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Disclosery

MAZE MAZE THERAPEUTICS INC

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Stock (common), issuer CIK 1842295

139 managers (143 13F filers) reported a position in MAZE shares at 2025-12-31, 48,366,868 shares in all. 51 filers opened a position and 8 filers sold out during the quarter.

Managers
139
13F filers
143
New
51
Added
46
Reduced
20
Sold out
8
Shares held by filers
48,366,868

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q4 2025

Filers in the available 13F reports with a share position at 2025-12-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
Frazier Life Sciences Management, L.P.4,567,274$189M5.08%013F-HRTimeline
TRV GP IV, LLC4,473,958$185M72.65%-1,600,00013F-HRTimeline
Deep Track Capital, LP4,246,440$176M4.01%+297,53013F-HRTimeline
ARCH Venture Management, LLC4,120,053$171M26.19%013F-HRTimeline
JANUS HENDERSON GROUP PLCin group Janus Henderson3,142,587$130M0.06%+2,390,71313F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.2,287,155$94.8M<0.01%+971,13913F-HRTimelineGroup
a16z Capital Management, L.L.C.in group a16z Capital Management, L.L.…1,702,225$70.5M4.46%013F-HRTimelineGroup
VANGUARD GROUP INCin group VANGUARD GROUP INC1,697,015$70.3M<0.01%+362,06013F-HRTimelineGroup
Venrock Adviser, LLC1,548,569$64.2M3.17%+317,80013F-HRTimeline
Alphabet Inc.in group Alphabet Inc.1,388,583$57.5M2.23%-1,023,88813F-HRTimelineGroup
General Catalyst Group Management, LLC1,035,910$42.9M19.35%013F-HRTimeline
Woodline Partners LP1,035,229$42.9M0.17%013F-HRTimeline
TRV GP V, LLC950,800$39.4M9.18%013F-HRTimeline
Logos Global Management LP950,000$39.4M2.62%-277,30013F-HRTimeline
Bellevue Group AGin group Bellevue Group AG887,708$36.8M0.7%new13F-HRTimelineGroup
MARSHALL WACE, LLPin group MARSHALL WACE, LLP847,472$35.1M0.03%+69,77113F-HRTimelineGroup
ArrowMark Colorado Holdings LLC767,383$31.8M0.7%+222,25113F-HRTimeline
Casdin Capital, LLC758,857$31.4M1.95%013F-HRTimeline
FMR LLCin group FMR LLC728,605$30.2M<0.01%+72,99113F-HRTimelineGroup
Ikarian Capital, LLCin group Ikarian Capital, LLC644,680$26.7M3.46%-96,14513F-HRTimelineGroup
Foresite Capital Management VI LLCgroup of 2 filers holding608,948$25.2M0Timeline
Caligan Partners LP550,191$22.8M2.09%new13F-HRTimeline
STATE STREET CORPin group STATE STREET CORP533,005$22.1M<0.01%+148,30313F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC527,281$21.9M<0.01%+53,73213F-HRTimelineGroup
Squadron Capital Management LLC490,000$20.3M9.06%13F-HRTimeline
BESSEMER GROUP INCin group BESSEMER GROUP INC481,790$20M0.03%013F-HRTimelineGroup
Matrix Capital Management Company, LP480,000$19.9M34.52%-1,173,68413F-HRTimeline
HHLR ADVISORS, LTD.in group HHLR ADVISORS, LTD.457,535$19M0.61%013F-HRTimelineGroup
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC448,217$18.6M0.01%new13F-HRTimelineGroup
BOOTHBAY FUND MANAGEMENT, LLC409,372$17M0.44%+57,49713F-HRTimeline
Driehaus Capital Management LLC378,015$15.7M0.11%013F-HRTimeline
EVENTIDE ASSET MANAGEMENT, LLC324,041$13.4M0.21%new13F-HRTimeline
WASHINGTON UNIVERSITY280,802$11.6M5.88%+70,12113F-HRTimeline
MORGAN STANLEYin group MORGAN STANLEY258,086$10.7M<0.01%+45,32413F-HR/ATimelineGroup
Mass General Brigham, Inc239,994$9.94M1.23%13F-HRTimeline
Parkman Healthcare Partners LLC209,266$8.67M0.83%+9,26613F-HRTimeline
Balyasny Asset Management L.P.in group Balyasny Asset Management199,212$8.25M0.02%-234,51313F-HRTimelineGroup
Alyeska Investment Group, L.P.in group Alyeska Investment Group, L.P.196,124$8.13M0.02%+71,12413F-HRTimelineGroup
Ensign Peak Advisors, Inc185,794$7.7M0.01%+115,12913F-HR/ATimeline
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC179,532$7.44M0.56%+153,48713F-HR/ATimelineGroup
