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Disclosery

DSGN DESIGN THERAPEUTICS INC

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COM (common), issuer CIK 1807120

93 managers (95 13F filers) reported a position in DSGN shares at 2025-09-30, 34,492,576 shares in all. 14 filers opened a position and 12 filers sold out during the quarter.

Managers
93
13F filers
95
New
14
Added
17
Reduced
38
Sold out
12
Shares held by filers
34,492,576

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q3 2025

Filers in the available 13F reports with a share position at 2025-09-30, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
SR One Capital Management, LP6,526,476$49.1M7.11%013F-HRTimeline
Logos Global Management LP3,655,000$27.5M2.72%-562,62713F-HRTimeline
Point72 Asset Management, L.P.in group Point72 Asset Management, L.P.3,340,552$25.2M0.05%+1,533,33413F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.2,044,388$15.4M<0.01%-351,35513F-HRTimelineGroup
Frazier Life Sciences Management, L.P.1,953,547$14.7M0.44%013F-HRTimeline
TANG CAPITAL MANAGEMENT LLCin group TANG CAPITAL MANAGEMENT LLC1,780,975$13.4M0.52%013F-HRTimelineGroup
BAKER BROS. ADVISORS LPin group BAKER BROS. ADVISORS LP1,712,882$12.9M0.09%013F-HRTimelineGroup
Almitas Capital LLC1,530,435$11.5M2.64%013F-HR/ATimeline
VANGUARD GROUP INCin group VANGUARD GROUP INC1,443,701$10.9M<0.01%-27,87313F-HRTimelineGroup
Driehaus Capital Management LLC1,076,236$8.1M0.06%013F-HRTimeline
Kynam Capital Management, LP1,029,579$7.75M0.58%013F-HRTimeline
FMR LLCin group FMR LLC740,849$5.58M<0.01%-210,34913F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC695,613$5.24M<0.01%-98,39513F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP634,397$4.78M<0.01%-84,81513F-HRTimelineGroup
ACADIAN ASSET MANAGEMENT LLCin group ACADIAN ASSET MANAGEMENT LLC617,489$4.65M0.01%-9,85913F-HRTimelineGroup
Woodline Partners LP612,712$4.61M0.02%-164,82513F-HRTimeline
MPM BIOIMPACT LLC555,187$4.18M0.68%013F-HRTimeline
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC554,020$4.17M<0.01%-286,77313F-HRTimelineGroup
RA CAPITAL MANAGEMENT, L.P.in group RA CAPITAL MANAGEMENT, L.P.475,699$3.58M0.04%new13F-HRTimelineGroup
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.373,276$2.81M<0.01%-17,37213F-HRTimelineGroup
NORTHERN TRUST CORPin group NORTHERN TRUST CORP296,529$2.23M<0.01%-65,98913F-HRTimelineGroup
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP279,817$2.11M<0.01%-33,54613F-HRTimelineGroup
RENAISSANCE TECHNOLOGIES LLC274,300$2.07M<0.01%+6,50013F-HRTimeline
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC261,445$1.97M<0.01%+21,98613F-HRTimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co247,934$1.87M<0.01%-3,01513F-HRTimelineGroup
BRIDGEWAY CAPITAL MANAGEMENT, LLC188,200$1.42M0.03%013F-HRTimeline
MORGAN STANLEYin group MORGAN STANLEY175,991$1.33M<0.01%-37,55913F-HR/ATimelineGroup
Nuveen, LLCin group TIAA133,028$1M<0.01%013F-HRTimelineGroup
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC117,833$887K<0.01%+86,75413F-HRTimelineGroup
TWO SIGMA INVESTMENTS, LPgroup of 2 filers holding99,737$751K-98,074Timeline
BARCLAYS PLCin group BARCLAYS PLC88,176$664K<0.01%-21,36013F-HR/ATimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp87,475$659K<0.01%-7,12813F-HRTimelineGroup
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC68,823$518K<0.01%new13F-HRTimelineGroup
Lynx1 Capital Management LPin group Lynx1 Capital Management LP65,954$497K0.1%013F-HRTimelineGroup
Palumbo Wealth Management LLC52,081$392K0.13%-8,47413F-HRTimeline
AMERICAN CENTURY COMPANIES INCin group AMERICAN CENTURY COMPANIES INC50,852$383K<0.01%+4,46713F-HRTimelineGroup
DLD Asset Management, LP50,000$376K0.05%new13F-HR/ATimeline
RHUMBLINE ADVISERS46,334$349K<0.01%-1,98313F-HRTimeline
ALLIANCEBERNSTEIN L.P.46,120$347K<0.01%+1,09013F-HRTimeline
PRUDENTIAL FINANCIAL INCin group PRUDENTIAL FINANCIAL INC44,825$338K<0.01%-13,10013F-HRTimelineGroup
China Universal Asset Management Co., L…34,982$263K0.02%+23,58013F-HRTimeline
