Medicxi Ventures Management (Jersey) Ltd More: the full row for Medicxi Ventures Management (Jersey) Ltd 19,963,157 $319M 60.35% 0 13F-HR Timeline GENERAL ATLANTIC, L.P. More: the full row for GENERAL ATLANTIC, L.P. 9,681,818 $155M 4.4% 0 13F-HR Timeline PERCEPTIVE ADVISORS LLC in group PERCEPTIVE ADVISORS LLC More: the full row for PERCEPTIVE ADVISORS LLC 6,282,290 $100M 2.16% +2,348,983 13F-HR Timeline Group First Light Asset Management, LLC More: the full row for First Light Asset Management, LLC 5,940,132 $95M 7.9% +1,159,572 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 4,679,021 $74.8M 0.01% +1,148,648 13F-HR Timeline ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 4,195,000 $67.1M 0.12% +1,070,000 13F-HR Timeline Group Vida Ventures Advisors, LLC More: the full row for Vida Ventures Advisors, LLC 3,931,818 $62.9M 45.36% 0 13F-HR Timeline T. Rowe Price Investment Management, In… More: the full row for T. Rowe Price Investment Management, Inc. 3,556,023 $56.9M 0.03% +2,722,030 13F-HR Timeline Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 3,258,677 $52.1M 2.61% 13F-HR Timeline Group EcoR1 Capital, LLC More: the full row for EcoR1 Capital, LLC 3,223,851 $51.5M 1.77% -2,490,553 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 2,916,494 $46.6M <0.01% +129,300 13F-HR Timeline Group TCG Crossover Management, LLC More: the full row for TCG Crossover Management, LLC 2,890,816 $46.2M 3.92% 0 13F-HR Timeline FARALLON CAPITAL MANAGEMENT, L.L.C. More: the full row for FARALLON CAPITAL MANAGEMENT, L.L.C. 2,814,318 $45M 0.25% +818,318 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 2,715,663 $43.4M 0.15% +953,659 13F-HR Timeline Group Cormorant Asset Management, LP More: the full row for Cormorant Asset Management, LP 2,561,600 $41M 2.17% +950,000 13F-HR Timeline FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 2,302,546 $38.4M 0.01% +1,145,823 13F-HR/A Timeline Group Driehaus Capital Management LLC More: the full row for Driehaus Capital Management LLC 2,161,728 $34.6M 0.3% +69,717 13F-HR Timeline Avidity Partners Management LP More: the full row for Avidity Partners Management LP 2,132,000 $34.1M 1.74% new 13F-HR Timeline Octagon Capital Advisors LP More: the full row for Octagon Capital Advisors LP 2,012,052 $32.2M 5.15% -333,023 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 1,379,651 $22.1M <0.01% -670,741 13F-HR/A Timeline Group Commodore Capital LP in group Commodore Capital LP More: the full row for Commodore Capital LP 1,350,000 $21.6M 1.35% new 13F-HR Timeline Group Deep Track Capital, LP More: the full row for Deep Track Capital, LP 1,350,000 $21.6M 0.69% new 13F-HR Timeline JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 1,294,864 $20.7M 0.01% new 13F-HR Timeline Group 5AM Venture Management, LLC More: the full row for 5AM Venture Management, LLC 1,285,000 $20.5M 4.25% +40,000 13F-HR Timeline BAKER BROS. ADVISORS LP in group BAKER BROS. ADVISORS LP More: the full row for BAKER BROS. ADVISORS LP 1,227,178 $19.6M 0.2% +677,966 13F-HR Timeline Group AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 1,139,546 $18.2M 0.01% +204,395 13F-HR Timeline Group Affinity Asset Advisors, LLC More: the full row for Affinity Asset Advisors, LLC 965,612 $15.4M 2.4% -170,090 13F-HR Timeline SILVERARC CAPITAL MANAGEMENT, LLC in group SILVERARC CAPITAL MANAGEMENT,… More: the full row for SILVERARC CAPITAL MANAGEMENT, LLC 744,592 $11.9M 2.68% new 13F-HR Timeline Group Tanager Wealth Management LLP More: the full row for Tanager Wealth Management LLP 696,096 $11.1M 1.5% 0 13F-HR Timeline Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 681,421 $10.9M 0.03% -341,701 13F-HR Timeline Group Polar Capital Holdings Plc in group Polar Capital Holdings Plc More: the full row for Polar Capital Holdings Plc 640,000 $10.2M 0.05% new 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 587,518 $9.39M 0.01% +549,242 