Medicxi Ventures Management (Jersey) Ltd More: the full row for Medicxi Ventures Management (Jersey) Ltd 19,963,157 $287M 65.59% 0 13F-HR Timeline Index Venture Life Associates VI Ltd More: the full row for Index Venture Life Associates VI Ltd 9,961,789 $143M 100% 0 13F-HR Timeline GENERAL ATLANTIC, L.P. More: the full row for GENERAL ATLANTIC, L.P. 9,681,818 $139M 4.67% 0 13F-HR Timeline ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 6,954,000 $100M 0.19% +1,834,973 13F-HR Timeline Group JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 5,922,486 $86.4M 0.05% +1,012,999 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 5,342,344 $76.8M 0.01% -22,048 13F-HR Timeline First Light Asset Management, LLC More: the full row for First Light Asset Management, LLC 4,874,124 $70.1M 8% -931,060 13F-HR Timeline FARALLON CAPITAL MANAGEMENT, L.L.C. More: the full row for FARALLON CAPITAL MANAGEMENT, L.L.C. 4,334,318 $62.3M 0.34% +835,609 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. Avoro Capital Advisors LLC More: the full row for Avoro Capital Advisors LLC 4,050,000 $58.2M 0.91% new 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 3,826,194 $55M <0.01% +174,600 13F-HR Timeline Group PERCEPTIVE ADVISORS LLC in group PERCEPTIVE ADVISORS LLC More: the full row for PERCEPTIVE ADVISORS LLC 3,040,395 $43.7M 1.55% -3,308,825 13F-HR/A Timeline Group Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 2,960,029 $42.6M 2.4% -44,648 13F-HR/A Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 2,937,467 $42.2M <0.01% +1,012,958 13F-HR Timeline Group TCG Crossover Management, LLC More: the full row for TCG Crossover Management, LLC 2,890,816 $41.6M 5.67% 0 13F-HR Timeline FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 2,541,999 $36.6M 0.01% +233,453 13F-HR Timeline Group Commodore Capital LP in group Commodore Capital LP More: the full row for Commodore Capital LP 2,367,578 $34M 2.51% +149,153 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 2,286,433 $32.9M 0.09% -1,140,166 13F-HR/A Timeline Group Cormorant Asset Management, LP More: the full row for Cormorant Asset Management, LP 2,261,600 $32.5M 2.46% -300,000 13F-HR Timeline Holocene Advisors, LP More: the full row for Holocene Advisors, LP 2,255,679 $32.4M 0.1% new 13F-HR Timeline T. Rowe Price Investment Management, In… More: the full row for T. Rowe Price Investment Management, Inc. 1,753,248 $25.2M 0.02% -1,665,352 13F-HR Timeline Affinity Asset Advisors, LLC More: the full row for Affinity Asset Advisors, LLC 1,546,662 $22.2M 3.48% +450,738 13F-HR Timeline Octagon Capital Advisors LP More: the full row for Octagon Capital Advisors LP 1,425,000 $20.5M 4.03% -568,052 13F-HR/A Timeline Foresite Capital Management VI LLC in group Foresite Capital Management V… More: the full row for Foresite Capital Management VI LLC 1,253,379 $18M 9.87% 0 13F-HR Timeline Group BAKER BROS. ADVISORS LP in group BAKER BROS. ADVISORS LP More: the full row for BAKER BROS. ADVISORS LP 1,227,178 $17.6M 0.2% 0 13F-HR Timeline Group Driehaus Capital Management LLC More: the full row for Driehaus Capital Management LLC 1,095,533 $15.8M 0.15% -502,650 13F-HR Timeline AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 1,092,754 $15.7M 0.01% +13,046 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 899,505 $12.9M 0.02% +883,759 13F-HR Timeline Group 5AM Venture Management, LLC More: the full row for 5AM Venture Management, LLC 830,945 $11.9M 4.52% 0 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 706,331 $10.2M 0.01% +81,015 13F-HR Timeline Group Tanager Wealth Management LLP More: the full row for Tanager Wealth Management LLP 696,096 $10M 1.3% 0 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 