Frazier Life Sciences Management, L.P. More: the full row for Frazier Life Sciences Management, L.P. 16,701,956 $475M 14.23% +94,882 13F-HR Timeline Bain Capital Life Sciences Investors, L… in group Bain Capital Life Sciences In… More: the full row for Bain Capital Life Sciences Investors, LLC 10,719,110 $305M 20.23% 0 13F-HR Timeline Group RA CAPITAL MANAGEMENT, L.P. in group RA CAPITAL MANAGEMENT, L.P. More: the full row for RA CAPITAL MANAGEMENT, L.P. 10,138,938 $288M 3.55% 0 13F-HR Timeline Group Capital World Investors More: the full row for Capital World Investors 9,822,711 $279M 0.04% +1,434,986 13F-HR Timeline FCPM III SERVICES B.V. in group FCPM III SERVICES B.V. More: the full row for FCPM III SERVICES B.V. 9,212,384 $262M 52.36% -1,419,729 13F-HR Timeline Group VIKING GLOBAL INVESTORS LP in group VIKING GLOBAL INVESTORS LP More: the full row for VIKING GLOBAL INVESTORS LP 6,475,534 $184M 0.48% -503,000 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 5,535,293 $157M 0.01% +3,630,743 13F-HR Timeline Group DEERFIELD MANAGEMENT COMPANY, L.P. in group DEERFIELD MANAGEMENT COMPANY,… More: the full row for DEERFIELD MANAGEMENT COMPANY, L.P. 4,266,693 $121M 1.86% -849,260 13F-HR Timeline Group JENNISON ASSOCIATES LLC More: the full row for JENNISON ASSOCIATES LLC 4,198,554 $119M 0.07% +1,252,451 13F-HR Timeline WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 4,020,126 $114M 0.02% +697,129 13F-HR Timeline Group Polar Capital Holdings Plc in group Polar Capital Holdings Plc More: the full row for Polar Capital Holdings Plc 2,911,634 $82.8M 0.4% +393,855 13F-HR Timeline Group Medicxi Ventures Management (Jersey) Ltd More: the full row for Medicxi Ventures Management (Jersey) Ltd 2,869,565 $81.6M 10.96% 0 13F-HR Timeline ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 2,576,631 $73.3M 0.12% -436,378 13F-HR Timeline Group Cormorant Asset Management, LP More: the full row for Cormorant Asset Management, LP 2,175,000 $61.9M 4.27% 0 13F-HR Timeline ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 2,141,778 $60.9M 0.02% -189,805 13F-HR Timeline JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 2,117,075 $60.1M 0.03% +155,015 13F-HR Timeline Group Capital International Investors in group Capital International Investo… More: the full row for Capital International Investors 2,062,535 $58.7M 0.01% 0 13F-HR Timeline Group Duquesne Family Office LLC More: the full row for Duquesne Family Office LLC 1,923,700 $54.7M 1.39% +1,091,525 13F-HR Timeline MAVERICK CAPITAL LTD More: the full row for MAVERICK CAPITAL LTD 1,504,747 $42.8M 0.57% -27,127 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 1,497,479 $42.6M <0.01% +859,772 13F-HR/A Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 1,302,498 $37M <0.01% -156,399 13F-HR/A Timeline Group Pictet Asset Management Holding SA in group Pictet Asset Management Holdi… More: the full row for Pictet Asset Management Holding SA 1,292,150 $36.7M 0.04% -524,575 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 1,157,867 $32.9M 0.16% -739,330 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 880,552 $25M <0.01% -69,428 13F-HR Timeline Group TimesSquare Capital Management, LLC More: the full row for TimesSquare Capital Management, LLC 837,368 $23.8M 0.34% -35,169 13F-HR Timeline UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 768,520 $21.9M -180,003 Timeline Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 765,705 $21.8M 0.85% -428,535 13F-HR Timeline Group First Turn Management, LLC More: the full row for First Turn Management, LLC 716,971 $20.4M 3.06% +195,874 13F-HR Timeline Aberdeen Group plc in group Aberdeen Group plc More: the full row for Aberdeen Group plc 661,946 $18.8M 0.03% -73,086 13F-HR Timeline Group Decheng Capital LLC More: the full row for Decheng Capital LLC 657,051 $18.7M 3.26% -112,949 13F-HR Timeline AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 