FMR LLC in group FMR LLC More: the full row for FMR LLC 21,585,984 $941M 0.05% +5,400,193 13F-HR Timeline Group JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 14,522,915 $633M 0.29% +3,745,598 13F-HR Timeline Group VANGUARD GROUP INC group of 2 filers holding More: the full row for VANGUARD GROUP INC 13,229,553 $576M +3,972,092 Timeline RTW INVESTMENTS, LP More: the full row for RTW INVESTMENTS, LP 11,372,829 $496M 6.11% +1,753,984 13F-HR Timeline WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 10,065,187 $439M 0.08% +815,497 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 9,787,417 $426M 0.05% -1,021,310 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 9,202,579 $401M 0.01% -134,255 13F-HR Timeline Group RA CAPITAL MANAGEMENT, L.P. in group RA CAPITAL MANAGEMENT, L.P. More: the full row for RA CAPITAL MANAGEMENT, L.P. 8,641,031 $376M 4.64% +1,375,000 13F-HR Timeline Group Avoro Capital Advisors LLC More: the full row for Avoro Capital Advisors LLC 7,645,000 $333M 4.31% +595,000 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 4,888,632 $213M 0.01% +687,123 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 2,858,049 $125M 0.01% +10,084 13F-HR Timeline Group Polar Capital Holdings Plc in group Polar Capital Holdings Plc More: the full row for Polar Capital Holdings Plc 2,796,760 $122M 0.59% +1,026,373 13F-HR Timeline Group Bellevue Group AG in group Bellevue Group AG More: the full row for Bellevue Group AG 2,152,862 $93.8M 1.95% new 13F-HR Timeline Group Casdin Capital, LLC More: the full row for Casdin Capital, LLC 1,780,000 $77.6M 6.47% +5,000 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 1,732,469 $75.5M 0.01% +586,935 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 1,725,186 $75.2M 0.01% -114,129 13F-HR/A Timeline Group ORBIMED ADVISORS LLC in group ORBIMED ADVISORS LLC More: the full row for ORBIMED ADVISORS LLC 1,638,886 $71.4M 1.71% -174,000 13F-HR Timeline Group UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 1,489,854 $64.9M +497,335 Timeline T. Rowe Price Investment Management, In… More: the full row for T. Rowe Price Investment Management, Inc. 1,401,906 $61.1M 0.04% +588,001 13F-HR Timeline Pictet Asset Management Holding SA in group Pictet Asset Management Holdi… More: the full row for Pictet Asset Management Holding SA 1,338,091 $58.2M 0.06% +370,489 13F-HR Timeline Group Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 1,285,610 $56M 2.19% +175,000 13F-HR Timeline Group Fiera Capital Corp in group Fiera Capital Corp More: the full row for Fiera Capital Corp 1,202,384 $52.4M 0.17% +420,476 13F-HR Timeline Group ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 1,200,000 $52.3M 0.08% -327,000 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 1,123,777 $49M 0.01% +75,558 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 975,056 $42.5M 0.01% -21,999 13F-HR Timeline Group Artisan Partners Limited Partnership More: the full row for Artisan Partners Limited Partnership 903,292 $39.4M 0.06% +21,338 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 899,764 $39.2M 0.03% +878,042 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 899,557 $39.2M <0.01% +319,282 13F-HR/A Timeline Group Sofinnova Investments, Inc. More: the full row for Sofinnova Investments, Inc. 875,925 $38.2M 2.34% +291,124 13F-HR Timeline SILVERARC CAPITAL MANAGEMENT, LLC in group SILVERARC CAPITAL MANAGEMENT,… More: the full row for SILVERARC