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 559,720 $8.95M <0.01% 13F-HR Timeline Group TD Asset Management Inc More: the full row for TD Asset Management Inc 558,714 $8.82M 0.01% +237,546 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 516,379 $8.26M 0.07% +392,918 13F-HR Timeline Nantahala Capital Management, LLC in group Nantahala Capital Management,… More: the full row for Nantahala Capital Management, LLC 512,647 $8.2M 0.69% +62,647 13F-HR Timeline Group PLATINUM INVESTMENT MANAGEMENT LTD More: the full row for PLATINUM INVESTMENT MANAGEMENT LTD 429,701 $6.87M 0.31% -66,194 13F-HR Timeline TANG CAPITAL MANAGEMENT LLC in group TANG CAPITAL MANAGEMENT LLC More: the full row for TANG CAPITAL MANAGEMENT LLC 400,000 $6.4M 0.46% new 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 313,338 $5.01M <0.01% +240,061 13F-HR Timeline Group Ally Bridge Group (NY) LLC More: the full row for Ally Bridge Group (NY) LLC 309,614 $4.95M 2.65% new 13F-HR Timeline LORD, ABBETT & CO. LLC More: the full row for LORD, ABBETT & CO. LLC 269,205 $4.3M 0.01% new 13F-HR/A Timeline PFM Health Sciences, LP More: the full row for PFM Health Sciences, LP 269,158 $4.3M 0.25% -366,485 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 264,969 $4.24M <0.01% +124,075 13F-HR Timeline Group Blue Owl Capital Holdings LP More: the full row for Blue Owl Capital Holdings LP 255,000 $4.08M 0.79% new 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 230,379 $3.68M <0.01% +180,894 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 209,600 $3.35M 0.01% +35,900 13F-HR Timeline MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 180,853 $2.89M <0.01% -44,095 13F-HR Timeline Group FRED ALGER MANAGEMENT, LLC in group FRED ALGER MANAGEMENT, LLC More: the full row for FRED ALGER MANAGEMENT, LLC 177,553 $2.84M 0.01% +166,560 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 177,260 $2.83M <0.01% new 13F-HR Timeline Group Trexquant Investment LP More: the full row for Trexquant Investment LP 170,951 $2.73M 0.03% +127,203 13F-HR Timeline HighMark Wealth Management LLC More: the full row for HighMark Wealth Management LLC 167,135 $2.67M 1.46% +74,135 13F-HR Timeline Monashee Investment Management LLC More: the full row for Monashee Investment Management LLC 161,293 $2.58M 0.28% +58,102 13F-HR Timeline Exome Asset Management LLC More: the full row for Exome Asset Management LLC 138,152 $2.21M 1.49% -136,748 13F-HR/A Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 135,903 $2.17M <0.01% +129,335 13F-HR/A Timeline Group Cubist Systematic Strategies, LLC More: the full row for Cubist Systematic Strategies, LLC 134,120 $2.14M 0.03% +108,047 13F-HR Timeline DAFNA Capital Management LLC More: the full row for DAFNA Capital Management LLC 120,351 $1.92M 0.45% -2,531 13F-HR Timeline TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 103,908 $1.66M <0.01% +52,108 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 100,613 $1.61M <0.01% new 13F-HR Timeline Group Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 96,515 $1.54M <0.01% +92,992 13F-HR Timeline GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 93,658 $1.5M 0.11% +37,275 13F-HR Timeline STEMPOINT CAPITAL LP More: the full row for STEMPOINT CAPITAL LP 83,662 $1.34M 0.4% new 13F-HR Timeline Artia Global Partners LP More: the full row for Artia Global Partners LP 80,380 $1.29M 0.36% new 13F-HR Timeline Ensign Peak Advisors, Inc More: the full row for Ensign Peak Advisors, Inc 79,000 $1.26M <0.01% new 13F-HR Timeline MONTANOVA CAPITAL, LLC More: the full row for MONTANOVA CAPITAL, LLC 70,000 $1.12M 0.04% new 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 56,597 $905K <0.01% +23,058 13F-HR Timeline Group RTW INVESTMENTS, LP More: the full row for RTW INVESTMENTS, LP 50,000 $800K 0.01% new 13F-HR Timeline Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 49,111 $785K 0.02% +24,735 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 