13F-HR filed by EcoR1 Capital, LLC
EcoR1 Capital, LLC filed this 13F-HR for the quarter ended 2025-03-31, filed 2025-05-15, with 46 holding rows worth $1,686,022,983.
- Accession
- 0000935836-25-000338
- Filer
- CIK 1587114
- Filed
- 2025-05-15
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q1 2025
A holdings report, 46 entries on the cover page, a total value of $1,686,022,983 stated on the cover page (in dollars after the unit check, H1), rows summing to $1,686,022,983 with VALUE read as dollars as filed, 13F file number 028-16764. The quarter's positions are built on this report. The resolved quarter.
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| APELLIS PHARMACEUTICALS INC | 03753U106 | COM | 11,895,808 | $260,161,321 | dollars as filed | |
| JAZZ PHARMACEUTICALS PLC SHS USD | G50871105 | Stock | 1,706,469 | $211,858,126 | dollars as filed | |
| ZYMEWORKS INC | 98985Y108 | COM | 17,259,548 | $205,561,217 | dollars as filed | |
| ANAPTYSBIO INC | 032724106 | COM | 7,880,094 | $146,490,947 | dollars as filed | |
| CRINETICS PHARMACEUTICALS INC COM | 22663K107 | Stock | 4,288,120 | $143,823,545 | dollars as filed | |
| PROTHENA CORP PLC SHS | G72800108 | Stock | 11,584,280 | $143,355,465 | dollars as filed | |
| SAREPTA THERAPEUTICS INC | 803607100 | COM | 1,292,386 | $82,480,075 | dollars as filed | |
| XENCOR INC | 98401F105 | COMMON STOCK | 6,144,767 | $65,380,321 | dollars as filed | |
| CRISPR THERAPEUTICS AG NAMEN AKT | H17182108 | Stock | 1,389,276 | $47,277,062 | dollars as filed | |
| UNIQURE NV | N90064101 | SHS | 3,988,971 | $42,283,093 | dollars as filed | |
| JANUX THERAPEUTICS INC | 47103J105 | COM | 1,469,818 | $39,685,086 | dollars as filed | |
| IMMUNOME INC | 45257U108 | COM | 4,079,415 | $27,454,463 | dollars as filed | |
| ETON PHARMACEUTICALS INC | 29772L108 | COMMON STOCK | 1,939,288 | $25,171,958 | dollars as filed | |
| MADRIGAL PHARMACEUTICALS INC COM | 558868105 | Stock | 75,000 | $24,842,250 | dollars as filed | |
| ORIC PHARMACEUTICALS INC | 68622P109 | COM | 3,418,068 | $19,072,819 | dollars as filed | |
| AKERO THERAPEUTICS INC | 00973Y108 | COM | 440,000 | $17,811,200 | dollars as filed | |
| KURA ONCOLOGY INC COM | 50127T109 | Stock | 2,640,298 | $17,425,967 | dollars as filed | |
| TECTONIC THERAPEUTIC INC | 878972108 | COMMON STOCK | 935,121 | $16,560,993 | dollars as filed | |
| AVIDITY BIOSCIENCES INC COM | 05370A108 | Stock | 557,576 | $16,459,644 | dollars as filed | |
| NEUROGENE INC | 64135M105 | COMMON STOCK | 1,271,342 | $14,887,415 | dollars as filed | |
| TANGO THERAPEUTICS INC | 87583X109 | COM | 10,630,736 | $14,564,108 | dollars as filed | |
| VOYAGER THERAPEUTICS INC | 92915B106 | COMMON STOCK | 3,917,546 | $13,241,305 | dollars as filed | |
| BEAM THERAPEUTICS INC | 07373V105 | COM | 526,685 | $10,286,158 | dollars as filed | |
| MBX BIOSCIENCES INC COM | 55287L101 | Stock | 1,259,273 | $9,293,435 | dollars as filed | |
| GINKGO BIOWORKS HOLDINGS INC | 37611X209 | COMMON STOCK | 1,462,328 | $8,335,270 | dollars as filed | |
| REPLIMUNE GROUP INC | 76029N106 | COMMON STOCK | 850,341 | $8,290,825 | dollars as filed | |
| BICYCLE THERAPEUTICS PLC-ADR | 088786108 | SPONSORED ADS | 910,000 | $7,725,900 | dollars as filed | |
| Day One Biopharmaceuticals Inc | 23954D109 | Common Stock | 862,068 | $6,836,199 | dollars as filed | |
| VERVE THERAPEUTICS INC | 92539P101 | COM | 1,250,000 | $5,712,500 | dollars as filed | |
| ADAPTIMMUNE THERAPEUTICS PLC | 00653A107 | SPONDS ADR | 27,404,070 | $5,398,602 | dollars as filed | |
| LAKEFRONT BIOTHERAPEUTICS NV | 36315X101 | SPON ADR | 155,006 | $3,893,751 | dollars as filed | |
| WHITEHAWK THERAPEUTICS INC | 00032Q104 | CMN | 2,082,000 | $3,705,960 | dollars as filed | |
| ATARA BIOTHERAPEUTICS INC | 046513206 | COM NEW | 573,183 | $3,404,707 | dollars as filed | |
| SOLID BIOSCIENCES INC | 83422E204 | COMMON STOCK | 744,450 | $2,754,465 | dollars as filed | |
| KEROS THERAPEUTICS INC COM | 492327101 | Stock | 187,500 | $1,910,625 | dollars as filed | |
| NUVATION BIO INC | 67080N119 | WARR | 963,333 | $1,695,466 | dollars as filed | |
| RELAY THERAPEUTICS INC COM | 75943R102 | Stock | 641,426 | $1,680,536 | dollars as filed | |
| KALARIS THERAPEUTICS INC | 482929106 | COM | 201,718 | $1,619,796 | dollars as filed | |
| UNIQURE NV | N90064101 | SHS | 135,000 | $1,431,000 | dollars as filed | call |
| PRIME MEDICINE INC | 74168J101 | COM | 700,000 | $1,393,000 | dollars as filed | |
| METSERA INC | 59267L107 | COM | 50,000 | $1,361,000 | dollars as filed | |
| Tscan Therapeutics Inc | 89854M101 | COM | 662,833 | $914,710 | dollars as filed | |
| SURROZEN INC | 86889P117 | *W EXP 08/01/203 | 66,665 | $777,314 | dollars as filed | Value about 1,000 times the price other filers imply, kept as filed and left out of ratios. |
| ALIGOS THERAPEUTICS INC | 01626L204 | COM NEW | 88,569 | $730,694 | dollars as filed | |
| ETON PHARMACEUTICALS INC | 29772L108 | COMMON STOCK | 50,500 | $655,490 | dollars as filed | call |
| UPSTREAM BIO INC | 91678A107 | COMMON STOCK | 60,000 | $367,200 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0000935836-25-000338 | this filing | 2025-05-15 | acceptance time not in the bulk data set |