BVF INC/IL in group BVF INC/IL More: the full row for BVF INC/IL 1,355,257 $24.6M 0.83% +1 13F-HR Timeline Group Nantahala Capital Management, LLC in group Nantahala Capital Management,… More: the full row for Nantahala Capital Management, LLC 1,235,000 $22.4M 1.34% 0 13F-HR Timeline Group ORBIMED ADVISORS LLC in group ORBIMED ADVISORS LLC More: the full row for ORBIMED ADVISORS LLC 1,187,300 $21.6M 0.44% -162,000 13F-HR Timeline Group Affinity Asset Advisors, LLC More: the full row for Affinity Asset Advisors, LLC 1,051,054 $19.1M 1.37% +44,837 13F-HR Timeline Caligan Partners LP More: the full row for Caligan Partners LP 881,533 $16M 1.47% +48,200 13F-HR Timeline VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 804,084 $14.6M <0.01% +111,447 13F-HR Timeline Group RA CAPITAL MANAGEMENT, L.P. in group RA CAPITAL MANAGEMENT, L.P. More: the full row for RA CAPITAL MANAGEMENT, L.P. 662,968 $12M 0.12% 0 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 659,979 $12M 0.01% +522,548 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 627,502 $11.4M 0.02% -426,481 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 621,350 $11.3M <0.01% +15,508 13F-HR Timeline Group ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 550,000 $9.99M 0.02% +291,231 13F-HR Timeline Group SILVERARC CAPITAL MANAGEMENT, LLC in group SILVERARC CAPITAL MANAGEMENT,… More: the full row for SILVERARC CAPITAL MANAGEMENT, LLC 524,436 $9.52M 1.38% -196,486 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 507,550 $9.22M 0.01% +451,541 13F-HR Timeline Group Commodore Capital LP in group Commodore Capital LP More: the full row for Commodore Capital LP 483,000 $8.77M 0.58% 0 13F-HR Timeline Group TCG Crossover Management, LLC More: the full row for TCG Crossover Management, LLC 483,000 $8.77M 0.29% 0 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 477,816 $8.68M <0.01% +432,608 13F-HR Timeline Group JENNISON ASSOCIATES LLC More: the full row for JENNISON ASSOCIATES LLC 475,625 $8.64M 0.01% new 13F-HR Timeline Soleus Capital Management, L.P. More: the full row for Soleus Capital Management, L.P. 441,978 $8.03M 0.34% new 13F-HR Timeline Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 439,312 $7.98M 0.01% -378,124 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 419,491 $7.62M 0.01% -62,178 13F-HR Timeline Group Patient Square Capital LP More: the full row for Patient Square Capital LP 311,966 $5.67M 1.21% +211,966 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 289,571 $5.26M <0.01% +135,320 13F-HR Timeline Group Boxer Capital Management, LLC in group Boxer Capital Management, LLC More: the full row for Boxer Capital Management, LLC 275,000 $4.99M 1.09% +150,000 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 264,907 $4.81M <0.01% +264,897 13F-HR/A Timeline Group Velan Capital Investment Management LP More: the full row for Velan Capital Investment Management LP 263,642 $4.79M 2.79% 0 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 220,300 $4M <0.01% new 13F-HR Timeline Group AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 217,974 $3.96M <0.01% +4,402 13F-HR Timeline Group Jain Global LLC More: the full row for Jain Global LLC 217,292 $3.95M 0.04% new 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 210,994 $3.83M 0.01% +163,596 13F-HR Timeline Group BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 202,127 $3.67M 0.09% -26,170 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 197,747 $3.59M <0.01% +197,742 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 197,637 $3.59M +148,395 Timeline SummitTX Capital, L.P. More: the full row for SummitTX Capital, L.P. 195,873 $3.56M 0.11% new 13F-HR Timeline NAN FUNG TRINITY (HK) LTD More: the full row for NAN FUNG TRINITY (HK) LTD 189,000 $3.43M 0.27% new 13F-HR Timeline JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 178,855 $3.25M <0.01% new 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 166,152 $3.02M <0.01% +61,963 13F-HR Timeline Group SUPERSTRING CAPITAL MANAGEMENT LP More: the full row for SUPERSTRING CAPITAL MANAGEMENT LP 153,313 $2.78M 1.49% -34,767 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 150,000 $2.72M <0.01% new 13F-HR Timeline Group PERCEPTIVE ADVISORS LLC in group PERCEPTIVE ADVISORS LLC More: the full row for PERCEPTIVE ADVISORS LLC 139,667 $2.54M 0.05% 0 13F-HR Timeline Group STEMPOINT CAPITAL LP More: the full row for STEMPOINT CAPITAL LP 135,552 $2.46M 0.42% new 13F-HR Timeline Moody Aldrich Partners LLC More: the full row for Moody Aldrich Partners LLC 133,231 $2.42M 0.45% new 13F-HR