FMR LLC in group FMR LLC More: the full row for FMR LLC 2,879,481 $43M <0.01% +2,659,181 13F-HR Timeline Group T. Rowe Price Investment Management, In… More: the full row for T. Rowe Price Investment Management, Inc. 2,162,684 $32.3M 0.02% new 13F-HR Timeline Caligan Partners LP More: the full row for Caligan Partners LP 1,635,023 $24.4M 1.73% +753,490 13F-HR Timeline BVF INC/IL in group BVF INC/IL More: the full row for BVF INC/IL 1,632,845 $24.4M 0.78% +277,588 13F-HR Timeline Group Avoro Capital Advisors LLC More: the full row for Avoro Capital Advisors LLC 1,410,000 $21.1M 0.21% new 13F-HR Timeline Affinity Asset Advisors, LLC More: the full row for Affinity Asset Advisors, LLC 1,340,840 $20M 1.17% +289,786 13F-HR Timeline Nantahala Capital Management, LLC in group Nantahala Capital Management,… More: the full row for Nantahala Capital Management, LLC 1,235,000 $18.4M 1.15% 0 13F-HR Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 1,141,980 $17M <0.01% +664,164 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 916,142 $13.7M 0.02% +288,640 13F-HR Timeline Group FARALLON CAPITAL MANAGEMENT, L.L.C. More: the full row for FARALLON CAPITAL MANAGEMENT, L.L.C. 916,000 $13.7M 0.08% new 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. RTW INVESTMENTS, LP More: the full row for RTW INVESTMENTS, LP 856,962 $12.8M 0.13% new 13F-HR Timeline ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 854,000 $12.8M 0.02% +304,000 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 835,484 $12.5M 0.01% +175,505 13F-HR Timeline Group VANGUARD GROUP INC group of 3 filers holding More: the full row for VANGUARD GROUP INC 811,733 $12.1M new Timeline TCG Crossover Management, LLC More: the full row for TCG Crossover Management, LLC 738,383 $11M 0.32% +255,383 13F-HR Timeline Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 731,586 $10.9M 0.02% +292,274 13F-HR Timeline Group RA CAPITAL MANAGEMENT, L.P. in group RA CAPITAL MANAGEMENT, L.P. More: the full row for RA CAPITAL MANAGEMENT, L.P. 662,968 $9.9M 0.1% 0 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 643,000 $9.6M <0.01% +21,650 13F-HR Timeline Group Commodore Capital LP in group Commodore Capital LP More: the full row for Commodore Capital LP 483,000 $7.21M 0.42% 0 13F-HR Timeline Group ORBIMED ADVISORS LLC in group ORBIMED ADVISORS LLC More: the full row for ORBIMED ADVISORS LLC 475,165 $7.09M 0.15% -712,135 13F-HR Timeline Group JENNISON ASSOCIATES LLC More: the full row for JENNISON ASSOCIATES LLC 470,775 $7.03M <0.01% -4,850 13F-HR Timeline Caption Management, LLC More: the full row for Caption Management, LLC 455,000 $6.79M 0.32% +402,359 13F-HR Timeline Soleus Capital Management, L.P. More: the full row for Soleus Capital Management, L.P. 441,978 $6.6M 0.27% 0 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 422,781 $6.31M <0.01% +225,034 13F-HR Timeline Group KENNEDY CAPITAL MANAGEMENT LLC More: the full row for KENNEDY CAPITAL MANAGEMENT LLC 387,982 $5.79M 0.12% new 13F-HR Timeline DV Trading LLC More: the full row for DV Trading LLC 360,064 $5.38M 0.49% new 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 327,082 $4.88M <0.01% +37,511 13F-HR Timeline Group BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 324,258 $4.84M 0.11% +122,131 13F-HR Timeline Logos Global Management LP More: the full row for Logos Global Management LP 300,000 $4.48M 0.23% new 13F-HR Timeline Boxer Capital Management, LLC in group Boxer Capital Management, LLC More: the full row for Boxer Capital Management, LLC 300,000 $4.48M 0.59% +25,000 13F-HR Timeline Group Pivotal bioVenture Partners Investment … in group Pivotal