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13F-HR filed by ARCH Venture Management, LLC

ARCH Venture Management, LLC filed this 13F-HR for the quarter ended 2025-12-31, filed 2026-02-17, with 9 holding rows worth $651,681,142.

Accession
0001012975-26-000153
Filed
2026-02-17
Accepted by EDGAR
acceptance time not in the bulk data set
Ingested
Source
SEC quarterly data set

Original filing

13F report for Q4 2025

A holdings report, 9 entries on the cover page, a total value of $651,681,142 stated on the cover page (in dollars after the unit check, H1), rows summing to $651,681,142 with VALUE read as dollars as filed, 13F file number 028-19358. The quarter's positions are built on this report. The resolved quarter.

The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).

Issuer as filedCUSIPClassAmountValueValue read asType
MAZE THERAPEUTICS INC COM578784100Stock4,120,053$170,693,796dollars as filed
BEAM THERAPEUTICS INC07373V105COM4,540,132$125,852,459dollars as filed
RAPPORT THERAPEUTICS INC COM75383L102Stock3,728,738$113,129,911dollars as filed
LYELL IMMUNOPHARMA INC COM NEW55083R203Stock2,759,072$84,924,236dollars as filed
VIR BIOTECHNOLOGY INC92764N102COM12,916,663$77,887,478dollars as filed
ERASCA INC COM29479A108Stock11,055,554$41,126,661dollars as filed
GOSSAMER BIO INC COM38341P102Stock8,055,916$24,973,340dollars as filed
10X GENOMICS INC CL A COM88025U109Stock737,539$12,029,261dollars as filed
Q32 BIO INC746964105Common Stock320,482$1,064,000dollars as filed

Amendment chain

FilingRoleFiledAcceptedIngested
13F-HR 0001012975-26-000153this filing2026-02-17acceptance time not in the bulk data set