Timeline Squadron Capital Management LLC More: the full row for Squadron Capital Management LLC 130,000 $2.36M 1.05% 13F-HR Timeline GREAT POINT PARTNERS LLC More: the full row for GREAT POINT PARTNERS LLC 124,666 $2.26M 0.73% new 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 105,814 $1.92M <0.01% +96,468 13F-HR Timeline Group HighVista Strategies LLC More: the full row for HighVista Strategies LLC 95,631 $1.74M 0.45% +67,853 13F-HR Timeline Aberdeen Group plc in group Aberdeen Group plc More: the full row for Aberdeen Group plc 95,426 $1.73M <0.01% +22,626 13F-HR Timeline Group FRED ALGER MANAGEMENT, LLC in group FRED ALGER MANAGEMENT, LLC More: the full row for FRED ALGER MANAGEMENT, LLC 80,092 $1.45M 0.01% new 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 79,254 $1.44M <0.01% +33,800 13F-HR Timeline Group Sio Capital Management, LLC More: the full row for Sio Capital Management, LLC 72,173 $1.31M 0.22% 0 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 65,313 $1.19M <0.01% new 13F-HR/A Timeline Group Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 64,463 $1.17M <0.01% new 13F-HR Timeline Seven Fleet Capital Management LP More: the full row for Seven Fleet Capital Management LP 63,343 $1.15M 0.78% 13F-HR/A Timeline 683 Capital Management, LLC in group 683 Capital Management, LLC More: the full row for 683 Capital Management, LLC 56,850 $1.03M 0.09% new 13F-HR Timeline Group Quadrature Capital Ltd in group Quadrature Capital Ltd More: the full row for Quadrature Capital Ltd 53,044 $963K 0.01% -1,955 13F-HR Timeline Group Caption Management, LLC More: the full row for Caption Management, LLC 52,641 $956K 0.04% new 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 52,041 $945K <0.01% new 13F-HR Timeline Atom Investors LP More: the full row for Atom Investors LP 51,194 $930K 0.07% new 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 44,431 $807K <0.01% +42,858 13F-HR Timeline Group Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 41,693 $757K <0.01% -3,050 13F-HR Timeline Group Artia Global Partners LP More: the full row for Artia Global Partners LP 41,570 $755K 0.12% new 13F-HR Timeline Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 40,854 $742K <0.01% new 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 40,458 $735K 0.02% +26,508 13F-HR Timeline Group ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 32,267 $586K 0.01% new 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 32,204 $585K <0.01% +13,629 13F-HR Timeline Group Ikarian Capital, LLC in group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 31,106 $565K 0.07% -128,671 13F-HR Timeline Group GLENMEDE TRUST CO NA in group GLENMEDE TRUST CO NA More: the full row for GLENMEDE TRUST CO NA 20,450 $371K <0.01% 13F-HR Timeline Group OMERS ADMINISTRATION Corp More: the full row for OMERS ADMINISTRATION Corp 19,600 $356K <0.01% new 13F-HR Timeline RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 18,300 $332K <0.01% -80,400 13F-HR Timeline Hudson Bay Capital Management LP in group Hudson Bay Capital Management… More: the full row for Hudson Bay Capital Management LP 16,771 $305K <0.01% new 13F-HR Timeline Group ENVESTNET ASSET MANAGEMENT INC in group ENVESTNET ASSET MANAGEMENT INC More: the full row for ENVESTNET ASSET MANAGEMENT INC 16,039 $291K <0.01% new 13F-HR Timeline Group Persistent Asset Partners Ltd More: the full row for Persistent Asset Partners Ltd 15,087 $274K 0.13% new 13F-HR Timeline Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 13,092 $238K <0.01% new 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 8,737 $159K <0.01% +8,711 13F-HR Timeline Group Belvedere Trading LLC More: the full row for Belvedere Trading LLC 4,526 $82.2K 0.02% new 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 2,733 $49.6K <0.01% new 13F-HR Timeline Group PFS Partners, LLC More: the full row for PFS Partners, LLC 2,000 $36.3K 0.02% +1,000 13F-HR Timeline ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 1,471 $26K <0.01% new 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 1,143 $20.8K <0.01% +743 13F-HR Timeline Group GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 1 $18 <0.01% -280 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 1 $18 <0.01% -1 13F-HR Timeline Group Parallel Advisors, LLC More: the full row for Parallel Advisors, LLC 1 $18 <0.01% 0 13F-HR Timeline Key Financial Inc More: the full row for Key Financial Inc 1 $18 <0.01% 0 13F-HR Timeline Activest Wealth Management More: the full row for Activest Wealth Management 1 $18 <0.01% 0 13F-HR Timeline