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RTW INVESTMENTS, LP

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13F filer, CIK 1493215, NEW YORK, NY

RTW INVESTMENTS, LP reported $9,983,316,876 across 91 holdings for the quarter ended 2025-12-31, in a 13F-HR filed 2026-02-17. Its ten largest share positions make up 50.46% of the portfolio.

Filed (acceptance time not in the bulk data set), ingested 13F-HR 0001493215-26-000060

Period
2025-12-31
Reported value
$9.98B
Holdings
91
Top 10 weight
50.46%
New
29
Sold out
12

Largest buys vs the previous quarter

SecurityShares changeApprox. value
INSMadded+1,758,321$306M
IRTCnew+1,181,990$210M
APLSnew+7,666,764$193M
RGENnew+1,064,000$174M
COGTadded+4,124,755$147M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

SecurityShares changeApprox. value
RNAMexited-11,372,829-$496M
AKROexited-5,477,561-$260M
MERUS N Vexited-2,025,277-$191M
NTRAreduced-500,000-$115M
SYKreduced-245,000-$86.1M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q4 2025

Share positions as resolved from 13F-HR 0001493215-26-000060, largest first. % of portfolio is the value over $9,983,316,876, the sum of the share positions whose value is usable for ratios (method).

SecurityHistorySharesValue% of portfolioChangeLatest eventTimeline
MDGLMADRIGAL PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,993,687 shares; 2024Q4: 1,993,687 shares; 2025Q1: 1,993,687 shares; 2025Q2: 1,993,687 shares; 2025Q3: 1,993,687 shares; 2025Q4: 1,993,687 shares 1,993,687$1.16B11.63%0Timeline
INSMINSMED INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 3,272,008 shares; 2024Q4: 3,014,558 shares; 2025Q1: 3,014,558 shares; 2025Q2: 3,084,558 shares; 2025Q3: 3,084,558 shares; 2025Q4: 4,842,879 shares 4,842,879$843M8.44%+1,758,321Timeline
PTCTPTC THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 7,393,127 shares; 2024Q4: 7,393,127 shares; 2025Q1: 7,483,127 shares; 2025Q2: 7,746,415 shares; 2025Q3: 7,746,415 shares; 2025Q4: 7,746,415 shares 7,746,415$588M5.89%0Timeline
ARGXARGENX SEQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 654,430 shares; 2024Q4: 673,497 shares; 2025Q1: 673,497 shares; 2025Q2: 673,497 shares; 2025Q3: 673,497 shares; 2025Q4: 673,497 shares 673,497$566M5.67%0Timeline
PTGXPROTAGONIST THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 5,426,112 shares; 2024Q4: 5,498,545 shares; 2025Q1: 5,719,415 shares; 2025Q2: 5,756,277 shares; 2025Q3: 5,756,277 shares; 2025Q4: 5,059,053 shares 5,059,053$442M4.43%-697,224Timeline
NTRANATERA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,593,323 shares; 2024Q4: 2,593,323 shares; 2025Q1: 2,593,546 shares; 2025Q2: 2,593,645 shares; 2025Q3: 2,000,000 shares; 2025Q4: 1,500,000 shares 1,500,000$344M3.44%-500,000Timeline
RDNTRADNET INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,808,604 shares; 2024Q4: 1,978,582 shares; 2025Q1: 2,317,582 shares; 2025Q2: 2,690,344 shares; 2025Q3: 2,815,544 shares; 2025Q4: 3,938,500 shares 3,938,500$281M2.81%+1,122,956Timeline
TARSTARSUS PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 3,412,486 shares; 2024Q4: 3,236,549 shares; 2025Q1: 3,316,032 shares; 2025Q2: 3,111,680 shares; 2025Q3: 3,177,436 shares; 2025Q4: 3,335,320 shares 3,335,320$273M2.74%+157,884Timeline
COGTCOGENT BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 3,467,486 shares; 2025Q4: 7,592,241 shares 7,592,241$270M2.7%+4,124,755Timeline
PENPENUMBRA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 795,750 shares; 2024Q4: 862,450 shares; 2025Q1: 862,770 shares; 2025Q2: 863,553 shares; 2025Q3: 866,499 shares; 2025Q4: 866,499 shares 866,499$269M2.7%0Timeline
IRTCIRHYTHM HOLDINGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 1,181,990 shares 1,181,990$210M2.1%newTimeline
APGEAPOGEE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,712,096 shares; 2024Q4: 2,712,097 shares; 2025Q1: 2,712,097 shares; 2025Q2: 2,712,097 shares; 2025Q3: 2,712,097 shares; 2025Q4: 2,712,097 shares 2,712,097$205M2.05%0Timeline
