Skip to content
Disclosery

IONS IONIS PHARMACEUTICALS INC

Follow

Stock (common), issuer CIK 874015

339 managers (347 13F filers) reported a position in IONS shares at 2025-03-31, 166,719,479 shares in all. 51 filers opened a position and 60 filers sold out during the quarter.

Managers
339
13F filers
347
New
51
Added
102
Reduced
124
Sold out
60
Shares held by filers
166,719,479

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q1 2025

Filers in the available 13F reports with a share position at 2025-03-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
FMR LLCin group FMR LLC23,613,585$712M0.05%+924,09413F-HRTimelineGroup
VANGUARD GROUP INCgroup of 2 filers holding16,394,247$495M-90,563Timeline
T. Rowe Price Investment Management, In…16,175,533$488M0.32%+2,006,33413F-HRTimeline
Capital World Investors12,361,994$373M0.06%+896,58113F-HRTimeline
BlackRock, Inc.in group BlackRock, Inc.11,264,442$340M0.01%-401,10613F-HRTimelineGroup
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…8,416,421$254M0.05%-255,72713F-HRTimelineGroup
Bellevue Group AGin group Bellevue Group AG7,853,198$237M5.31%-15,50213F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP4,845,133$146M0.01%-581,28013F-HRTimelineGroup
Deep Track Capital, LP4,564,207$138M4.46%+2,630,27913F-HRTimeline
TWO SIGMA INVESTMENTS, LPgroup of 2 filers holding3,777,864$114M+1,507,214Timeline
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC3,480,062$105M0.1%+1,314,14613F-HRTimelineGroup
PRICE T ROWE ASSOCIATES INC /MD/3,265,034$98.5M0.01%-561,90513F-HRTimeline
Tweedy, Browne Co LLC2,983,518$90M7.98%-265,34513F-HRTimeline
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC2,842,954$85.8M0.01%+155,70613F-HRTimelineGroup
UBS Group AGgroup of 2 filers holding2,550,037$76.9M+12,788Timeline
ORBIMED ADVISORS LLCin group ORBIMED ADVISORS LLC2,540,136$76.6M1.84%-277,21113F-HRTimelineGroup
BVF INC/ILin group BVF INC/IL1,913,385$57.7M2.35%new13F-HRTimelineGroup
MACQUARIE GROUP LTDin group MACQUARIE GROUP LTD1,667,194$50.3M0.06%-102,54913F-HR/ATimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co1,443,629$43.6M0.01%-37,81113F-HR/ATimelineGroup
BNP PARIBAS ASSET MANAGEMENT Holding S.…in group BNP PARIBAS ASSET MANAGEMENT …1,196,392$36.1M0.1%+116,05113F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY1,144,181$34.5M<0.01%-185,74813F-HRTimelineGroup
TD Asset Management Inc1,100,466$33.2M0.03%+50,47613F-HRTimeline
ADAGE CAPITAL PARTNERS GP, L.L.C.in group ADAGE CAPITAL PARTNERS GP, L.…1,075,600$32.5M0.06%+800,60013F-HRTimelineGroup
Hudson Bay Capital Management LPin group Hudson Bay Capital Management…1,049,900$31.7M0.2%+228,70013F-HRTimelineGroup
ARK Investment Management LLCin group ARK Investment Management LLC1,000,527$30.2M0.3%-24,73313F-HRTimelineGroup
Candriam S.C.A.993,704$30M0.19%+143,88013F-HRTimeline
Invesco Ltd.in group Invesco Ltd.874,834$26.4M0.01%+86,23513F-HRTimelineGroup
NORGES BANK858,228$25.9M<0.01%-856,53413F-HR/ATimeline
NORTHERN TRUST CORPin group NORTHERN TRUST CORP834,847$25.2M<0.01%-5,42413F-HRTimelineGroup
BANK OF MONTREAL /CAN/in group BANK OF MONTREAL /CAN/782,835$23.6M0.01%+470,68913F-HRTimelineGroup
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/767,432$23.2M<0.01%+344,57113F-HRTimelineGroup
Camber Capital Management LP725,000$21.9M1.36%+100,00013F-HRTimeline
