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Disclosery

DSGN DESIGN THERAPEUTICS INC

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COM (common), issuer CIK 1807120

114 managers (117 13F filers) reported a position in DSGN shares at 2025-12-31, 38,119,032 shares in all. 27 filers opened a position and 8 filers sold out during the quarter.

Managers
114
13F filers
117
New
27
Added
39
Reduced
28
Sold out
8
Shares held by filers
38,119,032

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q4 2025

Filers in the available 13F reports with a share position at 2025-12-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
SR One Capital Management, LP6,526,476$61.2M8.67%013F-HRTimeline
Point72 Asset Management, L.P.in group Point72 Asset Management, L.P.5,372,004$50.4M0.08%+2,031,45213F-HRTimelineGroup
Logos Global Management LP2,500,000$23.4M1.56%-1,155,00013F-HRTimeline
BAKER BROS. ADVISORS LPin group BAKER BROS. ADVISORS LP2,233,099$20.9M0.12%+520,21713F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.2,117,156$19.9M<0.01%+72,76813F-HRTimelineGroup
VANGUARD GROUP INCin group VANGUARD GROUP INC1,630,910$15.3M<0.01%+187,20913F-HRTimelineGroup
Vivo Capital, LLC1,612,903$15.1M0.98%new13F-HRTimeline
Almitas Capital LLC1,530,435$14.4M3.16%013F-HRTimeline
RA CAPITAL MANAGEMENT, L.P.in group RA CAPITAL MANAGEMENT, L.P.1,461,381$13.7M0.14%+985,68213F-HRTimelineGroup
Driehaus Capital Management LLC1,179,817$11.1M0.08%+103,58113F-HRTimeline
Woodline Partners LP944,039$8.86M0.03%+331,32713F-HRTimeline
Kynam Capital Management, LP784,606$7.36M0.48%-244,97313F-HRTimeline
FMR LLCin group FMR LLC771,268$7.23M<0.01%+30,41913F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY702,306$6.59M<0.01%+526,31513F-HR/ATimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC679,590$6.38M<0.01%-16,02313F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP647,636$6.07M<0.01%+13,23913F-HRTimelineGroup
ACADIAN ASSET MANAGEMENT LLCin group ACADIAN ASSET MANAGEMENT LLC612,768$5.74M0.01%-4,72113F-HRTimelineGroup
Frazier Life Sciences Management, L.P.521,000$4.89M0.13%-1,432,54713F-HRTimeline
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC459,874$4.31M<0.01%-94,14613F-HRTimelineGroup
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.438,894$4.12M<0.01%+65,61813F-HRTimelineGroup
Invesco Ltd.in group Invesco Ltd.305,757$2.87M<0.01%+291,16813F-HRTimelineGroup
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP297,921$2.8M<0.01%+18,10413F-HRTimelineGroup
RENAISSANCE TECHNOLOGIES LLC287,100$2.69M<0.01%+12,80013F-HRTimeline
NORTHERN TRUST CORPin group NORTHERN TRUST CORP286,572$2.69M<0.01%-9,95713F-HRTimelineGroup
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC270,654$2.54M<0.01%+9,20913F-HR/ATimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co236,863$2.22M<0.01%-11,07113F-HRTimelineGroup
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC226,512$2.12M<0.01%+108,67913F-HRTimelineGroup
MARSHALL WACE, LLPin group MARSHALL WACE, LLP225,528$2.12M<0.01%new13F-HRTimelineGroup
Elmind Capital, LP207,900$1.95M0.58%13F-HRTimeline
JACOBS LEVY EQUITY MANAGEMENT, INC194,611$1.83M0.01%new13F-HRTimeline
