13F-HR filed by SPHERA FUNDS MANAGEMENT LTD.
SPHERA FUNDS MANAGEMENT LTD. filed this 13F-HR for the quarter ended 2024-12-31, filed 2025-02-14, with 107 holding rows worth $553,148,198.
- Accession
- 0001496201-25-000001
- Filer
- CIK 1496201
- Filed
- 2025-02-14
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q4 2024
A holdings report, 108 entries on the cover page, a total value of $553,148,198 stated on the cover page (in dollars after the unit check, H1), rows summing to $553,148,198 with VALUE read as dollars as filed, 13F file number 028-15863. The quarter's positions are built on this report. The resolved quarter.
Other managers
- included managerSphera Global Healthcare Management LP028-15865
- included managerSphera Global Healthcare GP Ltd.028-15864
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS | 881624209 | ADR | 1,569,181 | $34,584,749 | dollars as filed | |
| BRIDGEBIO PHARMA INC | 10806X102 | COM | 905,279 | $24,840,856 | dollars as filed | |
| SANOFI SA SPONSORED ADR | 80105N105 | ADR | 384,515 | $18,545,158 | dollars as filed | |
| SYNDAX PHARMACEUTICALS INC | 87164F105 | COM | 1,381,241 | $18,260,006 | dollars as filed | |
| ASTRAZENECA PLC SPONSORED ADR | 046353108 | ADR | 225,060 | $14,745,931 | dollars as filed | |
| Amazon.com, Inc | 023135106 | COM | 62,607 | $13,735,350 | dollars as filed | |
| NOVA LTD COM | M7516K103 | Stock | 68,146 | $13,421,355 | dollars as filed | |
| META PLATFORMS INC CL A | 30303M102 | COM | 21,001 | $12,296,296 | dollars as filed | |
| SAREPTA THERAPEUTICS INC | 803607100 | COM | 98,921 | $12,027,804 | dollars as filed | |
| CELLDEX THERAPEUTICS INC NEW | 15117B202 | COM NEW | 474,103 | $11,980,583 | dollars as filed | |
| ELEDON PHARMACEUTICALS INC | 28617k101 | COM | 2,551,619 | $10,512,670 | dollars as filed | |
| Eli Lilly and Company | 532457108 | COM | 13,190 | $10,182,680 | dollars as filed | |
| Johnson & Johnson | 478160104 | COM | 69,831 | $10,098,959 | dollars as filed | |
| ULTRAGENYX PHARMACEUTICAL IN | 90400D108 | COM | 228,776 | $9,624,606 | dollars as filed | |
| Microsoft Corp | 594918104 | COM | 22,327 | $9,410,831 | dollars as filed | |
| MARVELL TECHNOLOGY INC | 573874104 | COM | 78,611 | $8,682,585 | dollars as filed | |
| TOWER SEMICONDUCTOR LTD SHS NEW | M87915274 | Stock | 166,149 | $8,558,335 | dollars as filed | |
| NOVO-NORDISK A S ADR | 670100205 | ADR | 98,080 | $8,436,842 | dollars as filed | |
| WIX COM LTD SHS | M98068105 | Stock | 39,253 | $8,421,731 | dollars as filed | |
| Alphabet Inc. Reg. Shares C | 02079K107 | COM | 43,500 | $8,284,140 | dollars as filed | |
| PHARVARIS NV | N69605108 | COMMON STOCK | 388,183 | $7,441,468 | dollars as filed | |
| NICE LTD SPONSORED ADR | 653656108 | ADR | 42,500 | $7,218,200 | dollars as filed | |
| CYTOKINETICS INC | 23282W605 | COM NEW | 153,021 | $7,198,108 | dollars as filed | |
| PRAXIS PRECISION MEDICINES I | 74006W207 | COM NEW | 91,583 | $7,048,228 | dollars as filed | |
| CHECK POINT SOFTWARE TECH LTD ORD | M22465104 | Stock | 35,635 | $6,653,055 | dollars as filed | |
| APELLIS PHARMACEUTICALS INC | 03753U106 | COM | 206,251 | $6,581,469 | dollars as filed | |
| IMMATICS N.V | N44445109 | SHS | 921,111 | $6,549,099 | dollars as filed | |
| PRAXIS PRECISION MEDICINES I | 74006W207 | COM NEW | 83,000 | $6,387,680 | dollars as filed | call |
| ANNEXON INC | 03589W102 | COM | 1,243,039 | $6,376,790 | dollars as filed | |
| AbbVie,Inc. | 00287Y109 | COM | 34,256 | $6,087,291 | dollars as filed | |