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC652,518$19.7M<0.01%+274,31013F-HR/ATimelineGroup
Pictet Asset Management Holding SAin group Pictet Asset Management Holdi…618,550$19.2M0.02%-2,24813F-HRTimelineGroup
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC635,370$19.2M0.02%-138,84513F-HRTimelineGroup
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA616,081$18.6M<0.01%-27,11113F-HR/ATimelineGroup
PINNACLE ASSOCIATES LTD608,517$18.4M0.27%+60,87513F-HRTimeline
GROUPAMA ASSET MANAGMENT569,211$17.7M0.35%+52,02013F-HRTimeline
AXA S.A.in group AXA S.A.566,486$17.1M0.06%-38,85913F-HRTimelineGroup
Schonfeld Strategic Advisors LLC560,359$16.9M0.11%+188,97813F-HRTimeline
Bank of New York Mellon Corpin group Bank of New York Mellon Corp544,633$16.4M<0.01%-71,43813F-HRTimelineGroup
Eversept Partners, LP517,021$15.6M1.77%+302,06913F-HRTimeline
TEACHER RETIREMENT SYSTEM OF TEXAS500,451$15.1M0.06%+434,65913F-HRTimeline
Aberdeen Group plcin group Aberdeen Group plc446,197$13.5M0.03%+44,69613F-HRTimelineGroup
CITIGROUP INCin group CITIGROUP INC426,480$12.9M0.01%+257,32513F-HRTimelineGroup
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO421,511$12.7M<0.01%+5,59213F-HRTimelineGroup
C WorldWide Group Holding A/Sin group C WorldWide Group Holding A/S400,000$12.1M0.15%013F-HRTimelineGroup
VOLORIDGE INVESTMENT MANAGEMENT, LLC377,204$11.4M0.04%+60,26113F-HRTimeline
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC360,188$10.9M<0.01%-27,26013F-HRTimelineGroup
BAKER BROS. ADVISORS LPin group BAKER BROS. ADVISORS LP357,915$10.8M0.12%013F-HRTimelineGroup
BARCLAYS PLCin group BARCLAYS PLC353,937$10.7M<0.01%-242,13513F-HR/ATimelineGroup
Legal & General Group Plcin group Legal & General Group Plc338,462$10.2M<0.01%+170,38213F-HRTimelineGroup
Sovran Advisors, LLC328,904$9.34M1.21%+157,09213F-HRTimeline
Nuveen, LLCin group TIAA308,777$9.32M<0.01%13F-HRTimelineGroup
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS308,293$9.3M0.01%+53,77213F-HRTimelineGroup
J. Goldman & Co LP307,770$9.29M0.33%-299,72913F-HRTimeline
Squarepoint Ops LLCin group Squarepoint Ops LLC305,373$9.21M0.02%+138,90513F-HR/ATimelineGroup
Point72 Asset Management, L.P.in group Point72 Asset Management, L.P.287,204$8.66M0.02%new13F-HR/ATimelineGroup
SECTOR GAMMA AS285,842$8.62M2.76%+50,00013F-HRTimeline
Swiss National Bank275,300$8.31M0.01%-3,90013F-HRTimeline
Privium Fund Management B.V.267,594$8.07M2.1%+80013F-HRTimeline
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN256,233$7.73M<0.01%-74,77613F-HRTimelineGroup
GREAT POINT PARTNERS LLC250,000$7.54M4.1%-255,00713F-HRTimeline
Corient Private Wealth LPin group Corient Private Wealth LP237,133$7.15M0.01%-2,03013F-HRTimelineGroup
NOMURA ASSET MANAGEMENT CO LTDgroup of 2 filers holding236,426$7.13M-120,829Timeline
SUSQUEHANNA INTERNATIONAL GROUP, LLPgroup of 2 filers holding230,420$6.95M-8,659Timeline
Orion Investment Co215,290$6.5M2.66%-71013F-HRTimeline
Artisan Partners Limited Partnership203,178$6.13M0.01%-49,45713F-HRTimeline
STIFEL FINANCIAL CORPin group STIFEL FINANCIAL CORP200,942$6.06M0.01%-10,55113F-HRTimelineGroup
California Public Employees Retirement …191,004$5.76M<0.01%-1,12613F-HRTimeline
RHUMBLINE ADVISERS188,216$5.68M0.01%-3,67713F-HR/ATimeline
