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Disclosery

SION SIONNA THERAPEUTICS INC

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COMMON STOCK (common), issuer CIK 2036042

78 managers (78 13F filers) reported a position in SION shares at 2025-09-30, 42,840,565 shares in all. 19 filers opened a position and 6 filers sold out during the quarter.

Managers
78
13F filers
78
New
19
Added
20
Reduced
19
Sold out
6
Shares held by filers
42,840,565

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q3 2025

Filers in the available 13F reports with a share position at 2025-09-30, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
RA CAPITAL MANAGEMENT, L.P.in group RA CAPITAL MANAGEMENT, L.P.10,445,322$307M3.79%013F-HRTimelineGroup
TPG GP A, LLCin group TPG GP A, LLC6,744,962$198M10.8%013F-HRTimelineGroup
ORBIMED ADVISORS LLCin group ORBIMED ADVISORS LLC3,704,959$109M2.61%013F-HRTimelineGroup
Atlas Venture Life Science Advisors, LLC3,615,527$106M14.13%-78,49313F-HRTimeline
VIKING GLOBAL INVESTORS LPin group VIKING GLOBAL INVESTORS LP3,195,181$94M0.24%013F-HRTimelineGroup
ENAVATE SCIENCES GP, LLC2,478,030$72.9M22.25%013F-HRTimeline
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO1,978,626$58.2M<0.01%-242,56213F-HR/ATimelineGroup
PERCEPTIVE ADVISORS LLCin group PERCEPTIVE ADVISORS LLC1,179,098$34.7M1%-36,94713F-HRTimelineGroup
VANGUARD GROUP INCin group VANGUARD GROUP INC1,143,154$33.6M<0.01%+512,80313F-HRTimelineGroup
JENNISON ASSOCIATES LLC997,375$29.3M0.02%+244,57513F-HRTimeline
DEERFIELD MANAGEMENT COMPANY, L.P.in group DEERFIELD MANAGEMENT COMPANY,…970,590$28.5M0.44%013F-HRTimelineGroup
Aberdeen Group plcin group Aberdeen Group plc950,547$28M0.04%013F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.844,605$24.8M<0.01%+207,50113F-HRTimelineGroup
PRICE T ROWE ASSOCIATES INC /MD/637,760$18.8M<0.01%-223,47813F-HRTimeline
Soleus Capital Management, L.P.413,500$12.2M0.65%+37,50013F-HRTimeline
BAKER BROS. ADVISORS LPin group BAKER BROS. ADVISORS LP400,000$11.8M0.09%013F-HRTimelineGroup
Siren, L.L.C.in group Siren, L.L.C.325,000$9.56M0.37%013F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC316,564$9.31M<0.01%+27,28913F-HRTimelineGroup
BRAIDWELL LP314,013$9.24M0.27%-767,84213F-HRTimeline
FRANKLIN RESOURCES INCin group Franklin Resources242,147$7.12M<0.01%-257,87613F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP240,199$7.06M<0.01%+115,68113F-HRTimelineGroup
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC214,085$6.3M<0.01%+200,05113F-HRTimelineGroup
Alyeska Investment Group, L.P.in group Alyeska Investment Group, L.P.186,222$5.48M0.02%013F-HRTimelineGroup
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC153,151$4.5M<0.01%-83,66213F-HRTimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co111,496$3.28M<0.01%+18,66413F-HRTimelineGroup
SILVERARC CAPITAL MANAGEMENT, LLCin group SILVERARC CAPITAL MANAGEMENT,…108,801$3.2M0.46%-77,21413F-HRTimelineGroup
Rock Springs Capital Management LP99,429$2.92M0.17%013F-HRTimeline
NORTHERN TRUST CORPin group NORTHERN TRUST CORP97,711$2.87M<0.01%+5,82113F-HRTimelineGroup
TD Asset Management Inc87,082$2.56M<0.01%+37,11613F-HRTimeline
Driehaus Capital Management LLC83,850$2.47M0.02%013F-HRTimeline
Longaeva Partners L.P.61,457$1.81M0.38%new13F-HRTimeline
Holocene Advisors, LP50,000$1.47M<0.01%013F-HRTimeline
UBS Group AGin group UBS Group AG46,666$1.37M<0.01%-4,70113F-HRTimelineGroup
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…42,234$1.24M<0.01%new13F-HRTimelineGroup
