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Disclosery

KPTI KARYOPHARM THERAPEUTICS INC

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COMMON STOCK (common), issuer CIK 1503802

73 managers (76 13F filers) reported a position in KPTI shares at 2026-03-31, 17,581,541 shares in all. 20 filers opened a position and 14 filers sold out during the quarter.

Managers
73
13F filers
76
New
20
Added
32
Reduced
9
Sold out
14
Shares held by filers
17,581,541

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

Each filer's latest stake. The shares are the aggregate the reporting persons state, which can include entities that file no 13F.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q1 2026

Filers in the available 13F reports with a share position at 2026-03-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
Commodore Capital LPin group Commodore Capital LP1,950,000$10.9M0.63%new13F-HRTimelineGroup
RA CAPITAL MANAGEMENT, L.P.in group RA CAPITAL MANAGEMENT, L.P.1,917,354$10.7M0.11%new13F-HRTimelineGroup
ADAGE CAPITAL PARTNERS GP, L.L.C.in group ADAGE CAPITAL PARTNERS GP, L.…1,806,322$10.1M0.02%+1,385,00013F-HRTimelineGroup
T. Rowe Price Investment Management, In…1,542,090$8.59M0.01%+50,68113F-HRTimeline
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC947,579$5.28M<0.01%new13F-HRTimelineGroup
Catalio Capital Management, LP897,709$5M1.04%+754,72513F-HRTimeline
VANGUARD GROUP INCgroup of 3 filers holding862,886$4.81MnewTimeline
Ikarian Capital, LLCin group Ikarian Capital, LLC733,435$4.09M0.58%+188,88113F-HRTimelineGroup
Affinity Asset Advisors, LLC500,000$2.79M0.16%-389,57513F-HRTimeline
Avidity Partners Management LP463,741$2.58M0.52%+329,17513F-HR/ATimeline
Soleus Capital Management, L.P.440,000$2.45M0.1%013F-HRTimeline
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC420,571$2.34M<0.01%new13F-HRTimelineGroup
Boxer Capital Management, LLCin group Boxer Capital Management, LLC302,536$1.69M0.22%+50,00013F-HRTimelineGroup
Davidson Kempner Capital Management LP300,000$1.67M0.03%-10,02013F-HRTimelineThe filing omitted confidential holdings, a later amendment may add them.
ACORN CAPITAL ADVISORS, LLC287,826$1.6M0.46%new13F-HRTimeline
Eversept Partners, LP276,174$1.54M0.1%new13F-HRTimeline
Jump Financial, LLCin group Jump Financial, LLC262,146$1.46M0.02%+208,33013F-HRTimelineGroup
Trexquant Investment LP257,903$1.44M0.01%+216,17013F-HRTimeline
ACADIAN ASSET MANAGEMENT LLCin group ACADIAN ASSET MANAGEMENT LLC248,957$1.38M<0.01%+245,23113F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.244,899$1.36M<0.01%-2,65913F-HRTimelineGroup
BOOTHBAY FUND MANAGEMENT, LLC213,810$1.19M0.03%+69,18213F-HRTimeline
Brevan Howard Capital Management LPin group Brevan Howard Capital Managem…212,367$1.18M0.01%new13F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC206,133$1.15M<0.01%+18,39913F-HRTimelineGroup
UBS Group AGin group UBS Group AG194,017$1.08M<0.01%+105,56213F-HRTimelineGroup
GROUP ONE TRADING LLC191,527$1.07M0.04%+89,10813F-HRTimeline
XTX Topco Ltdin group XTX Topco Ltd164,443$916K0.02%+152,53913F-HRTimelineGroup
TWO SIGMA INVESTMENTS, LPin group TWO SIGMA INVESTMENTS, LP151,232$842K<0.01%+2,43913F-HRTimelineGroup
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC136,736$762K0.05%+86,73613F-HRTimelineGroup
MARSHALL WACE, LLPin group MARSHALL WACE, LLP128,451$715K<0.01%013F-HRTimelineGroup
Engineers Gate Manager LP112,432$626K0.01%new13F-HRTimeline
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC105,901$590K<0.01%+70,36813F-HRTimelineGroup
RENAISSANCE TECHNOLOGIES LLC105,414$587K<0.01%+45,50013F-HRTimeline
