERCEPTIVE ADVISORS LLCin group PERCEPTIVE ADVISORS LLC1,179,098$48.5M0.89%013F-HRTimelineGroup
JENNISON ASSOCIATES LLC1,115,278$45.9M0.03%+117,90313F-HRTimeline
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC1,087,325$44.7M0.03%+1,051,40213F-HRTimelineGroup
DEERFIELD MANAGEMENT COMPANY, L.P.in group DEERFIELD MANAGEMENT COMPANY,…970,590$39.9M0.51%013F-HRTimelineGroup
Aberdeen Group plcin group Aberdeen Group plc839,960$34.6M0.05%-110,58713F-HRTimelineGroup
PRICE T ROWE ASSOCIATES INC /MD/831,373$34.2M<0.01%+193,61313F-HRTimeline
STATE STREET CORPin group STATE STREET CORP693,395$28.5M<0.01%+453,19613F-HRTimelineGroup
EVENTIDE ASSET MANAGEMENT, LLC639,045$26.3M0.41%new13F-HRTimeline
BAKER BROS. ADVISORS LPin group BAKER BROS. ADVISORS LP400,000$16.5M0.1%013F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC380,042$15.6M<0.01%+63,47813F-HRTimelineGroup
Siren, L.L.C.in group Siren, L.L.C.300,000$12.3M0.37%-25,00013F-HRTimelineGroup
Soleus Capital Management, L.P.268,500$11M0.47%-145,00013F-HRTimeline
Kalehua Capital Management LLC197,072$8.11M8.02%13F-HRTimeline
SUPERSTRING CAPITAL MANAGEMENT LP180,593$7.43M3.98%new13F-HRTimeline
FRANKLIN RESOURCES INCin group Franklin Resources175,483$7.22M<0.01%-66,66413F-HRTimelineGroup
Alyeska Investment Group, L.P.in group Alyeska Investment Group, L.P.136,222$5.6M0.02%-50,00013F-HRTimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co123,686$5.09M<0.01%+12,19013F-HRTimelineGroup
Artia Global Partners LP119,741$4.93M0.79%new13F-HRTimeline
TD Asset Management Inc113,352$4.66M<0.01%+26,27013F-HRTimeline
NORTHERN TRUST CORPin group NORTHERN TRUST CORP112,116$4.61M<0.01%+14,40513F-HRTimelineGroup
Invesco Ltd.in group Invesco Ltd.111,162$4.57M<0.01%new13F-HRTimelineGroup
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC101,643$4.18M<0.01%-51,50813F-HRTimelineGroup
Rock Springs Capital Management LP99,429$4.09M0.21%013F-HRTimeline
UBS Group AGin group UBS Group AG89,177$3.67M<0.01%+42,51113F-HRTimelineGroup
Driehaus Capital Management LLC83,850$3.45M0.02%013F-HRTimeline
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC80,546$3.31M<0.01%-133,53913F-HRTimelineGroup
Ensign Peak Advisors, Inc79,862$3.29M0.01%new13F-HR/ATimeline
Longaeva Partners L.P.79,729$3.28M0.39%+18,27213F-HRTimeline
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …69,424$2.87M<0.01%+37,34413F-HRTimelineGroup
SEVEN GRAND MANAGERS, LLC50,000$2.06M0.16%new13F-HRTimeline
MORGAN STANLEYin group MORGAN STANLEY49,876$2.05M<0.01%+27,03913F-HR/ATimelineGroup
BARCLAYS PLCin group BARCLAYS PLC48,172$1.98M<0.01%+30,52913F-HRTimelineGroup
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/43,567$1.79M<0.01%+37,02613F-HRTimelineGroup
SILVERARC CAPITAL MANAGEMENT, LLCin group SILVERARC CAPITAL MANAGEMENT,…41,460$1.71M0.25%-67,34113F-HRTimelineGroup
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…38,347$1.58M<0.01%-3,88713F-HRTimelineGroup
ALPS ADVISORS INCin group ALPS ADVISORS INC36,648$1.51M0.01%new13F-HRTimelineGroup
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC36,269$1.49M<0.01%+24,09113F-HR/ATimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp35,134$1.45M<0.01%+7,67113F-HRTimelineGroup
POLEN CAPITAL MANAGEMENT LLC31,258$1.29M0.01%013F-HRTimeline
Rafferty Asset Management, LLC24,690$1.02M<0.01%new13F-HRTimeline
Nuveen, LLCin group TIAA23,734$976K<0.01%+7,69413F-HRTimelineGroup
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…21,941$903K<0.01%+20,91913F-HRTimelineGroup
RHUMBLINE ADVISERS17,694$728K<0.01%+45413F-HRTimeline
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN17,551$722K<0.01%+9,97513F-HRTimelineGroup