624,285 $17.8M 0.01% +91,369 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 622,515 $17.7M <0.01% +50,842 13F-HR Timeline Group Rock Springs Capital Management LP More: the full row for Rock Springs Capital Management LP 595,929 $16.9M 0.99% +59,818 13F-HR Timeline Eversept Partners, LP More: the full row for Eversept Partners, LP 488,592 $13.9M 1.06% +74,162 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 472,100 $13.4M <0.01% -11,904 13F-HR/A Timeline Group FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 405,825 $11.5M <0.01% +71,613 13F-HR Timeline Group Handelsbanken Fonder AB More: the full row for Handelsbanken Fonder AB 405,800 $11.5M 0.04% +64,200 13F-HR Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 332,998 $9.47M <0.01% -19,954 13F-HR Timeline Group Slate Path Capital LP More: the full row for Slate Path Capital LP 319,000 $9.07M 0.14% 0 13F-HR Timeline ArrowMark Colorado Holdings LLC More: the full row for ArrowMark Colorado Holdings LLC 310,999 $8.84M 0.16% -47,615 13F-HR Timeline Affinity Asset Advisors, LLC More: the full row for Affinity Asset Advisors, LLC 275,000 $7.82M 0.73% 0 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 206,461 $5.87M <0.01% -113,682 13F-HR Timeline Group AXA Investment Managers S.A. More: the full row for AXA Investment Managers S.A. 196,782 $5.6M 0.02% 13F-HR Timeline Artia Global Partners LP More: the full row for Artia Global Partners LP 194,838 $5.54M 0.97% +167,519 13F-HR/A Timeline Nicholas Investment Partners, LP More: the full row for Nicholas Investment Partners, LP 177,538 $5.05M 0.39% +61,799 13F-HR Timeline DCF Advisers, LLC More: the full row for DCF Advisers, LLC 175,250 $4.98M 1.89% +2,750 13F-HR Timeline VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 172,466 $4.9M <0.01% -6,380 13F-HR Timeline Group Saturn V Capital Management LP More: the full row for Saturn V Capital Management LP 153,147 $4.36M 0.96% -67,548 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 151,837 $4.32M 0.01% +62,010 13F-HR Timeline Group STEMPOINT CAPITAL LP More: the full row for STEMPOINT CAPITAL LP 150,573 $4.28M 0.86% -2,079 13F-HR Timeline KENNEDY CAPITAL MANAGEMENT LLC More: the full row for KENNEDY CAPITAL MANAGEMENT LLC 146,715 $4.17M 0.09% +133,040 13F-HR Timeline AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 145,327 $4.13M <0.01% -62,754 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 138,329 $3.94M <0.01% new 13F-HR Timeline ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 114,359 $3.25M 0.32% +2,000 13F-HR Timeline Group Ikarian Capital, LLC in group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 106,800 $3.04M 0.61% -100,000 13F-HR Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 104,676 $2.98M <0.01% -29,359 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 101,958 $2.9M <0.01% +2,501 13F-HR Timeline Group Swiss National Bank More: the full row for Swiss National Bank 87,100 $2.48M <0.01% +3,200 13F-HR Timeline CenterBook Partners LP More: the full row for CenterBook Partners LP 70,613 $2.01M 0.1% +2,423 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 68,425 $1.95M <0.01% +333 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 63,810 $1.81M <0.01% -17,494 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 47,862 $1.36M <0.01% 0 13F-HR Timeline Lisanti Capital Growth, LLC More: the full row for Lisanti Capital Growth, LLC 47,445 $1.35M 0.33% -1,665 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 45,738 $1.3M <0.01% +1,503 13F-HR Timeline Group FRED ALGER MANAGEMENT, LLC in group FRED ALGER MANAGEMENT, LLC More: the full row for FRED ALGER MANAGEMENT, LLC 41,264 $1.17M <0.01% +19,227 13F-HR Timeline Group BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 40,714 $1.16M 0.03% -19,340 13F-HR Timeline GILDER GAGNON HOWE & CO LLC More: the full row for GILDER GAGNON HOWE & CO LLC 36,384 $1.03M 