C WorldWide Group Holding A/Sin group C WorldWide Group Holding A/S100,000$557K0.01%013F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP80,742$450K<0.01%+21,80013F-HRTimelineGroup
Connor, Clark & Lunn Investment Managem…79,081$440K<0.01%+21,86913F-HRTimeline
BRIDGEWAY CAPITAL MANAGEMENT, LLC71,873$400K0.01%+6,00013F-HRTimeline
Balyasny Asset Management L.P.in group Balyasny Asset Management70,748$394K<0.01%new13F-HRTimelineGroup
SILVERBACK ASSET MANAGEMENT LLC65,000$362K0.07%+25,00013F-HR/ATimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA60,399$336K<0.01%+2,39913F-HRTimelineGroup
Tetragon Partners GP Ltdin group Tetragon Partners GP Ltd52,984$295K0.06%new13F-HRTimelineGroup
SUSQUEHANNA INTERNATIONAL GROUP, LLPgroup of 2 filers holding49,159$274K-98,539Timeline
DAFNA Capital Management LLC45,800$255K0.06%-5,20013F-HRTimeline
NORTHERN TRUST CORPin group NORTHERN TRUST CORP38,556$215K<0.01%+9,53313F-HRTimelineGroup
Zimmer Partners, LP37,500$209K0.01%new13F-HRTimeline
Centiva Capital, LP30,210$168K0.01%new13F-HRTimeline
China Universal Asset Management Co., L…30,000$167K0.01%new13F-HRTimeline
Baird Financial Group, Inc.in group Baird Financial Group, Inc.29,791$166K<0.01%+1,79813F-HRTimelineGroup
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/19,472$108K<0.01%-28,61613F-HRTimelineGroup
OMERS ADMINISTRATION Corp19,400$108K<0.01%new13F-HRTimeline
MORGAN STANLEYin group MORGAN STANLEY18,570$103K<0.01%+9,71213F-HRTimelineGroup
Invesco Ltd.in group Invesco Ltd.16,738$93.2K<0.01%new13F-HRTimelineGroup
Velan Capital Investment Management LP15,000$83.5K0.05%new13F-HRTimeline
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co13,429$74.8K<0.01%new13F-HRTimelineGroup
HSBC HOLDINGS PLCin group HSBC HOLDINGS PLC11,495$65.6K<0.01%new13F-HRTimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp11,399$63.5K<0.01%+31213F-HRTimelineGroup
PRICE T ROWE ASSOCIATES INC /MD/10,886$61K<0.01%013F-HRTimeline
BARCLAYS PLCin group BARCLAYS PLC7,424$41.4K<0.01%+3,31513F-HRTimelineGroup
CITIGROUP INCin group CITIGROUP INC4,941$27.5K<0.01%+4,94013F-HRTimelineGroup
TD Waterhouse Canada Inc.3,203$18.6K<0.01%013F-HRTimeline
Rockefeller Capital Management L.P.in group Rockefeller Capital Managemen…733$4.08K<0.01%013F-HRTimelineGroup
FMR LLCin group FMR LLC665$3.7K<0.01%-1413F-HRTimelineGroup
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO471$2.5K<0.01%-1,27013F-HR/ATimelineGroup
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.402$2.24K<0.01%+12013F-HRTimelineGroup
HARBOUR INVESTMENTS, INC.285$1.59K<0.01%+20013F-HRTimeline
Quent Capital, LLC235$1.31K<0.01%013F-HRTimeline
MB, LEVIS & ASSOCIATES, LLC100$557<0.01%013F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS84$468<0.01%+213F-HRTimelineGroup
SBI Securities Co., Ltd.67$373<0.01%-713F-HRTimeline
Activest Wealth Management66$368<0.01%013F-HRTimeline
Allworth Financial LP26$145<0.01%013F-HRTimeline
Advisory Services Network, LLC12$67<0.01%new13F-HRTimeline
West Branch Capital LLC3$17<0.01%013F-HRTimeline
PlanVest Financial, Inc1$6<0.01%13F-HRTimeline

Events

  • ACORN BIOVENTURES, L.P. and 4 other reporting persons reported 1,021,668 KPTI shares, 4.5% of the class, as of 2026-10-02, in a 13G/A filed 2026-10-08. 0001636587-26-000086

    Accepted , ingested

  • ACORN BIOVENTURES, L.P. and 4 other reporting persons reported 1,284,221 KPTI shares, 5.7% of the class, as of 2026-09-22, in a 13G/A filed 2026-09-25. 0001636587-26-000084

    Accepted , ingested

  • ACORN BIOVENTURES, L.P. and 4 other reporting persons reported 1,284,221 KPTI shares, 5.7% of the class, as of 2026-09-22, in a 13G/A filed 2026-09-25. 0001636587-26-000083

    Accepted , ingested