TRV GP IV, LLC More: the full row for TRV GP IV, LLC 6,073,958 $66.9M 72.02% new 13F-HR Timeline Frazier Life Sciences Management, L.P. More: the full row for Frazier Life Sciences Management, L.P. 4,129,001 $45.5M 2.08% new 13F-HR Timeline ARCH Venture Management, LLC More: the full row for ARCH Venture Management, LLC 4,120,053 $45.4M 22% new 13F-HR Timeline Deep Track Capital, LP More: the full row for Deep Track Capital, LP 3,269,126 $36M 1.17% new 13F-HR Timeline Matrix Capital Management Company, LP More: the full row for Matrix Capital Management Company, LP 2,486,184 $27.4M 7.88% new 13F-HR Timeline Foresite Capital Management VI LLC group of 2 filers holding More: the full row for Foresite Capital Management VI LLC 2,457,110 $27.1M new Timeline Alphabet Inc. in group Alphabet Inc. More: the full row for Alphabet Inc. 2,412,471 $26.6M 1.68% new 13F-HR Timeline Group a16z Capital Management, L.L.C. in group a16z Capital Management, L.L.… More: the full row for a16z Capital Management, L.L.C. 1,702,225 $18.7M 2.67% new 13F-HR Timeline Group JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 1,246,370 $14.3M 0.01% new 13F-HR Timeline Group General Catalyst Group Management, LLC More: the full row for General Catalyst Group Management, LLC 1,035,910 $11.4M 1.29% new 13F-HR Timeline ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 1,016,446 $11.2M <0.01% new 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 968,383 $10.7M <0.01% new 13F-HR Timeline Group TRV GP V, LLC More: the full row for TRV GP V, LLC 950,800 $10.5M 8.37% new 13F-HR Timeline Casdin Capital, LLC More: the full row for Casdin Capital, LLC 946,357 $10.4M 0.85% new 13F-HR Timeline Logos Global Management LP More: the full row for Logos Global Management LP 936,914 $10.3M 1.83% new 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 929,102 $10.2M 0.07% new 13F-HR Timeline VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 666,554 $7.34M <0.01% new 13F-HR Timeline Group HARVARD MANAGEMENT CO INC More: the full row for HARVARD MANAGEMENT CO INC 637,528 $7.02M 0.62% new 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 582,588 $6.41M <0.01% new 13F-HR Timeline Group BESSEMER GROUP INC in group BESSEMER GROUP INC More: the full row for BESSEMER GROUP INC 481,790 $5.3M 0.01% new 13F-HR Timeline Group Octagon Capital Advisors LP More: the full row for Octagon Capital Advisors LP 468,000 $5.15M 1.01% new 13F-HR/A Timeline HHLR ADVISORS, LTD. in group HHLR ADVISORS, LTD. More: the full row for HHLR ADVISORS, LTD. 457,535 $5.04M 0.14% new 13F-HR Timeline Group SPHERA FUNDS MANAGEMENT LTD. in group SPHERA FUNDS MANAGEMENT LTD. More: the full row for SPHERA FUNDS MANAGEMENT LTD. 355,554 $3.91M 0.97% new 13F-HR Timeline Group Ikarian Capital, LLC in group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 322,740 $3.55M 1.16% new 13F-HR Timeline Group Affinity Asset Advisors, LLC More: the full row for Affinity Asset Advisors, LLC 250,000 $2.75M 0.43% new 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 212,464 $2.34M <0.01% new 13F-HR Timeline Group Driehaus Capital Management LLC More: the full row for Driehaus Capital Management LLC 132,115 $1.45M 0.01% new 13F-HR Timeline Alyeska Investment Group, L.P. in group Alyeska Investment Group, L.P. More: the full row for Alyeska Investment Group, L.P. 125,000 $1.38M 0.01% new 13F-HR Timeline Group BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 96,968 $1.07M 0.04% new 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 88,064 $970K <0.01% new 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 72,305 $796K <0.01% new 13F-HR/A Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 70,838 $780K <0.01% new 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 64,713 $712K <0.01% new 13F-HR Timeline Group Ghisallo Capital Management LLC More: the full row for Ghisallo Capital Management LLC 30,000 $330K 0.03% new 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 23,893 $263K <0.01% new 13F-HR Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 20,552 $226K <0.01% new 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 20,000 $220K <0.01% new 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 19,597 $216K <0.01% new 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 17,233 $190K <0.01% new 13F-HR Timeline Group OXFORD ASSET MANAGEMENT LLP More: the full row for OXFORD ASSET MANAGEMENT LLP 17,000 $187K 0.09% new 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 14,644 $161K <0.01% new 13F-HR/A Timeline Group Davidson Kempner Capital Management LP More: the full row for Davidson Kempner Capital Management LP 13,670 $151K <0.01% new 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 13,129 $145K <0.01% new 13F-HR/A Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 11,375 $125K <0.01% 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 10,608 $117K <0.01% new 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 10,141 $112K <0.01% new 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 8,885 $97.8K <0.01% new 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 7,235 $79.7K <0.01% new 13F-HR/A Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 6,216 $68.4K <0.01% new 13F-HR Timeline Group MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. in group Mirae Asset Global Investment… More: the full row for MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 5,135 $56.5K <0.01% new 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 4,693 $51.7K <0.01% new 13F-HR Timeline Group Corebridge Financial, Inc. in group Corebridge Financial, Inc. More: the full row for Corebridge Financial, Inc. 4,328 $47.7K <0.01% new 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 4,327 $47.6K <0.01% new 13F-HR Timeline Group NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 2,300 $25.3K <0.01% new 13F-HR/A Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 2,241 $24.7K <0.01% new 13F-HR Timeline STRS OHIO More: the full row for STRS OHIO 1,600 $17.6K <0.01% new 13F-HR Timeline Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 894 $9.84K <0.01% new 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 871 $9.59K <0.01% new 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 834 $9.18K <0.01% new 13F-HR Timeline Group COMERICA BANK More: the full row for COMERICA BANK 636 $7K <0.01% new 13F-HR Timeline CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 554 $6.1K <0.01% new 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 400 $4.4K <0.01% new 13F-HR Timeline Group AMALGAMATED BANK More: the full row for AMALGAMATED BANK 305 $3K <0.01% new 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 133 $1K <0.01% new 13F-HR/A Timeline Group Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 74 $815 <0.01% new 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 26 $286 <0.01% new 13F-HR Timeline NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 18 $198 <0.01% new 13F-HR Timeline CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 new 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.