bioVenture Partners I… More: the full row for Pivotal bioVenture Partners Investment Advisor LLC 295,933 $4.42M 1.58% new 13F-HR Timeline Group Seven Fleet Capital Management LP More: the full row for Seven Fleet Capital Management LP 213,819 $3.19M 1% +150,476 13F-HR/A Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 193,735 $2.89M <0.01% -225,756 13F-HR Timeline Group NAN FUNG TRINITY (HK) LTD More: the full row for NAN FUNG TRINITY (HK) LTD 189,000 $2.82M 0.31% 0 13F-HR Timeline Velan Capital Investment Management LP More: the full row for Velan Capital Investment Management LP 185,122 $2.76M 1.73% -78,520 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 194,391 $2.71M <0.01% +149,960 13F-HR/A Timeline Group Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 174,506 $2.61M <0.01% +110,043 13F-HR Timeline JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 173,320 $2.59M <0.01% -5,535 13F-HR Timeline Group AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 172,149 $2.57M <0.01% -45,825 13F-HR/A Timeline Group Aberdeen Group plc in group Aberdeen Group plc More: the full row for Aberdeen Group plc 171,679 $2.56M <0.01% +76,253 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 169,889 $2.54M <0.01% +3,737 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 161,392 $2.41M <0.01% -103,515 13F-HR Timeline Group Hudson Bay Capital Management LP in group Hudson Bay Capital Management… More: the full row for Hudson Bay Capital Management LP 161,087 $2.41M 0.01% +144,316 13F-HR Timeline Group Exome Asset Management LLC More: the full row for Exome Asset Management LLC 159,341 $2.38M 1.4% new 13F-HR Timeline Moody Aldrich Partners LLC More: the full row for Moody Aldrich Partners LLC 159,324 $2.38M 0.43% +26,093 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 150,000 $2.24M <0.01% 0 13F-HR Timeline Group PERCEPTIVE ADVISORS LLC in group PERCEPTIVE ADVISORS LLC More: the full row for PERCEPTIVE ADVISORS LLC 139,667 $2.09M 0.04% 0 13F-HR/A Timeline Group STEMPOINT CAPITAL LP More: the full row for STEMPOINT CAPITAL LP 134,742 $2.01M 0.39% -810 13F-HR/A Timeline MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 129,136 $1.93M <0.01% -378,414 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 126,732 $1.89M 0.03% +86,274 13F-HR Timeline Group Quadrature Capital Ltd in group Quadrature Capital Ltd More: the full row for Quadrature Capital Ltd 125,195 $1.87M 0.02% +72,151 13F-HR Timeline Group GREAT POINT PARTNERS LLC More: the full row for GREAT POINT PARTNERS LLC 124,666 $1.86M 0.46% 0 13F-HR Timeline RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 120,114 $1.79M <0.01% +101,814 13F-HR Timeline Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 81,285 $1.21M <0.01% +40,431 13F-HR Timeline Group Rosalind Advisors, Inc. More: the full row for Rosalind Advisors, Inc. 75,000 $1.12M 0.46% new 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 71,654 $1.07M <0.01% -7,600 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 64,425 $962K <0.01% -83,812 13F-HR Timeline Group ACUTA CAPITAL PARTNERS, LLC More: the full row for ACUTA CAPITAL PARTNERS, LLC 60,808 $908K 0.65% new 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 60,106 $897K <0.01% -5,207 13F-HR Timeline Group HighVista Strategies LLC More: the full row for HighVista Strategies LLC 58,622 $875K 0.24% -37,009 13F-HR Timeline SEI INVESTMENTS CO in group SEI INVESTMENTS CO More: the full row for SEI INVESTMENTS CO 56,854 $849K <0.01% new 13F-HR Timeline Group 683 Capital Management, LLC in group 683 Capital Management, LLC More: the full row for 683 Capital Management, LLC 56,850 $849K 