APLSAPELLIS PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 7,666,764 shares 7,666,764$193M1.93%newTimeline
ACADACADIA PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 13,707,506 shares; 2024Q4: 8,705,501 shares; 2025Q1: 8,540,117 shares; 2025Q2: 8,995,547 shares; 2025Q3: 7,144,524 shares; 2025Q4: 7,144,524 shares 7,144,524$191M1.91%0Timeline
ESTAESTABLISHMENT LABS HLDGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,645,703 shares; 2024Q4: 2,569,687 shares; 2025Q1: 2,583,887 shares; 2025Q2: 2,584,131 shares; 2025Q3: 2,588,831 shares; 2025Q4: 2,588,831 shares 2,588,831$189M1.89%0Timeline
STOKSTOKE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 4,652,285 shares; 2024Q4: 5,123,525 shares; 2025Q1: 5,123,525 shares; 2025Q2: 5,123,525 shares; 2025Q3: 5,123,525 shares; 2025Q4: 5,546,856 shares 5,546,856$176M1.76%+423,331Timeline
RGENREPLIGEN CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 1,064,000 shares 1,064,000$174M1.75%newTimeline
CYTKCYTOKINETICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,721,158 shares; 2024Q4: 2,721,158 shares; 2025Q1: 2,721,158 shares; 2025Q2: 2,721,158 shares; 2025Q3: 2,721,158 shares; 2025Q4: 2,721,158 shares 2,721,158$173M1.73%0Timeline
IMCRIMMUNOCORE HLDGS PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 4,869,798 shares; 2024Q4: 4,869,798 shares; 2025Q1: 4,869,798 shares; 2025Q2: 4,869,798 shares; 2025Q3: 4,869,798 shares; 2025Q4: 4,869,798 shares 4,869,798$169M1.69%0Timeline
AXSMAXSOME THERAPEUTICS INC.Quarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 4,189,557 shares; 2024Q4: 4,051,365 shares; 2025Q1: 2,922,729 shares; 2025Q2: 1,516,903 shares; 2025Q3: 1,118,883 shares; 2025Q4: 888,001 shares 888,001$162M1.62%-230,882Timeline
GHGUARDANT HEALTH INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 856,501 shares; 2025Q3: 1,481,033 shares; 2025Q4: 1,481,033 shares 1,481,033$151M1.52%0Timeline
NBIXNEUROCRINE BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 1,062,072 shares; 2025Q3: 1,062,072 shares; 2025Q4: 1,062,072 shares 1,062,072$151M1.51%0Timeline
SYRESPYRE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 3,258,360 shares; 2024Q4: 3,621,996 shares; 2025Q1: 3,621,996 shares; 2025Q2: 3,621,996 shares; 2025Q3: 3,621,996 shares; 2025Q4: 4,171,996 shares 4,171,996$137M1.37%+550,000Timeline
ZLABZAI LAB LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 2,509,119 shares; 2025Q1: 3,136,680 shares; 2025Q2: 5,536,876 shares; 2025Q3: 2,291,372 shares; 2025Q4: 6,959,032 shares 6,959,032$123M1.23%+4,667,660Timeline
IMTXIMMATICS N.VQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 10,000,000 shares; 2024Q4: 6,540,540 shares; 2025Q1: 6,909,510 shares; 2025Q2: 6,970,152 shares; 2025Q3: 8,815,617 shares; 2025Q4: 11,433,354 shares 11,433,354$120M1.2%+2,617,737Timeline
BLTEBELITE BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 312,500 shares; 2025Q4: 715,332 shares 715,332$114M1.15%+402,832Timeline
URGNUROGEN PHARMA LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 3,787,347 shares; 2024Q4: 3,834,794 shares; 2025Q1: 3,834,794 shares; 2025Q2: 4,543,895 shares; 2025Q3: 4,543,895 shares; 2025Q4: 4,543,895 shares 4,543,895$106M1.07%0Timeline
XNCRXENCOR INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 575,000 shares; 2024Q4: 2,402,883 shares; 2025Q1: 2,402,883 shares; 2025Q2: 2,402,883 shares; 2025Q3: 6,221,054 shares; 2025Q4: 6,777,461 shares 6,777,461$104M1.04%+556,407Timeline
PODDINSULET CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 324,600 shares 324,600$92.3M0.92%newTimeline
TSHATAYSHA GENE THERAPIES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 14,946,420 shares; 2024Q4: 8,672,630 shares; 2025Q1: 18,787,866 shares; 2025Q2: 25,021,584 shares; 2025Q3: 24,354,291 shares; 2025Q4: 16,398,297 shares 16,398,297$90.2M0.9%-7,955,994Timeline