CAPITAL MANAGEMENT, LLC 844,633 $36.8M 5.33% +434,633 13F-HR Timeline Group Franklin Resources group of 2 filers holding More: the full row for Franklin Resources 774,266 $33.7M +736,836 Timeline EcoR1 Capital, LLC More: the full row for EcoR1 Capital, LLC 765,000 $33.3M 1.6% +265,000 13F-HR Timeline MPM BIOIMPACT LLC More: the full row for MPM BIOIMPACT LLC 760,022 $33.1M 5.42% 0 13F-HR Timeline MONTANOVA CAPITAL, LLC More: the full row for MONTANOVA CAPITAL, LLC 750,000 $32.7M 0.99% new 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 691,512 $30.1M <0.01% +245,632 13F-HR/A Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 639,584 $27.9M 0.03% +579,361 13F-HR Timeline Group BAKER BROS. ADVISORS LP in group BAKER BROS. ADVISORS LP More: the full row for BAKER BROS. ADVISORS LP 625,000 $27.2M 0.2% new 13F-HR Timeline Group Frazier Life Sciences Management, L.P. More: the full row for Frazier Life Sciences Management, L.P. 625,000 $27.2M 0.82% 0 13F-HR Timeline Logos Global Management LP More: the full row for Logos Global Management LP 600,000 $26.1M 2.58% -350,000 13F-HR Timeline Ensign Peak Advisors, Inc More: the full row for Ensign Peak Advisors, Inc 580,857 $25.3M 0.04% +50,043 13F-HR/A Timeline Candriam S.C.A. More: the full row for Candriam S.C.A. 487,917 $21.3M 0.11% +45,144 13F-HR Timeline TD Asset Management Inc More: the full row for TD Asset Management Inc 457,172 $19.9M 0.02% +52,776 13F-HR Timeline ALETHEA CAPITAL MANAGEMENT, LLC More: the full row for ALETHEA CAPITAL MANAGEMENT, LLC 446,127 $19.4M 12.51% +17,503 13F-HR Timeline SCHRODER INVESTMENT MANAGEMENT GROUP More: the full row for SCHRODER INVESTMENT MANAGEMENT GROUP 406,031 $17.3M 0.01% +62,313 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 392,644 $17.1M 0.02% +120,365 13F-HR Timeline DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 385,485 $16.8M <0.01% +54,928 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 381,828 $16.6M <0.01% -1,332 13F-HR Timeline Group EVENTIDE ASSET MANAGEMENT, LLC More: the full row for EVENTIDE ASSET MANAGEMENT, LLC 375,989 $16.4M 0.27% +65 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 352,287 $15.3M 0.01% -19,483 13F-HR/A Timeline Group VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 343,549 $15M 0.01% -5,634 13F-HR Timeline Group BRAIDWELL LP More: the full row for BRAIDWELL LP 331,907 $14.5M 0.43% new 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 323,774 $14.1M 0.07% -311,320 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 316,459 $13.8M <0.01% -290,248 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 307,394 $13.4M <0.01% +51,796 13F-HR Timeline Group Aberdeen Group plc in group Aberdeen Group plc More: the full row for Aberdeen Group plc 304,828 $13.3M 0.02% +25,000 13F-HR Timeline Group Eversept Partners, LP More: the full row for Eversept Partners, LP 302,911 $13.2M 1.01% new 13F-HR Timeline Cormorant Asset Management, LP More: the full row for Cormorant Asset Management, LP 300,000 $13.1M 0.9% +100,000 13F-HR Timeline VICTORY CAPITAL MANAGEMENT INC More: the full row for VICTORY CAPITAL MANAGEMENT INC 291,047 $12.7M 0.01% +243,579 13F-HR Timeline University of Wisconsin Foundation More: the full row for University of Wisconsin Foundation 289,201 $12.6M 10.67% new 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 265,809 $11.6M 0.01% +2,475 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 264,614 $11.5M <0.01% +23,611 13F-HR