TOCQUEVILLE ASSET MANAGEMENT L.P.in group TOCQUEVILLE ASSET MANAGEMENT …187,395$5.65M0.09%-164,74513F-HRTimelineGroup
Sicart Associates LLC185,646$5.6M1.94%-17513F-HRTimeline
GW&K Investment Management, LLC182,309$5.5M0.05%-4,91113F-HRTimeline
Rafferty Asset Management, LLC176,248$5.32M0.02%-61,08913F-HRTimeline
Aquatic Capital Management LLC156,157$4.71M0.12%-73,85913F-HRTimeline
Sonora Investment Management Group, LLC154,147$4.65M0.37%+5,37113F-HRTimeline
RENAISSANCE TECHNOLOGIES LLC153,514$4.63M0.01%-52,00013F-HRTimeline
STATE BOARD OF ADMINISTRATION OF FLORID…152,315$4.6M0.01%013F-HRTimeline
BLB&B Advisors, LLC152,200$4.59M0.23%+15013F-HRTimeline
KENNEDY CAPITAL MANAGEMENT LLC150,424$4.54M0.11%-72,85413F-HRTimeline
TANG CAPITAL MANAGEMENT LLCin group TANG CAPITAL MANAGEMENT LLC150,000$4.53M0.25%013F-HRTimelineGroup
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC148,690$4.49M<0.01%+43,07113F-HRTimelineGroup
Universal- Beteiligungs- und Serviceges…in group Universal- Beteiligungs- und …143,870$4.34M0.01%new13F-HRTimelineGroup
Sumitomo Mitsui Trust Group, Inc.in group Sumitomo Mitsui Trust Group, …142,433$4.3M<0.01%-14,22413F-HRTimelineGroup
Amova Asset Management Americas, Inc.in group Amova Asset Management Americ…142,433$4.3M0.06%-14,22413F-HRTimelineGroup
Exome Asset Management LLC135,616$4.09M3.66%+74,24913F-HR/ATimeline
CALIFORNIA STATE TEACHERS RETIREMENT SY…132,238$3.99M<0.01%-1,66413F-HRTimeline
Connor, Clark & Lunn Investment Managem…129,273$3.9M0.02%+3,88413F-HRTimeline
EDMOND DE ROTHSCHILD HOLDING S.A.in group EDMOND DE ROTHSCHILD HOLDING …124,200$3.75M0.07%new13F-HRTimelineGroup
AMERICAN CENTURY COMPANIES INCin group AMERICAN CENTURY COMPANIES INC116,768$3.52M<0.01%new13F-HRTimelineGroup
STATE OF WISCONSIN INVESTMENT BOARD108,316$3.27M0.01%+7,08513F-HRTimeline
Walleye Capital LLCgroup of 2 filers holding104,351$3.15M+78,176Timeline
NEUBERGER BERMAN GROUP LLCin group NEUBERGER BERMAN GROUP LLC102,473$3.09M<0.01%+5,84213F-HRTimelineGroup
ALLIANCEBERNSTEIN L.P.100,749$3.04M<0.01%+48,61313F-HRTimeline
PDT Partners, LLC96,056$2.9M0.21%+67,06213F-HRTimeline
DekaBank Deutsche Girozentrale93,807$2.87M0.01%013F-HRTimeline
DCF Advisers, LLC95,000$2.87M1.54%+12,11813F-HRTimeline
OCONNOR, A Distinct Business Unit of UB…90,779$2.74M0.07%+30,19913F-HRTimelineThe filing omitted confidential holdings, a later amendment may add them.
NICOLA WEALTH MANAGEMENT LTD.87,000$2.62M0.26%013F-HR/ATimeline
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\84,810$2.56M<0.01%-7,09113F-HRTimelineGroup
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …83,440$2.52M<0.01%-202,83913F-HRTimelineGroup
Jump Financial, LLCin group Jump Financial, LLC81,321$2.45M0.04%+41,58413F-HR/ATimelineGroup
Rhenman & Partners Asset Management AB81,000$2.44M0.28%-131,50013F-HRTimeline
NEW YORK STATE COMMON RETIREMENT FUND78,261$2.36M<0.01%-6,00013F-HR/ATimeline
HSBC HOLDINGS PLCin group HSBC HOLDINGS PLC74,833$2.22M<0.01%-8,22213F-HRTimelineGroup
Treasurer of the State of North Carolina71,593$2.16M0.01%+2,79013F-HRTimeline
SEI INVESTMENTS COin group SEI INVESTMENTS CO71,558$2.16M<0.01%+1,46713F-HR/ATimelineGroup
Granite Investment Partners, LLC68,434$2.06M0.1%-5,43213F-HRTimeline
JANUS HENDERSON GROUP PLCin group Janus Henderson63,877$1.99M<0.01%013F-HRTimelineGroup
SIMPLEX TRADING, LLC64,581$1.95M0.07%new13F-HRTimeline
