Medicxi Ventures Management (Jersey) Ltd More: the full row for Medicxi Ventures Management (Jersey) Ltd 19,963,157 $484M 65.03% 0 13F-HR Timeline Avoro Capital Advisors LLC More: the full row for Avoro Capital Advisors LLC 10,808,080 $262M 3.39% +5,808,080 13F-HR Timeline ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 10,035,000 $243M 0.39% +1,632,000 13F-HR Timeline Group Index Venture Life Associates VI Ltd More: the full row for Index Venture Life Associates VI Ltd 9,961,789 $242M 100% 0 13F-HR Timeline GENERAL ATLANTIC, L.P. More: the full row for GENERAL ATLANTIC, L.P. 9,681,818 $235M 7.05% 0 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 6,277,243 $152M 0.01% +2,451,049 13F-HR Timeline Group JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 5,408,199 $131M 0.06% -1,124,569 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 4,804,056 $116M 0.01% -1,103,936 13F-HR Timeline FARALLON CAPITAL MANAGEMENT, L.L.C. More: the full row for FARALLON CAPITAL MANAGEMENT, L.L.C. 4,331,318 $105M 0.59% -198,000 13F-HR/A Timeline First Light Asset Management, LLC More: the full row for First Light Asset Management, LLC 3,635,816 $88.2M 8.31% -657,595 13F-HR Timeline Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 3,227,517 $78.3M 3.06% -232,512 13F-HR Timeline Group TCG Crossover Management, LLC More: the full row for TCG Crossover Management, LLC 3,136,480 $76.1M 3.74% +245,664 13F-HR Timeline PERCEPTIVE ADVISORS LLC in group PERCEPTIVE ADVISORS LLC More: the full row for PERCEPTIVE ADVISORS LLC 3,100,902 $75.2M 2.17% +1,953,967 13F-HR Timeline Group Commodore Capital LP in group Commodore Capital LP More: the full row for Commodore Capital LP 2,850,000 $69.1M 3.37% -448,289 13F-HR Timeline Group FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 2,558,414 $62M 0.02% +14,875 13F-HR Timeline Group RTW INVESTMENTS, LP More: the full row for RTW INVESTMENTS, LP 2,291,747 $55.6M 0.68% +761,911 13F-HR Timeline Cormorant Asset Management, LP More: the full row for Cormorant Asset Management, LP 1,925,000 $46.7M 3.22% -161,600 13F-HR Timeline FEDERATED HERMES, INC. in group FEDERATED HERMES, INC. More: the full row for FEDERATED HERMES, INC. 1,749,650 $42.4M 0.07% new 13F-HR Timeline Group Foresite Capital Management VI LLC in group Foresite Capital Management V… More: the full row for Foresite Capital Management VI LLC 1,314,019 $31.9M 12.31% +60,640 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 1,124,445 $27.3M <0.01% -669,026 13F-HR/A Timeline Group Affinity Asset Advisors, LLC More: the full row for Affinity Asset Advisors, LLC 1,107,162 $26.8M 2.5% +207,000 13F-HR Timeline AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 1,096,704 $26.6M 0.01% -34,004 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 1,072,665 $26M 0.06% -1,518,931 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 902,268 $21.9M 0.02% -755,619 13F-HR Timeline Group Octagon Capital Advisors LP More: the full row for Octagon Capital Advisors LP 830,000 $20.1M 3.14% -200,000 13F-HR Timeline Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 805,611 $19.5M 0.04% -415,999 13F-HR Timeline Group Saturn V Capital Management LP More: the full row for Saturn V Capital Management LP 734,539 $17.8M 3.91% -58,788 13F-HR Timeline Capital World Investors More: the full row for Capital World Investors 684,805 $16.6M <0.01% +267,982 13F-HR Timeline 5AM Venture Management, LLC More: the full row for 5AM Venture Management, LLC 680,945 $16.5M 6.05% -150,000 13F-HR Timeline PFM Health Sciences, LP More: the full row for PFM Health Sciences, LP 666,196 $16.2M 1.38% +321,224 13F-HR Timeline STEMPOINT CAPITAL