609,188 $8.76M 0.01% +210,737 13F-HR Timeline Group STEMPOINT CAPITAL LP More: the full row for STEMPOINT CAPITAL LP 593,335 $8.53M 2.73% -48,629 13F-HR Timeline TD Asset Management Inc More: the full row for TD Asset Management Inc 588,122 $8.46M 0.01% -53,592 13F-HR Timeline PFM Health Sciences, LP More: the full row for PFM Health Sciences, LP 570,546 $8.2M 0.63% +198,780 13F-HR Timeline Nantahala Capital Management, LLC in group Nantahala Capital Management,… More: the full row for Nantahala Capital Management, LLC 554,803 $7.98M 0.66% +42,156 13F-HR Timeline Group Avidity Partners Management LP More: the full row for Avidity Partners Management LP 529,000 $7.61M 1.57% -636,800 13F-HR Timeline ARMISTICE CAPITAL, LLC More: the full row for ARMISTICE CAPITAL, LLC 468,000 $6.73M 0.18% new 13F-HR Timeline Saturn V Capital Management LP More: the full row for Saturn V Capital Management LP 448,692 $6.45M 3.26% new 13F-HR Timeline LORD, ABBETT & CO. LLC More: the full row for LORD, ABBETT & CO. LLC 446,196 $6.42M 0.02% +5,701 13F-HR Timeline Ensign Peak Advisors, Inc More: the full row for Ensign Peak Advisors, Inc 438,133 $6.3M 0.01% +359,133 13F-HR Timeline Cutter Capital Management, LP More: the full row for Cutter Capital Management, LP 418,127 $6.01M 2.62% +271,051 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 401,764 $5.78M <0.01% +226,198 13F-HR/A Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 400,278 $5.76M 0.04% -145,367 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 399,966 $5.75M <0.01% -100,958 13F-HR Timeline Group Allostery Investments LP More: the full row for Allostery Investments LP 382,524 $5.5M 7.93% +98,007 13F-HR Timeline Blue Owl Capital Holdings LP More: the full row for Blue Owl Capital Holdings LP 315,000 $4.53M 1.46% +95,000 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 302,646 $4.35M <0.01% -14,683 13F-HR Timeline Group Wildcat Capital Management, LLC More: the full row for Wildcat Capital Management, LLC 281,859 $4.05M 2.16% new 13F-HR Timeline Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 277,570 $3.99M 0.03% -87,630 13F-HR Timeline PLATINUM INVESTMENT MANAGEMENT LTD More: the full row for PLATINUM INVESTMENT MANAGEMENT LTD 267,887 $3.85M 0.22% -102,391 13F-HR Timeline Trexquant Investment LP More: the full row for Trexquant Investment LP 263,994 $3.8M 0.04% +2,810 13F-HR Timeline DZ BANK AG Deutsche Zentral Genossensch… in group DZ BANK AG Deutsche Zentral G… More: the full row for DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main 257,418 $3.7M <0.01% -46,061 13F-HR Timeline Group Ally Bridge Group (NY) LLC More: the full row for Ally Bridge Group (NY) LLC 243,086 $3.5M 3.15% -1,452 13F-HR Timeline HighMark Wealth Management LLC More: the full row for HighMark Wealth Management LLC 235,785 $3.39M 2% +69,650 13F-HR Timeline SILVERARC CAPITAL MANAGEMENT, LLC in group SILVERARC CAPITAL MANAGEMENT,… More: the full row for SILVERARC CAPITAL MANAGEMENT, LLC 232,758 $3.35M 0.7% -366,194 13F-HR Timeline Group Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 227,598 $3.27M <0.01% new 13F-HR Timeline Group ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 216,166 $3.11M 0.6% +62,139 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 207,028 $2.98M <0.01% +163,320 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 178,000 $2.56M <0.01% -600 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 167,732 $2.41M <0.01% -22,653 13F-HR Timeline Group DIADEMA PARTNERS LP More: the full row for DIADEMA PARTNERS LP 164,048 $2.36M 1.88% +32,186 13F-HR Timeline JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 151,296 $2.18M <0.01% new 13F-HR/A Timeline Group GREAT POINT