MASIMASIMO CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,462,400 shares; 2024Q4: 683,294 shares; 2025Q1: 683,294 shares; 2025Q2: 683,294 shares; 2025Q3: 683,294 shares; 2025Q4: 683,294 shares 683,294$88.9M0.89%0Timeline
QUREUNIQURE NVQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 10,000 shares; 2024Q4: 903,625 shares; 2025Q1: 4,265,428 shares; 2025Q2: 5,158,231 shares; 2025Q3: 4,424,968 shares; 2025Q4: 3,711,462 shares 3,711,462$88.8M0.89%-713,506Timeline
SYKSTRYKER CORPORATIONQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 396,921 shares; 2024Q4: 590,221 shares; 2025Q1: 590,221 shares; 2025Q2: 590,517 shares; 2025Q3: 490,000 shares; 2025Q4: 245,000 shares 245,000$86.1M0.86%-245,000Timeline
CGONCG ONCOLOGY INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,344,074 shares; 2024Q4: 1,701,216 shares; 2025Q1: 1,701,216 shares; 2025Q2: 1,701,216 shares; 2025Q3: 1,701,216 shares; 2025Q4: 2,012,127 shares 2,012,127$83.5M0.84%+310,911Timeline
CSTLCASTLE BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 2,115,237 shares 2,115,237$82.3M0.82%newTimeline
IMVTIMMUNOVANT INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 530,614 shares; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 3,177,850 shares 3,177,850$80.8M0.81%newTimeline
BBNXBETA BIONICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 3,299,870 shares; 2025Q2: 3,299,191 shares; 2025Q3: 3,299,191 shares; 2025Q4: 2,500,000 shares 2,500,000$76.2M0.76%-799,191Timeline
GHRSGH RESEARCH PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 3,327,129 shares; 2024Q4: 3,327,129 shares; 2025Q1: 5,499,769 shares; 2025Q2: 5,540,457 shares; 2025Q3: 5,569,564 shares; 2025Q4: 5,933,815 shares 5,933,815$75.4M0.75%+364,251Timeline
REPLREPLIMUNE GROUP INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,133,787 shares; 2024Q4: 2,065,010 shares; 2025Q1: 2,065,010 shares; 2025Q2: 2,065,010 shares; 2025Q3: 6,395,732 shares; 2025Q4: 7,140,352 shares 7,140,352$69.4M0.7%+744,620Timeline
RAREULTRAGENYX PHARMACEUTICAL INQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,968,002 shares; 2024Q4: 1,968,002 shares; 2025Q1: 1,707,402 shares; 2025Q2: 1,707,402 shares; 2025Q3: 3,258,266 shares; 2025Q4: 3,000,139 shares 3,000,139$69M0.69%-258,127Timeline
CRNXCRINETICS PHARMACEUTICALS INQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 467,000 shares; 2025Q3: 872,387 shares; 2025Q4: 1,351,326 shares 1,351,326$62.9M0.63%+478,939Timeline
ORKAORUKA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,850,648 shares; 2024Q4: 1,945,649 shares; 2025Q1: 1,945,649 shares; 2025Q2: 1,945,649 shares; 2025Q3: 1,945,649 shares; 2025Q4: 2,058,148 shares 2,058,148$62.4M0.62%+112,499Timeline
RCKTROCKET PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 17,687,772 shares; 2024Q4: 17,687,772 shares; 2025Q1: 17,687,772 shares; 2025Q2: 17,687,772 shares; 2025Q3: 17,687,772 shares; 2025Q4: 17,687,772 shares 17,687,772$62.1M0.62%0Timeline
CMPSCOMPASS PATHWAYS PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 3,098,987 shares; 2025Q1: 5,538,168 shares; 2025Q2: 8,221,929 shares; 2025Q3: 8,707,390 shares; 2025Q4: 8,757,390 shares 8,757,390$60.4M0.61%+50,000Timeline
ISRGINTUITIVE SURGICAL INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 202,456 shares; 2025Q2: 202,456 shares; 2025Q3: 202,456 shares; 2025Q4: 101,228 shares 101,228$57.3M0.57%-101,228Timeline
RAPTRAPT THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 1,470,499 shares; 2025Q3: 1,470,499 shares; 2025Q4: 1,637,165 shares 1,637,165$55.5M0.56%+166,666Timeline
CELCCELCUITY INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 550,160 shares 550,160$54.9M0.55%newTimeline
VSTMVERASTEM INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 4,245,476 shares; 2025Q2: 4,251,616 shares; 2025Q3: 5,426,306 shares; 2025Q4: 6,576,306 shares 6,576,306$50.8M0.51%+1,150,000Timeline