0.01% new 13F-HR Timeline READYSTATE ASSET MANAGEMENT LP More: the full row for READYSTATE ASSET MANAGEMENT LP 34,353 $977K 0.05% -196,841 13F-HR Timeline Knights of Columbus Asset Advisors LLC More: the full row for Knights of Columbus Asset Advisors LLC 33,610 $956K 0.05% +777 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 33,299 $947K <0.01% +2,988 13F-HR Timeline Group HighVista Strategies LLC More: the full row for HighVista Strategies LLC 31,831 $905K 0.22% +12,557 13F-HR Timeline Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 30,290 $861K -5,430 Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 27,328 $777K <0.01% -1,949 13F-HR Timeline Group NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 26,680 $759K <0.01% new 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 26,502 $754K <0.01% +8,170 13F-HR Timeline Group Yarbrough Capital, LLC More: the full row for Yarbrough Capital, LLC 23,960 $681K 0.02% 0 13F-HR Timeline Legato Capital Management LLC More: the full row for Legato Capital Management LLC 23,370 $665K 0.07% +4,581 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 22,505 $640K <0.01% +11,637 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 20,959 $596K <0.01% +6,680 13F-HR Timeline Group Atle Fund Management AB More: the full row for Atle Fund Management AB 193,625 $585K 2.17% +36,402 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 19,742 $561K 0.05% -2,807 13F-HR Timeline VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 19,300 $549K <0.01% new 13F-HR Timeline Group TD Asset Management Inc More: the full row for TD Asset Management Inc 18,000 $512K <0.01% new 13F-HR Timeline KEYBANK NATIONAL ASSOCIATION/OH in group KEYBANK NATIONAL ASSOCIATION/… More: the full row for KEYBANK NATIONAL ASSOCIATION/OH 16,014 $455K <0.01% new 13F-HR Timeline Group PTM WEALTH MANAGEMENT, LLC More: the full row for PTM WEALTH MANAGEMENT, LLC 12,900 $419K 0.25% 0 13F-HR Timeline Bellevue Group AG in group Bellevue Group AG More: the full row for Bellevue Group AG 14,611 $416K 0.01% -5,944 13F-HR Timeline Group OMERS ADMINISTRATION Corp More: the full row for OMERS ADMINISTRATION Corp 13,900 $395K <0.01% new 13F-HR Timeline Verition Fund Management LLC More: the full row for Verition Fund Management LLC 13,828 $393K <0.01% 0 13F-HR Timeline ARIZONA STATE RETIREMENT SYSTEM More: the full row for ARIZONA STATE RETIREMENT SYSTEM 13,251 $377K <0.01% +483 13F-HR Timeline BANK OF MONTREAL /CAN/ in group BANK OF MONTREAL /CAN/ More: the full row for BANK OF MONTREAL /CAN/ 12,388 $352K <0.01% new 13F-HR Timeline Group Jefferies Financial Group Inc. in group Jefferies Financial Group Inc. More: the full row for Jefferies Financial Group Inc. 12,000 $341K <0.01% new 13F-HR Timeline Group LETKO, BROSSEAU & ASSOCIATES INC More: the full row for LETKO, BROSSEAU & ASSOCIATES INC 11,775 $335K 0.01% 0 13F-HR Timeline TEACHER RETIREMENT SYSTEM OF TEXAS More: the full row for TEACHER RETIREMENT SYSTEM OF TEXAS 10,783 $307K <0.01% -917 13F-HR Timeline AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 10,196 $290K <0.01% new 13F-HR Timeline Group KLP KAPITALFORVALTNING AS More: the full row for KLP KAPITALFORVALTNING AS 9,100 $259K <0.01% 0 13F-HR Timeline Mesirow Financial Investment Management… More: the full row for Mesirow Financial Investment Management, Inc. 8,215 $234K <0.01% new 13F-HR Timeline CIBC Private Wealth Group LLC in group CIBC Bancorp USA Inc. More: the full row for CIBC Private Wealth Group LLC 7,640 $217K <0.01% 0 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 7,579 $216K 0.01% new 13F-HR Timeline Group Avanza Fonder AB More: the full row for Avanza Fonder AB 7,505 $213K 0.01% 0 13F-HR Timeline MARSHALL FINANCIAL GROUP INC /ADV More: the full row for MARSHALL FINANCIAL GROUP INC /ADV 7,500 $213K 0.06% new 13F-HR Timeline Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 7,404 $211K <0.01% -136 