AyurMaya Capital Management Company, LP More: the full row for AyurMaya Capital Management Company, LP 15,139,707 $45.4M 100% +4,493,741 13F-HR Timeline Foresite Capital Management VI LLC group of 2 filers holding More: the full row for Foresite Capital Management VI LLC 10,027,018 $30.1M +45,000 Timeline SAMSARA BIOCAPITAL, LLC More: the full row for SAMSARA BIOCAPITAL, LLC 4,801,370 $14.4M 2.95% +1,534,872 13F-HR Timeline venBio Partners LLC More: the full row for venBio Partners LLC 4,619,803 $13.9M 12.08% +1,832,405 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 4,175,713 $12.5M <0.01% +2,717,986 13F-HR Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 3,404,211 $10.2M <0.01% +2,467,015 13F-HR Timeline Group Nextech Invest Ltd. More: the full row for Nextech Invest Ltd. 2,915,998 $8.75M 1.66% +1,439,000 13F-HR Timeline Trium Capital LLP More: the full row for Trium Capital LLP 2,648,039 $7.94M 1.98% new 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. Cormorant Asset Management, LP More: the full row for Cormorant Asset Management, LP 2,147,396 $6.44M 0.48% 0 13F-HR Timeline TANG CAPITAL MANAGEMENT LLC in group TANG CAPITAL MANAGEMENT LLC More: the full row for TANG CAPITAL MANAGEMENT LLC 1,996,797 $5.99M 0.3% new 13F-HR Timeline Group SR One Capital Management, LP More: the full row for SR One Capital Management, LP 1,959,896 $5.88M 1.27% 0 13F-HR Timeline ORBIMED ADVISORS LLC in group ORBIMED ADVISORS LLC More: the full row for ORBIMED ADVISORS LLC 1,926,423 $5.78M 0.15% new 13F-HR Timeline Group Madison Avenue Partners, LP More: the full row for Madison Avenue Partners, LP 1,842,269 $5.53M 0.37% new 13F-HR Timeline Velan Capital Investment Management LP More: the full row for Velan Capital Investment Management LP 1,620,846 $4.86M 4.87% new 13F-HR Timeline BAKER BROS. ADVISORS LP in group BAKER BROS. ADVISORS LP More: the full row for BAKER BROS. ADVISORS LP 1,562,500 $4.69M 0.05% 0 13F-HR Timeline Group TYBOURNE CAPITAL MANAGEMENT (HK) LTD More: the full row for TYBOURNE CAPITAL MANAGEMENT (HK) LTD 1,399,250 $4.2M 12.15% new 13F-HR Timeline GENERAL ATLANTIC, L.P. More: the full row for GENERAL ATLANTIC, L.P. 1,297,530 $3.89M 0.11% new 13F-HR Timeline BML Capital Management, LLC More: the full row for BML Capital Management, LLC 1,210,415 $3.63M 2.78% +1,160,788 13F-HR Timeline UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 1,207,555 $3.62M +1,107,927 Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 1,167,832 $3.5M <0.01% +724,133 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 1,109,091 $3.33M <0.01% +893,556 13F-HR Timeline Group Yu Fan More: the full row for Yu Fan 789,618 $2.37M 3.24% 0 13F-HR Timeline Opaleye Management Inc. More: the full row for Opaleye Management Inc. 775,000 $2.33M 0.47% new 13F-HR/A Timeline Omega Fund Management, LLC More: the full row for Omega Fund Management, LLC 653,223 $1.96M 1.27% 0 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 609,065 $1.83M <0.01% +582,868 13F-HR Timeline Group CANTOR FITZGERALD, L. P. in group CANTOR FITZGERALD, L. P. More: the full row for CANTOR FITZGERALD, L. P. 559,201 $1.68M 0.04% new 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 501,085 $1.5M <0.01% new 13F-HR Timeline Group TOWERVIEW LLC More: the full row for TOWERVIEW LLC 495,000 $1.49M 1.06% +65,000 13F-HR Timeline CREDIT INDUSTRIEL ET COMMERCIAL More: the full row for CREDIT INDUSTRIEL ET COMMERCIAL 387,002 $1.16M 0.18% +248,202 13F-HR/A Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 378,850 $1.14M <0.01% +250,996 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 378,306 $1.13M <0.01% +223,233 13F-HR Timeline Group Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 351,138 $1.05M <0.01% new 13F-HR Timeline Group Stonepine Capital Management, LLC More: the full row for Stonepine