SPHERA FUNDS MANAGEMENT LTD.in group SPHERA FUNDS MANAGEMENT LTD.63,821$1.93M0.47%013F-HRTimelineGroup
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC63,767$1.92M<0.01%-28,76413F-HR/ATimelineGroup
LAZARD ASSET MANAGEMENT LLCin group LAZARD ASSET MANAGEMENT LLC60,758$1.83M<0.01%+54,20113F-HRTimelineGroup
State of New Jersey Common Pension Fund…in group State of New Jersey Common Pe…60,662$1.83M0.01%-2,54413F-HRTimelineGroup
Avidity Partners Management LP60,000$1.81M0.37%new13F-HRTimeline
Skandinaviska Enskilda Banken AB (publ)59,626$1.8M0.01%013F-HRTimeline
CAPITAL FUND MANAGEMENT S.A.58,014$1.75M0.02%new13F-HRTimeline
Police & Firemen's Retirement System of…57,549$1.74M0.02%+85413F-HRTimeline
DAVENPORT & Co LLC56,393$1.7M0.01%-6,34713F-HRTimeline
Ensign Peak Advisors, Inc55,100$1.66M<0.01%+1,78013F-HRTimeline
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC54,117$1.63M<0.01%-110,51713F-HR/ATimelineGroup
Erste Asset Management GmbHin group Erste Asset Management GmbH51,300$1.6M0.02%013F-HRTimelineGroup
Verition Fund Management LLC52,287$1.58M0.01%-147,89713F-HRTimeline
PUBLIC EMPLOYEES RETIREMENT SYSTEM OF O…48,177$1.45M0.01%-5,57113F-HRTimeline
SCHRODER INVESTMENT MANAGEMENT GROUP45,950$1.43M<0.01%-54,70913F-HRTimeline
READYSTATE ASSET MANAGEMENT LP46,394$1.4M0.07%new13F-HRTimeline
CANADA LIFE ASSURANCE Coin group CANADA LIFE ASSURANCE Co43,853$1.33M<0.01%+4,63913F-HRTimelineGroup
Handelsbanken Fonder AB43,211$1.3M0.01%-60013F-HRTimeline
Raiffeisen Bank International AGin group Raiffeisen Bank International…41,754$1.3M0.02%+40,00013F-HRTimelineGroup
NJ State Employees Deferred Compensatio…42,000$1.27M0.16%013F-HRTimeline
GUGGENHEIM CAPITAL LLCin group GUGGENHEIM CAPITAL LLC41,414$1.25M0.01%+6,04113F-HRTimelineGroup
Point72 (DIFC) Ltd41,347$1.25M0.12%new13F-HRTimeline
ARIZONA STATE RETIREMENT SYSTEM40,687$1.23M0.01%-46013F-HRTimeline
BLAIR WILLIAM & CO/IL38,381$1.16M<0.01%-1,50113F-HRTimeline
PRELUDE CAPITAL MANAGEMENT, LLC37,772$1.14M0.11%+22,17713F-HRTimeline
GRANDFIELD & DODD, LLC37,761$1.14M0.07%+1,87413F-HRTimeline
CAPITAL COUNSEL LLC/NY37,080$1.12M0.05%013F-HRTimeline
Zurcher Kantonalbank (Zurich Cantonalba…36,509$1.1M<0.01%+18713F-HRTimeline
Creative Planningin group Creative Planning36,122$1.09M<0.01%-10,68113F-HRTimelineGroup
SummitTX Capital, L.P.35,103$1.06M0.05%13F-HRTimeline
Allostery Investments LP35,000$1.06M1.52%-30,00013F-HRTimeline
PROFUND ADVISORS LLC34,887$1.05M0.05%-8,67213F-HRTimeline
Private Advisor Group, LLC34,531$1.04M0.01%-6,14213F-HRTimeline
Pathstone Holdings, LLCin group Pathstone Holdings, LLC34,372$1.03M<0.01%+8,31413F-HRTimelineGroup
Mariner, LLCin group Mariner, LLC33,483$1.01M<0.01%+5,82213F-HRTimelineGroup
China Universal Asset Management Co., L…31,886$962K0.09%-1,59413F-HRTimeline
Liontrust Investment Partners LLP30,390$917K0.01%-11,23113F-HRTimeline
AXQ CAPITAL, LP30,104$908K0.36%new13F-HRTimeline
Alpine Global Management, LLC28,097$848K0.23%new13F-HRTimeline
KLP KAPITALFORVALTNING AS27,400$827K<0.01%-1,80013F-HRTimeline
ExodusPoint Capital Management, LP26,261$792K0.01%new13F-HRTimeline
HRT FINANCIAL LP25,824$779K<0.01%new13F-HRTimeline
NEOS Investment Management LLC25,141$759K0.01%-31,70313F-HRTimeline
Tema ETFs LLC25,141$759K0.23%-31,70313F-HRTimeline