LP More: the full row for STEMPOINT CAPITAL LP 655,385 $15.9M 3.2% -610,287 13F-HR Timeline Tanager Wealth Management LLP More: the full row for Tanager Wealth Management LLP 598,044 $14.5M 1.52% 0 13F-HR Timeline Ensign Peak Advisors, Inc More: the full row for Ensign Peak Advisors, Inc 559,744 $13.6M 0.02% 0 13F-HR/A Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 553,007 $13.4M <0.01% +417,209 13F-HR/A Timeline Group EcoR1 Capital, LLC More: the full row for EcoR1 Capital, LLC 550,000 $13.3M 0.64% new 13F-HR Timeline Logos Global Management LP More: the full row for Logos Global Management LP 525,000 $12.7M 1.26% new 13F-HR Timeline Driehaus Capital Management LLC More: the full row for Driehaus Capital Management LLC 515,979 $12.5M 0.09% +5,200 13F-HR Timeline TD Asset Management Inc More: the full row for TD Asset Management Inc 466,960 $11.3M 0.01% -86,332 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 408,386 $9.9M <0.01% +27,261 13F-HR Timeline Group Nantahala Capital Management, LLC in group Nantahala Capital Management,… More: the full row for Nantahala Capital Management, LLC 404,803 $9.82M 0.61% -150,000 13F-HR Timeline Group ARMISTICE CAPITAL, LLC More: the full row for ARMISTICE CAPITAL, LLC 378,000 $9.17M 0.29% -22,000 13F-HR Timeline Candriam S.C.A. More: the full row for Candriam S.C.A. 343,207 $8.32M 0.04% -4,392 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 262,146 $6.36M 0.01% -55,428 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 247,555 $6M <0.01% -311,728 13F-HR Timeline Group ROYCE & ASSOCIATES LP More: the full row for ROYCE & ASSOCIATES LP 247,387 $6M 0.06% new 13F-HR Timeline Jain Global LLC More: the full row for Jain Global LLC 241,975 $5.87M 0.08% new 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 241,895 $5.87M <0.01% -186,539 13F-HR/A Timeline Group HighMark Wealth Management LLC More: the full row for HighMark Wealth Management LLC 237,285 $5.75M 2.53% 0 13F-HR Timeline TANG CAPITAL MANAGEMENT LLC in group TANG CAPITAL MANAGEMENT LLC More: the full row for TANG CAPITAL MANAGEMENT LLC 200,000 $4.85M 0.19% +150,000 13F-HR Timeline Group FRED ALGER MANAGEMENT, LLC in group FRED ALGER MANAGEMENT, LLC More: the full row for FRED ALGER MANAGEMENT, LLC 190,360 $4.62M 0.02% +66,604 13F-HR Timeline Group PLATINUM INVESTMENT MANAGEMENT LTD More: the full row for PLATINUM INVESTMENT MANAGEMENT LTD 186,399 $4.52M 0.29% -104,437 13F-HR Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 182,300 $4.42M 0.01% +41,335 13F-HR Timeline Group Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 172,696 $4.19M 0.03% +54,533 13F-HR Timeline Blue Owl Capital Holdings LP More: the full row for Blue Owl Capital Holdings LP 169,450 $4.11M 1.28% -161,150 13F-HR Timeline RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 164,600 $3.99M 0.01% -220,300 13F-HR Timeline Windmill Hill Asset Management Ltd More: the full row for Windmill Hill Asset Management Ltd 163,768 $3.97M 1.04% 0 13F-HR Timeline SILVERARC CAPITAL MANAGEMENT, LLC in group SILVERARC CAPITAL MANAGEMENT,… More: the full row for SILVERARC CAPITAL MANAGEMENT, LLC 141,238 $3.43M 0.5% +136,238 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 137,201 $3.33M <0.01% new 13F-HR Timeline Group Artia Global Partners LP More: the full row for Artia Global Partners LP 133,291 $3.23M 0.57% new 13F-HR/A Timeline Caption Management, LLC More: the full row for Caption Management, LLC 125,309 $3.04M 0.18% new 13F-HR Timeline DZ BANK AG Deutsche Zentral Genossensch… in group DZ BANK AG Deutsche Zentral G… More: the full row for DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main 116,397 $2.82M <0.01% -141,021 13F-HR Timeline Group Verition Fund Management LLC More: the full row for Verition Fund Management LLC 114,306 $2.77M 0.02% new 13F-HR Timeline MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 113,590 $2.75M <0.01% -229,728 13F-HR Timeline Group AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 108,002 $2.62M <0.01% new 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 107,671 $2.61M 0.01% -292,607 13F-HR Timeline Cubist Systematic Strategies, LLC More: the full row for Cubist Systematic Strategies, LLC 103,909 $2.52M 0.04% -172,543 13F-HR Timeline Eagle Health Investments LP More: the full row for Eagle Health Investments LP 103,100 $2.5M 0.66% new 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 101,693 $2.46M <0.01% +3,437 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 95,032 $2.3M <0.01% +7,597 13F-HR Timeline Group Cinctive Capital Management LP More: the full row for Cinctive Capital Management LP 92,628 $2.25M 0.11% new 13F-HR Timeline Exome Asset Management LLC More: the full row for Exome Asset Management LLC 88,024 $2.13M 1.41% -78,920 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 85,178 $2.07M <0.01% -124,572 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 82,665 $2M <0.01% -66,786 13F-HR Timeline Group Rock Springs Capital Management LP More: the full row for Rock Springs Capital Management LP 69,240 $1.68M 0.1% new 13F-HR Timeline D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 64,389 $1.56M <0.01% +48,625 13F-HR Timeline Group HighVista Strategies LLC More: the full row for HighVista Strategies LLC 63,301 $1.54M 0.38% +22,617 13F-HR Timeline Trexquant Investment LP More: the full row for Trexquant Investment LP 62,310 $1.51M 0.02% -89,042 13F-HR Timeline TUDOR INVESTMENT CORP ET AL More: the full row for TUDOR INVESTMENT CORP ET AL 57,810 $1.4M 0.01% +6,959 13F-HR/A Timeline TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 57,444 $1.39M <0.01% -14,700 13F-HR Timeline Group ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 53,666 $1.3M 0.13% -243,100 13F-HR Timeline Group Aberdeen Group plc in group Aberdeen Group plc More: the full row for Aberdeen Group plc 53,574 $1.3M <0.01% -65,815 13F-HR Timeline Group VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 29,670 $719K <0.01% 0 13F-HR Timeline Group PRELUDE CAPITAL MANAGEMENT, LLC More: the full row for PRELUDE CAPITAL MANAGEMENT, LLC 26,656 $646K 0.05% -23,444 13F-HR Timeline Campbell & CO Investment Adviser LLC More: the full row for Campbell & CO Investment Adviser LLC 25,845 $627K 0.05% +9,226 13F-HR Timeline JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 24,091 $584K <0.01% -70,274 13F-HR Timeline Group SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 23,586 $572K <0.01% new 13F-HR Timeline BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 21,319 $517K 0.01% -20,581 13F-HR Timeline Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 19,413 $471K <0.01% -20,347 13F-HR Timeline Group GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 18,761 $455K 0.04% new 13F-HR Timeline Meridian Wealth Partners, LLC More: the full row for Meridian Wealth Partners, LLC 18,101 $439K 0.06% -20,000 13F-HR Timeline OMERS ADMINISTRATION Corp More: the full row for OMERS ADMINISTRATION Corp 17,500 $424K <0.01% -37,700 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 16,816 $408K 0.03% -2,365 13F-HR Timeline Pictet Asset Management Holding SA in group Pictet Asset Management Holdi… More: the full row for Pictet Asset Management Holding SA 13,869 $336K <0.01% new 13F-HR Timeline Group Atria Investments, Inc More: the full row for Atria