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Disclosery

KPTI KARYOPHARM THERAPEUTICS INC

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COMMON STOCK (common), issuer CIK 1503802

51 managers (51 13F filers) reported a position in KPTI shares at 2025-09-30, 2,947,993 shares in all. 7 filers opened a position and 5 filers sold out during the quarter.

Managers
51
13F filers
51
New
7
Added
7
Reduced
20
Sold out
5
Shares held by filers
2,947,993

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

Each filer's latest stake. The shares are the aggregate the reporting persons state, which can include entities that file no 13F.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q3 2025

Filers in the available 13F reports with a share position at 2025-09-30, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
T. Rowe Price Investment Management, In…700,992$4.58M<0.01%-27,77413F-HRTimeline
ADAGE CAPITAL PARTNERS GP, L.L.C.in group ADAGE CAPITAL PARTNERS GP, L.…421,322$2.76M<0.01%013F-HRTimelineGroup
VANGUARD GROUP INCin group VANGUARD GROUP INC408,222$2.67M<0.01%-110,04713F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.231,951$1.52M<0.01%-4,69013F-HRTimelineGroup
Catalio Capital Management, LP142,984$935K0.17%-3,02913F-HRTimeline
Avidity Partners Management LP134,566$880K0.2%013F-HRTimeline
MARSHALL WACE, LLPin group MARSHALL WACE, LLP128,451$840K<0.01%013F-HRTimelineGroup
C WorldWide Group Holding A/Sin group C WorldWide Group Holding A/S100,000$654K0.01%013F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC93,289$610K<0.01%+1,44813F-HRTimelineGroup
GROUP ONE TRADING LLC68,436$448K0.01%-29,46413F-HRTimeline
RENAISSANCE TECHNOLOGIES LLC64,714$423K<0.01%-1,10013F-HRTimeline
UBS Group AGin group UBS Group AG59,685$390K<0.01%-102,21513F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP46,342$303K<0.01%+13,04713F-HRTimelineGroup
SILVERBACK ASSET MANAGEMENT LLC40,000$262K0.03%-30,00013F-HRTimeline
SUSQUEHANNA INTERNATIONAL GROUP, LLPin group SUSQUEHANNA INTERNATIONAL GRO…35,339$231K<0.01%new13F-HRTimelineGroup
BRIDGEWAY CAPITAL MANAGEMENT, LLC34,873$228K<0.01%-2,96313F-HRTimeline
Ikarian Capital, LLCin group Ikarian Capital, LLC27,257$178K0.04%013F-HRTimelineGroup
Baird Financial Group, Inc.in group Baird Financial Group, Inc.25,932$170K<0.01%+15,40013F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY25,766$169K<0.01%+67513F-HR/ATimelineGroup
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC25,000$164K0.02%new13F-HRTimelineGroup
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC24,885$163K<0.01%-84,51913F-HRTimelineGroup
NORTHERN TRUST CORPin group NORTHERN TRUST CORP18,876$123K<0.01%-3413F-HRTimelineGroup
Belvedere Trading LLC14,563$95.2K0.01%new13F-HRTimeline
XTX Topco Ltdin group XTX Topco Ltd14,402$94.2K<0.01%+1,34613F-HRTimelineGroup
GSA CAPITAL PARTNERS LLP14,076$92K0.01%+18213F-HRTimeline
Bank of New York Mellon Corpin group Bank of New York Mellon Corp11,086$72.5K<0.01%013F-HRTimelineGroup
PRICE T ROWE ASSOCIATES INC /MD/10,886$72K<0.01%013F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA6,734$44K<0.01%-69513F-HRTimelineGroup
SIMPLEX TRADING, LLC5,862$38K<0.01%-2,37113F-HRTimeline
BARCLAYS PLCin group BARCLAYS PLC4,109$26.9K<0.01%-1,22413F-HR/ATimelineGroup
TD Waterhouse Canada Inc.3,203$19.9K<0.01%013F-HRTimeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…1,089$7.12K<0.01%+23913F-HRTimelineGroup
FMR LLCin group FMR LLC679$4.44K<0.01%-8613F-HRTimelineGroup
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO550$3.6K<0.01%-255,89313F-HR/ATimelineGroup
CITIGROUP INCin group CITIGROUP INC513$3.35K<0.01%-6,52713F-HRTimelineGroup
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.346$2.41K<0.01%013F-HRTimelineGroup
Quent Capital, LLC231$1.51K<0.01%new13F-HRTimeline
Rise Advisors, LLC131$857<0.01%new13F-HRTimeline
MB, LEVIS & ASSOCIATES, LLC100$654<0.01%013F-HRTimeline
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/94$615<0.01%-168,44013F-HR/ATimelineGroup
HARBOUR INVESTMENTS, INC.85$556<0.01%013F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS82$536<0.01%-29,55513F-HRTimelineGroup
Fortitude Family Office, LLC81$530<0.01%013F-HRTimeline
SBI Securities Co., Ltd.74$484<0.01%013F-HRTimeline
Activest Wealth Management66$432<0.01%013F-HRTimeline
Allworth Financial LP26$171<0.01%-613F-HRTimeline
Bruce G. Allen Investments, LLC22$144<0.01%013F-HRTimeline
Advisory Services Network, LLC12$78<0.01%new13F-HRTimeline
PITTENGER & ANDERSON INC3$20<0.01%new13F-HRTimeline
CIBC Private Wealth Group LLCin group CIBC Bancorp USA Inc.3$20<0.01%013F-HRTimelineGroup
West Branch Capital LLC3$20<0.01%013F-HRTimeline

Events

  • ACORN BIOVENTURES, L.P. and 4 other reporting persons reported 1,021,668 KPTI shares, 4.5% of the class, as of 2026-10-02, in a 13G/A filed 2026-10-08. 0001636587-26-000086

    Accepted , ingested

  • ACORN BIOVENTURES, L.P. and 4 other reporting persons reported 1,284,221 KPTI shares, 5.7% of the class, as of 2026-09-22, in a 13G/A filed 2026-09-25. 0001636587-26-000084

    Accepted , ingested

  • ACORN BIOVENTURES, L.P. and 4 other reporting persons reported 1,284,221 KPTI shares, 5.7% of the class, as of 2026-09-22, in a 13G/A filed 2026-09-25. 0001636587-26-000083

    Accepted , ingested