NORTHERN TRUST CORPin group NORTHERN TRUST CORP176,259$7.3M<0.01%-63113F-HRTimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co175,969$7.29M<0.01%+8,04113F-HRTimelineGroup
TCG Crossover Management, LLC173,816$7.2M0.24%new13F-HRTimeline
HighVista Strategies LLC170,353$7.06M1.82%new13F-HRTimeline
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC154,470$6.4M<0.01%new13F-HRTimelineGroup
Invesco Ltd.in group Invesco Ltd.134,033$5.55M<0.01%+1,97113F-HRTimelineGroup
STEMPOINT CAPITAL LP125,877$5.22M0.89%new13F-HRTimeline
Freestone Grove Partners LP118,876$4.93M0.04%new13F-HRTimeline
PRICE T ROWE ASSOCIATES INC /MD/115,711$4.79M<0.01%+105,23713F-HRTimeline
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC114,455$4.74M<0.01%new13F-HR/ATimelineGroup
Integral Health Asset Management, LLC100,000$4.14M0.21%new13F-HRTimeline
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC96,688$4.01M<0.01%new13F-HRTimelineGroup
MPM BIOIMPACT LLC81,145$3.36M0.38%new13F-HRTimeline
SPHERA FUNDS MANAGEMENT LTD.in group SPHERA FUNDS MANAGEMENT LTD.71,843$2.98M0.62%-82,50013F-HRTimelineGroup
SummitTX Capital, L.P.69,560$2.88M0.09%new13F-HRTimeline
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC67,718$2.81M<0.01%new13F-HRTimelineGroup
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…61,205$2.54M<0.01%new13F-HRTimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp60,436$2.5M<0.01%+15,19613F-HRTimelineGroup
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.59,762$2.48M<0.01%+29,23713F-HRTimelineGroup
Nuveen, LLCin group TIAA57,258$2.37M<0.01%+26,95413F-HRTimelineGroup
FRANKLIN RESOURCES INCin group Franklin Resources55,229$2.29M<0.01%+37,03113F-HRTimelineGroup
Trexquant Investment LP52,459$2.17M0.02%new13F-HRTimeline
SEVEN GRAND MANAGERS, LLC50,000$2.07M0.16%new13F-HRTimeline
Schonfeld Strategic Advisors LLC48,200$2M0.01%-65,84913F-HRTimeline
BARCLAYS PLCin group BARCLAYS PLC39,508$1.64M<0.01%+11,99213F-HRTimelineGroup
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.33,694$1.4M<0.01%new13F-HRTimelineGroup
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding33,633$1.39M+24,555Timeline
ALLIANCEBERNSTEIN L.P.33,220$1.38M<0.01%-26,88013F-HRTimeline
XTX Topco Ltdin group XTX Topco Ltd33,021$1.37M0.04%+6,15413F-HRTimelineGroup
Cinctive Capital Management LP29,134$1.21M0.07%new13F-HRTimeline
UBS Group AGgroup of 2 filers holding28,797$1.19M+1,004Timeline
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC27,439$1.14M<0.01%-17613F-HRTimelineGroup
RENAISSANCE TECHNOLOGIES LLC27,100$1.12M<0.01%-59,00013F-HRTimeline
TUDOR INVESTMENT CORP ET AL24,059$997K0.01%new13F-HRTimeline
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN24,008$995K<0.01%+9,22913F-HRTimelineGroup
RHUMBLINE ADVISERS23,731$983K<0.01%+2,76113F-HRTimeline
GILDER GAGNON HOWE & CO LLC23,282$965K0.01%new13F-HRTimeline
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…22,545$934K<0.01%+20,63813F-HRTimelineGroup
Verition Fund Management LLC22,512$933K0.01%new13F-HRTimeline
TWO SIGMA INVESTMENTS, LPgroup of 2 filers holding22,045$913K+10,895Timeline
AMERICAN CENTURY COMPANIES INCin group AMERICAN CENTURY COMPANIES INC21,509$891K<0.01%new13F-HRTimelineGroup
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO20,007$829K<0.01%+12,11713F-HRTimelineGroup
ACUTA CAPITAL PARTNERS, LLC20,000$829K0.56%new13F-HRTimeline
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/18,381$762K<0.01%+8,80713F-HRTimelineGroup
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\15,522$643K<0.01%+6,63713F-HRTimelineGroup
LOS ANGELES CAPITAL MANAGEMENT LLC19,100$635K<0.01%new13F-HRTimeline
PSP Research LLC12,672$525K0.46%13F-HRTimeline
