AyurMaya Capital Management Company, LP More: the full row for AyurMaya Capital Management Company, LP 15,139,706 $148M 100% 0 13F-HR Timeline Foresite Capital Management VI LLC group of 2 filers holding More: the full row for Foresite Capital Management VI LLC 10,027,018 $97.9M 0 Timeline SAMSARA BIOCAPITAL, LLC More: the full row for SAMSARA BIOCAPITAL, LLC 5,756,984 $56.2M 5.8% +955,614 13F-HR Timeline venBio Partners LLC More: the full row for venBio Partners LLC 4,619,803 $45.1M 20.85% 0 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 4,566,502 $44.6M <0.01% +373,425 13F-HR Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 4,103,290 $40M <0.01% +73,675 13F-HR Timeline Group Cormorant Asset Management, LP More: the full row for Cormorant Asset Management, LP 3,635,596 $35.5M 2.01% +1,488,200 13F-HR Timeline Saturn V Capital Management LP More: the full row for Saturn V Capital Management LP 3,135,953 $30.6M 5.62% new 13F-HR Timeline Nextech Invest Ltd. More: the full row for Nextech Invest Ltd. 2,915,998 $28.5M 2.75% 0 13F-HR Timeline Octagon Capital Advisors LP More: the full row for Octagon Capital Advisors LP 2,530,700 $24.7M 3.09% new 13F-HR Timeline MPM BIOIMPACT LLC More: the full row for MPM BIOIMPACT LLC 2,401,992 $23.4M 2.68% new 13F-HR Timeline SR One Capital Management, LP More: the full row for SR One Capital Management, LP 1,959,896 $19.1M 2.71% 0 13F-HR Timeline BAKER BROS. ADVISORS LP in group BAKER BROS. ADVISORS LP More: the full row for BAKER BROS. ADVISORS LP 1,562,500 $15.2M 0.09% 0 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 1,487,626 $14.5M <0.01% +94,340 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 1,259,446 $12.3M <0.01% +157,560 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 1,151,118 $11.2M 0.01% +834,089 13F-HR Timeline Group ORBIMED ADVISORS LLC in group ORBIMED ADVISORS LLC More: the full row for ORBIMED ADVISORS LLC 1,102,730 $10.8M 0.22% -823,693 13F-HR Timeline Group Trium Capital LLP More: the full row for Trium Capital LLP 893,107 $8.72M 6.77% -2,229,004 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. Yu Fan More: the full row for Yu Fan 789,618 $7.71M 8.35% 0 13F-HR Timeline Omega Fund Management, LLC More: the full row for Omega Fund Management, LLC 653,223 $6.38M 2.23% 0 13F-HR Timeline Opaleye Management Inc. More: the full row for Opaleye Management Inc. 535,000 $5.22M 0.69% -130,000 13F-HR/A Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 506,529 $4.94M <0.01% +174,123 13F-HR/A Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 504,075 $4.92M <0.01% +13,073 13F-HR Timeline Group Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 500,000 $4.88M 0.15% new 13F-HR Timeline Group TOWERVIEW LLC More: the full row for TOWERVIEW LLC 495,000 $4.83M 3.51% 0 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 427,072 $4.17M <0.01% +9,992 13F-HR/A Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 421,819 $4.12M <0.01% +292,250 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 418,248 $4.08M <0.01% -20,724 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 2 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 380,912 $3.72M -140,490 Timeline MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 372,901 $3.64M <0.01% new 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 356,337 $3.48M <0.01% +87,670 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 336,293 $3.28M +216,735 Timeline Exome Asset Management LLC More: the full row for Exome Asset Management LLC 292,250 $2.85M 1.41% -520 13F-HR Timeline D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 231,747 $2.26M <0.01% new 13F-HR Timeline Group STIFEL FINANCIAL CORP in group STIFEL FINANCIAL CORP More: the full row for STIFEL FINANCIAL CORP 209,729 $2.05M <0.01% 0 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 173,833 $1.7M <0.01% +146,724 13F-HR Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 169,506 $1.65M <0.01% +68,771 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 169,093 $1.65M <0.01% +3,590 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 160,138 $1.56M <0.01% +23,426 13F-HR Timeline Group Mariner, LLC in group Mariner, LLC More: the full row for Mariner, LLC 145,045 $1.42M <0.01% +60,172 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 138,341 $1.35M <0.01% -125,576 13F-HR Timeline Group AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 137,792 $1.34M <0.01% -3,125 13F-HR Timeline Group