ALGERT GLOBAL LLC187,769$1.76M0.03%new13F-HR/ATimeline
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC180,866$1.7M<0.01%+112,04313F-HRTimelineGroup
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC158,383$1.49M<0.01%new13F-HRTimelineGroup
ACUTA CAPITAL PARTNERS, LLC150,906$1.42M0.96%new13F-HRTimeline
Nuveen, LLCin group TIAA125,260$1.17M<0.01%-7,76813F-HRTimelineGroup
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC109,763$1.03M<0.01%new13F-HRTimelineGroup
DIADEMA PARTNERS LP100,320$941K0.56%new13F-HRTimeline
Trexquant Investment LP99,967$938K0.01%new13F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS94,828$889K<0.01%+89,69513F-HRTimelineGroup
BARCLAYS PLCin group BARCLAYS PLC87,060$817K<0.01%-1,11613F-HRTimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp84,975$797K<0.01%-2,50013F-HRTimelineGroup
Informed Momentum Co LLC78,949$741K0.08%new13F-HRTimeline
BRIDGEWAY CAPITAL MANAGEMENT, LLC78,500$736K0.02%-109,70013F-HRTimeline
TWO SIGMA INVESTMENTS, LPgroup of 2 filers holding71,537$671K-28,200Timeline
Lynx1 Capital Management LPin group Lynx1 Capital Management LP69,516$652K0.13%+3,56213F-HRTimelineGroup
Palumbo Wealth Management LLC69,377$651K0.16%+17,29613F-HRTimeline
SUSQUEHANNA INTERNATIONAL GROUP, LLPin group SUSQUEHANNA INTERNATIONAL GRO…61,852$580K<0.01%+47,82913F-HRTimelineGroup
AMERICAN CENTURY COMPANIES INCin group AMERICAN CENTURY COMPANIES INC57,798$542K<0.01%+6,94613F-HRTimelineGroup
CANADA PENSION PLAN INVESTMENT BOARD54,600$512K<0.01%new13F-HRTimeline
SEI INVESTMENTS COin group SEI INVESTMENTS CO52,730$495K<0.01%new13F-HRTimelineGroup
STATE OF WISCONSIN INVESTMENT BOARD50,657$475K<0.01%+23,59513F-HRTimeline
KENNEDY CAPITAL MANAGEMENT LLC50,023$469K0.01%+20,61213F-HRTimeline
ALPS ADVISORS INCin group ALPS ADVISORS INC46,771$439K<0.01%new13F-HRTimelineGroup
Squarepoint Ops LLCin group Squarepoint Ops LLC46,142$433K<0.01%new13F-HRTimelineGroup
ALLIANCEBERNSTEIN L.P.46,120$433K<0.01%013F-HRTimeline
PRUDENTIAL FINANCIAL INCin group PRUDENTIAL FINANCIAL INC42,710$401K<0.01%-2,11513F-HRTimelineGroup
XTX Topco Ltdin group XTX Topco Ltd35,284$331K0.01%+23,41613F-HRTimelineGroup
Persistent Asset Partners Ltd34,989$328K0.16%new13F-HRTimeline
RHUMBLINE ADVISERS34,778$326K<0.01%-11,55613F-HRTimeline
China Universal Asset Management Co., L…34,282$322K0.02%-70013F-HRTimeline
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/27,446$257K<0.01%+3,53913F-HRTimelineGroup
Corient Private Wealth LPin group Corient Private Wealth LP26,965$253K<0.01%new13F-HR/ATimelineGroup
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN26,786$251K<0.01%+8,46913F-HRTimelineGroup
UBS Group AGgroup of 2 filers holding25,917$243K+3,224Timeline
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…25,234$237K<0.01%+18,85713F-HRTimelineGroup
STRS OHIO25,200$236K<0.01%+2,60013F-HRTimeline
Virtu Financial LLCin group Virtu Financial LLC22,651$212K0.01%new13F-HRTimelineGroup
AlphaCentric Advisors LLC20,262$190K0.19%13F-HRTimeline
Baader Bank Aktiengesellschaft20,000$188K0.02%new13F-HRTimeline
Velan Capital Investment Management LP20,000$188K0.11%013F-HRTimeline
9823 Capital, L.P.19,197$180K0.12%13F-HRTimeline