MetLife Investment Management, LLCin group MetLife Investment Management…11,801$489K<0.01%013F-HRTimelineGroup
China Universal Asset Management Co., L…11,441$474K0.04%+9,44113F-HRTimeline
CITIGROUP INCin group CITIGROUP INC11,252$466K<0.01%+10,98313F-HRTimelineGroup
STRS OHIO11,200$464K<0.01%-6,70013F-HRTimeline
Falcon Wealth Planning10,030$416K0.03%new13F-HRTimeline
SG Americas Securities, LLC8,493$352K<0.01%+3,47813F-HRTimeline
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …6,897$286K<0.01%new13F-HRTimelineGroup
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…6,846$284K0.08%-1,55113F-HRTimelineGroup
NEW YORK STATE COMMON RETIREMENT FUND6,700$278K<0.01%013F-HRTimeline
Persistent Asset Partners Ltd6,605$274K0.13%new13F-HRTimeline
INTECH INVESTMENT MANAGEMENT LLC6,443$267K<0.01%new13F-HRTimeline
LANDSCAPE CAPITAL MANAGEMENT, L.L.C.in group LANDSCAPE CAPITAL MANAGEMENT,…6,050$251K0.02%new13F-HRTimelineGroup
ProShare Advisors LLC6,047$251K<0.01%new13F-HRTimeline
PROFUND ADVISORS LLC6,016$249K0.01%new13F-HRTimeline
Police & Firemen's Retirement System of…5,961$247K<0.01%+93113F-HRTimeline
SEI INVESTMENTS COin group SEI INVESTMENTS CO5,668$235K<0.01%new13F-HRTimelineGroup
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS5,473$227K<0.01%-6,54513F-HRTimelineGroup
CIBC Private Wealth Group LLCin group CIBC Bancorp USA Inc.5,400$224K<0.01%new13F-HRTimelineGroup
Legal & General Group Plcin group Legal & General Group Plc5,379$223K<0.01%+16013F-HRTimelineGroup
Rafferty Asset Management, LLC5,244$217K<0.01%new13F-HRTimeline
Quantbot Technologies LP5,221$216K0.01%new13F-HRTimeline
WestHill Financial Advisors, Inc.5,186$215K0.04%new13F-HRTimeline
Brevan Howard Capital Management LPin group Brevan Howard Capital Managem…5,042$209K<0.01%new13F-HRTimelineGroup
IFP Advisors, Inc3,514$146K<0.01%new13F-HRTimeline
Caitong International Asset Management …3,501$145K0.04%new13F-HR/ATimeline
CWM, LLCin group CWM, LLC2,229$92K<0.01%+9113F-HRTimelineGroup
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…1,632$67.6K<0.01%013F-HRTimelineGroup
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…1,349$55.9K<0.01%-66313F-HRTimelineGroup
CALIFORNIA STATE TEACHERS RETIREMENT SY…1,321$54.7K<0.01%+76613F-HRTimeline
Sterling Capital Management LLC1,161$48.1K<0.01%-9913F-HRTimeline
GF FUND MANAGEMENT CO. LTD.944$39.1K<0.01%new13F-HRTimeline
AMALGAMATED BANK674$28K<0.01%+36913F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA646$27K<0.01%+36313F-HRTimelineGroup
Farther Finance Advisors, LLC359$14.9K<0.01%-2413F-HRTimeline
NISA INVESTMENT ADVISORS, LLC204$8.45K<0.01%+17813F-HRTimeline
GAMMA Investing LLC172$7.13K<0.01%+1313F-HRTimeline
Daiwa Securities Group Inc.in group Daiwa Securities Group Inc.160$7K<0.01%new13F-HRTimelineGroup
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…149$6.17K<0.01%013F-HRTimelineGroup
Torren Management, LLC112$4.64K<0.01%13F-HRTimeline
JONES FINANCIAL COMPANIES LLLPin group JONES FINANCIAL COMPANIES LLLP90$3.73K<0.01%new13F-HRTimelineGroup
SBI Securities Co., Ltd.67$2.78K<0.01%+613F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…58$2.4K<0.01%-3513F-HRTimelineGroup
SageView Advisory Group, LLC54$2.24K<0.01%new13F-HRTimeline
US BANCORP \DE\in group US BANCORP \DE\41$1.7K<0.01%new13F-HRTimelineGroup
Cornerstone Financial Management LLC28$1.16K<0.01%13F-HR/ATimeline
SIGNATUREFD, LLC14$580<0.01%new13F-HRTimeline
Sunbelt Securities, Inc.12$497<0.01%013F-HRTimeline
ROTHSCHILD INVESTMENT LLC10$414<0.01%013F-HRTimeline
Essential Partners LLC7$290<0.01%013F-HRTimeline
Rachor Investment Advisory Services, LLC6$249<0.01%13F-HRTimeline
Allworth Financial LP5$208<0.01%new13F-HRTimeline
True Wealth Design, LLC5$208<0.01%013F-HRTimeline