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Disclosery

IONS IONIS PHARMACEUTICALS INC

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Stock (common), issuer CIK 874015

357 managers (364 13F filers) reported a position in IONS shares at 2025-06-30, 168,850,863 shares in all. 79 filers opened a position and 61 filers sold out during the quarter.

Managers
357
13F filers
364
New
79
Added
121
Reduced
109
Sold out
61
Shares held by filers
168,850,863

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q2 2025

Filers in the available 13F reports with a share position at 2025-06-30, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
FMR LLCin group FMR LLC23,642,990$934M0.05%+29,40513F-HRTimelineGroup
VANGUARD GROUP INCgroup of 2 filers holding16,726,918$661M+332,671Timeline
T. Rowe Price Investment Management, In…16,048,721$634M0.4%-126,81213F-HRTimeline
Capital World Investors12,540,188$495M0.07%+178,19413F-HRTimeline
BlackRock, Inc.in group BlackRock, Inc.10,896,937$431M0.01%-367,50513F-HRTimelineGroup
Bellevue Group AGin group Bellevue Group AG7,853,198$310M6.84%013F-HRTimelineGroup
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…6,345,776$251M0.05%-2,070,64513F-HRTimelineGroup
Deep Track Capital, LP4,891,544$193M6.21%+327,33713F-HRTimeline
STATE STREET CORPin group STATE STREET CORP4,530,398$179M0.01%-314,73513F-HRTimelineGroup
TWO SIGMA INVESTMENTS, LPgroup of 2 filers holding4,455,978$176M+678,114Timeline
ADAGE CAPITAL PARTNERS GP, L.L.C.in group ADAGE CAPITAL PARTNERS GP, L.…3,800,000$150M0.25%+2,724,40013F-HRTimelineGroup
PRICE T ROWE ASSOCIATES INC /MD/3,126,073$124M0.01%-138,96113F-HRTimeline
Tweedy, Browne Co LLC2,891,948$114M10.6%-91,57013F-HRTimeline
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC2,891,095$114M0.01%+48,14113F-HRTimelineGroup
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC2,649,527$105M0.09%+2,014,15713F-HRTimelineGroup
UBS Group AGgroup of 2 filers holding2,320,395$91.7M-229,642Timeline
BVF INC/ILin group BVF INC/IL1,913,385$75.6M2.7%013F-HRTimelineGroup
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC1,494,981$59.1M0.05%-1,985,08113F-HRTimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co1,487,818$58.8M0.01%+44,18913F-HRTimelineGroup
MACQUARIE GROUP LTDin group MACQUARIE GROUP LTD1,434,073$56.7M0.07%-233,12113F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY1,362,209$53.8M<0.01%+218,02813F-HRTimelineGroup
BNP PARIBAS ASSET MANAGEMENT Holding S.…in group BNP PARIBAS ASSET MANAGEMENT …1,350,879$53.4M0.13%+154,48713F-HRTimelineGroup
TD Asset Management Inc1,104,690$43.6M0.04%+4,22413F-HRTimeline
Polar Capital Holdings Plcin group Polar Capital Holdings Plc1,000,000$39.5M0.21%new13F-HRTimelineGroup
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/995,890$39.3M<0.01%+228,45813F-HRTimelineGroup
ARK Investment Management LLCin group ARK Investment Management LLC900,318$35.6M0.26%-100,20913F-HRTimelineGroup
VOLORIDGE INVESTMENT MANAGEMENT, LLC854,634$33.8M0.12%+477,43013F-HRTimeline
NORTHERN TRUST CORPin group NORTHERN TRUST CORP814,250$32.2M<0.01%-20,59713F-HRTimelineGroup
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA799,912$31.6M0.01%+183,83113F-HR/ATimelineGroup
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC777,940$30.7M<0.01%+125,42213F-HRTimelineGroup
Balyasny Asset Management L.P.in group Balyasny Asset Management768,648$30.4M0.07%new13F-HRTimelineGroup
