GENERAL ATLANTIC, L.P. More: the full row for GENERAL ATLANTIC, L.P. 8,031,252 $200M 6.02% +500,000 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 6,399,158 $160M 0.01% +976,765 13F-HR Timeline Group Foresite Capital Management IV, LLC in group Foresite Capital Management V… More: the full row for Foresite Capital Management IV, LLC 4,778,581 $119M 65.29% +368,000 13F-HR Timeline Group venBio Partners LLC More: the full row for venBio Partners LLC 4,639,304 $116M 65.62% +350,000 13F-HR Timeline VIKING GLOBAL INVESTORS LP in group VIKING GLOBAL INVESTORS LP More: the full row for VIKING GLOBAL INVESTORS LP 3,653,310 $91.2M 0.24% 0 13F-HR Timeline Group EQT Fund Management S.a r.l. More: the full row for EQT Fund Management S.a r.l. 3,424,609 $85.4M 4.59% 13F-HR Timeline Bain Capital Life Sciences Investors, L… in group Bain Capital Life Sciences In… More: the full row for Bain Capital Life Sciences Investors, LLC 3,181,275 $79.4M 5.27% -122,106 13F-HR Timeline Group DEERFIELD MANAGEMENT COMPANY, L.P. in group DEERFIELD MANAGEMENT COMPANY,… More: the full row for DEERFIELD MANAGEMENT COMPANY, L.P. 2,442,464 $60.9M 0.93% +425,000 13F-HR Timeline Group Commodore Capital LP in group Commodore Capital LP More: the full row for Commodore Capital LP 2,418,476 $60.3M 2.95% +507,043 13F-HR Timeline Group Paradigm Biocapital Advisors LP in group Paradigm Biocapital Advisors … More: the full row for Paradigm Biocapital Advisors LP 1,835,494 $45.8M 1.36% +772,583 13F-HR Timeline Group NOVO HOLDINGS A/S More: the full row for NOVO HOLDINGS A/S 1,750,000 $43.7M 2.81% +25,000 13F-HR Timeline WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 1,734,743 $43.3M 0.01% new 13F-HR Timeline Group Cormorant Asset Management, LP More: the full row for Cormorant Asset Management, LP 1,363,200 $34M 2.35% -91,460 13F-HR Timeline Saturn V Capital Management LP More: the full row for Saturn V Capital Management LP 886,332 $22.1M 4.85% new 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 816,808 $20.4M <0.01% +49,493 13F-HR Timeline 5AM Venture Management, LLC More: the full row for 5AM Venture Management, LLC 797,600 $19.9M 7.29% 0 13F-HR Timeline Sofinnova Investments, Inc. More: the full row for Sofinnova Investments, Inc. 739,876 $18.5M 1.13% +154,344 13F-HR Timeline Octagon Capital Advisors LP More: the full row for Octagon Capital Advisors LP 722,595 $18M 2.81% +50,000 13F-HR Timeline Kynam Capital Management, LP More: the full row for Kynam Capital Management, LP 675,000 $16.8M 1.25% new 13F-HR Timeline Venrock Adviser, LLC More: the full row for Venrock Adviser, LLC 674,599 $16.8M 0.95% -1,373,021 13F-HR Timeline Soleus Capital Management, L.P. More: the full row for Soleus Capital Management, L.P. 647,052 $16.1M 0.86% -85,916 13F-HR Timeline Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 625,758 $15.6M 0.03% new 13F-HR Timeline Group Rock Springs Capital Management LP More: the full row for Rock Springs Capital Management LP 623,402 $15.6M 0.91% 0 13F-HR Timeline Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 519,381 $13M 0.03% +481,769 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 414,417 $10.3M <0.01% +213,328 13F-HR Timeline Group BAKER BROS. ADVISORS LP in group BAKER BROS. ADVISORS LP More: the full row for BAKER BROS. ADVISORS LP 375,000 $9.36M 0.07% new 13F-HR Timeline Group Patient Square Capital LP More: the full row for Patient Square Capital LP 345,381 $8.62M 2.3% +101,098 13F-HR Timeline Polar Capital Holdings Plc in group Polar Capital Holdings Plc More: the full row for Polar Capital Holdings Plc 264,693 $6.6M 0.03% new 13F-HR Timeline Group Ikarian Capital, LLC in group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 210,165 $5.24M 1.06% new 13F-HR Timeline Group Integral Health Asset Management, LLC More: the full row for Integral Health Asset Management, LLC 200,000 $4.99M 0.36% new 13F-HR Timeline Tetragon Partners GP Ltd in group Tetragon Partners GP Ltd More: the full row for Tetragon Partners GP Ltd 194,612 $4.86M 0.71% +6,512 13F-HR Timeline Group SILVERARC CAPITAL MANAGEMENT, LLC in group SILVERARC CAPITAL MANAGEMENT,… More: the full row for SILVERARC CAPITAL MANAGEMENT, LLC 183,903 $4.59M 0.66% new 13F-HR Timeline Group GREAT POINT PARTNERS LLC More: the full row for GREAT POINT PARTNERS LLC 155,105 $3.87M 1.62% new 13F-HR Timeline Logos Global Management LP More: the full row for Logos Global Management LP 150,000 $3.74M 0.37% new 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 142,775 $3.56M <0.01% +49,102 13F-HR Timeline Group BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 135,181 $3.37M 0.09% +118,994 13F-HR Timeline UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 130,752 $3.26M +71,632 Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 129,738 $3.24M <0.01% +100,517 13F-HR Timeline Group Alyeska Investment Group, L.P. in group Alyeska Investment Group, L.P. More: the full row for Alyeska Investment Group, L.P. 125,000 $3.12M 0.01% new 13F-HR Timeline Group SPHERA FUNDS MANAGEMENT LTD. in group SPHERA FUNDS MANAGEMENT LTD. More: the full row for SPHERA FUNDS MANAGEMENT LTD. 119,406 $2.98M 0.71% -190,525 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 106,548 $2.66M <0.01% +93,263 13F-HR Timeline Group TD Asset Management Inc More: the full row for TD Asset Management Inc 104,356 $2.6M <0.01% +4,846 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 100,000 $2.5M 0.01% new 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 78,540 $1.96M <0.01% +24,438 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 77,955 $1.94M <0.01% -17,314 13F-HR Timeline Group TUDOR INVESTMENT CORP ET AL More: the full row for TUDOR INVESTMENT CORP ET AL 77,891 $1.94M 0.01% new 13F-HR/A Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 59,790 $1.49M <0.01% +10,933 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 58,263 $1.45M <0.01% -1,509 13F-HR/A Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 51,805 $1.29M <0.01% +23,619 13F-HR Timeline Group Swiss National Bank More: the full row for Swiss National Bank 42,357 $1.06M <0.01% +16,100 13F-HR Timeline Amundi in group Amundi More: the full row for Amundi 41,517 $965K <0.01% +14,100 13F-HR Timeline Group ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 34,124 $851K 0.08% 0 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 27,096 $676K <0.01% new 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 27,085 $676K <0.01% +23,743 13F-HR/A Timeline Group HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 26,202 $653K <0.01% new 13F-HR Timeline CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 23,462 $585K <0.01% +9,414 13F-HR Timeline D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 22,886 $571K <0.01% new 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 22,666 $566K <0.01% +11,116 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 21,197 $529K <0.01% new 13F-HR Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 19,310 $482K <0.01% new 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 18,656 $465K <0.01% +2,633 13F-HR/A Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 17,007 $424K <0.01% new 13F-HR Timeline Group Palumbo Wealth Management LLC More: the full row for Palumbo Wealth Management LLC 16,641 $415K 0.13% +2,092 13F-HR Timeline Birchview Capital, LP More: the full row for Birchview Capital, LP 14,847 $370K 0.28% new 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 14,476 $361K <0.01% new 13F-HR Timeline Group SCHRODER INVESTMENT MANAGEMENT GROUP More: the full row for SCHRODER INVESTMENT MANAGEMENT GROUP 12,073 $293K <0.01% new 13F-HR Timeline Cubist Systematic Strategies, LLC More: the full row for Cubist Systematic Strategies, LLC 11,639 $290K <0.01% +9,078 13F-HR Timeline TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 10,607 $265K <0.01% new 13F-HR Timeline Group ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 8,980 $224K <0.01% new 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 8,213 $205K 0.01% new 13F-HR Timeline Group Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 6,604 $165K 0.05% +1,147 13F-HR Timeline Group PUBLIC EMPLOYEES RETIREMENT SYSTEM OF O… More: the full row for PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO 6,269 $156K <0.01% +1,769 13F-HR Timeline KLP KAPITALFORVALTNING AS More: the full row for KLP KAPITALFORVALTNING AS 5,800 $145K <0.01% 0 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 5,489 $137K <0.01% +3,120 13F-HR Timeline BNP PARIBAS ASSET MANAGEMENT Holding S.… in group BNP PARIBAS ASSET MANAGEMENT … More: the full row for BNP PARIBAS ASSET MANAGEMENT Holding S.A. 3,261 $81K <0.01% 0 13F-HR Timeline Group China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 3,000 $74.8K 0.01% new 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 564 $14.1K <0.01% +7 13F-HR Timeline Group Quarry LP More: the full row for Quarry LP 442 $11K <0.01% new 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 413 $10.3K <0.01% +54 13F-HR Timeline Group Centerpoint Advisors, LLC More: the full row for Centerpoint Advisors, LLC 100 $2K <0.01% 0 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 76 $2K <0.01% +18 13F-HR Timeline Group SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 3 $75 <0.01% +2 13F-HR Timeline Point72 Asia (Singapore) Pte. Ltd. More: the full row for Point72 Asia (Singapore) Pte. Ltd. 1 $25 <0.01% -368 13F-HR Timeline