48,592 $777K <0.01% new 13F-HR Timeline Group D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 48,078 $769K <0.01% new 13F-HR Timeline Group HighVista Strategies LLC More: the full row for HighVista Strategies LLC 46,116 $737K 0.25% new 13F-HR Timeline PRELUDE CAPITAL MANAGEMENT, LLC More: the full row for PRELUDE CAPITAL MANAGEMENT, LLC 36,900 $590K 0.05% -32,000 13F-HR/A Timeline TWO SIGMA SECURITIES, LLC More: the full row for TWO SIGMA SECURITIES, LLC 32,917 $526K 0.04% new 13F-HR Timeline Rathbones Group PLC More: the full row for Rathbones Group PLC 30,400 $486K <0.01% -900 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 27,884 $446K <0.01% new 13F-HR Timeline Group ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 23,302 $373K 0.06% -229,895 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 20,121 $322K <0.01% new 13F-HR Timeline Group Lynx1 Capital Management LP in group Lynx1 Capital Management LP More: the full row for Lynx1 Capital Management LP 17,400 $278K 0.1% 0 13F-HR Timeline Group Atria Investments, Inc More: the full row for Atria Investments, Inc 17,134 $274K <0.01% +1,116 13F-HR Timeline Harbour Capital Advisors, LLC More: the full row for Harbour Capital Advisors, LLC 16,675 $259K 0.06% new 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 14,094 $225K <0.01% +12,866 13F-HR Timeline Group EntryPoint Capital, LLC More: the full row for EntryPoint Capital, LLC 13,651 $218K 0.12% +5,515 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 13,593 $217K 0.02% +6,785 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 13,055 $209K <0.01% new 13F-HR Timeline Group Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 11,721 $187K <0.01% new 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 10,174 $163K 0.01% -6,211 13F-HR Timeline Group VIRTUS ADVISERS, LLC in group Virtus Investment Advisers, L… More: the full row for VIRTUS ADVISERS, LLC 9,285 $148K 0.07% +169 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 6,279 $101K <0.01% +5,162 13F-HR Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 5,007 $80.1K <0.01% +2,198 13F-HR Timeline Group Sandia Investment Management LP More: the full row for Sandia Investment Management LP 5,000 $80K 0.13% -5,000 13F-HR Timeline Advisors Preferred, LLC in group Advisors Preferred, LLC More: the full row for Advisors Preferred, LLC 4,555 $78.3K 0.01% new 13F-HR Timeline Group GAMMA Investing LLC More: the full row for GAMMA Investing LLC 2,972 $47.5K <0.01% +1,509 13F-HR Timeline Mirae Asset Global Investments Co., Ltd. in group Mirae Asset Global Investment… More: the full row for Mirae Asset Global Investments Co., Ltd. 2,556 $40.4K <0.01% +826 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 2,289 $36.6K <0.01% +991 13F-HR Timeline Group Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 2,199 $35.2K <0.01% -35 13F-HR/A Timeline Ascentis Independent Advisors in group Ascentis Wealth Management, L… More: the full row for Ascentis Independent Advisors 1,700 $27.2K <0.01% new 13F-HR Timeline Group ADIRONDACK TRUST CO More: the full row for ADIRONDACK TRUST CO 925 $14.8K 0.01% 0 13F-HR Timeline Global Retirement Partners, LLC More: the full row for Global Retirement Partners, LLC 700 $11.2K <0.01% 0 13F-HR Timeline Blue Trust, Inc. More: the full row for Blue Trust, Inc. 1,015 $9.16K <0.01% +306 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 350 $5.6K <0.01% new 13F-HR/A Timeline Group Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 211 $3K <0.01% 0 13F-HR Timeline Group LANARK FINANCIAL, INC. More: the full row for LANARK FINANCIAL, INC. 138 $2K <0.01% 0 13F-HR Timeline CALDWELL SUTTER CAPITAL, INC. More: the full row for CALDWELL SUTTER CAPITAL, INC. 86 $1.38K <0.01% 0 13F-HR Timeline SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 108 $1K <0.01% new 13F-HR Timeline CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.