| Merck & Co.,Inc. | 58933Y105 | COM | 59,600 | $5,929,008 | dollars as filed | |
| BIOHAVEN LTD | G1110E107 | COM | 156,494 | $5,845,051 | dollars as filed | |
| REZOLUTE INC | 76200L309 | COMMON STOCK | 1,165,895 | $5,712,886 | dollars as filed | |
| JFROG LTD ORD SHS | M6191J100 | Stock | 190,381 | $5,599,105 | dollars as filed | |
| DYNE THERAPEUTICS INC COM | 26818M108 | Stock | 236,262 | $5,566,333 | dollars as filed | |
| MERUS N V | N5749R100 | COM | 130,532 | $5,488,871 | dollars as filed | |
| INTELLIA THERAPEUTICS INC | 45826J105 | COM | 466,080 | $5,434,493 | dollars as filed | |
| ORMAT TECHNOLOGIES INC | 686688102 | COM | 79,000 | $5,349,880 | dollars as filed | |
| KURA ONCOLOGY INC COM | 50127T109 | Stock | 610,087 | $5,313,858 | dollars as filed | |
| ACADIA PHARMACEUTICALS INC | 004225108 | COM | 288,539 | $5,294,691 | dollars as filed | |
| SOLAREDGE TECHNOLOGIES INC | 83417M104 | COM | 375,000 | $5,100,000 | dollars as filed | |
| ORMAT TECHNOLOGIES INC | 686688AC6 | DEBT 2.500% 7/1 | 5,037,000 | $5,018,251 | dollars as filed | |
| NOVARTIS AG SPONSORED ADR | 66987V109 | ADR | 50,000 | $4,865,500 | dollars as filed | |
| CYBIN INC | 23256X407 | COM NEW | 538,111 | $4,746,140 | dollars as filed | |
| SKYE BIOSCIENCE INC | 83086J200 | COM NEW | 1,564,628 | $4,427,897 | dollars as filed | |
| GSK PLC SPONSORED ADR | 37733W204 | ADR | 130,000 | $4,396,600 | dollars as filed | |
| 89BIO INC | 282559103 | COM | 556,532 | $4,352,080 | dollars as filed | |
| VIR BIOTECHNOLOGY INC | 92764N102 | COM | 581,829 | $4,270,625 | dollars as filed | |
| Day One Biopharmaceuticals Inc | 23954D109 | Common Stock | 334,987 | $4,244,285 | dollars as filed | |
| VIKING THERAPEUTICS INC | 92686J106 | COM | 103,270 | $4,155,585 | dollars as filed | |
| PLIANT THERAPEUTICS INC | 729139105 | COM | 297,362 | $3,916,258 | dollars as filed | |
| Broadcom Inc. | 11135F101 | COM | 16,880 | $3,913,459 | dollars as filed | |
| SCHOLAR ROCK HLDG CORP | 80706P103 | COM | 90,193 | $3,898,141 | dollars as filed | |
| TRAVERE THERAPEUTICS INC | 89422G107 | COM | 220,700 | $3,844,594 | dollars as filed | |
| ENGENE HOLDINGS INC | 29286M105 | COM | 560,000 | $3,724,000 | dollars as filed | |
| SAVARA INC | 805111101 | COM | 1,211,533 | $3,719,406 | dollars as filed | |
| ARROWHEAD PHARMACEUTICALS IN | 04280A100 | COM | 197,550 | $3,713,940 | dollars as filed | |
| JANUX THERAPEUTICS INC | 47103J105 | COM | 68,333 | $3,658,549 | dollars as filed | |
| ALPHA COGNITION INC | 02074J501 | COM NEW | 620,000 | $3,651,800 | dollars as filed | |
| SPRINGWORKS THERAPEUTICS INC | 85205L107 | COM | 100,000 | $3,613,000 | dollars as filed | |
| BIOGEN INC COM | 09062X103 | Stock | 22,738 | $3,477,095 | dollars as filed | |
| ENPHASE ENERGY INC COM | 29355A107 | Stock | 50,198 | $3,447,599 | dollars as filed | |
| ROCKET PHARMACEUTICALS INC | 77313F106 | COM | 271,792 | $3,416,425 | dollars as filed | |
| INOZYME PHARMA INC | 45790W108 | COM | 1,191,140 | $3,299,458 | dollars as filed | |
| CAMTEK LTD ORD | M20791105 | Stock | 36,287 | $2,930,901 | dollars as filed | |
| JASPER THERAPEUTICS INC | 471871202 | COM NEW | 135,720 | $2,901,694 | dollars as filed | |
| CORVUS PHARMACEUTICALS INC | 221015100 | COM | 500,491 | $2,677,627 | dollars as filed | |
| CARGO THERAPEUTICS INC COM | 14179K101 | Stock | 179,674 | $2,590,899 | dollars as filed | |
| WORKDAY INC CL A | 98138H101 | Stock | 10,000 | $2,580,300 | dollars as filed | |
| VIGIL NEUROSCIENCE INC | 92673K108 | COM | 1,502,429 | $2,554,129 | dollars as filed | |