Quantinno Capital Management LP More: the full row for Quantinno Capital Management LP 135,446 $1.32M <0.01% +47,838 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 129,448 $1.26M <0.01% +40,182 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 122,210 $1.19M <0.01% +38,842 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 119,311 $1.16M <0.01% -219,940 13F-HR Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 113,997 $1.11M <0.01% -648,678 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 108,200 $1.06M <0.01% -43,368 13F-HR Timeline PRELUDE CAPITAL MANAGEMENT, LLC More: the full row for PRELUDE CAPITAL MANAGEMENT, LLC 87,832 $857K 0.06% 0 13F-HR Timeline Verition Fund Management LLC More: the full row for Verition Fund Management LLC 80,062 $781K <0.01% new 13F-HR Timeline LOS ANGELES CAPITAL MANAGEMENT LLC More: the full row for LOS ANGELES CAPITAL MANAGEMENT LLC 163,084 $760K <0.01% +40,383 13F-HR Timeline ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 76,594 $748K <0.01% -4,306 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 69,236 $676K <0.01% -4,793 13F-HR Timeline BRIDGEWAY CAPITAL MANAGEMENT, LLC More: the full row for BRIDGEWAY CAPITAL MANAGEMENT, LLC 56,728 $554K 0.01% -17,000 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 50,422 $493K <0.01% +22,148 13F-HR Timeline Virtu Financial LLC in group Virtu Financial LLC More: the full row for Virtu Financial LLC 50,283 $491K 0.02% new 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 46,884 $458K <0.01% +35,114 13F-HR Timeline Group PSP Research LLC More: the full row for PSP Research LLC 43,769 $427K 0.37% 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 41,112 $401K <0.01% +16,376 13F-HR Timeline Group LMR Partners LLP in group LMR Partners LLP More: the full row for LMR Partners LLP 40,000 $390K <0.01% -218,442 13F-HR Timeline Group Creative Planning in group Creative Planning More: the full row for Creative Planning 38,110 $372K <0.01% new 13F-HR Timeline Group FOX RUN MANAGEMENT, L.L.C. More: the full row for FOX RUN MANAGEMENT, L.L.C. 37,707 $368K 0.06% new 13F-HR Timeline Brevan Howard Capital Management LP in group Brevan Howard Capital Managem… More: the full row for Brevan Howard Capital Management LP 34,917 $341K 0.01% new 13F-HR Timeline Group MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 32,479 $317K <0.01% -110 13F-HR Timeline Group Grange Capital, LLC More: the full row for Grange Capital, LLC 32,000 $312K 0.3% new 13F-HR Timeline Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 30,964 $302K +1,248 Timeline GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 30,913 $302K 0.03% new 13F-HR Timeline INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 29,303 $286K <0.01% +5,757 13F-HR Timeline Kera Capital Partners, Inc. More: the full row for Kera Capital Partners, Inc. 11,003 $270K 0.03% +26 13F-HR Timeline Inscription Capital, LLC More: the full row for Inscription Capital, LLC 26,667 $260K 0.03% +6,233 13F-HR Timeline Dynamic Technology Lab Private Ltd More: the full row for Dynamic Technology Lab Private Ltd 26,567 $259K 0.06% new 13F-HR Timeline AXQ CAPITAL, LP More: the full row for AXQ CAPITAL, LP 26,417 $258K 0.06% +6,965 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 24,955 $244K 0.01% +343 13F-HR Timeline Group Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 24,769 $242K <0.01% new 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 23,987 $234K <0.01% +17,056 13F-HR Timeline Group Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 23,153 $226K 0.06% new 13F-HR Timeline Group Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 23,028 $225K <0.01% new 13F-HR Timeline BANK OF NOVA SCOTIA in group BANK OF NOVA SCOTIA More: the full row for BANK OF NOVA SCOTIA 20,900 $204K <0.01% new 13F-HR Timeline Group DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 20,516 $200K <0.01% 0 13F-HR Timeline Group MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 17,661 $172K <0.01% +318 13F-HR Timeline Group IEQ CAPITAL, LLC More: the full row for IEQ CAPITAL, LLC 17,421 $170K <0.01% +690 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 15,840 $155K 0.01% -1,142 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 15,340 $150K <0.01% 0 13F-HR Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 15,029 $147K <0.01% +8,610 13F-HR Timeline Group MERCER GLOBAL ADVISORS INC /ADV More: the full row for MERCER GLOBAL ADVISORS INC /ADV 14,908 $146K <0.01% new 13F-HR Timeline ProShare Advisors LLC More: the full row for ProShare Advisors LLC 14,627 $143K <0.01% +1,618 13F-HR Timeline PDT Partners, LLC More: the full row for PDT Partners, LLC 14,562 $142K 0.01% new 13F-HR Timeline Banco BTG Pactual S.A. More: the full row for Banco BTG Pactual S.A. 14,302 $140K 0.02% new 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 14,070 $137K <0.01% +10,405 13F-HR Timeline Group NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 11,767 $115K <0.01% 0 13F-HR Timeline ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 11,197 $109K <0.01% -155,574 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 10,431 $102K <0.01% +47 13F-HR Timeline Group AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 10,322 $101K <0.01% -992 13F-HR Timeline Group Birchview Capital, LP More: the full row for Birchview Capital, LP 10,000 $97.6K 0.06% 0 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 4,954 $48.4K <0.01% -362 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 4,827 $47.1K <0.01% 0 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 3,481 $34K <0.01% +39 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 3,253 $31.7K <0.01% -604 13F-HR Timeline Essential Partners LLC More: the full row for Essential Partners LLC 2,892 $28.2K 0.01% 0 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 2,202 $21K <0.01% -30,546 13F-HR Timeline Group Parallel Advisors, LLC More: the full row for Parallel Advisors, LLC 2,059 $20.1K <0.01% +36 13F-HR Timeline GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 1,910 $18.6K <0.01% -174 13F-HR Timeline AMALGAMATED BANK More: the full row for AMALGAMATED BANK 1,776 $17K <0.01% +143 13F-HR Timeline GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 1,405 $13.7K <0.01% -21,178 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 1,298 $12.7K <0.01% -2,306 13F-HR Timeline Group SIGNATUREFD, LLC More: the full row for SIGNATUREFD, LLC 1,266 $12.4K <0.01% new 13F-HR Timeline Arax Advisory Partners More: the full row for Arax Advisory Partners 1,036 $10.1K <0.01% -12,624 13F-HR Timeline COMERICA BANK More: the full row for COMERICA BANK 932 $9.1K <0.01% 0 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 792 $7.73K <0.01% new 13F-HR Timeline NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 755 $7.37K <0.01% +502 13F-HR Timeline Aster Capital Management (DIFC) Ltd More: the full row for Aster Capital Management (DIFC) Ltd 728 $7.11K <0.01% new 13F-HR Timeline Versant Capital Management, Inc More: the full row for Versant Capital Management, Inc 650 $6.34K <0.01% +508 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 581 $5.67K <0.01% +328 13F-HR Timeline Group STRS OHIO More: the full row for STRS OHIO 500 $4.88K <0.01% -23,326 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 450 $4.39K <0.01% -102 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 447 $4.36K <0.01% -657 13F-HR Timeline Group ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 415 $4.05K <0.01% -30 13F-HR Timeline PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 388 $3.79K <0.01% -262 13F-HR Timeline Group Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 347 $3K <0.01% 0 13F-HR Timeline Group Optiver Holding B.V. in group Optiver Holding B.V. More: the full row for Optiver Holding B.V. 306 $2.99K <0.01% new 13F-HR Timeline Group True Wealth Design, LLC More: the full row for True Wealth Design, LLC 244 $2.38K <0.01% +2 13F-HR Timeline BFSG, LLC More: the full row for BFSG, LLC 192 $1.87K <0.01% 0 13F-HR Timeline Transamerica Financial Advisors, LLC in group Transamerica Financial Adviso… More: the full row for Transamerica Financial Advisors, LLC 97 $947 <0.01% -31 13F-HR Timeline Group Global Retirement Partners, LLC More: the full row for Global Retirement Partners, LLC 65 $634 <0.01% new 13F-HR Timeline IFP Advisors, Inc More: the full row for IFP Advisors, Inc 55 $537 <0.01% 0 13F-HR Timeline CoreCap Advisors, LLC More: the full row for CoreCap Advisors, LLC 26 $254 <0.01% 0 13F-HR Timeline Torren Management, LLC More: the full row for Torren Management, LLC 14 $137 <0.01% 13F-HR Timeline Larson Financial Group LLC More: the full row for Larson Financial Group LLC 10 $98 <0.01% new 13F-HR Timeline Sunbelt Securities, Inc. More: the full row for Sunbelt Securities, Inc. 7 $68 <0.01% new 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 3 $29 <0.01% -420 13F-HR Timeline