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC35,923$1.06M<0.01%-93,98913F-HRTimelineGroup
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …32,080$943K<0.01%-5,95813F-HRTimelineGroup
POLEN CAPITAL MANAGEMENT LLC31,258$919K<0.01%+14,28313F-HRTimeline
MARSHALL WACE, LLPin group MARSHALL WACE, LLP30,103$885K<0.01%new13F-HRTimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp27,463$808K<0.01%+3,33213F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY22,837$672K<0.01%-21,18113F-HR/ATimelineGroup
BARCLAYS PLCin group BARCLAYS PLC17,643$519K<0.01%-5,37913F-HR/ATimelineGroup
RHUMBLINE ADVISERS17,240$507K<0.01%-43013F-HRTimeline
Nuveen, LLCin group TIAA16,040$472K<0.01%013F-HRTimelineGroup
RENAISSANCE TECHNOLOGIES LLC14,600$429K<0.01%-11,40013F-HRTimeline
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC12,178$358K<0.01%-33,87013F-HRTimelineGroup
Squarepoint Ops LLCin group Squarepoint Ops LLC10,162$299K<0.01%new13F-HRTimelineGroup
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\9,596$282K<0.01%013F-HRTimelineGroup
Jain Global LLC8,513$250K<0.01%new13F-HRTimeline
MetLife Investment Management, LLCin group MetLife Investment Management…8,033$236K<0.01%013F-HRTimelineGroup
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN7,576$223K<0.01%+1,20213F-HRTimelineGroup
INTECH INVESTMENT MANAGEMENT LLC7,486$220K<0.01%new13F-HRTimeline
Legal & General Group Plcin group Legal & General Group Plc7,374$217K<0.01%+6,00013F-HRTimelineGroup
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…6,698$197K0.06%+1,16313F-HRTimelineGroup
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/6,541$192K<0.01%+52913F-HR/ATimelineGroup
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.in group Mirae Asset Global Investment…5,643$166K<0.01%-1,10413F-HRTimelineGroup
NEW YORK STATE COMMON RETIREMENT FUND5,300$156K<0.01%-1,50013F-HRTimeline
China Universal Asset Management Co., L…5,000$147K0.01%new13F-HRTimeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…4,490$132K<0.01%new13F-HRTimelineGroup
Police & Firemen's Retirement System of…3,234$95.1K<0.01%+62613F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS2,380$70K<0.01%+61913F-HRTimelineGroup
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…1,259$37K<0.01%013F-HRTimelineGroup
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…1,022$30.1K<0.01%new13F-HRTimelineGroup
CALIFORNIA STATE TEACHERS RETIREMENT SY…771$22.7K<0.01%+113F-HRTimeline
CITIGROUP INCin group CITIGROUP INC687$20.2K<0.01%-3,69313F-HRTimelineGroup
Aster Capital Management (DIFC) Ltd409$12K0.01%new13F-HRTimeline
AMALGAMATED BANK421$12K<0.01%013F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA378$11K<0.01%+31813F-HRTimelineGroup
FMR LLCin group FMR LLC234$6.88K<0.01%new13F-HRTimelineGroup
GAMMA Investing LLC153$4.5K<0.01%new13F-HRTimeline
FEDERATED HERMES, INC.in group FEDERATED HERMES, INC.113$3.32K<0.01%new13F-HRTimelineGroup
US BANCORP \DE\in group US BANCORP \DE\111$3.27K<0.01%new13F-HRTimelineGroup
Arax Advisory Partners92$2.71K<0.01%new13F-HRTimeline
CWM, LLCin group CWM, LLC60$2K<0.01%new13F-HRTimelineGroup
Hughes Financial Services, LLC44$1.57K<0.01%013F-HRTimeline
Sterling Capital Management LLC30$882<0.01%013F-HRTimeline
Allworth Financial LP22$648<0.01%new13F-HRTimeline
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…20$588<0.01%new13F-HRTimelineGroup
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…5$147<0.01%new13F-HRTimelineGroup