13F-HR Timeline Quarry LP More: the full row for Quarry LP 6,875 $196K 0.05% -125 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 5,718 $163K <0.01% -12,153 13F-HR/A Timeline Group Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 5,411 $154K 0.04% +940 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 5,102 $145K <0.01% +355 13F-HR Timeline Group PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 3,616 $103K <0.01% -978 13F-HR Timeline Group SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 3,372 $95K <0.01% -2,232 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 2,972 $84.5K <0.01% +2,424 13F-HR Timeline Group WOLVERINE ASSET MANAGEMENT LLC in group WOLVERINE ASSET MANAGEMENT LLC More: the full row for WOLVERINE ASSET MANAGEMENT LLC 2,429 $69.1K <0.01% new 13F-HR Timeline Group GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 2,423 $68.9K <0.01% +58 13F-HR Timeline NATIONAL BANK OF CANADA /FI/ in group NATIONAL BANK OF CANADA /FI/ More: the full row for NATIONAL BANK OF CANADA /FI/ 1,949 $55.3K <0.01% -32 13F-HR Timeline Group Parallel Advisors, LLC More: the full row for Parallel Advisors, LLC 1,400 $39.8K <0.01% 0 13F-HR Timeline GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 1,097 $31.2K <0.01% +872 13F-HR Timeline THURSTON, SPRINGER, MILLER, HERD & TITA… More: the full row for THURSTON, SPRINGER, MILLER, HERD & TITAK, INC. 1,067 $30.3K 0.06% new 13F-HR Timeline Cheviot Value Management, LLC More: the full row for Cheviot Value Management, LLC 796 $28.8K <0.01% 0 13F-HR Timeline MATHER GROUP, LLC. More: the full row for MATHER GROUP, LLC. 1,000 $28.4K <0.01% new 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 979 $28K <0.01% +42 13F-HR Timeline Group Strategic Wealth Partners, Ltd. More: the full row for Strategic Wealth Partners, Ltd. 975 $27.7K <0.01% new 13F-HR Timeline SIGNATUREFD, LLC More: the full row for SIGNATUREFD, LLC 647 $18.4K <0.01% 0 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 600 $17.1K <0.01% +400 13F-HR Timeline Group State of Wyoming More: the full row for State of Wyoming 580 $16.5K <0.01% +30 13F-HR Timeline Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 375 $11K <0.01% 0 13F-HR Timeline Group Stone House Investment Management, LLC More: the full row for Stone House Investment Management, LLC 325 $9.24K <0.01% 0 13F-HR Timeline Roxbury Financial LLC More: the full row for Roxbury Financial LLC 324 $9.21K 0.01% +60 13F-HR Timeline JONES FINANCIAL COMPANIES LLLP in group JONES FINANCIAL COMPANIES LLLP More: the full row for JONES FINANCIAL COMPANIES LLLP 249 $7.1K <0.01% 0 13F-HR Timeline Group Arax Advisory Partners More: the full row for Arax Advisory Partners 174 $4.95K <0.01% new 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 135 $3.84K <0.01% -137 13F-HR Timeline Group Clearstead Advisors, LLC More: the full row for Clearstead Advisors, LLC 88 $2.5K <0.01% 0 13F-HR Timeline True Wealth Design, LLC More: the full row for True Wealth Design, LLC 21 $598 <0.01% 0 13F-HR Timeline Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 16 $455 <0.01% new 13F-HR Timeline Kilter Group LLC More: the full row for Kilter Group LLC 10 $285 <0.01% 0 13F-HR Timeline Sunbelt Securities, Inc. More: the full row for Sunbelt Securities, Inc. 8 $228 <0.01% new 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 8 $228 <0.01% 0 13F-HR Timeline Group IFP Advisors, Inc More: the full row for IFP Advisors, Inc 3 $85 <0.01% 0 13F-HR/A Timeline Essential Partners LLC More: the full row for Essential Partners LLC 2 $57 <0.01% 0 13F-HR Timeline DUPONT CAPITAL MANAGEMENT CORP More: the full row for DUPONT CAPITAL MANAGEMENT CORP 1 $28 <0.01% 0 13F-HR Timeline NOMURA ASSET MANAGEMENT CO LTD in group NOMURA ASSET MANAGEMENT CO LTD More: the full row for NOMURA ASSET MANAGEMENT CO LTD 0 $0 0% 0 13F-HR Timeline Group Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.