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Disclosery

IONS IONIS PHARMACEUTICALS INC

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Stock (common), issuer CIK 874015

349 managers (358 13F filers) reported a position in IONS shares at 2024-12-31, 160,456,382 shares in all. 41 filers opened a position and 49 filers sold out during the quarter.

Managers
349
13F filers
358
New
41
Added
119
Reduced
122
Sold out
49
Shares held by filers
160,456,382

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q4 2024

Filers in the available 13F reports with a share position at 2024-12-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
FMR LLCin group FMR LLC22,689,491$793M0.05%+209,96213F-HRTimelineGroup
VANGUARD GROUP INCgroup of 2 filers holding16,484,810$576M+1,420,648Timeline
T. Rowe Price Investment Management, In…14,169,199$495M0.31%+1,08313F-HRTimeline
BlackRock, Inc.in group BlackRock, Inc.11,665,548$408M0.01%+852,52513F-HRTimelineGroup
Capital World Investors11,465,413$401M0.06%+3,637,04113F-HRTimeline
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…8,672,148$303M0.06%-63,63913F-HRTimelineGroup
Bellevue Group AGin group Bellevue Group AG7,868,700$275M5.3%-5,70013F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP5,426,413$190M0.01%+576,27613F-HRTimelineGroup
PRICE T ROWE ASSOCIATES INC /MD/3,826,939$134M0.02%-383,23313F-HRTimeline
Tweedy, Browne Co LLC3,248,863$114M7.66%-205,81313F-HRTimeline
ORBIMED ADVISORS LLCin group ORBIMED ADVISORS LLC2,817,347$98.5M2.05%+492,90013F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC2,687,248$94M0.01%+18,89013F-HRTimelineGroup
UBS Group AGgroup of 2 filers holding2,537,249$88.7M+2,083,672Timeline
TWO SIGMA INVESTMENTS, LPgroup of 2 filers holding2,270,650$79.4M+19,162Timeline
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC2,165,916$75.7M0.07%+1,764,76513F-HRTimelineGroup
Deep Track Capital, LP1,933,928$67.6M2.53%-266,07213F-HRTimeline
MACQUARIE GROUP LTDin group MACQUARIE GROUP LTD1,769,743$61.9M0.08%-100,06313F-HRTimelineGroup
NORGES BANK1,714,762$59.9M0.01%-312,39913F-HRTimeline
Franklin Resourcesgroup of 2 filers holding1,631,521$57M-81,027Timeline
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co1,481,440$51.8M0.01%+38,42013F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY1,329,929$46.5M<0.01%+19,47813F-HR/ATimelineGroup
BNP PARIBAS ASSET MANAGEMENT Holding S.…in group BNP PARIBAS ASSET MANAGEMENT …1,080,341$37.8M0.09%+300,62013F-HRTimelineGroup
TD Asset Management Inc1,049,990$36.7M0.03%-43,00013F-HRTimeline
ARK Investment Management LLCin group ARK Investment Management LLC1,025,260$35.8M0.3%-359,00913F-HRTimelineGroup
Candriam S.C.A.849,824$29.7M0.17%-98,44213F-HRTimeline
NORTHERN TRUST CORPin group NORTHERN TRUST CORP840,271$29.4M<0.01%+97,36713F-HRTimelineGroup
Hudson Bay Capital Management LPin group Hudson Bay Capital Management…821,200$28.7M0.17%+54,30013F-HRTimelineGroup
MARSHALL WACE, LLPin group MARSHALL WACE, LLP812,306$28.4M0.04%-1,108,15813F-HRTimelineGroup
Invesco Ltd.in group Invesco Ltd.788,599$27.6M0.01%-21,70213F-HRTimelineGroup
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC774,215$27.1M0.02%+343,49213F-HRTimelineGroup
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA643,192$22.5M<0.01%-26,95713F-HRTimelineGroup
Camber Capital Management LP625,000$21.9M0.85%new13F-HRTimeline
Pictet Asset Management Holding SAin group Pictet Asset Management Holdi…620,798$21.7M0.02%-682,70313F-HRTimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp616,071$21.5M<0.01%+5,17813F-HRTimelineGroup
J. Goldman & Co LP607,499$21.2M0.75%-1,91713F-HRTimeline
AXA S.A.in group AXA S.A.605,345$21.2M0.06%+44,10213F-HRTimelineGroup