ALKSALKERMES PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 6,654,033 shares; 2024Q4: 7,557,835 shares; 2025Q1: 6,884,698 shares; 2025Q2: 4,682,289 shares; 2025Q3: 1,672,356 shares; 2025Q4: 1,672,356 shares 1,672,356$46.8M0.47%0Timeline
CNTACENTESSA PHARMACEUTICALS PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 50,000 shares; 2024Q4: 50,000 shares; 2025Q1: 50,000 shares; 2025Q2: 1,529,836 shares; 2025Q3: 2,291,747 shares; 2025Q4: 1,790,837 shares 1,790,837$44.8M0.45%-500,910Timeline
KODKODIAK SCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 1,487,933 shares 1,487,933$41.6M0.42%newTimeline
AQSTAQUESTIVE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 6,250,000 shares; 2025Q4: 6,250,000 shares 6,250,000$40.4M0.4%0Timeline
ARWRARROWHEAD PHARMACEUTICALS INQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 584,716 shares 584,716$38.8M0.39%newTimeline
SVRASAVARA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 5,952,380 shares 5,952,380$35.9M0.36%newTimeline
OBIOORCHESTRA BIOMED HLDGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 8,206,159 shares; 2024Q4: 8,206,162 shares; 2025Q1: 8,206,162 shares; 2025Q2: 8,306,062 shares; 2025Q3: 8,306,063 shares; 2025Q4: 8,306,063 shares 8,306,063$34.5M0.35%0Timeline
NGNENEUROGENE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,135,256 shares; 2024Q4: 1,350,256 shares; 2025Q1: 1,348,656 shares; 2025Q2: 1,362,456 shares; 2025Q3: 1,362,456 shares; 2025Q4: 1,362,456 shares 1,362,456$28.1M0.28%0Timeline
WVEWAVE LIFE SCIENCES LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 900,000 shares; 2024Q4: 900,000 shares; 2025Q1: 900,000 shares; 2025Q2: 900,000 shares; 2025Q3: 900,000 shares; 2025Q4: 1,350,000 shares 1,350,000$22.9M0.23%+450,000Timeline
JBIOJADE BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 1,449,273 shares; 2025Q3: 1,449,273 shares; 2025Q4: 1,449,273 shares 1,449,273$22.4M0.22%0Timeline
EVMNEVOMMUNE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 1,283,671 shares 1,283,671$22M0.22%newTimeline
KYMRKYMERA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 240,000 shares 240,000$18.7M0.19%newTimeline
FLGTFULGENT GENETICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 705,027 shares 705,027$18.5M0.19%newTimeline
CGEMCULLINAN THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,705,960 shares; 2024Q4: 1,705,960 shares; 2025Q1: 1,705,960 shares; 2025Q2: 1,705,960 shares; 2025Q3: 1,705,960 shares; 2025Q4: 1,705,960 shares 1,705,960$17.7M0.18%0Timeline
HNGEHINGE HEALTH INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 353,500 shares 353,500$16.4M0.16%newTimeline
BEAMBEAM THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 438,659 shares; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 570,394 shares 570,394$15.8M0.16%newTimeline
HTFLHEARTFLOW INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 495,000 shares; 2025Q4: 495,000 shares 495,000$14.4M0.14%0Timeline
CMPXCOMPASS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 2,500,000 shares; 2025Q4: 2,500,000 shares 2,500,000$13.4M0.13%0Timeline
TNGXTANGO THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 1,491,228 shares 1,491,228$13.2M0.13%newTimeline
LMRILUMEXA IMAGING HOLDINGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 650,000 shares 650,000$12M0.12%newTimeline
LRMRLARIMAR THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 3,125,000 shares; 2025Q4: 3,125,000 shares 3,125,000$11.9M0.12%0Timeline
TEMTEMPUS AI INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 400,000 shares; 2024Q4: not reported; 2025Q1: 400,000 shares; 2025Q2: 400,000 shares; 2025Q3: 200,000 shares; 2025Q4: 200,000 shares 200,000$11.8M0.12%0Timeline
KLRSKALARIS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 1,300,000 shares 1,300,000$11M0.11%newTimeline
IQVIQVIA HLDGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 46,000 shares 46,000$10.4M0.1%newTimeline
FRNMPERCEPTIVE CAP SOLUTIONS CORQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 742,500 shares; 2024Q4: 742,500 shares; 2025Q1: 742,500 shares; 2025Q2: 742,500 shares; 2025Q3: 742,500 shares; 2025Q4: 742,500 shares 742,500$9.67M0.1%0Timeline