Hudson Bay Capital Management LPin group Hudson Bay Capital Management…750,000$29.6M0.19%-299,90013F-HR/ATimelineGroup
Woodline Partners LP732,813$29M0.15%new13F-HRTimeline
Candriam S.C.A.724,740$28.6M0.17%-268,96413F-HRTimeline
TEACHER RETIREMENT SYSTEM OF TEXAS668,273$26.4M0.11%+167,82213F-HRTimeline
GROUPAMA ASSET MANAGMENT660,957$26.3M0.44%+91,74613F-HRTimeline
Pictet Asset Management Holding SAin group Pictet Asset Management Holdi…608,640$24.2M0.02%-9,91013F-HRTimelineGroup
Eversept Partners, LP588,900$23.3M2.34%+71,87913F-HRTimeline
BARCLAYS PLCin group BARCLAYS PLC583,266$23M0.01%+229,32913F-HR/ATimelineGroup
AXA S.A.in group AXA S.A.566,883$22.4M0.06%+39713F-HRTimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp527,188$20.8M<0.01%-17,44513F-HRTimelineGroup
MASSACHUSETTS FINANCIAL SERVICES CO /MA/in group MASSACHUSETTS FINANCIAL SERVI…519,184$20.5M0.01%new13F-HRTimelineGroup
GREAT POINT PARTNERS LLC500,000$19.8M12.84%+250,00013F-HRTimeline
Vestal Point Capital, LP500,000$19.8M1.04%new13F-HRTimeline
PINNACLE ASSOCIATES LTD494,539$19.5M0.28%-113,97813F-HRTimeline
BANK OF MONTREAL /CAN/in group BANK OF MONTREAL /CAN/483,289$19.1M0.01%-299,54613F-HRTimelineGroup
AMERICAN CENTURY COMPANIES INCin group AMERICAN CENTURY COMPANIES INC472,749$18.7M0.01%+355,98113F-HRTimelineGroup
NORGES BANK450,254$17.8M<0.01%-407,97413F-HRTimeline
C WorldWide Group Holding A/Sin group C WorldWide Group Holding A/S450,000$17.8M0.24%+50,00013F-HRTimelineGroup
Schonfeld Strategic Advisors LLC449,206$17.7M0.13%-111,15313F-HRTimeline
GW&K Investment Management, LLC448,830$17.7M0.16%+266,52113F-HRTimeline
Aberdeen Group plcin group Aberdeen Group plc406,694$16.2M0.03%-39,50313F-HRTimelineGroup
Legal & General Group Plcin group Legal & General Group Plc404,366$16M<0.01%+65,90413F-HRTimelineGroup
GREAT LAKES ADVISORS, LLC399,646$15.8M0.13%new13F-HRTimeline
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO394,978$15.6M<0.01%-26,53313F-HRTimelineGroup
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC368,119$14.5M<0.01%+7,93113F-HRTimelineGroup
Artisan Partners Limited Partnership354,962$14M0.02%+151,78413F-HRTimeline
CITIGROUP INCin group CITIGROUP INC340,977$13.5M0.01%-85,50313F-HRTimelineGroup
Sovran Advisors, LLC321,913$13.3M1.39%-6,99113F-HRTimeline
Point72 Asset Management, L.P.in group Point72 Asset Management, L.P.292,647$11.6M0.03%+5,44313F-HRTimelineGroup
Swiss National Bank288,600$11.4M0.01%+13,30013F-HRTimeline
SECTOR GAMMA AS285,842$11.3M3.69%013F-HRTimeline
RENAISSANCE TECHNOLOGIES LLC270,714$10.7M0.01%+117,20013F-HRTimeline
Privium Fund Management B.V.267,594$10.7M2.31%013F-HRTimeline
Connor, Clark & Lunn Investment Managem…265,793$10.5M0.04%+136,52013F-HRTimeline
Invesco Ltd.in group Invesco Ltd.256,235$10.1M<0.01%-618,59913F-HRTimelineGroup
Nuveen, LLCin group TIAA245,085$9.68M<0.01%-63,69213F-HRTimelineGroup
Corient Private Wealth LPin group Corient Private Wealth LP237,840$9.4M0.01%+70713F-HR/ATimelineGroup
Verition Fund Management LLC232,687$9.19M0.05%+180,40013F-HRTimeline
Orion Investment Co217,370$8.59M3.04%+2,08013F-HRTimeline
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC210,592$8.32M<0.01%+61,90213F-HRTimelineGroup
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN209,857$8.29M<0.01%-46,37613F-HRTimelineGroup
