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Disclosery

KPTI KARYOPHARM THERAPEUTICS INC

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COMMON STOCK (common), issuer CIK 1503802

67 managers (68 13F filers) reported a position in KPTI shares at 2025-12-31, 9,456,156 shares in all. 26 filers opened a position and 9 filers sold out during the quarter.

Managers
67
13F filers
68
New
26
Added
19
Reduced
5
Sold out
9
Shares held by filers
9,456,156

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

Each filer's latest stake. The shares are the aggregate the reporting persons state, which can include entities that file no 13F.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q4 2025

Filers in the available 13F reports with a share position at 2025-12-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
T. Rowe Price Investment Management, In…1,491,409$11M0.01%+790,41713F-HR/ATimeline
Opaleye Management Inc.930,000$6.84M0.9%new13F-HR/ATimeline
Affinity Asset Advisors, LLC889,575$6.55M0.47%new13F-HRTimeline
VANGUARD GROUP INCin group VANGUARD GROUP INC559,619$4.12M<0.01%+151,39713F-HRTimelineGroup
Ikarian Capital, LLCin group Ikarian Capital, LLC544,554$4.01M0.52%+517,29713F-HRTimelineGroup
Soleus Capital Management, L.P.440,000$3.24M0.14%new13F-HRTimeline
ADAGE CAPITAL PARTNERS GP, L.L.C.in group ADAGE CAPITAL PARTNERS GP, L.…421,322$3.1M<0.01%013F-HRTimelineGroup
Davidson Kempner Capital Management LP310,020$2.28M0.03%new13F-HRTimelineThe filing omitted confidential holdings, a later amendment may add them.
BRAIDWELL LP303,370$2.23M0.07%new13F-HRTimeline
Exome Asset Management LLC295,541$2.18M1.07%new13F-HRTimeline
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC276,881$2.04M<0.01%new13F-HRTimelineGroup
Boxer Capital Management, LLCin group Boxer Capital Management, LLC252,536$1.86M0.41%new13F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.247,558$1.82M<0.01%+15,60713F-HRTimelineGroup
TWO SIGMA INVESTMENTS, LPgroup of 2 filers holding238,522$1.76MnewTimeline
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC187,734$1.38M<0.01%+94,44513F-HRTimelineGroup
SUSQUEHANNA INTERNATIONAL GROUP, LLPin group SUSQUEHANNA INTERNATIONAL GRO…147,698$1.09M<0.01%+112,35913F-HRTimelineGroup
BOOTHBAY FUND MANAGEMENT, LLC144,628$1.06M0.03%new13F-HRTimeline
Catalio Capital Management, LP142,984$1.05M0.19%013F-HR/ATimeline
Avidity Partners Management LP134,566$990K0.29%013F-HRTimeline
MARSHALL WACE, LLPin group MARSHALL WACE, LLP128,451$945K<0.01%013F-HRTimelineGroup
GROUP ONE TRADING LLC102,419$754K0.02%+33,98313F-HRTimeline
C WorldWide Group Holding A/Sin group C WorldWide Group Holding A/S100,000$736K0.01%013F-HRTimelineGroup
Walleye Capital LLCin group Walleye Capital LLC95,672$704K<0.01%new13F-HRTimelineGroup
UBS Group AGin group UBS Group AG88,455$651K<0.01%+28,77013F-HRTimelineGroup
BRIDGEWAY CAPITAL MANAGEMENT, LLC65,873$485K0.01%+31,00013F-HRTimeline
Context Capital Management, LLC62,995$464K0.01%new13F-HRTimeline
RENAISSANCE TECHNOLOGIES LLC59,914$441K<0.01%-4,80013F-HRTimeline
Quadrature Capital Ltdin group Quadrature Capital Ltd59,708$439K<0.01%new13F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP58,942$434K<0.01%+12,60013F-HRTimelineGroup
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA58,000$427K<0.01%+51,26613F-HRTimelineGroup