PRICE T ROWE ASSOCIATES INC /MD/15,711$148K<0.01%-60313F-HRTimeline
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\15,541$146K<0.01%new13F-HRTimelineGroup
MetLife Investment Management, LLCin group MetLife Investment Management…15,249$143K<0.01%+4,92913F-HRTimelineGroup
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO14,451$136K<0.01%-8,77013F-HRTimelineGroup
Engineers Gate Manager LP14,012$131K<0.01%new13F-HRTimeline
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding13,859$130K+933Timeline
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC13,730$129K<0.01%+6613F-HRTimelineGroup
Mariner, LLCin group Mariner, LLC12,822$120K<0.01%-3,25913F-HRTimelineGroup
NISA INVESTMENT ADVISORS, LLC11,824$111K<0.01%013F-HRTimeline
AXQ CAPITAL, LP11,728$110K0.02%new13F-HRTimeline
TWO SIGMA SECURITIES, LLC11,396$107K0.01%new13F-HRTimeline
PUBLIC EMPLOYEES RETIREMENT SYSTEM OF O…7,093$66.5K<0.01%new13F-HRTimeline
Police & Firemen's Retirement System of…6,598$61.9K<0.01%013F-HRTimeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…4,273$40.1K<0.01%+2,31413F-HRTimelineGroup
CAZ INVESTMENTS LPin group CAZ INVESTMENTS LP3,500$32.8K0.06%-1,50013F-HRTimelineGroup
CITIGROUP INCin group CITIGROUP INC3,113$29.2K<0.01%+1,52313F-HRTimelineGroup
Torren Management, LLC2,820$26.5K0.01%13F-HRTimeline
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…2,570$24.1K<0.01%013F-HRTimelineGroup
Legal & General Group Plcin group Legal & General Group Plc2,077$19.5K<0.01%013F-HRTimelineGroup
NEW YORK STATE COMMON RETIREMENT FUND2,026$19K<0.01%013F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…1,816$17K<0.01%-713F-HRTimelineGroup
CALIFORNIA STATE TEACHERS RETIREMENT SY…1,471$13.8K<0.01%-49813F-HRTimeline
Sterling Capital Management LLC1,377$12.9K<0.01%-27113F-HRTimeline
Zurcher Kantonalbank (Zurich Cantonalba…1,227$11.5K<0.01%013F-HRTimeline
GF FUND MANAGEMENT CO. LTD.1,118$10.5K<0.01%-9513F-HRTimeline
GAMMA Investing LLC750$7.04K<0.01%+30713F-HRTimeline
AMALGAMATED BANK751$7K<0.01%-42513F-HRTimeline
Rockefeller Capital Management L.P.in group Rockefeller Capital Managemen…738$6.92K<0.01%new13F-HR/ATimelineGroup
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA638$6K<0.01%+19313F-HRTimelineGroup
Clearstead Advisors, LLC610$5.72K<0.01%013F-HRTimeline
Private Wealth Management Group, LLC558$5.24K<0.01%013F-HRTimeline
Farther Finance Advisors, LLC385$3.61K<0.01%013F-HRTimeline
Optiver Holding B.V.in group Optiver Holding B.V.328$3.08K<0.01%013F-HRTimelineGroup
Physician Wealth Advisors, Inc.268$2.51K<0.01%013F-HRTimeline
MassMutual Private Wealth & Trust, FSB239$2.24K<0.01%013F-HRTimeline
CWM, LLCin group CWM, LLC239$2K<0.01%+1713F-HRTimelineGroup
Daiwa Securities Group Inc.in group Daiwa Securities Group Inc.100$1K<0.01%013F-HRTimelineGroup
Arax Advisory Partners47$441<0.01%-14713F-HRTimeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.10$94<0.01%new13F-HRTimelineGroup
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…3$28<0.01%-23213F-HRTimelineGroup
Larson Financial Group LLC3$28<0.01%013F-HRTimeline
True Wealth Design, LLC1$10<0.01%new13F-HRTimeline
Capital Advisors, Ltd. LLC12$00%013F-HRTimelineValue filed as zero, left out of ratios.