Investments, Inc 13,518 $328K <0.01% -411 13F-HR Timeline J. Goldman & Co LP More: the full row for J. Goldman & Co LP 13,105 $318K 0.01% -20,079 13F-HR Timeline Coastal Bridge Advisors, LLC More: the full row for Coastal Bridge Advisors, LLC 13,102 $318K 0.02% -6,551 13F-HR Timeline Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 9,451 $229K 0.07% +1,641 13F-HR Timeline Group DNB Asset Management AS in group DNB Asset Management AS More: the full row for DNB Asset Management AS 8,988 $218K <0.01% new 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 8,727 $212K <0.01% new 13F-HR Timeline Group Point72 Asia (Singapore) Pte. Ltd. More: the full row for Point72 Asia (Singapore) Pte. Ltd. 6,690 $162K 0.03% new 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 5,404 $131K <0.01% -2,094 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 4,968 $120K <0.01% -2,551 13F-HR/A Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 3,911 $94.8K <0.01% +3,432 13F-HR Timeline Group Mirae Asset Global Investments Co., Ltd. in group Mirae Asset Global Investment… More: the full row for Mirae Asset Global Investments Co., Ltd. 3,709 $89.9K <0.01% +20 13F-HR Timeline Group GAMMA Investing LLC More: the full row for GAMMA Investing LLC 3,612 $87.6K <0.01% +421 13F-HR Timeline Rockefeller Capital Management L.P. in group Rockefeller Capital Managemen… More: the full row for Rockefeller Capital Management L.P. 3,468 $84.1K <0.01% new 13F-HR Timeline Group SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 2,622 $63K <0.01% new 13F-HR Timeline GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 2,461 $59.7K <0.01% new 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 2,379 $57.7K <0.01% +2,229 13F-HR Timeline Group GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 2,064 $50.1K <0.01% -219 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 1,844 $44.7K <0.01% +23 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 1,198 $29.1K <0.01% -33,774 13F-HR Timeline Group ADIRONDACK TRUST CO More: the full row for ADIRONDACK TRUST CO 925 $22.4K 0.01% 0 13F-HR Timeline Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 481 $11.7K <0.01% -201 13F-HR Timeline Global Retirement Partners, LLC More: the full row for Global Retirement Partners, LLC 350 $8.49K <0.01% 0 13F-HR Timeline Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 294 $7K <0.01% 0 13F-HR Timeline Group Aspect Partners, LLC More: the full row for Aspect Partners, LLC 230 $5.58K <0.01% new 13F-HR Timeline Washington Trust Advisors, Inc. More: the full row for Washington Trust Advisors, Inc. 184 $4.46K <0.01% 0 13F-HR Timeline LANARK FINANCIAL, INC. More: the full row for LANARK FINANCIAL, INC. 138 $3.35K <0.01% 0 13F-HR Timeline Steward Partners Investment Advisory, L… More: the full row for Steward Partners Investment Advisory, LLC 81 $1.96K <0.01% new 13F-HR Timeline BELLEVUE ASSET MANAGEMENT, LLC More: the full row for BELLEVUE ASSET MANAGEMENT, LLC 70 $1.7K <0.01% new 13F-HR Timeline T. Rowe Price Investment Management, In… More: the full row for T. Rowe Price Investment Management, Inc. 20 $1K <0.01% -381 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 21 $509 <0.01% new 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 20 $485 <0.01% 0 13F-HR Timeline Group PRINCIPAL SECURITIES, INC. in group PRINCIPAL FINANCIAL GROUP INC More: the full row for PRINCIPAL SECURITIES, INC. 17 $412 <0.01% 0 13F-HR Timeline Group NOMURA ASSET MANAGEMENT CO LTD in group NOMURA ASSET MANAGEMENT CO LTD More: the full row for NOMURA ASSET MANAGEMENT CO LTD 0 $0 0% new 13F-HR Timeline Group Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.