13F-HR filed by Ikarian Capital, LLC
Ikarian Capital, LLC filed this 13F-HR for the quarter ended 2025-06-30, filed 2025-08-14, with 133 holding rows worth $520,629,177.
- Accession
- 0001420506-25-002181
- Filer
- CIK 1778253
- Filed
- 2025-08-14
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q2 2025
A holdings report, 133 entries on the cover page, a total value of $520,629,177 stated on the cover page (in dollars after the unit check, H1), rows summing to $520,629,177 with VALUE read as dollars as filed, 13F file number 028-19721. The quarter's positions are built on this report. The resolved quarter.
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| CIDARA THERAPEUTICS INC | 171757206 | COM NEW | 501,600 | $24,432,936 | dollars as filed | put |
| CIDARA THERAPEUTICS INC | 171757206 | COM NEW | 464,488 | $22,625,210 | dollars as filed | |
| ULTRAGENYX PHARMACEUTICAL IN | 90400D108 | COM | 563,100 | $20,474,316 | dollars as filed | call |
| ALNYLAM PHARMACEUTICALS INC COM | 02043Q107 | Stock | 56,594 | $18,454,737 | dollars as filed | |
| SOLENO THERAPEUTICS INC | 834203309 | COM | 200,000 | $16,756,000 | dollars as filed | put |
| SOLENO THERAPEUTICS INC | 834203309 | COM | 200,000 | $16,756,000 | dollars as filed | call |
| INSMED INC COM PAR $.01 | 457669307 | Stock | 163,751 | $16,479,900 | dollars as filed | |
| CIDARA THERAPEUTICS INC | 171757206 | COM NEW | 321,000 | $15,635,910 | dollars as filed | call |
| VERONA PHARMA PLC | 925050106 | SPONSORED ADS | 146,831 | $13,887,276 | dollars as filed | |
| CAPRICOR THERAPEUTICS INC | 14070B309 | COMMON STOCK | 1,360,200 | $13,506,786 | dollars as filed | put |
| CRINETICS PHARMACEUTICALS INC COM | 22663K107 | Stock | 433,431 | $12,465,476 | dollars as filed | |
| AKERO THERAPEUTICS INC | 00973Y108 | COM | 220,000 | $11,739,199 | dollars as filed | |
| PRAXIS PRECISION MEDICINES I | 74006W207 | COM NEW | 276,950 | $11,645,747 | dollars as filed | |
| UNIQURE NV | N90064901 | CALL | 800,000 | $11,152,000 | dollars as filed | call |
| ULTRAGENYX PHARMACEUTICAL IN | 90400D108 | COM | 300,000 | $10,908,000 | dollars as filed | put |
| PRAXIS PRECISION MEDICINES I | 74006W207 | COM NEW | 242,400 | $10,192,920 | dollars as filed | call |
| APOGEE THERAPEUTICS INC COM | 03770N101 | Stock | 232,047 | $10,077,802 | dollars as filed | |
| VAXCYTE INC COM | 92243G108 | Stock | 305,000 | $9,915,549 | dollars as filed | |
| VIKING THERAPEUTICS INC | 92686J106 | COM | 350,000 | $9,275,000 | dollars as filed | call |
| MOONLAKE IMMUNOTHERAPEUTICS CLASS A ORD | 61559X104 | Stock | 194,500 | $9,180,400 | dollars as filed | put |
| ALPHA COGNITION INC | 02074J501 | COM NEW | 917,867 | $8,563,699 | dollars as filed | |
| TARSUS PHARMACEUTICALS INC | 87650L103 | COMMON STOCK | 196,536 | $7,961,673 | dollars as filed | |
| CYTOKINETICS INC | 23282W605 | COM NEW | 233,464 | $7,713,651 | dollars as filed | |
| SAREPTA THERAPEUTICS INC | 803607100 | COM | 449,087 | $7,679,388 | dollars as filed | |
| TG THERAPEUTICS INC COM | 88322Q108 | Stock | 209,938 | $7,555,669 | dollars as filed | |
| COGENT BIOSCIENCES INC | 19240Q201 | COM | 1,035,528 | $7,435,090 | dollars as filed | |
| CAPRICOR THERAPEUTICS INC | 14070B309 | COMMON STOCK | 700,000 | $6,951,000 | dollars as filed | call |