| NUTRIEN LTD COM | 67077M108 | Stock | 55,894 | $2,501,257 | dollars as filed | |
| CULLINAN THERAPEUTICS INC | 230031106 | COM | 205,000 | $2,496,900 | dollars as filed | |
| Pfizer Inc. | 717081103 | COM | 90,000 | $2,387,700 | dollars as filed | |
| VISTAGEN THERAPEUTICS INC | 92840H400 | COM | 808,550 | $2,385,223 | dollars as filed | |
| CYTOKINETICS INC | 23282W605 | COM NEW | 50,000 | $2,352,000 | dollars as filed | call |
| MINERALYS THERAPEUTICS INC | 603170101 | COM | 190,672 | $2,347,172 | dollars as filed | |
| IONIS PHARMACEUTICALS INC COM | 462222100 | Stock | 63,821 | $2,231,182 | dollars as filed | |
| Ventyx Biosciences Inc | 92332V107 | Common Stock | 1,012,749 | $2,217,920 | dollars as filed | |
| ORIC PHARMACEUTICALS INC | 68622P109 | COM | 273,213 | $2,204,829 | dollars as filed | |
| CHEMOMAB THERAPEUTICS LTD | 16385C104 | SPONSORED ADS | 1,214,575 | $2,198,381 | dollars as filed | |
| XENON PHARMACEUTICALS INC COM | 98420N105 | Stock | 52,097 | $2,042,202 | dollars as filed | |
| PROMIS NEUROSCIENCES INC | 74346M406 | COM NEW | 1,929,297 | $1,828,588 | dollars as filed | |
| Uber Technologies | 90353T100 | COM | 30,000 | $1,809,600 | dollars as filed | |
| LARIMAR THERAPEUTICS INC | 517125100 | COM | 455,604 | $1,763,187 | dollars as filed | |
| ZURA BIO LTD | G9TY5A101 | COMMON STOCK | 690,718 | $1,726,795 | dollars as filed | |
| SHL TELEMEDICINE LTD SPONSORED ADS | 78423T200 | ADR | 632,456 | $1,676,008 | dollars as filed | |
| JASPER THERAPEUTICS INC | 471871202 | COM NEW | 77,500 | $1,656,950 | dollars as filed | put |
| PERSPECTIVE THERAPEUTICS INC | 46489V302 | COMMON STOCK | 460,247 | $1,468,188 | dollars as filed | |
| JASPER THERAPEUTICS INC | 471871202 | COM NEW | 61,100 | $1,306,318 | dollars as filed | call |
| ASTRIA THERAPEUTICS INC COM | 04635X102 | Stock | 139,800 | $1,249,812 | dollars as filed | |
| Bristol-Myers Squibb Company | 110122108 | COM | 20,000 | $1,131,200 | dollars as filed | |
| Mersana Therapeutics Inc | 59045L106 | Common Stock | 690,272 | $987,089 | dollars as filed | |
| ALUMIS INC | 022307102 | COM | 125,000 | $982,500 | dollars as filed | |
| WEREWOLF THERAPEUTICS INC | 95075A107 | CMN | 626,810 | $927,679 | dollars as filed | |
| APREA THERAPEUTICS INC | 03836J201 | COM NEW | 270,000 | $888,300 | dollars as filed | |
| Perion Network Ltd | M78673114 | COM | 102,612 | $869,124 | dollars as filed | |
| ONKURE THERAPEUTICS INC | 68277Q105 | COM CL A | 87,354 | $751,244 | dollars as filed | |
| KEZAR LIFE SCIENCES INC | 49372L209 | COM NEW | 108,473 | $728,939 | dollars as filed | |
| FATE THERAPEUTICS INC | 31189P102 | COM | 397,177 | $655,342 | dollars as filed | |
| ALECTOR INC | 014442107 | COMMON STOCK | 324,639 | $613,568 | dollars as filed | |
| ELEVATION ONCOLOGY INC COM | 28623U101 | Stock | 1,018,562 | $573,043 | dollars as filed | |
| CLIMB BIO INC | 28658R106 | COMMON STOCK | 251,935 | $453,483 | dollars as filed | |
| KYVERNA THERAPEUTICS INC | 501976104 | COMMON STOCK | 118,758 | $444,155 | dollars as filed | |
| COMPUGEN LTD | M25722105 | ORD | 177,094 | $270,954 | dollars as filed | |
| LAVA THERAPEUTICS NV | N51517105 | SHS | 126,328 | $120,138 | dollars as filed | |
| Applied Therapeutics Inc | 03828A101 | Common Stock | 50,000 | $42,810 | dollars as filed | |
| IMMATICS N.V | N44445117 | *W EXP 07/01/202 | 100,000 | $25,150 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001496201-25-000001 | this filing | 2025-02-14 | acceptance time not in the bulk data set |