Timeline Group Catalio Capital Management, LP More: the full row for Catalio Capital Management, LP 263,256 $11.5M 2.12% new 13F-HR Timeline Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 212,292 $9.25M <0.01% -57,122 13F-HR Timeline Group Swiss National Bank More: the full row for Swiss National Bank 208,800 $9.1M 0.01% +36,600 13F-HR Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 205,464 $8.95M 0.01% +203,702 13F-HR Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 188,363 $8.21M <0.01% -54,700 13F-HR Timeline Group ENVESTNET ASSET MANAGEMENT INC in group ENVESTNET ASSET MANAGEMENT INC More: the full row for ENVESTNET ASSET MANAGEMENT INC 179,103 $7.8M <0.01% +113,545 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 2 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 176,463 $7.69M -63,723 Timeline Alyeska Investment Group, L.P. in group Alyeska Investment Group, L.P. More: the full row for Alyeska Investment Group, L.P. 175,000 $7.62M 0.02% +50,000 13F-HR Timeline Group Rafferty Asset Management, LLC More: the full row for Rafferty Asset Management, LLC 173,480 $7.56M 0.02% +46,598 13F-HR Timeline RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 166,611 $7.26M <0.01% +15,376 13F-HR Timeline Group NEUBERGER BERMAN GROUP LLC in group NEUBERGER BERMAN GROUP LLC More: the full row for NEUBERGER BERMAN GROUP LLC 161,435 $7.03M 0.01% new 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 158,071 $6.89M 0.01% -17,288 13F-HR Timeline EFG Asset Management (North America) Co… More: the full row for EFG Asset Management (North America) Corp. 149,149 $6.5M 0.84% -20,383 13F-HR Timeline MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC in group MUTUAL OF AMERICA CAPITAL MAN… More: the full row for MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC 148,849 $6.49M 0.07% -26,778 13F-HR Timeline Group Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 144,324 $6.28M -9,301 Timeline ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 124,440 $5.42M <0.01% -6,390 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 121,814 $5.31M <0.01% +18,689 13F-HR Timeline Group CANTOR FITZGERALD, L. P. in group CANTOR FITZGERALD, L. P. More: the full row for CANTOR FITZGERALD, L. P. 114,236 $4.98M 0.1% new 13F-HR/A Timeline Group STEMPOINT CAPITAL LP More: the full row for STEMPOINT CAPITAL LP 114,053 $4.97M 1% new 13F-HR Timeline Artia Global Partners LP More: the full row for Artia Global Partners LP 110,100 $4.8M 0.84% +75,500 13F-HR/A Timeline Palo Alto Investors LP More: the full row for Palo Alto Investors LP 109,831 $4.79M 0.89% -9,055 13F-HR Timeline AXA Investment Managers S.A. More: the full row for AXA Investment Managers S.A. 101,658 $4.43M 0.01% 13F-HR Timeline CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 89,328 $3.89M <0.01% -930 13F-HR Timeline PRUDENTIAL FINANCIAL INC in group PRUDENTIAL FINANCIAL INC More: the full row for PRUDENTIAL FINANCIAL INC 84,865 $3.7M <0.01% -28,140 13F-HR Timeline Group Universal- Beteiligungs- und Serviceges… in group Universal- Beteiligungs- und … More: the full row for Universal- Beteiligungs- und Servicegesellschaft mbH 80,070 $3.49M 0.01% -1,289 13F-HR Timeline Group SEI INVESTMENTS CO in group SEI INVESTMENTS CO More: the full row for SEI INVESTMENTS CO 73,363 $3.2M <0.01% +17,684 13F-HR Timeline Group ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 70,573 $3.07M 0.02% +5,549 13F-HR Timeline Group HighVista