0.08% 0 13F-HR Timeline Group TD Asset Management Inc More: the full row for TD Asset Management Inc 51,408 $768K <0.01% new 13F-HR Timeline HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 48,105 $718K <0.01% new 13F-HR Timeline Man Group plc in group Man Group plc More: the full row for Man Group plc 46,553 $695K <0.01% new 13F-HR Timeline Group DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 40,821 $607K <0.01% new 13F-HR Timeline Group PRELUDE CAPITAL MANAGEMENT, LLC More: the full row for PRELUDE CAPITAL MANAGEMENT, LLC 35,096 $524K 0.04% new 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 30,556 $456K <0.01% -1,648 13F-HR Timeline Group EntryPoint Capital, LLC More: the full row for EntryPoint Capital, LLC 30,041 $449K 0.13% new 13F-HR Timeline Aquatic Capital Management LLC More: the full row for Aquatic Capital Management LLC 29,712 $444K 0.01% new 13F-HR Timeline Artia Global Partners LP More: the full row for Artia Global Partners LP 28,970 $433K 0.1% -12,600 13F-HR Timeline GLENMEDE TRUST CO NA in group GLENMEDE TRUST CO NA More: the full row for GLENMEDE TRUST CO NA 25,730 $384K <0.01% +5,280 13F-HR Timeline Group ENVESTNET ASSET MANAGEMENT INC in group ENVESTNET ASSET MANAGEMENT INC More: the full row for ENVESTNET ASSET MANAGEMENT INC 19,996 $299K <0.01% +3,957 13F-HR Timeline Group Brevan Howard Capital Management LP in group Brevan Howard Capital Managem… More: the full row for Brevan Howard Capital Management LP 19,321 $288K <0.01% new 13F-HR Timeline Group ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 17,751 $265K <0.01% -14,516 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 2 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 17,227 $257K -193,767 Timeline WESTFIELD CAPITAL MANAGEMENT CO LP More: the full row for WESTFIELD CAPITAL MANAGEMENT CO LP 15,639 $233K <0.01% new 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 14,642 $219K <0.01% -91,172 13F-HR Timeline Group Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 12,810 $191K <0.01% -282 13F-HR Timeline Group OMERS ADMINISTRATION Corp More: the full row for OMERS ADMINISTRATION Corp 11,800 $176K <0.01% -7,800 13F-HR Timeline AlphaCentric Advisors LLC More: the full row for AlphaCentric Advisors LLC 11,668 $174K 0.17% new 13F-HR Timeline Shay Capital LLC More: the full row for Shay Capital LLC 10,166 $152K 0.02% new 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 10,000 $149K <0.01% new 13F-HR Timeline Group Persistent Asset Partners Ltd More: the full row for Persistent Asset Partners Ltd 7,918 $118K 0.05% -7,169 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 3,387 $50.6K <0.01% +654 13F-HR Timeline Group PFS Partners, LLC More: the full row for PFS Partners, LLC 2,000 $29.9K 0.01% 0 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 216 $2K <0.01% new 13F-HR Timeline Group Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 75 $1.25K <0.01% new 13F-HR Timeline Fortitude Family Office, LLC More: the full row for Fortitude Family Office, LLC 63 $941 <0.01% new 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 35 $523 <0.01% new 13F-HR/A Timeline Group Parallel Advisors, LLC More: the full row for Parallel Advisors, LLC 1 $15 <0.01% 0 13F-HR/A Timeline Key Financial Inc More: the full row for Key Financial Inc 1 $15 <0.01% 0 13F-HR Timeline Activest Wealth Management More: the full row for Activest Wealth Management 1 $15 <0.01% 0 13F-HR Timeline Silver Grove Financial Group, Inc. More: the full row for Silver Grove Financial Group, Inc. 1 $15 <0.01% new 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 1 $14 <0.01% 0 13F-HR Timeline Group