PARTNERS LLC More: the full row for GREAT POINT PARTNERS LLC 149,702 $2.15M 1.17% new 13F-HR Timeline FRED ALGER MANAGEMENT, LLC in group FRED ALGER MANAGEMENT, LLC More: the full row for FRED ALGER MANAGEMENT, LLC 146,398 $2.11M 0.01% -44,053 13F-HR Timeline Group Exome Asset Management LLC More: the full row for Exome Asset Management LLC 142,744 $2.05M 1.84% +5,028 13F-HR/A Timeline WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 138,767 $2M <0.01% +23,660 13F-HR Timeline Group J. Goldman & Co LP More: the full row for J. Goldman & Co LP 136,674 $1.97M 0.07% -28,029 13F-HR Timeline MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 136,027 $1.96M <0.01% -3,705 13F-HR Timeline Group Windmill Hill Asset Management Ltd More: the full row for Windmill Hill Asset Management Ltd 117,913 $1.7M 0.52% new 13F-HR Timeline TUDOR INVESTMENT CORP ET AL More: the full row for TUDOR INVESTMENT CORP ET AL 105,925 $1.52M 0.01% new 13F-HR Timeline OAKMONT Corp More: the full row for OAKMONT Corp 92,064 $1.32M 0.26% new 13F-HR Timeline Aberdeen Group plc in group Aberdeen Group plc More: the full row for Aberdeen Group plc 90,883 $1.31M <0.01% new 13F-HR Timeline Group Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 82,199 $1.18M 0.01% new 13F-HR Timeline Group REGENTS OF THE UNIVERSITY OF CALIFORNIA More: the full row for REGENTS OF THE UNIVERSITY OF CALIFORNIA 81,884 $1.18M 0.25% new 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 76,051 $1.09M <0.01% +600 13F-HR Timeline Group LAZARD ASSET MANAGEMENT LLC in group LAZARD ASSET MANAGEMENT LLC More: the full row for LAZARD ASSET MANAGEMENT LLC 73,718 $1.06M <0.01% +529 13F-HR Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 73,483 $1.06M <0.01% -996,726 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 60,441 $869K <0.01% +3,184 13F-HR Timeline Group TANG CAPITAL MANAGEMENT LLC in group TANG CAPITAL MANAGEMENT LLC More: the full row for TANG CAPITAL MANAGEMENT LLC 50,000 $719K 0.04% new 13F-HR Timeline Group RTW INVESTMENTS, LP More: the full row for RTW INVESTMENTS, LP 50,000 $719K 0.01% 0 13F-HR Timeline Ellsworth Advisors, LLC More: the full row for Ellsworth Advisors, LLC 48,872 $703K 0.18% new 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 46,644 $671K <0.01% -1,462 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 42,862 $616K <0.01% +16,056 13F-HR/A Timeline Group Verition Fund Management LLC More: the full row for Verition Fund Management LLC 42,437 $610K <0.01% +6,242 13F-HR Timeline BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 41,900 $603K 0.02% 0 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 41,057 $590K 0.03% +18,377 13F-HR Timeline Group AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 40,868 $588K <0.01% +21,746 13F-HR Timeline Group HighVista Strategies LLC More: the full row for HighVista Strategies LLC 39,020 $561K 0.22% -7,096 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 38,174 $549K <0.01% +32,872 13F-HR/A Timeline Group Persistent Asset Partners Ltd More: the full row for Persistent Asset Partners Ltd 37,720 $542K 0.48% +19 13F-HR Timeline PRELUDE CAPITAL MANAGEMENT, LLC More: the full row for PRELUDE CAPITAL MANAGEMENT, LLC 35,800 $515K 0.05% 0 13F-HR Timeline Artia Global Partners LP More: the full row for Artia Global Partners LP 35,226 $507K 0.15% -45,154 13F-HR Timeline Cerity Partners LLC in group Cerity Partners LLC More: the full row for Cerity Partners LLC 32,754 $471K <0.01% new 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 31,446 $452K <0.01% new 13F-HR Timeline Group VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 29,670 $427K <0.01% 0 13F-HR/A Timeline Group Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 