BARCLAYS PLCin group BARCLAYS PLC596,072$20.8M0.01%-40,96013F-HR/ATimelineGroup
Vestal Point Capital, LP595,000$20.8M1.23%new13F-HRTimeline
PINNACLE ASSOCIATES LTD547,642$19.1M0.26%+88,66313F-HRTimeline
GROUPAMA ASSET MANAGMENT517,191$18.1M0.37%+101,13113F-HRTimeline
GREAT POINT PARTNERS LLC505,007$17.7M8.32%+250,00713F-HRTimeline
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/422,861$14.8M<0.01%-145,79913F-HRTimelineGroup
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO415,919$14.5M<0.01%-152,98713F-HRTimelineGroup
Aberdeen Group plcin group Aberdeen Group plc401,501$14M0.03%+98,22713F-HRTimelineGroup
C WorldWide Group Holding A/Sin group C WorldWide Group Holding A/S400,000$14M0.17%+100,00013F-HRTimelineGroup
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC387,448$13.5M<0.01%-10,45013F-HRTimelineGroup
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC378,208$13.2M<0.01%+142,49813F-HRTimelineGroup
Schonfeld Strategic Advisors LLC371,381$13M0.08%+8,49313F-HRTimeline
BAKER BROS. ADVISORS LPin group BAKER BROS. ADVISORS LP357,915$12.5M0.13%+134,44513F-HRTimelineGroup
NOMURA ASSET MANAGEMENT CO LTDgroup of 2 filers holding357,255$12.5M-95,814Timeline
TOCQUEVILLE ASSET MANAGEMENT L.P.in group TOCQUEVILLE ASSET MANAGEMENT …352,140$12.3M0.19%-54,73013F-HRTimelineGroup
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN331,009$11.6M<0.01%-11,14513F-HRTimelineGroup
VOLORIDGE INVESTMENT MANAGEMENT, LLC316,943$11.1M0.04%-63,69813F-HRTimeline
BANK OF MONTREAL /CAN/in group BANK OF MONTREAL /CAN/312,146$10.9M0.01%+98,26313F-HRTimelineGroup
Nuveen Asset Management, LLCin group TIAA290,954$10.2M<0.01%-13,82513F-HRTimelineGroup
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …286,279$10M0.01%-22,66813F-HRTimelineGroup
JACOBS LEVY EQUITY MANAGEMENT, INC281,813$9.85M0.03%-368,96613F-HRTimeline
Swiss National Bank279,200$9.76M0.01%+22,60013F-HRTimeline
ADAGE CAPITAL PARTNERS GP, L.L.C.in group ADAGE CAPITAL PARTNERS GP, L.…275,000$9.61M0.02%-225,00013F-HRTimelineGroup
Privium Fund Management B.V.266,794$9.33M2.11%+16,05013F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS254,521$8.9M0.01%+79,19313F-HRTimelineGroup
Artisan Partners Limited Partnership252,635$8.83M0.01%-1,987,82013F-HRTimeline
Siren, L.L.C.in group Siren, L.L.C.250,000$8.74M0.39%013F-HRTimelineGroup
Corient Private Wealth LPin group Corient Private Wealth LP239,163$8.36M0.01%+2,08713F-HRTimelineGroup
SUSQUEHANNA INTERNATIONAL GROUP, LLPgroup of 3 filers holding239,079$8.36M+170,946Timeline
Rafferty Asset Management, LLC237,337$8.3M0.03%+38,57813F-HRTimeline
SECTOR GAMMA AS235,842$8.25M2.83%+25,00013F-HRTimeline
Aquatic Capital Management LLC230,016$8.04M0.22%new13F-HRTimeline
KENNEDY CAPITAL MANAGEMENT LLC223,278$7.81M0.17%+61,20213F-HRTimeline
Orion Investment Co216,000$7.55M3.01%-2,52513F-HRTimeline
Eversept Partners, LP214,952$7.51M0.78%-256,40313F-HRTimeline
Rhenman & Partners Asset Management AB212,500$7.43M0.76%+17,50013F-HRTimeline
STIFEL FINANCIAL CORPin group STIFEL FINANCIAL CORP211,493$7.39M0.01%+28,98813F-HRTimelineGroup
RENAISSANCE TECHNOLOGIES LLC205,514$7.18M0.01%+15,00013F-HRTimeline
Verition Fund Management LLC200,184$7M0.04%new13F-HRTimeline
California Public Employees Retirement …192,130$6.72M<0.01%-19,62613F-HR/ATimeline
RHUMBLINE ADVISERS191,893$6.71M0.01%-5,04913F-HR/ATimeline
GW&K Investment Management, LLC187,220$6.54M0.06%new13F-HRTimeline
Sicart Associates LLC185,821$6.5M2.32%-5,70213F-HRTimeline
Driehaus Capital Management LLC180,002$6.29M0.05%-49,96713F-HRTimeline
CITIGROUP INCin group CITIGROUP INC169,155$5.91M0.01%+98,86013F-HRTimelineGroup