California Public Employees Retirement …201,993$7.98M0.01%+10,98913F-HRTimeline
EDMOND DE ROTHSCHILD HOLDING S.A.in group EDMOND DE ROTHSCHILD HOLDING …197,600$7.81M0.12%+73,40013F-HRTimelineGroup
STIFEL FINANCIAL CORPin group STIFEL FINANCIAL CORP196,357$7.76M0.01%-4,58513F-HRTimelineGroup
TOCQUEVILLE ASSET MANAGEMENT L.P.in group TOCQUEVILLE ASSET MANAGEMENT …187,345$7.4M0.11%-5013F-HRTimelineGroup
Sicart Associates LLC185,296$7.32M2.56%-35013F-HRTimeline
Rhenman & Partners Asset Management AB182,000$7.19M0.91%+101,00013F-HRTimeline
RHUMBLINE ADVISERS181,599$7.17M0.01%-6,61713F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS177,762$7.02M0.01%-130,53113F-HRTimelineGroup
Sonora Investment Management Group, LLC163,172$6.45M0.48%+9,02513F-HRTimeline
Alyeska Investment Group, L.P.in group Alyeska Investment Group, L.P.159,008$6.28M0.02%new13F-HRTimelineGroup
Aquatic Capital Management LLC158,086$6.25M0.13%+1,92913F-HRTimeline
STATE BOARD OF ADMINISTRATION OF FLORID…153,895$6.08M0.01%+1,58013F-HRTimeline
BLB&B Advisors, LLC151,550$5.99M0.28%-65013F-HRTimeline
TANG CAPITAL MANAGEMENT LLCin group TANG CAPITAL MANAGEMENT LLC150,000$5.93M0.3%013F-HRTimelineGroup
Universal- Beteiligungs- und Serviceges…in group Universal- Beteiligungs- und …149,839$5.92M0.01%+5,96913F-HRTimelineGroup
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC148,461$5.87M0.95%new13F-HRTimelineGroup
J. Goldman & Co LP147,682$5.83M0.18%-160,08813F-HRTimeline
CALIFORNIA STATE TEACHERS RETIREMENT SY…145,104$5.73M0.01%+12,86613F-HRTimeline
Rafferty Asset Management, LLC144,770$5.72M0.02%-31,47813F-HRTimeline
Sumitomo Mitsui Trust Group, Inc.in group Sumitomo Mitsui Trust Group, …139,739$5.52M<0.01%-2,69413F-HRTimelineGroup
Amova Asset Management Americas, Inc.in group Amova Asset Management Americ…139,739$5.52M0.06%-2,69413F-HRTimelineGroup
Squarepoint Ops LLCin group Squarepoint Ops LLC134,395$5.31M0.01%-170,97813F-HR/ATimelineGroup
KENNEDY CAPITAL MANAGEMENT LLC132,045$5.22M0.12%-18,37913F-HRTimeline
Trexquant Investment LP128,869$5.09M0.06%new13F-HRTimeline
Exome Asset Management LLC121,116$4.79M3.95%-14,50013F-HR/ATimeline
HEALTHCARE OF ONTARIO PENSION PLAN TRUS…116,000$4.58M0.01%new13F-HRTimeline
NEUBERGER BERMAN GROUP LLCin group NEUBERGER BERMAN GROUP LLC114,623$4.53M<0.01%+12,15013F-HR/ATimelineGroup
HSBC HOLDINGS PLCin group HSBC HOLDINGS PLC108,294$4.29M<0.01%+33,46113F-HRTimelineGroup
SEI INVESTMENTS COin group SEI INVESTMENTS CO98,348$3.89M<0.01%+26,79013F-HRTimelineGroup
SUPERSTRING CAPITAL MANAGEMENT LP98,267$3.88M4.84%new13F-HRTimeline
STATE OF WISCONSIN INVESTMENT BOARD96,694$3.82M0.01%-11,62213F-HRTimeline
DekaBank Deutsche Girozentrale93,807$3.72M0.01%013F-HRTimeline
SUSQUEHANNA INTERNATIONAL GROUP, LLPgroup of 3 filers holding92,900$3.67M-137,520Timeline
DCF Advisers, LLC91,750$3.63M1.74%-3,25013F-HRTimeline
NICOLA WEALTH MANAGEMENT LTD.87,000$3.44M0.32%013F-HRTimeline
NEW YORK STATE COMMON RETIREMENT FUND86,972$3.44M<0.01%+8,71113F-HR/ATimeline
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\85,278$3.37M<0.01%+46813F-HRTimelineGroup
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …83,386$3.29M<0.01%-5413F-HRTimelineGroup
Marex Group Ltdin group Marex Group Ltd83,361$3.29M0.06%new13F-HRTimelineGroup
OCONNOR, A Distinct Business Unit of UB…81,251$3.21M0.09%-9,52813F-HRTimelineThe filing omitted confidential holdings, a later amendment may add them.
