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Disclosery

KPTI KARYOPHARM THERAPEUTICS INC

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COMMON STOCK (common), issuer CIK 1503802

50 managers (50 13F filers) reported a position in KPTI shares at 2025-06-30, 4,384,792 shares in all. 12 filers opened a position and 10 filers sold out during the quarter.

Managers
50
13F filers
50
New
12
Added
12
Reduced
6
Sold out
10
Shares held by filers
4,384,792

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

Each filer's latest stake. The shares are the aggregate the reporting persons state, which can include entities that file no 13F.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q2 2025

Filers in the available 13F reports with a share position at 2025-06-30, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
T. Rowe Price Investment Management, In…728,766$3.14M<0.01%+589,12013F-HRTimeline
VANGUARD GROUP INCin group VANGUARD GROUP INC518,269$2.23M<0.01%+7,97513F-HRTimelineGroup
ADAGE CAPITAL PARTNERS GP, L.L.C.in group ADAGE CAPITAL PARTNERS GP, L.…421,322$1.82M<0.01%013F-HRTimelineGroup
Eversept Partners, LP257,154$1.11M0.11%013F-HRTimeline
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO256,443$1.11M<0.01%+85,65313F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.236,641$1.02M<0.01%-6,10113F-HRTimelineGroup
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC206,781$891K<0.01%-12813F-HRTimelineGroup
Palo Alto Investors LP187,911$810K0.17%new13F-HRTimeline
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/168,534$726K<0.01%+35,62613F-HRTimelineGroup
UBS Group AGin group UBS Group AG161,900$698K<0.01%+68,28813F-HRTimelineGroup
Catalio Capital Management, LP146,013$629K0.13%-9,60913F-HRTimeline
Avidity Partners Management LP134,566$580K0.12%013F-HRTimeline
MARSHALL WACE, LLPin group MARSHALL WACE, LLP128,451$554K<0.01%013F-HRTimelineGroup
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC109,404$472K<0.01%+23,99413F-HRTimelineGroup
C WorldWide Group Holding A/Sin group C WorldWide Group Holding A/S100,000$431K0.01%013F-HRTimelineGroup
GROUP ONE TRADING LLC97,900$422K0.01%new13F-HRTimeline
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC91,841$396K<0.01%-7,79913F-HRTimelineGroup
SILVERBACK ASSET MANAGEMENT LLC70,000$302K0.05%new13F-HRTimeline
RENAISSANCE TECHNOLOGIES LLC65,814$284K<0.01%+4,60013F-HRTimeline
BRIDGEWAY CAPITAL MANAGEMENT, LLC37,836$163K<0.01%new13F-HRTimeline
STATE STREET CORPin group STATE STREET CORP33,295$144K<0.01%+3,80013F-HRTimelineGroup
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC31,847$137K<0.01%-23,52013F-HRTimelineGroup
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS29,637$128K<0.01%+67613F-HRTimelineGroup
Ikarian Capital, LLCin group Ikarian Capital, LLC27,257$117K0.04%013F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY25,091$108K<0.01%+14,66813F-HRTimelineGroup
NORTHERN TRUST CORPin group NORTHERN TRUST CORP18,910$81.5K<0.01%013F-HRTimelineGroup
GSA CAPITAL PARTNERS LLP13,894$60K<0.01%new13F-HRTimeline
XTX Topco Ltdin group XTX Topco Ltd13,056$56.3K<0.01%new13F-HRTimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp11,086$47.8K<0.01%013F-HRTimelineGroup
PRICE T ROWE ASSOCIATES INC /MD/10,886$47K<0.01%new13F-HRTimeline
Baird Financial Group, Inc.in group Baird Financial Group, Inc.10,532$45.4K<0.01%new13F-HRTimelineGroup
SIMPLEX TRADING, LLC8,233$35K<0.01%new13F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA7,429$32K<0.01%+5,97013F-HR/ATimelineGroup
CITIGROUP INCin group CITIGROUP INC7,040$30.3K<0.01%-413F-HRTimelineGroup
BARCLAYS PLCin group BARCLAYS PLC5,333$23K<0.01%013F-HR/ATimelineGroup
TD Waterhouse Canada Inc.3,203$14K<0.01%013F-HRTimeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…850$3.66K<0.01%new13F-HRTimelineGroup
FMR LLCin group FMR LLC765$3.3K<0.01%+23813F-HRTimelineGroup
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.346$1.49K<0.01%013F-HR/ATimelineGroup
MB, LEVIS & ASSOCIATES, LLC100$431<0.01%013F-HRTimeline
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC90$388<0.01%new13F-HRTimelineGroup
HARBOUR INVESTMENTS, INC.85$366<0.01%013F-HRTimeline
Fortitude Family Office, LLC81$349<0.01%new13F-HRTimeline
SBI Securities Co., Ltd.74$319<0.01%013F-HRTimeline
Activest Wealth Management66$284<0.01%013F-HRTimeline
Allworth Financial LP32$138<0.01%013F-HRTimeline
Bruce G. Allen Investments, LLC22$95<0.01%013F-HRTimeline
CIBC Private Wealth Group LLCin group CIBC Bancorp USA Inc.3$13<0.01%013F-HRTimelineGroup
West Branch Capital LLC3$13<0.01%013F-HRTimeline
CONCOURSE FINANCIAL GROUP SECURITIES, I…0$0013F-HRTimelineValue filed as zero, left out of ratios. Amount filed as zero, left out of ratios.

Events

  • ACORN BIOVENTURES, L.P. and 4 other reporting persons reported 1,021,668 KPTI shares, 4.5% of the class, as of 2026-10-02, in a 13G/A filed 2026-10-08. 0001636587-26-000086

    Accepted , ingested

  • ACORN BIOVENTURES, L.P. and 4 other reporting persons reported 1,284,221 KPTI shares, 5.7% of the class, as of 2026-09-22, in a 13G/A filed 2026-09-25. 0001636587-26-000084

    Accepted , ingested

  • ACORN BIOVENTURES, L.P. and 4 other reporting persons reported 1,284,221 KPTI shares, 5.7% of the class, as of 2026-09-22, in a 13G/A filed 2026-09-25. 0001636587-26-000083

    Accepted , ingested