Legal & General Group Plcin group Legal & General Group Plc168,080$5.88M<0.01%+10,79313F-HRTimelineGroup
Squarepoint Ops LLCin group Squarepoint Ops LLC166,468$5.82M0.01%+39,12713F-HRTimelineGroup
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC164,634$5.76M0.01%-11,92613F-HRTimelineGroup
Sovran Advisors, LLC171,812$5.62M0.8%13F-HRTimeline
Sumitomo Mitsui Trust Group, Inc.in group Sumitomo Mitsui Trust Group, …156,657$5.48M<0.01%-39,45713F-HRTimelineGroup
Amova Asset Management Americas, Inc.in group Amova Asset Management Americ…156,657$5.47M0.06%-39,45713F-HRTimelineGroup
STATE BOARD OF ADMINISTRATION OF FLORID…152,315$5.32M0.01%+1,26013F-HRTimeline
BLB&B Advisors, LLC152,050$5.32M0.27%-20013F-HRTimeline
TANG CAPITAL MANAGEMENT LLCin group TANG CAPITAL MANAGEMENT LLC150,000$5.24M0.35%013F-HRTimelineGroup
Alyeska Investment Group, L.P.in group Alyeska Investment Group, L.P.150,000$5.24M0.02%-18,95113F-HRTimelineGroup
Sonora Investment Management Group, LLC148,776$5.2M0.4%-4,39913F-HRTimeline
Assenagon Asset Management S.A.141,917$4.96M0.01%+128,61913F-HRTimeline
CALIFORNIA STATE TEACHERS RETIREMENT SY…133,902$4.68M0.01%+7,72213F-HR/ATimeline
Connor, Clark & Lunn Investment Managem…125,389$4.38M0.02%+107,64813F-HRTimeline
NICOLA WEALTH MANAGEMENT LTD.87,000$4.37M0.41%013F-HRTimeline
Swedbank ABin group Swedbank AB124,237$4.34M0.01%-5,13613F-HRTimelineGroup
Woodline Partners LP107,610$3.76M0.03%new13F-HRTimeline
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC105,619$3.69M<0.01%13F-HR/ATimelineGroup
STATE OF WISCONSIN INVESTMENT BOARD101,231$3.54M0.01%+15,06513F-HRTimeline
SCHRODER INVESTMENT MANAGEMENT GROUP100,659$3.52M<0.01%+44,43713F-HRTimeline
Ghisallo Capital Management LLC100,000$3.5M0.2%-300,00013F-HRTimeline
NEUBERGER BERMAN GROUP LLCin group NEUBERGER BERMAN GROUP LLC96,631$3.38M<0.01%+31,75713F-HRTimelineGroup
DekaBank Deutsche Girozentrale93,807$3.32M0.01%013F-HRTimeline
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP94,157$3.29M<0.01%-17513F-HRTimelineGroup
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC92,531$3.23M<0.01%-3,29013F-HR/ATimelineGroup
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\91,901$3.21M<0.01%+17,02713F-HR/ATimelineGroup
Twin Tree Management, LP88,900$3.11M0.08%+76,47213F-HRTimeline
Trexquant Investment LP84,913$2.97M0.03%-45,94513F-HRTimeline
NEW YORK STATE COMMON RETIREMENT FUND84,261$2.95M<0.01%-114,49813F-HR/ATimeline
HSBC HOLDINGS PLCin group HSBC HOLDINGS PLC83,055$2.93M<0.01%new13F-HRTimelineGroup
DCF Advisers, LLC82,882$2.9M1.46%+43,38213F-HRTimeline
Granite Investment Partners, LLC73,866$2.58M0.11%-11,92713F-HRTimeline
SEI INVESTMENTS COin group SEI INVESTMENTS CO70,091$2.45M<0.01%-119,74613F-HRTimelineGroup
Treasurer of the State of North Carolina68,803$2.4M0.01%+44013F-HRTimeline
TEACHER RETIREMENT SYSTEM OF TEXAS65,792$2.3M0.01%+9,09313F-HRTimeline
Allostery Investments LP65,000$2.27M4.46%13F-HRTimeline
JANUS HENDERSON GROUP PLCin group Janus Henderson63,877$2.23M<0.01%+4,90013F-HRTimelineGroup
SPHERA FUNDS MANAGEMENT LTD.in group SPHERA FUNDS MANAGEMENT LTD.63,821$2.23M0.41%013F-HRTimelineGroup
State of New Jersey Common Pension Fund…in group State of New Jersey Common Pe…63,206$2.21M0.01%+11,43113F-HRTimelineGroup
DAVENPORT & Co LLC62,740$2.19M0.01%-12,85813F-HRTimeline
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…62,200$2.17M<0.01%-66,26913F-HRTimelineGroup
VAN ECK ASSOCIATES CORPin group VAN ECK ASSOCIATES CORP61,619$2.15M<0.01%+2,61313F-HRTimelineGroup
Exome Asset Management LLC61,367$2.15M1.61%new13F-HRTimeline
OCONNOR, A Distinct Business Unit of UB…60,580$2.12M0.05%+23,62313F-HRTimelineThe filing omitted confidential holdings, a later amendment may add them.