WORLDQUANT MILLENNIUM ADVISORS LLC74,438$2.94M0.01%new13F-HRTimeline
VAN ECK ASSOCIATES CORPin group VAN ECK ASSOCIATES CORP73,617$2.91M<0.01%+71,46013F-HRTimelineGroup
Treasurer of the State of North Carolina72,587$2.87M0.01%+99413F-HRTimeline
Walleye Capital LLCgroup of 2 filers holding66,482$2.63M-37,869Timeline
DAVENPORT & Co LLC64,843$2.56M0.01%+8,45013F-HRTimeline
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC64,517$2.55M<0.01%+75013F-HRTimelineGroup
JANUS HENDERSON GROUP PLCin group Janus Henderson63,877$2.52M<0.01%013F-HRTimelineGroup
LAZARD ASSET MANAGEMENT LLCin group LAZARD ASSET MANAGEMENT LLC60,749$2.4M<0.01%-913F-HRTimelineGroup
Police & Firemen's Retirement System of…59,723$2.36M0.02%+2,17413F-HRTimeline
Skandinaviska Enskilda Banken AB (publ)59,626$2.36M0.01%013F-HRTimeline
State of New Jersey Common Pension Fund…in group State of New Jersey Common Pe…58,918$2.33M0.01%-1,74413F-HRTimelineGroup
Raiffeisen Bank International AGin group Raiffeisen Bank International…56,754$2.27M0.03%+15,00013F-HRTimelineGroup
FIRST TRUST ADVISORS LPin group FIRST TRUST ADVISORS LP56,519$2.23M<0.01%new13F-HRTimelineGroup
PDT Partners, LLC54,365$2.15M0.12%-41,69113F-HRTimeline
Ensign Peak Advisors, Inc53,320$2.11M<0.01%-1,78013F-HRTimeline
Creative Planningin group Creative Planning53,289$2.11M<0.01%+17,16713F-HRTimelineGroup
ALLIANCEBERNSTEIN L.P.52,057$2.06M<0.01%-48,69213F-HRTimeline
Erste Asset Management GmbHin group Erste Asset Management GmbH51,300$2.04M0.02%013F-HRTimelineGroup
CAPITAL COUNSEL LLC/NY50,205$1.98M0.08%+13,12513F-HRTimeline
PUBLIC EMPLOYEES RETIREMENT SYSTEM OF O…48,244$1.91M0.01%+6713F-HRTimeline
CANADA LIFE ASSURANCE Coin group CANADA LIFE ASSURANCE Co46,501$1.84M<0.01%+2,64813F-HRTimelineGroup
SCHRODER INVESTMENT MANAGEMENT GROUP45,950$1.82M<0.01%013F-HRTimeline
ARIZONA STATE RETIREMENT SYSTEM44,040$1.74M0.01%+3,35313F-HRTimeline
Zurcher Kantonalbank (Zurich Cantonalba…43,615$1.72M<0.01%+7,10613F-HRTimeline
Handelsbanken Fonder AB43,211$1.71M0.01%013F-HRTimeline
Granite Investment Partners, LLC43,181$1.71M0.08%-25,25313F-HRTimeline
NJ State Employees Deferred Compensatio…42,000$1.66M0.2%013F-HRTimeline
GUGGENHEIM CAPITAL LLCin group GUGGENHEIM CAPITAL LLC40,857$1.61M0.01%-55713F-HRTimelineGroup
SIMPLEX TRADING, LLC39,638$1.57M0.04%-24,94313F-HRTimeline
PRELUDE CAPITAL MANAGEMENT, LLC39,423$1.56M0.15%+1,65113F-HRTimeline
ALGERT GLOBAL LLC38,090$1.5M0.03%new13F-HR/ATimeline
BLAIR WILLIAM & CO/IL37,891$1.5M<0.01%-49013F-HRTimeline
Y-Intercept (Hong Kong) Ltd37,649$1.49M0.04%new13F-HRTimeline
GRANDFIELD & DODD, LLC37,230$1.47M0.09%-53113F-HRTimeline
Mariner, LLCin group Mariner, LLC36,914$1.46M<0.01%+3,43113F-HRTimelineGroup
Engineers Gate Manager LP33,118$1.31M0.02%new13F-HRTimeline
Brevan Howard Capital Management LPin group Brevan Howard Capital Managem…32,732$1.29M0.01%+9,75913F-HRTimelineGroup
NOMURA ASSET MANAGEMENT CO LTDgroup of 2 filers holding32,161$1.27M-204,265Timeline
China Universal Asset Management Co., L…31,966$1.26M0.12%+8013F-HRTimeline
KLP KAPITALFORVALTNING AS31,500$1.24M0.01%+4,10013F-HRTimeline
CAPITAL FUND MANAGEMENT S.A.31,219$1.23M0.01%-26,79513F-HRTimeline
Pathstone Holdings, LLCin group Pathstone Holdings, LLC30,759$1.22M<0.01%-3,61313F-HRTimelineGroup