Squarepoint Ops LLCin group Squarepoint Ops LLC16,360$673K<0.01%+6,19813F-HRTimelineGroup
ALLIANCEBERNSTEIN L.P.15,620$643K<0.01%new13F-HRTimeline
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding11,084$456K+5,441Timeline
SG Americas Securities, LLC10,691$440K<0.01%new13F-HRTimeline
China Universal Asset Management Co., L…10,272$423K0.03%+5,27213F-HRTimeline
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\10,029$413K<0.01%+43313F-HRTimelineGroup
PROFUND ADVISORS LLC9,213$379K0.01%new13F-HRTimeline
MetLife Investment Management, LLCin group MetLife Investment Management…8,565$352K<0.01%+53213F-HRTimelineGroup
INTECH INVESTMENT MANAGEMENT LLC7,589$312K<0.01%+10313F-HRTimeline
KENNEDY CAPITAL MANAGEMENT LLC6,752$278K0.01%new13F-HRTimeline
TWO SIGMA INVESTMENTS, LPin group TWO SIGMA INVESTMENTS, LP6,400$263K<0.01%new13F-HRTimelineGroup
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…6,220$256K0.07%-47813F-HRTimelineGroup
AMERICAN CENTURY COMPANIES INCin group AMERICAN CENTURY COMPANIES INC6,180$254K<0.01%new13F-HRTimelineGroup
DARK FOREST CAPITAL MANAGEMENT LP5,991$246K0.01%new13F-HRTimeline
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.5,742$236K<0.01%new13F-HRTimelineGroup
NEW YORK STATE COMMON RETIREMENT FUND5,300$218K<0.01%013F-HRTimeline
CITIGROUP INCin group CITIGROUP INC5,185$213K<0.01%+4,49813F-HRTimelineGroup
XTX Topco Ltdin group XTX Topco Ltd4,926$203K0.01%new13F-HRTimelineGroup
ProShare Advisors LLC4,903$202K<0.01%new13F-HRTimeline
LOS ANGELES CAPITAL MANAGEMENT LLC5,189$197K<0.01%new13F-HRTimeline
CIBC Private Wealth Group LLCin group CIBC Bancorp USA Inc.4,500$185K<0.01%new13F-HRTimelineGroup
Police & Firemen's Retirement System of…4,232$174K<0.01%+99813F-HRTimeline
AlphaCentric Advisors LLC2,720$112K0.11%13F-HRTimeline
Cygnus Capital Advisors, LLC2,400$99K0.07%13F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS2,264$93.1K<0.01%-11613F-HRTimelineGroup
Legal & General Group Plcin group Legal & General Group Plc1,682$69.2K<0.01%-5,69213F-HRTimelineGroup
Balyasny Asset Management L.P.in group Balyasny Asset Management1,406$57.8K<0.01%new13F-HRTimelineGroup
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…1,302$53.6K<0.01%+4313F-HRTimelineGroup
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…1,129$46.4K<0.01%-3,36113F-HRTimelineGroup
CALIFORNIA STATE TEACHERS RETIREMENT SY…988$40.6K<0.01%+21713F-HRTimeline
GF FUND MANAGEMENT CO. LTD.876$36K<0.01%new13F-HRTimeline
AMALGAMATED BANK504$21K<0.01%+8313F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA489$21K<0.01%+11113F-HRTimelineGroup
FMR LLCin group FMR LLC384$15.8K<0.01%+15013F-HRTimelineGroup
Farther Finance Advisors, LLC190$7.82K<0.01%new13F-HRTimeline
GAMMA Investing LLC177$7.28K<0.01%+2413F-HRTimeline
Daiwa Securities Group Inc.in group Daiwa Securities Group Inc.149$6K<0.01%new13F-HRTimelineGroup
Sterling Capital Management LLC105$4.32K<0.01%+7513F-HRTimeline
CWM, LLCin group CWM, LLC80$3K<0.01%+2013F-HRTimelineGroup
US BANCORP \DE\in group US BANCORP \DE\65$2.67K<0.01%-4613F-HRTimelineGroup
Rockefeller Capital Management L.P.in group Rockefeller Capital Managemen…48$1.98K<0.01%new13F-HR/ATimelineGroup
Aster Capital Management (DIFC) Ltd37$1.52K<0.01%-37213F-HRTimeline
Allworth Financial LP28$1.15K<0.01%+613F-HRTimeline
Hughes Financial Services, LLC25$1.03K<0.01%-1913F-HRTimeline
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…20$823<0.01%013F-HRTimelineGroup
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…5$206<0.01%013F-HRTimelineGroup
ROTHSCHILD INVESTMENT LLC1$41<0.01%new13F-HRTimeline