Connor, Clark & Lunn Investment Managem…57,212$421K<0.01%new13F-HRTimeline
Jump Financial, LLCin group Jump Financial, LLC53,816$396K<0.01%new13F-HRTimelineGroup
DAFNA Capital Management LLC51,000$375K0.09%new13F-HRTimeline
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC50,000$368K0.03%+25,00013F-HR/ATimelineGroup
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/48,088$354K<0.01%+47,99413F-HRTimelineGroup
Trexquant Investment LP41,733$307K<0.01%new13F-HRTimeline
SILVERBACK ASSET MANAGEMENT LLC40,000$294K0.04%013F-HRTimeline
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC35,533$262K<0.01%new13F-HRTimelineGroup
SIMPLEX TRADING, LLC32,868$242K0.01%+27,00613F-HRTimeline
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC31,709$233K<0.01%new13F-HRTimelineGroup
NORTHERN TRUST CORPin group NORTHERN TRUST CORP29,023$214K<0.01%+10,14713F-HRTimelineGroup
PRELUDE CAPITAL MANAGEMENT, LLC28,723$211K0.02%new13F-HRTimeline
Baird Financial Group, Inc.in group Baird Financial Group, Inc.27,993$206K<0.01%+2,06113F-HRTimelineGroup
Persistent Asset Partners Ltd18,316$135K0.06%new13F-HRTimeline
TUDOR INVESTMENT CORP ET AL12,922$95.1K<0.01%new13F-HRTimeline
XTX Topco Ltdin group XTX Topco Ltd11,904$87.6K<0.01%-2,49813F-HRTimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp11,087$81.6K<0.01%+113F-HRTimelineGroup
PRICE T ROWE ASSOCIATES INC /MD/10,886$81K<0.01%013F-HRTimeline
MORGAN STANLEYin group MORGAN STANLEY8,858$65.2K<0.01%-16,90813F-HR/ATimelineGroup
BARCLAYS PLCin group BARCLAYS PLC4,109$30.2K<0.01%013F-HRTimelineGroup
ACADIAN ASSET MANAGEMENT LLCin group ACADIAN ASSET MANAGEMENT LLC3,726$27K<0.01%new13F-HRTimelineGroup
TD Waterhouse Canada Inc.3,203$23.5K<0.01%013F-HRTimeline
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO1,741$12.8K<0.01%+1,19113F-HRTimelineGroup
Rockefeller Capital Management L.P.in group Rockefeller Capital Managemen…733$5.39K<0.01%new13F-HR/ATimelineGroup
FMR LLCin group FMR LLC679$5K<0.01%013F-HRTimelineGroup
Aspect Partners, LLC391$2.88K<0.01%new13F-HRTimeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.282$2.08K<0.01%-6413F-HRTimelineGroup
Quent Capital, LLC235$1.73K<0.01%+413F-HRTimeline
MB, LEVIS & ASSOCIATES, LLC100$736<0.01%013F-HRTimeline
HARBOUR INVESTMENTS, INC.85$626<0.01%013F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS82$604<0.01%013F-HRTimelineGroup
SBI Securities Co., Ltd.74$545<0.01%013F-HRTimeline
Activest Wealth Management66$486<0.01%013F-HRTimeline
Allworth Financial LP26$192<0.01%013F-HRTimeline
West Branch Capital LLC3$23<0.01%013F-HRTimeline
CIBC Private Wealth Group LLCin group CIBC Bancorp USA Inc.3$22<0.01%013F-HRTimelineGroup
CITIGROUP INCin group CITIGROUP INC1$7<0.01%-51213F-HRTimelineGroup

Events

  • ACORN BIOVENTURES, L.P. and 4 other reporting persons reported 1,021,668 KPTI shares, 4.5% of the class, as of 2026-10-02, in a 13G/A filed 2026-10-08. 0001636587-26-000086

    Accepted , ingested

  • ACORN BIOVENTURES, L.P. and 4 other reporting persons reported 1,284,221 KPTI shares, 5.7% of the class, as of 2026-09-22, in a 13G/A filed 2026-09-25. 0001636587-26-000084

    Accepted , ingested

  • ACORN BIOVENTURES, L.P. and 4 other reporting persons reported 1,284,221 KPTI shares, 5.7% of the class, as of 2026-09-22, in a 13G/A filed 2026-09-25. 0001636587-26-000083

    Accepted , ingested