Capital Management, LLC 349,615 $1.05M 1.03% new 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 339,099 $1.02M <0.01% +110,101 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 292,181 $877K <0.01% +275,383 13F-HR Timeline Group LMR Partners LLP in group LMR Partners LLP More: the full row for LMR Partners LLP 232,942 $699K 0.01% new 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 226,815 $680K <0.01% new 13F-HR Timeline STIFEL FINANCIAL CORP in group STIFEL FINANCIAL CORP More: the full row for STIFEL FINANCIAL CORP 209,669 $629K <0.01% +100,000 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 192,490 $577K <0.01% new 13F-HR Timeline Palo Alto Investors LP More: the full row for Palo Alto Investors LP 143,437 $430K 0.09% new 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 132,110 $396K <0.01% +70,465 13F-HR Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 123,781 $371K <0.01% +106,684 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 122,777 $368K <0.01% +80,374 13F-HR Timeline Group LOS ANGELES CAPITAL MANAGEMENT LLC More: the full row for LOS ANGELES CAPITAL MANAGEMENT LLC 122,701 $368K <0.01% new 13F-HR Timeline JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 111,044 $333K <0.01% +92,953 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 107,075 $321K <0.01% new 13F-HR Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 102,858 $309K <0.01% +76,178 13F-HR Timeline Group SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 91,698 $275K 0.01% new 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 90,060 $270K <0.01% +63,616 13F-HR/A Timeline Group ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 88,300 $265K <0.01% new 13F-HR Timeline BRIDGEWAY CAPITAL MANAGEMENT, LLC More: the full row for BRIDGEWAY CAPITAL MANAGEMENT, LLC 73,728 $221K 0.01% new 13F-HR Timeline GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 69,815 $209K 0.01% new 13F-HR Timeline FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 69,766 $209K <0.01% new 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 69,599 $209K <0.01% +53,056 13F-HR Timeline BLAIR WILLIAM & CO/IL More: the full row for BLAIR WILLIAM & CO/IL 66,719 $200K <0.01% new 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 58,391 $175K <0.01% +40,336 13F-HR Timeline Group Engineers Gate Manager LP More: the full row for Engineers Gate Manager LP 45,700 $137K <0.01% new 13F-HR Timeline ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 44,222 $133K <0.01% new 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 41,693 $125K <0.01% +18,055 13F-HR Timeline Group ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 37,788 $113K 0.02% new 13F-HR Timeline Group AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 35,247 $106K <0.01% new 13F-HR Timeline Group INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 31,335 $94K <0.01% new 13F-HR Timeline SEI INVESTMENTS CO in group SEI INVESTMENTS CO More: the full row for SEI INVESTMENTS CO 31,316 $93.9K <0.01% new 13F-HR Timeline Group Mariner, LLC in group Mariner, LLC More: the full row for Mariner, LLC 30,604 $91.8K <0.01% new 13F-HR Timeline Group Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 30,073 $90.2K +15,958 Timeline Carlson Capital, L.P. More: the full row for Carlson Capital, L.P. 30,000 $90K 0.05% new 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 28,274 $85K <0.01% new 13F-HR Timeline STONERIDGE INVESTMENT PARTNERS LLC More: the full row for STONERIDGE INVESTMENT PARTNERS LLC 27,325 $82K 0.06% new 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 27,069 $81.2K <0.01% +26,268 13F-HR Timeline Group AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 26,114 $78.3K <0.01% new 13F-HR Timeline Group HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 25,089 $75K <0.01% new 13F-HR Timeline STRS OHIO More: the full row for STRS OHIO 23,826 $71.5K <0.01% +21,326 13F-HR Timeline Yakira Capital Management, Inc. More: the full row for Yakira Capital Management, Inc. 23,374 $70.1K 0.03% new 13F-HR Timeline DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 21,540 $64.6K <0.01% new 13F-HR Timeline Group SIG BROKERAGE, LP More: the full row for SIG BROKERAGE, LP 19,808 $59.4K 0.02% new 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 19,197 $57.6K 0.01% +9,725 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 18,808 $56.4K <0.01% new 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 18,452 $55.4K <0.01% +2,334 13F-HR Timeline Group VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 14,356 $43.1K <0.01% new 13F-HR Timeline Group ProShare Advisors LLC More: the full row for ProShare Advisors LLC 13,461 $40.4K <0.01% new 13F-HR Timeline Western Wealth Management, LLC More: the full row for Western Wealth Management, LLC 12,035 $36.1K <0.01% new 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 11,767 $35.3K <0.01% +7,467 13F-HR/A Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 11,453 $34.4K <0.01% +8,160 13F-HR Timeline Group PRELUDE CAPITAL MANAGEMENT, LLC More: the full row for PRELUDE CAPITAL MANAGEMENT, LLC 11,007 $33K <0.01% +587 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 10,753 $32.3K <0.01% +7,165 13F-HR Timeline Kera Capital Partners, Inc. More: the full row for Kera Capital Partners, Inc. 10,526 $31.6K 0.01% new 13F-HR Timeline Birchview Capital, LP More: the full row for Birchview Capital, LP 10,000 $30K 0.03% 0 13F-HR Timeline CSS LLC/IL More: the full row for CSS LLC/IL 8,028 $24.1K <0.01% new 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 5,743 $17.2K <0.01% -45,770 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 4,840 $14.5K <0.01% +3,186 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 4,827 $14.5K <0.01% +3,485 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 4,746 $14K <0.01% +3,991 13F-HR/A Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 4,347 $13K <0.01% +2,317 13F-HR Timeline Group GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 2,408 $7.22K <0.01% +1,236 13F-HR Timeline AMALGAMATED BANK More: the full row for AMALGAMATED BANK 1,633 $5K <0.01% +1,180 13F-HR Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 1,525 $4.58K <0.01% new 13F-HR Timeline Group Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 1,260 $3.78K <0.01% +1,088 13F-HR/A Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 920 $3K <0.01% +341 13F-HR Timeline Group Allworth Financial LP More: the full row for Allworth Financial LP 432 $1.3K <0.01% -21 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 388 $1.16K <0.01% new 13F-HR Timeline Group PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 372 $1.12K <0.01% +270 13F-HR Timeline Group Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 347 $1K <0.01% +191 13F-HR Timeline Group RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 215 $645 <0.01% new 13F-HR Timeline Group BFSG, LLC More: the full row for BFSG, LLC 192 $576 <0.01% new 13F-HR Timeline Fortitude Family Office, LLC More: the full row for Fortitude Family Office, LLC 104 $312 <0.01% new 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 90 $270 <0.01% +89 13F-HR Timeline Glenmede Investment Management, LP More: the full row for Glenmede Investment Management, LP 78 $234 <0.01% 13F-HR Timeline SALEM INVESTMENT COUNSELORS INC More: the full row for SALEM INVESTMENT COUNSELORS INC 20 $60 <0.01% 0 13F-HR/A Timeline IFP Advisors, Inc More: the full row for IFP Advisors, Inc 1 $3 <0.01% new 13F-HR Timeline Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 1 $3 <0.01% new 13F-HR Timeline CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.