HRT FINANCIAL LP31,903$240K<0.01%new13F-HRTimeline
KENNEDY CAPITAL MANAGEMENT LLC29,411$221K<0.01%+14,40113F-HRTimeline
STATE OF WISCONSIN INVESTMENT BOARD27,062$204K<0.01%-1,60013F-HRTimeline
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/23,907$180K<0.01%-71813F-HR/ATimelineGroup
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO23,221$175K<0.01%+4,89613F-HR/ATimelineGroup
UBS Group AGin group UBS Group AG22,693$171K<0.01%-4,64913F-HRTimelineGroup
STRS OHIO22,600$170K<0.01%013F-HRTimeline
SPHERA FUNDS MANAGEMENT LTD.in group SPHERA FUNDS MANAGEMENT LTD.21,918$165K0.04%new13F-HRTimelineGroup
Velan Capital Investment Management LP20,000$151K0.14%013F-HRTimeline
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN18,317$138K<0.01%-1,96713F-HRTimelineGroup
PRICE T ROWE ASSOCIATES INC /MD/16,314$123K<0.01%013F-HRTimeline
Mariner, LLCin group Mariner, LLC16,081$121K<0.01%+34113F-HRTimelineGroup
Invesco Ltd.in group Invesco Ltd.14,589$110K<0.01%+22513F-HRTimelineGroup
INTECH INVESTMENT MANAGEMENT LLC14,155$107K<0.01%-5,51313F-HRTimeline
SUSQUEHANNA INTERNATIONAL GROUP, LLPin group SUSQUEHANNA INTERNATIONAL GRO…14,023$106K<0.01%-24,14713F-HRTimelineGroup
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC13,664$103K<0.01%-15,06213F-HRTimelineGroup
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding12,926$97.3K-7,224Timeline
XTX Topco Ltdin group XTX Topco Ltd11,868$89.4K<0.01%new13F-HRTimelineGroup
NISA INVESTMENT ADVISORS, LLC11,824$89K<0.01%013F-HRTimeline
MetLife Investment Management, LLCin group MetLife Investment Management…10,320$77.7K<0.01%new13F-HRTimelineGroup
Police & Firemen's Retirement System of…6,598$49.7K<0.01%013F-HRTimeline
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…6,377$48K<0.01%+2,61813F-HRTimelineGroup
Point72 Asia (Singapore) Pte. Ltd.5,702$42.9K0.01%new13F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS5,133$38.7K<0.01%+1,31013F-HRTimelineGroup
CAZ INVESTMENTS LPin group CAZ INVESTMENTS LP5,000$37.6K0.07%-2,50013F-HRTimelineGroup
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…2,570$19.4K<0.01%013F-HRTimelineGroup
Legal & General Group Plcin group Legal & General Group Plc2,077$15.7K<0.01%-1,00113F-HRTimelineGroup
NEW YORK STATE COMMON RETIREMENT FUND2,026$15.3K<0.01%013F-HRTimeline
CALIFORNIA STATE TEACHERS RETIREMENT SY…1,969$14.8K<0.01%new13F-HRTimeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…1,959$14.8K<0.01%-7,73913F-HRTimelineGroup
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…1,823$13.7K<0.01%+15213F-HRTimelineGroup
Sterling Capital Management LLC1,648$12.4K<0.01%+80713F-HRTimeline
CITIGROUP INCin group CITIGROUP INC1,590$12K<0.01%-12,05813F-HRTimelineGroup
Zurcher Kantonalbank (Zurich Cantonalba…1,227$9.24K<0.01%-59013F-HRTimeline
GF FUND MANAGEMENT CO. LTD.1,213$9.13K<0.01%-23613F-HRTimeline
AMALGAMATED BANK1,176$9K<0.01%013F-HRTimeline
Clearstead Advisors, LLC610$4.59K<0.01%013F-HRTimeline
Private Wealth Management Group, LLC558$4.2K<0.01%013F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA445$4K<0.01%-3,36713F-HRTimelineGroup
GAMMA Investing LLC443$3.34K<0.01%new13F-HRTimeline
Farther Finance Advisors, LLC385$2.9K<0.01%+36613F-HRTimeline
Optiver Holding B.V.in group Optiver Holding B.V.328$2.47K<0.01%new13F-HRTimelineGroup
Physician Wealth Advisors, Inc.268$2.02K<0.01%013F-HRTimeline
CWM, LLCin group CWM, LLC222$2K<0.01%-4913F-HRTimelineGroup
MassMutual Private Wealth & Trust, FSB239$1.8K<0.01%013F-HRTimeline
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…235$1.77K<0.01%013F-HRTimelineGroup
Arax Advisory Partners194$1.46K<0.01%new13F-HRTimeline
Daiwa Securities Group Inc.in group Daiwa Securities Group Inc.100$1K<0.01%-25013F-HRTimelineGroup
Rise Advisors, LLC130$979<0.01%013F-HRTimeline
Versant Capital Management, Inc71$535<0.01%new13F-HRTimeline
Larson Financial Group LLC3$23<0.01%new13F-HRTimeline
Capital Advisors, Ltd. LLC12$00%013F-HRTimelineValue filed as zero, left out of ratios.