| VIRIDIAN THERAPEUTICS INC | 92790C104 | COM | 469,949 | $6,569,886 | dollars as filed | |
| ARVINAS INC | 04335A105 | COM | 850,000 | $6,256,000 | dollars as filed | |
| FORTE BIOSCIENCES INC | 34962G208 | COMMON STOCK | 476,443 | $6,160,407 | dollars as filed | |
| SAREPTA THERAPEUTICS INC | 803607100 | COM | 332,100 | $5,678,910 | dollars as filed | call |
| VIR BIOTECHNOLOGY INC | 92764N102 | COM | 1,068,062 | $5,383,032 | dollars as filed | |
| CYTOKINETICS INC | 23282W605 | COM NEW | 150,000 | $4,956,000 | dollars as filed | call |
| CATALYST PHARMACEUTICALS INC | 14888U101 | COM | 209,649 | $4,549,384 | dollars as filed | |
| KALVISTA PHARMACEUTICALS INC | 483497103 | COM | 400,000 | $4,522,001 | dollars as filed | call |
| MOONLAKE IMMUNOTHERAPEUTICS CLASS A ORD | 61559X104 | Stock | 94,500 | $4,460,400 | dollars as filed | call |
| DELCATH SYSTEMS INC | 24661P807 | COMMON STOCK | 322,390 | $4,384,503 | dollars as filed | |
| JAZZ PHARMACEUTICALS PLC SHS USD | G50871105 | Stock | 40,000 | $4,244,799 | dollars as filed | |
| BIOHAVEN LTD | G1110E907 | COM | 300,000 | $4,233,000 | dollars as filed | call |
| CG ONCOLOGY INC | 156944100 | COMMON STOCK | 155,000 | $4,030,000 | dollars as filed | |
| NEURONETICS INC | 64131A105 | COM | 1,099,700 | $3,837,953 | dollars as filed | |
| STRUCTURE THERAPEUTICS INC COMP | 86366E106 | EQUITY | 183,085 | $3,797,183 | dollars as filed | |
| NEWAMSTERDAM PHARMA CO NV | N62509109 | COMMON STOCK | 206,800 | $3,745,148 | dollars as filed | |
| FULCRUM THERAPEUTICS INC | 359616109 | COMMON STOCK | 534,000 | $3,673,920 | dollars as filed | call |
| VERA THERAPEUTICS INC | 92337R101 | COMMON STOCK | 153,200 | $3,609,392 | dollars as filed | call |
| SCHOLAR ROCK HLDG CORP | 80706P103 | COM | 100,000 | $3,542,000 | dollars as filed | call |
| DYNE THERAPEUTICS INC COM | 26818M108 | Stock | 363,837 | $3,463,728 | dollars as filed | |
| APOGEE THERAPEUTICS INC COM | 03770N101 | Stock | 79,100 | $3,435,313 | dollars as filed | put |
| TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS | 881624209 | ADR | 200,000 | $3,352,000 | dollars as filed | call |
| TECTONIC THERAPEUTIC INC | 878972108 | COMMON STOCK | 163,696 | $3,252,639 | dollars as filed | |
| MAZE THERAPEUTICS INC COM | 578784100 | Stock | 262,740 | $3,223,819 | dollars as filed | |
| ALTIMMUNE INC | 02155H200 | COM NEW | 827,500 | $3,202,425 | dollars as filed | call |
| JANUX THERAPEUTICS INC | 47103J105 | COM | 129,691 | $2,995,863 | dollars as filed | |
| FULCRUM THERAPEUTICS INC | 359616109 | COMMON STOCK | 428,521 | $2,948,225 | dollars as filed | |
| ELEDON PHARMACEUTICALS INC | 28617k101 | COM | 1,000,221 | $2,710,599 | dollars as filed | |
| BIOGEN INC COM | 09062X103 | Stock | 21,516 | $2,702,195 | dollars as filed | |
| VIKING THERAPEUTICS INC | 92686J106 | COM | 100,000 | $2,650,001 | dollars as filed | |
| CENTESSA PHARMACEUTICALS PLC | 152309100 | SPONSORED ADS | 200,000 | $2,628,000 | dollars as filed | call |
| RELAY THERAPEUTICS INC COM | 75943R102 | Stock | 743,308 | $2,571,846 | dollars as filed | |
| AKERO THERAPEUTICS INC | 00973Y108 | COM | 44,400 | $2,369,184 | dollars as filed | call |
| ARCTURUS THERAPEUTICS HLDGS | 03969T109 | COM | 175,000 | $2,276,750 | dollars as filed | |