Strategies LLC More: the full row for HighVista Strategies LLC 65,580 $2.86M 0.7% +24,716 13F-HR Timeline Mirador Capital Partners LP More: the full row for Mirador Capital Partners LP 64,055 $2.79M 0.4% +22,666 13F-HR Timeline Driehaus Capital Management LLC More: the full row for Driehaus Capital Management LLC 60,577 $2.64M 0.02% new 13F-HR Timeline Maven Securities LTD in group Maven Securities LTD More: the full row for Maven Securities LTD 60,000 $2.61M 0.5% new 13F-HR Timeline Group Burkehill Global Management, LP More: the full row for Burkehill Global Management, LP 60,000 $2.61M 0.15% new 13F-HR Timeline MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 59,278 $2.58M 0.01% -8,873 13F-HR Timeline Group ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 58,835 $2.56M 0.04% new 13F-HR Timeline RK Capital Management, LLC/FL More: the full row for RK Capital Management, LLC/FL 58,600 $2.55M 3.95% new 13F-HR Timeline STATE OF WISCONSIN INVESTMENT BOARD More: the full row for STATE OF WISCONSIN INVESTMENT BOARD 56,350 $2.46M 0.01% -8,668 13F-HR Timeline ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 53,656 $2.34M 0.23% new 13F-HR Timeline Group Privium Fund Management B.V. More: the full row for Privium Fund Management B.V. 53,000 $2.31M 0.42% +7,000 13F-HR Timeline INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 52,953 $2.31M 0.02% -2,986 13F-HR Timeline BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 52,687 $2.3M 0.06% +42,687 13F-HR Timeline Creative Planning in group Creative Planning More: the full row for Creative Planning 52,333 $2.28M <0.01% +13,073 13F-HR Timeline Group Marex Group Ltd in group Marex Group Ltd More: the full row for Marex Group Ltd 52,000 $2.27M 0.03% new 13F-HR Timeline Group ASSETMARK, INC in group ASSETMARK, INC More: the full row for ASSETMARK, INC 51,186 $2.23M <0.01% +21,507 13F-HR Timeline Group Monashee Investment Management LLC More: the full row for Monashee Investment Management LLC 50,000 $2.18M 1.09% new 13F-HR Timeline SummitTX Capital, L.P. More: the full row for SummitTX Capital, L.P. 49,142 $2.14M 0.09% +27,046 13F-HR Timeline State of New Jersey Common Pension Fund… in group State of New Jersey Common Pe… More: the full row for State of New Jersey Common Pension Fund D 47,628 $2.08M 0.01% -13,503 13F-HR Timeline Group KENNEDY CAPITAL MANAGEMENT LLC More: the full row for KENNEDY CAPITAL MANAGEMENT LLC 47,593 $2.07M 0.05% new 13F-HR Timeline Assenagon Asset Management S.A. More: the full row for Assenagon Asset Management S.A. 45,923 $2M <0.01% +28,055 13F-HR Timeline SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 44,898 $1.96M 0.04% +42,002 13F-HR Timeline MML INVESTORS SERVICES, LLC More: the full row for MML INVESTORS SERVICES, LLC 44,849 $1.95M 0.01% new 13F-HR Timeline Foresite Capital Management VI LLC in group Foresite Capital Management V… More: the full row for Foresite Capital Management VI LLC 40,000 $1.74M 0.67% 0 13F-HR Timeline Group GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 39,196 $1.71M 0.05% +15,902 13F-HR Timeline PROFUND ADVISORS LLC More: the full row for PROFUND ADVISORS LLC 37,654 $1.64M 0.05% +10,330 13F-HR Timeline DekaBank Deutsche Girozentrale More: the full row for DekaBank Deutsche Girozentrale 60,000 $1.59M <0.01% 0 13F-HR Timeline Verition Fund Management LLC More: the full row for Verition Fund Management LLC 35,827 $1.56M 0.01% +4,460 13F-HR Timeline Erste Asset Management