One Capital Management, LLC29,865$1.18M0.04%new13F-HRTimeline
Future Fund LLC29,595$1.17M0.52%new13F-HRTimeline
Entropy Technologies, LP29,452$1.16M0.09%new13F-HRTimeline
PROFUND ADVISORS LLC28,859$1.14M0.04%-6,02813F-HRTimeline
NEOS Investment Management LLC28,161$1.11M0.01%+3,02013F-HRTimeline
Tema ETFs LLC28,161$1.11M0.3%+3,02013F-HRTimeline
Daiwa Securities Group Inc.in group Daiwa Securities Group Inc.26,141$1.03M<0.01%+4,00013F-HRTimelineGroup
Alpine Global Management, LLC25,437$1.01M0.24%-2,66013F-HRTimeline
LPL Financial LLC24,872$983K<0.01%+90613F-HRTimeline
TEACHERS RETIREMENT SYSTEM OF THE STATE…24,083$952K0.01%013F-HRTimeline
XPONANCE LLC22,754$899K0.01%+2,43513F-HRTimeline
OXFORD ASSET MANAGEMENT LLP22,405$885K0.29%new13F-HRTimeline
Jefferies Financial Group Inc.in group Jefferies Financial Group Inc.22,381$884K0.01%-46013F-HRTimelineGroup
Graham Capital Management, L.P.20,935$827K0.03%new13F-HRTimeline
Nicollet Investment Management, Inc.20,747$820K0.27%-70413F-HRTimeline
VICTORY CAPITAL MANAGEMENT INC18,516$732K<0.01%-12513F-HRTimeline
Bleakley Financial Group, LLC18,129$716K0.02%-4,15513F-HRTimeline
Assenagon Asset Management S.A.17,654$698K<0.01%new13F-HRTimeline
Quantinno Capital Management LP17,542$693K<0.01%+9,02713F-HRTimeline
Fieldview Capital Management, LLC17,306$684K0.1%new13F-HRTimeline
SummitTX Capital, L.P.17,149$678K0.03%-17,95413F-HRTimeline
NORTH STAR ASSET MANAGEMENT INC16,610$656K0.03%+3,00013F-HRTimeline
Bayesian Capital Management, LP16,600$656K0.1%+8,10013F-HRTimeline
E Fund Management Co., Ltd.16,160$638K0.03%-31113F-HRTimeline
PUBLIC EMPLOYEES RETIREMENT ASSOCIATION…15,589$616K<0.01%013F-HRTimeline
Significant Wealth Partners LLC15,504$613K0.3%+1,89913F-HRTimeline
Corton Capital Inc.14,424$570K0.66%new13F-HRTimeline
Vestmark Advisory Solutions, Inc.14,341$567K0.01%new13F-HRTimeline
Gotham Asset Management, LLC14,279$564K<0.01%new13F-HRTimeline
COMMONWEALTH EQUITY SERVICES, LLC13,942$551K<0.01%-2,45613F-HRTimeline
ENVESTNET ASSET MANAGEMENT INCin group ENVESTNET ASSET MANAGEMENT INC13,544$535K<0.01%-1,49513F-HRTimelineGroup
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding13,219$524K-306Timeline
IQ EQ FUND MANAGEMENT (IRELAND) Ltd13,263$524K0.05%+5,20413F-HRTimeline
MARSHALL WACE, LLPin group MARSHALL WACE, LLP13,100$518K<0.01%+3,99813F-HRTimelineGroup
Westmount Partners, LLC12,961$512K0.14%013F-HRTimeline
Annis Gardner Whiting Capital Advisors,…12,801$506K0.18%+2,06513F-HRTimeline
Paloma Partners Management Coin group Paloma Partners Management Co12,557$496K0.11%new13F-HRTimelineGroup
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…12,476$493K0.17%+2,77513F-HRTimelineGroup
DNB Asset Management ASin group DNB Asset Management AS12,271$485K<0.01%new13F-HRTimelineGroup
NORTHWESTERN MUTUAL WEALTH MANAGEMENT COin group NORTHWESTERN MUTUAL INVESTMEN…12,244$484K<0.01%-11413F-HRTimelineGroup
BROWN ADVISORY INCin group BROWN ADVISORY INC12,191$482K<0.01%+16513F-HRTimelineGroup
Vident Advisory, LLCin group Vident Advisory, LLC12,000$474K0.01%new13F-HRTimelineGroup
HORIZON KINETICS ASSET MANAGEMENT LLC11,952$472K0.01%-52413F-HRTimeline
&PARTNERS11,758$465K<0.01%+75413F-HRTimeline
AMALGAMATED BANK11,526$455K<0.01%+95313F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…11,411$451K<0.01%+42413F-HRTimelineGroup