29,434 $423K <0.01% -77,624 13F-HR Timeline SummitTX Capital, L.P. More: the full row for SummitTX Capital, L.P. 28,381 $408K 0.02% 13F-HR Timeline Caption Management, LLC More: the full row for Caption Management, LLC 21,917 $315K 0.01% new 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 18,311 $263K 0.02% -598 13F-HR Timeline Rathbones Group PLC More: the full row for Rathbones Group PLC 16,500 $237K <0.01% -150 13F-HR Timeline Shay Capital LLC More: the full row for Shay Capital LLC 16,269 $234K 0.07% +2,000 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 15,785 $227K <0.01% new 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 15,300 $220K <0.01% -22,600 13F-HR Timeline Group Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 14,888 $214K 0.02% new 13F-HR Timeline Harbour Capital Advisors, LLC More: the full row for Harbour Capital Advisors, LLC 16,375 $214K 0.05% 0 13F-HR Timeline Graham Capital Management, L.P. More: the full row for Graham Capital Management, L.P. 14,617 $210K 0.01% new 13F-HR Timeline Atria Investments, Inc More: the full row for Atria Investments, Inc 13,547 $195K <0.01% -227 13F-HR Timeline OneAscent Financial Services LLC in group OneAscent Financial Services … More: the full row for OneAscent Financial Services LLC 13,216 $190K 0.01% new 13F-HR Timeline Group Engineers Gate Manager LP More: the full row for Engineers Gate Manager LP 12,090 $174K <0.01% new 13F-HR Timeline FOX RUN MANAGEMENT, L.L.C. More: the full row for FOX RUN MANAGEMENT, L.L.C. 11,111 $160K 0.02% new 13F-HR Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 10,257 $147K <0.01% new 13F-HR Timeline Group Virtus Investment Advisers, LLC group of 2 filers holding More: the full row for Virtus Investment Advisers, LLC 9,733 $140K +5,519 Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 6,755 $97K <0.01% -1,588 13F-HR/A Timeline Group GAMMA Investing LLC More: the full row for GAMMA Investing LLC 4,295 $61.8K <0.01% +458 13F-HR/A Timeline Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 3,215 $46.2K 0.03% +3,194 13F-HR Timeline Mirae Asset Global Investments Co., Ltd. in group Mirae Asset Global Investment… More: the full row for Mirae Asset Global Investments Co., Ltd. 3,055 $44.6K <0.01% +83 13F-HR Timeline Group GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 2,283 $32.8K <0.01% +411 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 1,330 $19.1K <0.01% +151 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 1,118 $16.1K <0.01% -8,554 13F-HR Timeline Group ADIRONDACK TRUST CO More: the full row for ADIRONDACK TRUST CO 925 $13.3K 0.01% 0 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 919 $13.2K <0.01% -942 13F-HR Timeline Group Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 755 $10.9K <0.01% -1,058 13F-HR Timeline NATIONAL BANK OF CANADA /FI/ in group NATIONAL BANK OF CANADA /FI/ More: the full row for NATIONAL BANK OF CANADA /FI/ 600 $8.62K <0.01% 0 13F-HR Timeline Group Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 294 $4K <0.01% 0 13F-HR Timeline Group Washington Trust Advisors, Inc. More: the full row for Washington Trust Advisors, Inc. 184 $2.65K <0.01% new 13F-HR Timeline BELLEVUE ASSET MANAGEMENT, LLC More: the full row for BELLEVUE ASSET MANAGEMENT, LLC 70 $1.01K <0.01% new 13F-HR Timeline LANARK FINANCIAL, INC. More: the full row for LANARK FINANCIAL, INC. 138 $1K <0.01% new 13F-HR Timeline CALDWELL SUTTER CAPITAL, INC. More: the full row for CALDWELL SUTTER CAPITAL, INC. 43 $618 <0.01% 0 13F-HR Timeline Bell Investment Advisors, Inc More: the full row for Bell Investment Advisors, Inc 31 $446 <0.01% 0 13F-HR Timeline CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.