Skandinaviska Enskilda Banken AB (publ)59,626$2.08M0.01%013F-HRTimeline
NEOS Investment Management LLC56,844$1.99M0.05%-2,40013F-HRTimeline
Tema ETFs LLC56,844$1.99M0.83%13F-HRTimeline
Police & Firemen's Retirement System of…56,695$1.98M0.02%13F-HRTimeline
PUBLIC EMPLOYEES RETIREMENT SYSTEM OF O…53,748$1.88M0.01%-3,07713F-HRTimeline
Ensign Peak Advisors, Inc53,320$1.86M<0.01%-16,56013F-HRTimeline
Erste Asset Management GmbHin group Erste Asset Management GmbH51,300$1.84M0.02%013F-HRTimelineGroup
ENVESTNET ASSET MANAGEMENT INCin group ENVESTNET ASSET MANAGEMENT INC52,688$1.84M<0.01%-6,12613F-HRTimelineGroup
ALLIANCEBERNSTEIN L.P.52,136$1.82M<0.01%-2613F-HRTimeline
Fieldview Capital Management, LLC51,282$1.79M0.28%13F-HRTimeline
Creative Planningin group Creative Planning46,803$1.64M<0.01%+18,42113F-HRTimelineGroup
Qsemble Capital Management, LP46,573$1.63M0.22%new13F-HRTimeline
Handelsbanken Fonder AB43,811$1.53M0.01%+80013F-HRTimeline
PROFUND ADVISORS LLC43,559$1.52M0.06%+5,96313F-HRTimeline
NJ State Employees Deferred Compensatio…42,000$1.47M0.18%013F-HRTimeline
Liontrust Investment Partners LLP41,621$1.46M0.02%-18,02313F-HRTimeline
ARIZONA STATE RETIREMENT SYSTEM41,147$1.44M0.01%+3,32013F-HRTimeline
Private Advisor Group, LLC40,673$1.42M0.01%-3,11413F-HRTimeline
LPL Financial LLC40,376$1.41M<0.01%-2,24413F-HRTimeline
BLAIR WILLIAM & CO/IL39,882$1.39M<0.01%-6,76913F-HRTimeline
Jump Financial, LLCin group Jump Financial, LLC39,737$1.39M0.03%new13F-HRTimelineGroup
CANADA LIFE ASSURANCE Coin group CANADA LIFE ASSURANCE Co39,214$1.37M<0.01%-62113F-HRTimelineGroup
CAPITAL COUNSEL LLC/NY37,080$1.3M0.06%013F-HR/ATimeline
Zurcher Kantonalbank (Zurich Cantonalba…36,322$1.27M<0.01%+5,40013F-HRTimeline
GRANDFIELD & DODD, LLC35,887$1.25M0.08%+1,07413F-HRTimeline
GUGGENHEIM CAPITAL LLCin group GUGGENHEIM CAPITAL LLC35,373$1.24M0.01%-1,78613F-HRTimelineGroup
China Universal Asset Management Co., L…33,480$1.17M0.11%+5,35913F-HRTimeline
Natixis Investment Managersgroup of 2 filers holding30,939$1.08M+9,859Timeline
KLP KAPITALFORVALTNING AS29,200$1.02M<0.01%13F-HRTimeline
PDT Partners, LLC28,994$1.01M0.09%+15,59413F-HRTimeline
Mariner, LLCin group Mariner, LLC27,661$967K<0.01%+4,53413F-HRTimelineGroup
BlueCrest Capital Management Ltd26,200$916K0.05%new13F-HRTimeline
Walleye Capital LLCgroup of 2 filers holding26,175$915K-101,554Timeline
Pathstone Holdings, LLCin group Pathstone Holdings, LLC26,058$911K<0.01%-1,74913F-HRTimelineGroup
XTX Topco Ltdin group XTX Topco Ltd25,362$887K0.07%+8,55713F-HRTimelineGroup
TEACHERS RETIREMENT SYSTEM OF THE STATE…24,083$842K0.01%013F-HRTimeline
Castle Hook Partners LP23,940$837K0.02%013F-HRTimeline
SG Americas Securities, LLC23,927$836K<0.01%+16,50813F-HRTimeline
