TRV GP IV, LLC More: the full row for TRV GP IV, LLC 6,073,958 $74.5M 45.63% 0 13F-HR Timeline Frazier Life Sciences Management, L.P. More: the full row for Frazier Life Sciences Management, L.P. 4,567,275 $56M 2.24% +438,274 13F-HR Timeline ARCH Venture Management, LLC More: the full row for ARCH Venture Management, LLC 4,120,053 $50.6M 16.91% 0 13F-HR Timeline Deep Track Capital, LP More: the full row for Deep Track Capital, LP 3,948,910 $48.5M 1.56% +679,784 13F-HR Timeline Matrix Capital Management Company, LP More: the full row for Matrix Capital Management Company, LP 2,486,184 $30.5M 13.69% 0 13F-HR Timeline Foresite Capital Management VI LLC group of 2 filers holding More: the full row for Foresite Capital Management VI LLC 2,457,110 $30.1M 0 Timeline Alphabet Inc. in group Alphabet Inc. More: the full row for Alphabet Inc. 2,412,471 $29.6M 1.39% 0 13F-HR Timeline Group a16z Capital Management, L.L.C. in group a16z Capital Management, L.L.… More: the full row for a16z Capital Management, L.L.C. 1,702,225 $20.9M 6.67% 0 13F-HR Timeline Group JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 1,401,260 $17.3M 0.01% +154,890 13F-HR Timeline Group General Catalyst Group Management, LLC More: the full row for General Catalyst Group Management, LLC 1,035,910 $12.7M 0.3% 0 13F-HR Timeline TRV GP V, LLC More: the full row for TRV GP V, LLC 950,800 $11.7M 7.04% 0 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 940,700 $11.5M 0.06% +11,598 13F-HR Timeline Casdin Capital, LLC More: the full row for Casdin Capital, LLC 758,857 $9.31M 0.85% -187,500 13F-HR Timeline HARVARD MANAGEMENT CO INC More: the full row for HARVARD MANAGEMENT CO INC 637,528 $7.82M 0.54% 0 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 614,704 $7.54M <0.01% +32,116 13F-HR Timeline Group Logos Global Management LP More: the full row for Logos Global Management LP 611,914 $7.51M 1% -325,000 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 554,534 $6.8M <0.01% -413,849 13F-HR Timeline Group BESSEMER GROUP INC in group BESSEMER GROUP INC More: the full row for BESSEMER GROUP INC 481,790 $5.91M 0.01% 0 13F-HR Timeline Group HHLR ADVISORS, LTD. in group HHLR ADVISORS, LTD. More: the full row for HHLR ADVISORS, LTD. 457,535 $5.61M 0.18% 0 13F-HR Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 419,613 $5.15M <0.01% -246,941 13F-HR Timeline Group SPHERA FUNDS MANAGEMENT LTD. in group SPHERA FUNDS MANAGEMENT LTD. More: the full row for SPHERA FUNDS MANAGEMENT LTD. 356,453 $4.37M 1.14% +899 13F-HR Timeline Group Ikarian Capital, LLC in group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 262,740 $3.22M 1.07% -60,000 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 231,237 $2.84M <0.01% +18,773 13F-HR Timeline Group Driehaus Capital Management LLC More: the full row for Driehaus Capital Management LLC 193,400 $2.37M 0.02% +61,285 13F-HR Timeline Octagon Capital Advisors LP More: the full row for Octagon Capital Advisors LP 177,667 $2.18M 0.48% -290,333 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 144,685 $1.78M <0.01% +79,972 13F-HR Timeline Group Alyeska Investment Group, L.P. in group Alyeska Investment Group, L.P. More: the full row for Alyeska Investment Group, L.P. 125,000 $1.53M 0.01% 0 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 85,546 $1.05M <0.01% +14,708 13F-HR Timeline Group BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 75,530 $927K 0.03% -21,438 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 75,171 $922K <0.01% +2,866 13F-HR Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 51,402 $631K <0.01% -36,662 13F-HR Timeline Group STRS OHIO More: the full row for STRS OHIO 46,900 $575K <0.01% +45,300 13F-HR Timeline ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 31,796 $390K <0.01% -984,650 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 31,781 $390K <0.01% +7,888 13F-HR Timeline Group CW Advisors, LLC More: the full row for CW Advisors, LLC 30,235 $371K <0.01% new 13F-HR Timeline Ghisallo Capital Management LLC More: the full row for Ghisallo Capital Management LLC 30,000 $368K 0.01% 0 13F-HR Timeline AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 27,467 $337K <0.01% new 13F-HR Timeline Group ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 23,577 $289K <0.01% new 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 21,546 $264K <0.01% +4,313 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 19,597 $240K <0.01% 0 13F-HR Timeline Group Ensign Peak Advisors, Inc More: the full row for Ensign Peak Advisors, Inc 18,539 $227K <0.01% new 13F-HR Timeline Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 18,430 $226K <0.01% -2,122 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 14,641 $180K <0.01% -3 13F-HR/A Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 12,990 $159K <0.01% +6,774 13F-HR Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 11,375 $140K <0.01% 0 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 10,567 $130K <0.01% -41 13F-HR Timeline Group Engineers Gate Manager LP More: the full row for Engineers Gate Manager LP 10,212 $125K <0.01% new 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 8,885 $109K <0.01% 0 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 7,714 $94.6K <0.01% +479 13F-HR Timeline Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 6,940 $85.2K 0.03% new 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 5,782 $70.9K <0.01% +1,455 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 5,615 $68.9K <0.01% +922 13F-HR Timeline Group MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. in group Mirae Asset Global Investment… More: the full row for MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 4,901 $60.1K <0.01% -234 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 4,608 $56.5K <0.01% +3,774 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 4,366 $53.6K <0.01% -5,775 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 4,242 $52K <0.01% +3,371 13F-HR Timeline Group NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 2,300 $28.2K <0.01% 0 13F-HR/A Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 2,266 $28K <0.01% new 13F-HR Timeline Group Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 2,241 $27.5K <0.01% 0 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 1,086 $13K <0.01% +953 13F-HR/A Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 894 $11K <0.01% 0 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 759 $9.31K <0.01% +359 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 554 $6.8K <0.01% 0 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 505 $6.2K <0.01% +479 13F-HR Timeline AMALGAMATED BANK More: the full row for AMALGAMATED BANK 305 $4K <0.01% 0 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 224 $2.75K <0.01% +150 13F-HR/A Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 182 $2.23K <0.01% new 13F-HR Timeline Group EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 114 $1.4K <0.01% new 13F-HR Timeline Group GAMMA Investing LLC More: the full row for GAMMA Investing LLC 51 $626 <0.01% new 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 54 $595 <0.01% new 13F-HR/A Timeline Group NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 26 $319 <0.01% +8 13F-HR Timeline Essential Partners LLC More: the full row for Essential Partners LLC 7 $86 <0.01% 13F-HR Timeline True Wealth Design, LLC More: the full row for True Wealth Design, LLC 5 $62 <0.01% new 13F-HR Timeline IFP Advisors, Inc More: the full row for IFP Advisors, Inc 3 $37 <0.01% new 13F-HR Timeline CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.