BlueCrest Capital Management Ltd24,800$748K0.12%-1,40013F-HRTimeline
TEACHERS RETIREMENT SYSTEM OF THE STATE…24,083$727K0.01%013F-HRTimeline
LPL Financial LLC23,966$723K<0.01%-16,41013F-HRTimeline
Castle Hook Partners LP23,940$722K0.02%013F-HRTimeline
Brevan Howard Capital Management LPin group Brevan Howard Capital Managem…22,973$693K0.02%+1,60713F-HRTimelineGroup
Jefferies Financial Group Inc.in group Jefferies Financial Group Inc.22,841$689K0.01%+46013F-HRTimelineGroup
Bleakley Financial Group, LLC22,284$672K0.02%+5,34213F-HRTimeline
Daiwa Securities Group Inc.in group Daiwa Securities Group Inc.22,141$667K<0.01%+21,60013F-HRTimelineGroup
Tidal Investments LLCin group Tidal Investments LLC21,833$659K0.01%+4,42613F-HRTimelineGroup
Nicollet Investment Management, Inc.21,451$647K0.23%+1,66513F-HRTimeline
Bridgefront Capital, LLC20,528$619K0.18%-1,27413F-HRTimeline
XPONANCE LLC20,319$613K0.01%+98013F-HRTimeline
SG Americas Securities, LLC20,050$605K<0.01%-3,87713F-HRTimeline
VICTORY CAPITAL MANAGEMENT INC18,641$562K<0.01%+63713F-HRTimeline
NBT BANK, N.A.in group NBT BANK, N.A.17,050$514K0.04%013F-HRTimelineGroup
VIRGINIA RETIREMENT SYSTEMS ET Al16,522$498K<0.01%13F-HRTimeline
E Fund Management Co., Ltd.16,471$497K0.02%-39713F-HRTimeline
COMMONWEALTH EQUITY SERVICES, LLC16,398$495K<0.01%-5,42813F-HRTimeline
TWINBEECH CAPITAL LP15,938$481K0.01%new13F-HRTimeline
PUBLIC EMPLOYEES RETIREMENT ASSOCIATION…15,589$470K<0.01%013F-HRTimeline
ENVESTNET ASSET MANAGEMENT INCin group ENVESTNET ASSET MANAGEMENT INC15,039$454K<0.01%-37,64913F-HRTimelineGroup
JONES FINANCIAL COMPANIES LLLPin group JONES FINANCIAL COMPANIES LLLP13,735$428K<0.01%+4,39713F-HR/ATimelineGroup
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding13,525$421K-1,187Timeline
NORTH STAR ASSET MANAGEMENT INC13,610$411K0.02%-3013F-HRTimeline
Significant Wealth Partners LLC13,605$410K0.21%+2,70013F-HRTimeline
Westmount Partners, LLC12,961$391K0.12%-50113F-HRTimeline
Point72 Hong Kong Ltd12,862$388K0.03%new13F-HRTimeline
HORIZON KINETICS ASSET MANAGEMENT LLC12,476$376K<0.01%013F-HRTimeline
XTX Topco Ltdin group XTX Topco Ltd12,404$374K0.02%-12,95813F-HRTimelineGroup
NORTHWESTERN MUTUAL WEALTH MANAGEMENT COin group NORTHWESTERN MUTUAL INVESTMEN…12,358$373K<0.01%+1,03113F-HRTimelineGroup
INTECH INVESTMENT MANAGEMENT LLC12,207$368K<0.01%new13F-HRTimeline
BROWN ADVISORY INCin group BROWN ADVISORY INC12,026$363K<0.01%-70413F-HRTimelineGroup
SIH Partners, LLLPin group SIH Partners, LLLP11,999$362K0.03%new13F-HRTimelineGroup
FORA Capital, LLC11,570$349K0.04%new13F-HRTimeline
Twin Tree Management, LP11,385$343K0.01%-77,51513F-HRTimeline
&PARTNERS11,004$343K<0.01%+68713F-HRTimeline
Plancorp, LLC11,128$336K0.01%013F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…10,987$331K<0.01%-713F-HRTimelineGroup
MONTANOVA CAPITAL, LLC10,800$326K0.01%013F-HRTimeline
Annis Gardner Whiting Capital Advisors,…10,736$324K0.14%013F-HRTimeline
AMALGAMATED BANK10,573$319K<0.01%+28113F-HRTimeline
PRINCIPAL FINANCIAL GROUP INCgroup of 2 filers holding10,514$318K-3,169Timeline
Harbor Advisors LLC10,500$317K0.06%013F-HRTimeline
Capula Management Ltdin group Capula Management Ltd10,382$313K<0.01%new13F-HRTimelineGroupThe filing omitted confidential holdings, a later amendment may add them.
Teza Capital Management LLC10,244$309K0.14%+1,71913F-HRTimeline