| GERON CORP | 374163103 | COM | 1,600,000 | $2,256,000 | dollars as filed | |
| KALVISTA PHARMACEUTICALS INC | 483497103 | COM | 198,528 | $2,244,360 | dollars as filed | |
| KODIAK SCIENCES INC | 50015M109 | COM | 599,534 | $2,236,261 | dollars as filed | |
| LEXEO THERAPEUTICS INC | 52886X107 | COMMON STOCK | 550,029 | $2,211,117 | dollars as filed | |
| METSERA INC | 59267L107 | COM | 77,316 | $2,199,640 | dollars as filed | |
| Ventyx Biosciences Inc | 92332V107 | Common Stock | 967,590 | $2,070,643 | dollars as filed | |
| CUMBERLAND PHARMACEUTICALS I | 230770109 | COM | 595,932 | $1,996,372 | dollars as filed | |
| COGENT BIOSCIENCES INC | 19240Q201 | COM | 262,600 | $1,885,468 | dollars as filed | call |
| PROQR THERAPEUTICS NV | N71542109 | SHS EURO | 868,069 | $1,770,860 | dollars as filed | |
| SCHOLAR ROCK HLDG CORP | 80706P103 | COM | 49,179 | $1,741,920 | dollars as filed | |
| BRIGHT MINDS BIOSCIENCES INC | 10919W405 | COMMON STOCK | 65,431 | $1,708,403 | dollars as filed | |
| UNIQURE NV | N90064101 | SHS | 119,986 | $1,672,605 | dollars as filed | |
| SILENCE THERAPEUTICS PLC | 82686Q101 | ADS | 873,568 | $1,397,709 | dollars as filed | |
| ARCUS BIOSCIENCES INC | 03969F109 | COM | 163,363 | $1,329,775 | dollars as filed | |
| APELLIS PHARMACEUTICALS INC | 03753U106 | COM | 75,000 | $1,298,250 | dollars as filed | |
| ALECTOR INC | 014442107 | COMMON STOCK | 900,000 | $1,260,000 | dollars as filed | |
| NUVATION BIO INC COM CL A | 67080N101 | Stock | 619,258 | $1,207,553 | dollars as filed | |
| VISTAGEN THERAPEUTICS INC | 92840H400 | COM | 601,703 | $1,203,406 | dollars as filed | |
| CYBIN INC | 23256X407 | COM NEW | 140,475 | $1,178,585 | dollars as filed | |
| Tourmaline Bio Inc | 89157D105 | Common Stock | 67,927 | $1,086,152 | dollars as filed | |
| WAVE LIFE SCIENCES LTD SHS | Y95308105 | Stock | 161,137 | $1,047,392 | dollars as filed | |
| Veru Inc | 92536C103 | Common Stock | 1,425,239 | $829,204 | dollars as filed | |
| ORUKA THERAPEUTICS INC COM | 687604108 | Stock | 68,574 | $768,715 | dollars as filed | |
| ISHARES TR | 464287556 | ISHARES BIOTECH | 5,755 | $728,065 | dollars as filed | |
| SANGAMO THERAPEUTICS INC | 800677106 | COM | 1,260,179 | $682,134 | dollars as filed | |
| IMMUNIC INC | 4525EP101 | COM | 914,170 | $637,633 | dollars as filed | |
| PROTHENA CORP PLC SHS | G72800108 | Stock | 100,000 | $607,000 | dollars as filed | call |
| INHIBRX BIOSCIENCES INC | 45720N103 | COM | 42,122 | $601,081 | dollars as filed | |
| Inflarx Nv | N44821101 | COM | 705,010 | $556,958 | dollars as filed | |
| KEZAR LIFE SCIENCES INC | 49372L209 | COM NEW | 106,901 | $489,607 | dollars as filed | |
| VYNE THERAPEUTICS INC | 92941V308 | COM | 290,000 | $478,501 | dollars as filed | |
| IBIO INC | 451033708 | CMN | 599,913 | $457,794 | dollars as filed | |
| KYMERA THERAPEUTICS INC | 501575104 | COM | 10,000 | $436,400 | dollars as filed | put |
| MIND MEDICINE MINDMED INC | 60255C885 | COM NEW | 62,691 | $406,864 | dollars as filed | |
| BIOMX INC | 09090D301 | COM | 892,976 | $401,839 | dollars as filed | |
| LYELL IMMUNOPHARMA INC COM NEW | 55083R203 | Stock | 43,799 | $387,183 | dollars as filed | |
| NYXOAH S A | B6S7WD106 | SHS | 50,627 | $378,691 | dollars as filed | |