GmbH in group Erste Asset Management GmbH More: the full row for Erste Asset Management GmbH 36,000 $1.53M 0.01% new 13F-HR Timeline Group Handelsbanken Fonder AB More: the full row for Handelsbanken Fonder AB 34,500 $1.5M <0.01% +6,400 13F-HR Timeline ARIZONA STATE RETIREMENT SYSTEM More: the full row for ARIZONA STATE RETIREMENT SYSTEM 31,902 $1.39M 0.01% +5,623 13F-HR Timeline GUGGENHEIM CAPITAL LLC in group GUGGENHEIM CAPITAL LLC More: the full row for GUGGENHEIM CAPITAL LLC 31,359 $1.37M 0.01% -1,243 13F-HR Timeline Group Fort Point Capital Partners LLC More: the full row for Fort Point Capital Partners LLC 31,278 $1.36M 0.17% +183 13F-HR Timeline JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 31,223 $1.36M <0.01% -21,269 13F-HR Timeline Group Orion Porfolio Solutions, LLC More: the full row for Orion Porfolio Solutions, LLC 30,827 $1.34M 0.01% +8,382 13F-HR Timeline TEACHERS RETIREMENT SYSTEM OF THE STATE… More: the full row for TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY 30,079 $1.31M 0.01% -523 13F-HR Timeline Cinctive Capital Management LP More: the full row for Cinctive Capital Management LP 30,077 $1.31M 0.07% new 13F-HR Timeline Hudson Bay Capital Management LP in group Hudson Bay Capital Management… More: the full row for Hudson Bay Capital Management LP 30,000 $1.31M 0.01% -45,000 13F-HR/A Timeline Group DIADEMA PARTNERS LP More: the full row for DIADEMA PARTNERS LP 30,000 $1.31M 0.91% new 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 29,623 $1.29M <0.01% -207,368 13F-HR Timeline Group Man Group plc in group Man Group plc More: the full row for Man Group plc 29,450 $1.28M <0.01% +12,127 13F-HR Timeline Group Steward Partners Investment Advisory, L… More: the full row for Steward Partners Investment Advisory, LLC 29,340 $1.28M 0.01% +7,157 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 29,327 $1.28M <0.01% -260,527 13F-HR Timeline Group NewEdge Advisors, LLC More: the full row for NewEdge Advisors, LLC 29,211 $1.27M 0.01% +4,069 13F-HR Timeline Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 28,680 $1.25M <0.01% -987 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 28,495 $1.24M 0.01% +2,855 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 27,291 $1.19M <0.01% +10,396 13F-HR Timeline Group SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 26,316 $1.15M <0.01% +4,386 13F-HR Timeline STATE BOARD OF ADMINISTRATION OF FLORID… More: the full row for STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 25,496 $1.11M <0.01% 0 13F-HR Timeline KLP KAPITALFORVALTNING AS More: the full row for KLP KAPITALFORVALTNING AS 23,300 $1.02M <0.01% +4,300 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 22,551 $983K 0.08% -1,659 13F-HR Timeline Moss Adams Wealth Advisors LLC More: the full row for Moss Adams Wealth Advisors LLC 22,496 $980K 0.08% 0 13F-HR Timeline TEACHER RETIREMENT SYSTEM OF TEXAS More: the full row for TEACHER RETIREMENT SYSTEM OF TEXAS 22,170 $966K <0.01% -2,126 13F-HR Timeline ProShare Advisors LLC More: the full row for ProShare Advisors LLC 22,020 $959K <0.01% -5,948 13F-HR Timeline CANADA LIFE ASSURANCE Co in group CANADA LIFE ASSURANCE Co More: the full row for CANADA LIFE ASSURANCE Co 22,347 $951K <0.01% +14,054 13F-HR Timeline Group STIFEL FINANCIAL CORP in group STIFEL FINANCIAL CORP More: the full row for STIFEL FINANCIAL CORP 19,936 $869K <0.01% +5,220 13F-HR Timeline Group WINTON GROUP Ltd in group WINTON