ATAIBECKLEY INCATAIBECKLEY INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 2,000,000 shares 2,000,000$8.18M0.08%new
ALURALLURION TECHNOLOGIES INC COMQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 1,050,063 shares; 2025Q2: 2,542,603 shares; 2025Q3: 2,542,603 shares; 2025Q4: 5,891,430 shares 5,891,430$7.25M0.07%+3,348,827Timeline
CAPRCAPRICOR THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 250,000 shares 250,000$7.21M0.07%newTimeline
GPCRSTRUCTURE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 125,000 shares; 2024Q4: 125,000 shares; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 100,000 shares 100,000$6.96M0.07%newTimeline
IVAINVENTIVA SAQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 1,298,701 shares 1,298,701$6.04M0.06%newTimeline
MISTMILESTONE PHARMACEUTICALS INQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 3,256,102 shares; 2024Q4: 2,506,102 shares; 2025Q1: 2,506,102 shares; 2025Q2: 2,506,102 shares; 2025Q3: 2,506,102 shares; 2025Q4: 2,506,102 shares 2,506,102$5.06M0.05%0Timeline
XGNEXAGEN INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,511,866 shares; 2024Q4: 1,511,866 shares; 2025Q1: 1,511,866 shares; 2025Q2: 1,696,866 shares; 2025Q3: 1,696,866 shares; 2025Q4: 790,462 shares 790,462$4.81M0.05%-906,404Timeline
TENXTENAX THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 378,346 shares; 2025Q2: 378,346 shares; 2025Q3: 378,346 shares; 2025Q4: 378,346 shares 378,346$4.61M0.05%0Timeline
CBIOCRESCENT BIOPHARMA INC.Quarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 372,856 shares 372,856$4.42M0.04%newTimeline
MIND MEDICINE MINDMED INCMIND MEDICINE MINDMED INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 300,000 shares 300,000$4.02M0.04%new
FDMT4D MOLECULAR THERAPEUTICS INQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 475,737 shares 475,737$3.57M0.04%newTimeline
CRVSCORVUS PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 2,679,479 shares; 2025Q1: 2,679,479 shares; 2025Q2: 2,679,479 shares; 2025Q3: 2,679,479 shares; 2025Q4: 447,607 shares 447,607$3.45M0.03%-2,231,872Timeline
OMDAOMADA HEALTH INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 200,000 shares; 2025Q3: 200,000 shares; 2025Q4: 200,000 shares 200,000$3.16M0.03%0Timeline
MDLNMEDLINE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 70,000 shares 70,000$2.94M0.03%newTimeline
IRONDISC MEDICINE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 30,000 shares 30,000$2.38M0.02%newTimeline
IMAIMAGENEBIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 334,445 shares; 2025Q4: 334,445 shares 334,445$2.31M0.02%0Timeline
ERASERASCA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 146,651 shares 146,651$546K0.01%newTimeline
RCKTWROCKET PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 350,000 shares; 2024Q4: 350,000 shares; 2025Q1: 350,000 shares; 2025Q2: 350,000 shares; 2025Q3: 350,000 shares; 2025Q4: 350,000 shares 350,000$8.51K<0.01%0Timeline

Sold out in Q4 2025

Positions in the previous quarter's report that this quarter's report no longer lists.

SecurityShares beforeValue beforeType
RNAMAVIDITY BIOSCIENCES INC11,372,829$496Mshares
AKROAKERO THERAPEUTICS INC5,477,561$260Mshares
MERUS N VMERUS N V2,025,277$191Mshares
DGXQUEST DIAGNOSTICS INC250,000$47.6Mshares
LENZLENZ THERAPEUTICS INC863,389$40.2Mshares
DYNDYNE THERAPEUTICS INC2,890,567$36.6Mshares
ABVXABIVAX SA350,000$29.7Mshares
GEHCGE HEALTHCARE TECHNOLOGIES I393,500$29.6Mshares
ALECALECTOR INC6,990,806$20.7Mshares
CTMXCYTOMX THERAPEUTICS INC.3,461,500$11Mshares
PEPGPEPGEN INC1,500,000$6.93Mshares
ADGMADAGIO MED HLDGS INC209,361$406Kshares

How Q4 2025 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

FilingRoleAmendmentFiledAcceptedIngested
13F-HR 0001493215-26-000060 base2026-02-17acceptance time not in the bulk data set