| APOGEE THERAPEUTICS INC COM | 03770N101 | Stock | 8,400 | $364,812 | dollars as filed | call |
| ANAPTYSBIO INC | 032724106 | COM | 15,662 | $347,696 | dollars as filed | |
| VERA THERAPEUTICS INC | 92337R101 | COMMON STOCK | 14,096 | $332,102 | dollars as filed | |
| ZYMEWORKS INC | 98985Y108 | COM | 25,000 | $313,751 | dollars as filed | |
| ACUMEN PHARMACEUTICALS INC | 00509G209 | CMN | 265,769 | $308,292 | dollars as filed | |
| IMMATICS N.V | N44445109 | SHS | 49,396 | $265,750 | dollars as filed | |
| VIGIL NEUROSCIENCE INC | 92673K108 | COM | 31,360 | $249,311 | dollars as filed | |
| CHEMOMAB THERAPEUTICS LTD | 16385C104 | SPONSORED ADS | 213,052 | $247,141 | dollars as filed | |
| ALTO NEUROSCIENCE INC COM SHS | 02157Q109 | Stock | 110,000 | $242,001 | dollars as filed | |
| CARTESIAN THERAPEUTICS INC | 816212302 | COMMON STOCK | 22,166 | $230,304 | dollars as filed | |
| ANEBULO PHARMACEUTICALS INC | 034569103 | COM | 157,720 | $227,117 | dollars as filed | |
| VAXCYTE INC COM | 92243G108 | Stock | 6,900 | $224,319 | dollars as filed | call |
| TERNS PHARMACEUTICALS INC COM | 880881107 | Stock | 58,491 | $218,172 | dollars as filed | |
| EVAXION AS | 29970R303 | SPONSORED ADS | 80,000 | $196,000 | dollars as filed | |
| FAETH THERAPEUTICS INC | 81728A207 | COM NEW | 22,497 | $193,025 | dollars as filed | |
| LYRA THERAPEUTICS INC | 55234L204 | COM NEW | 21,161 | $189,603 | dollars as filed | |
| AETHLON MED INC | 00808Y505 | COM NEW | 153,659 | $184,391 | dollars as filed | |
| AVALO THERAPEUTICS INC | 05338F306 | COMMON STOCK | 35,300 | $176,147 | dollars as filed | |
| VOYAGER THERAPEUTICS INC | 92915B106 | COMMON STOCK | 55,766 | $173,433 | dollars as filed | |
| LEXICON PHARMACEUTICALS INC | 528872302 | COMMON STOCK | 176,479 | $166,897 | dollars as filed | |
| PEPGEN INC COM | 713317105 | Stock | 150,000 | $166,500 | dollars as filed | |
| JASPER THERAPEUTICS INC | 471871202 | COM NEW | 25,107 | $139,344 | dollars as filed | |
| KARYOPHARM THERAPEUTICS INC | 48576U205 | COMMON STOCK | 27,257 | $117,478 | dollars as filed | |
| MACROGENICS INC | 556099109 | COM | 80,071 | $96,886 | dollars as filed | |
| SAGIMET BIOSCIENCES INC A | 786700104 | COMMON STOCK | 11,984 | $91,318 | dollars as filed | |
| AIRSCULPT TECHNOLOGIES INC | 009496100 | COMMON STOCK | 17,951 | $86,703 | dollars as filed | |
| SPRUCE BIOSCIENCES INC | 85209E109 | COM | 1,000,000 | $72,501 | dollars as filed | |
| ALPHA TEKNOVA INC | 02080L102 | COMMON STOCK | 14,008 | $68,779 | dollars as filed | |
| HOOKIPA PHARMA INC | 43906K209 | COM NEW | 52,996 | $66,510 | dollars as filed | |
| THERIVA BIOLOGICS INC | 87164U508 | COM NEW | 120,031 | $52,070 | dollars as filed | |
| TRAWS PHARMA INC | 68232V884 | COM NEW | 28,493 | $42,170 | dollars as filed | |
| AUTONOMIX MED INC | 05330T205 | COM NEW | 20,000 | $31,401 | dollars as filed | |
| SYNLOGIC INC | 87166L209 | COM | 20,422 | $25,936 | dollars as filed | |
| RELMADA THERAPEUTICS INC | 75955J402 | COMMON STOCK | 40,270 | $24,174 | dollars as filed | |
| NEUMORA THERAPEUTICS INC. | 640979100 | COM | 12,498 | $9,164 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001420506-25-002181 | this filing | 2025-08-14 | acceptance time not in the bulk data set |