GROUP Ltd More: the full row for WINTON GROUP Ltd 17,600 $767K 0.03% new 13F-HR Timeline Group LPL Financial LLC More: the full row for LPL Financial LLC 17,392 $758K <0.01% +4,969 13F-HR Timeline Sender Co & Partners, Inc. More: the full row for Sender Co & Partners, Inc. 16,406 $715K 0.28% new 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 15,652 $682K 0.04% new 13F-HR Timeline Group READYSTATE ASSET MANAGEMENT LP More: the full row for READYSTATE ASSET MANAGEMENT LP 15,505 $676K 0.03% new 13F-HR Timeline Brevan Howard Capital Management LP in group Brevan Howard Capital Managem… More: the full row for Brevan Howard Capital Management LP 14,977 $653K 0.01% new 13F-HR Timeline Group Allianz Asset Management GmbH in group Allianz SE More: the full row for Allianz Asset Management GmbH 14,500 $632K <0.01% new 13F-HR Timeline Group AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 13,784 $601K <0.01% +821 13F-HR Timeline Group BRANDYWINE MANAGERS, LLC in group BRANDYWINE MANAGERS, LLC More: the full row for BRANDYWINE MANAGERS, LLC 12,540 $546K 0.52% new 13F-HR Timeline Group NWAM LLC More: the full row for NWAM LLC 10,824 $530K 0.03% -2,773 13F-HR/A Timeline Caption Management, LLC More: the full row for Caption Management, LLC 12,138 $529K 0.03% new 13F-HR Timeline Cetera Investment Advisers More: the full row for Cetera Investment Advisers 12,092 $527K <0.01% new 13F-HR Timeline NEOS Investment Management LLC More: the full row for NEOS Investment Management LLC 11,978 $522K <0.01% new 13F-HR Timeline Tema ETFs LLC More: the full row for Tema ETFs LLC 11,978 $522K 0.04% new 13F-HR Timeline D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 11,577 $504K <0.01% -225,820 13F-HR Timeline Group Snowden Capital Advisors LLC More: the full row for Snowden Capital Advisors LLC 11,535 $503K 0.01% +2,719 13F-HR Timeline Quantinno Capital Management LP More: the full row for Quantinno Capital Management LP 10,995 $479K <0.01% +3,232 13F-HR Timeline Janney Montgomery Scott LLC More: the full row for Janney Montgomery Scott LLC 10,970 $478K <0.01% new 13F-HR Timeline OPPENHEIMER ASSET MANAGEMENT INC. in group OPPENHEIMER ASSET MANAGEMENT … More: the full row for OPPENHEIMER ASSET MANAGEMENT INC. 10,894 $475K 0.01% +3,768 13F-HR Timeline Group CIBC Bancorp USA Inc. in group CIBC Bancorp USA Inc. More: the full row for CIBC Bancorp USA Inc. 10,871 $474K <0.01% 13F-HR/A Timeline Group Capricorn Fund Managers Ltd More: the full row for Capricorn Fund Managers Ltd 10,800 $471K 0.16% new 13F-HR Timeline OXFORD ASSET MANAGEMENT LLP More: the full row for OXFORD ASSET MANAGEMENT LLP 10,581 $461K 0.15% new 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. STRS OHIO More: the full row for STRS OHIO 10,300 $449K <0.01% +4,700 13F-HR Timeline BANQUE PICTET & CIE SA More: the full row for BANQUE PICTET & CIE SA 9,942 $433K <0.01% new 13F-HR Timeline Aaron Wealth Advisors LLC More: the full row for Aaron Wealth Advisors LLC 8,540 $372K 0.02% +1,206 13F-HR Timeline Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 8,520 $371K 0.01% -3,091 13F-HR Timeline Group PRINCIPAL FINANCIAL GROUP INC group of 2 filers holding More: the full row for PRINCIPAL FINANCIAL GROUP INC 8,235 $359K +2 Timeline Waverly Advisors, LLC More: the full row for Waverly Advisors, LLC 8,228 $358K <0.01% 0 13F-HR Timeline J. Goldman & Co LP More: the full row for J. Goldman & Co LP 8,039 $350K 0.01% new 13F-HR Timeline Corsicana & Co. More: the full row for Corsicana & Co. 8,000 $349K 0.2% 13F-HR Timeline XPONANCE LLC More: the full row for XPONANCE LLC 7,987 $348K <0.01% -894 13F-HR Timeline PUBLIC EMPLOYEES RETIREMENT ASSOCIATION… More: the full row for PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO 7,806 $340K <0.01% 0 13F-HR Timeline Sumitomo Mitsui Trust Group, Inc. in group Sumitomo Mitsui Trust Group, … More: the full row for Sumitomo Mitsui Trust Group, Inc. 7,755 $338K <0.01% new 13F-HR Timeline Group FNY Investment Advisers, LLC More: the full row for FNY Investment Advisers, LLC 7,594 $330K 0.11% new 13F-HR Timeline Mitsubishi UFJ Asset Management Co., Lt… in group Mitsubishi UFJ Trust & Bankin… More: the full row for Mitsubishi UFJ Asset Management Co., Ltd. 7,476 $326K <0.01% +15 13F-HR Timeline Group DNB Asset Management AS in group DNB Asset Management AS More: the full row for DNB Asset Management AS 7,474 $326K <0.01% new 13F-HR Timeline Group Y-Intercept (Hong Kong) Ltd More: the full row for Y-Intercept (Hong Kong) Ltd 7,041 $307K 0.01% new 13F-HR Timeline Dorsey & Whitney Trust CO LLC More: the full row for Dorsey & Whitney Trust CO LLC 6,990 $305K 0.02% new 13F-HR Timeline Persistent Asset Partners Ltd More: the full row for Persistent Asset Partners Ltd 6,864 $299K 0.22% new 13F-HR/A Timeline Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 6,775 $295K <0.01% +4,427 13F-HR Timeline Group FRED ALGER MANAGEMENT, LLC in group FRED ALGER MANAGEMENT, LLC More: the full row for FRED ALGER MANAGEMENT, LLC 6,565 $286K <0.01% new 13F-HR Timeline Group WOLVERINE TRADING, LLC More: the full row for WOLVERINE TRADING, LLC 6,697 $285K 0.01% new 13F-HR Timeline MACKENZIE FINANCIAL CORP More: the full row for MACKENZIE FINANCIAL CORP 6,314 $275K <0.01% -1,023 13F-HR Timeline DLK Investment Management, LLC More: the full row for DLK Investment Management, LLC 5,700 $248K 0.09% -2,000 13F-HR Timeline PARK AVENUE SECURITIES LLC in group PARK AVENUE SECURITIES LLC More: the full row for PARK AVENUE SECURITIES LLC 5,596 $244K <0.01% new 13F-HR Timeline Group Atle Fund Management AB More: the full row for Atle Fund Management AB 51,978 $240K 0.89% new 13F-HR Timeline Beirne Wealth Consulting Services, LLC More: the full row for Beirne Wealth Consulting Services, LLC 5,346 $233K 0.06% new 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 5,336 $232K <0.01% +41 13F-HR Timeline Group Koa Wealth Management, LLC More: the full row for Koa Wealth Management, LLC 5,000 $218K 0.16% new 13F-HR Timeline Swiss Life Asset Management Ltd in group Swiss Life Asset Management L… More: the full row for Swiss Life Asset Management Ltd 4,899 $213K <0.01% new 13F-HR Timeline Group PRAXIS INVESTMENT MANAGEMENT INC More: the full row for PRAXIS INVESTMENT MANAGEMENT INC 4,851 $211K 0.01% new 13F-HR Timeline O'SHAUGHNESSY ASSET MANAGEMENT, LLC More: the full row for O'SHAUGHNESSY ASSET MANAGEMENT, LLC 4,823 $210K <0.01% new 13F-HR Timeline Integrated Wealth Concepts LLC More: the full row for Integrated Wealth Concepts LLC 4,736 $206K <0.01% new 13F-HR Timeline Private Advisor Group, LLC More: the full row for Private Advisor Group, LLC 4,713 $205K <0.01% new 13F-HR Timeline TRUIST FINANCIAL CORP in group TRUIST FINANCIAL CORP More: the full row for TRUIST FINANCIAL CORP 4,627 $202K <0.01% new 13F-HR Timeline Group Atria Investments, Inc More: the full row for Atria Investments, Inc 4,617 $201K <0.01% new 13F-HR Timeline