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.23,123$808K<0.01%-121,96813F-HRTimelineGroup
Jefferies Financial Group Inc.in group Jefferies Financial Group Inc.22,381$782K0.01%-30,40013F-HR/ATimelineGroup
COMMONWEALTH EQUITY SERVICES, LLC21,826$763K<0.01%+37313F-HRTimeline
Bridgefront Capital, LLC21,802$762K0.26%+10,60613F-HRTimeline
Brevan Howard Capital Management LPin group Brevan Howard Capital Managem…21,366$747K0.02%-7,11313F-HRTimelineGroup
CANADA PENSION PLAN INVESTMENT BOARD19,900$696K<0.01%+8,70013F-HRTimeline
Nicollet Investment Management, Inc.19,786$692K0.24%-61613F-HRTimeline
XPONANCE LLC19,339$676K0.01%+31813F-HRTimeline
VICTORY CAPITAL MANAGEMENT INC18,004$629K<0.01%-34613F-HRTimeline
Aigen Investment Management, LP17,723$620K0.11%+6,11113F-HRTimeline
Tidal Investments LLCin group Tidal Investments LLC17,407$609K<0.01%-1,50113F-HRTimelineGroup
NBT BANK, N.A.in group NBT BANK, N.A.17,050$596K0.04%013F-HRTimelineGroup
Bleakley Financial Group, LLC16,942$592K0.02%+26413F-HRTimeline
E Fund Management Co., Ltd.16,868$590K0.03%+4,11613F-HRTimeline
Campbell & CO Investment Adviser LLC15,681$548K0.04%new13F-HRTimeline
PRELUDE CAPITAL MANAGEMENT, LLC15,595$545K0.05%new13F-HRTimeline
PUBLIC EMPLOYEES RETIREMENT ASSOCIATION…15,589$545K<0.01%013F-HRTimeline
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding14,712$519K+1,599Timeline
INCEPTIONR LLC14,390$503K0.11%new13F-HRTimeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…14,157$495K0.01%+9,85613F-HRTimelineGroup
PRINCIPAL FINANCIAL GROUP INCgroup of 2 filers holding13,683$478K+567Timeline
NORTH STAR ASSET MANAGEMENT INC13,640$477K0.02%013F-HRTimeline
COMMERCE BANKin group COMMERCE BANK13,584$475K<0.01%-63,96913F-HRTimelineGroup
Westmount Partners, LLC13,462$471K0.14%013F-HRTimeline
Stratos Wealth Partners, LTD.in group Stratos Wealth Partners, LTD.12,813$448K0.01%+2513F-HRTimelineGroup
BROWN ADVISORY INCin group BROWN ADVISORY INC12,730$445K<0.01%-1613F-HRTimelineGroup
HORIZON KINETICS ASSET MANAGEMENT LLC12,476$436K0.01%+52413F-HRTimeline
Essential Planning, LLC.11,440$428K<0.01%new13F-HRTimeline
NORTHWESTERN MUTUAL WEALTH MANAGEMENT COin group NORTHWESTERN MUTUAL INVESTMEN…11,327$396K<0.01%+6413F-HRTimelineGroup
Plancorp, LLC11,128$389K0.02%-15813F-HRTimeline
Amundiin group Amundi11,374$388K<0.01%-116,92513F-HRTimelineGroup
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…10,994$384K<0.01%+1,10113F-HRTimelineGroup
Significant Wealth Partners LLC10,905$381K0.2%new13F-HRTimeline
MONTANOVA CAPITAL, LLC10,800$378K0.01%013F-HRTimeline
Annis Gardner Whiting Capital Advisors,…10,736$375K0.11%+80013F-HRTimeline
Harbor Advisors LLC10,500$367K0.06%+5,00013F-HRTimeline
AMALGAMATED BANK10,292$360K<0.01%+33513F-HRTimeline