Medicxi Ventures Management (Jersey) Ltd More: the full row for Medicxi Ventures Management (Jersey) Ltd 19,963,157 $262M 61.4% 0 13F-HR Timeline Index Venture Life Associates VI Ltd More: the full row for Index Venture Life Associates VI Ltd 9,961,789 $131M 100% 0 13F-HR Timeline GENERAL ATLANTIC, L.P. More: the full row for GENERAL ATLANTIC, L.P. 9,681,818 $127M 3.51% 0 13F-HR Timeline ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 8,403,000 $110M 0.19% +1,449,000 13F-HR Timeline Group JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 6,532,768 $85.8M 0.04% +610,282 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 5,907,992 $77.6M 0.01% +565,648 13F-HR Timeline Avoro Capital Advisors LLC More: the full row for Avoro Capital Advisors LLC 5,000,000 $65.7M 1.15% +950,000 13F-HR Timeline FARALLON CAPITAL MANAGEMENT, L.L.C. More: the full row for FARALLON CAPITAL MANAGEMENT, L.L.C. 4,529,318 $59.5M 0.27% +195,000 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. First Light Asset Management, LLC More: the full row for First Light Asset Management, LLC 4,293,411 $56.4M 7.31% -580,713 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 3,826,194 $50.3M <0.01% 0 13F-HR Timeline Group Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 3,460,029 $45.5M 2.35% +500,000 13F-HR Timeline Group Commodore Capital LP in group Commodore Capital LP More: the full row for Commodore Capital LP 3,298,289 $43.3M 3.06% +930,711 13F-HR Timeline Group TCG Crossover Management, LLC More: the full row for TCG Crossover Management, LLC 2,890,816 $38M 4.34% 0 13F-HR Timeline Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 2,591,596 $34.1M 0.08% +305,163 13F-HR Timeline Group FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 2,543,539 $33.4M 0.01% +1,540 13F-HR Timeline Group Cormorant Asset Management, LP More: the full row for Cormorant Asset Management, LP 2,086,600 $27.4M 2.04% -175,000 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 1,793,471 $23.6M <0.01% -1,143,996 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 1,657,887 $21.8M 0.02% +1,048,699 13F-HR Timeline Group RTW INVESTMENTS, LP More: the full row for RTW INVESTMENTS, LP 1,529,836 $20.1M 0.29% +1,479,836 13F-HR Timeline STEMPOINT CAPITAL LP More: the full row for STEMPOINT CAPITAL LP 1,265,672 $16.6M 5.35% +672,337 13F-HR Timeline Foresite Capital Management VI LLC in group Foresite Capital Management V… More: the full row for Foresite Capital Management VI LLC 1,253,379 $16.5M 9.26% 0 13F-HR Timeline Group Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 1,221,610 $16.1M 0.04% new 13F-HR Timeline Group PERCEPTIVE ADVISORS LLC in group PERCEPTIVE ADVISORS LLC More: the full row for PERCEPTIVE ADVISORS LLC 1,146,935 $15.1M 0.57% -1,893,460 13F-HR Timeline Group AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 1,130,708 $14.9M 0.01% +37,954 13F-HR Timeline Group Octagon Capital Advisors LP More: the full row for Octagon Capital Advisors LP 1,030,000 $13.5M 2.97% -395,000 13F-HR Timeline Polar Capital Holdings Plc in group Polar Capital Holdings Plc More: the full row for Polar Capital Holdings Plc 1,000,000 $13.1M 0.07% new 13F-HR Timeline Group Affinity Asset Advisors, LLC More: the full row for Affinity Asset Advisors, LLC 900,162 $11.8M 1.75% -646,500 13F-HR Timeline 5AM Venture Management, LLC More: the full row for 5AM Venture Management, LLC 830,945 $10.9M 4.2% 0 13F-HR Timeline Saturn V Capital Management LP More: the full row for Saturn V Capital Management LP 793,327 $10.4M 4.22% +344,635 13F-HR Timeline Tanager Wealth Management LLP More: the full row for Tanager Wealth Management LLP 598,044 $7.86M 0.93% -98,052 13F-HR Timeline Ensign Peak Advisors, Inc More: the full row for Ensign Peak Advisors, Inc 559,744 $7.36M 0.01% +121,611 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 559,283 $7.35M <0.01% +157,519 13F-HR Timeline Group Nantahala Capital Management, LLC in group Nantahala Capital Management,… More: the full row for Nantahala Capital Management, LLC 554,803 $7.29M 0.52% 0 13F-HR Timeline Group TD Asset Management Inc More: the full row for TD Asset Management Inc 553,292 $7.27M 0.01% -34,830 13F-HR Timeline Driehaus Capital Management LLC More: the full row for Driehaus Capital Management LLC 510,779 $6.71M 0.05% -584,754 13F-HR Timeline Deep Track Capital, LP More: the full row for Deep Track Capital, LP 500,000 $6.57M 0.21% new 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 428,434 $5.63M <0.01% +260,702 13F-HR Timeline Group Capital World Investors More: the full row for Capital World Investors 416,823 $5.48M <0.01% new 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 400,278 $5.26M 0.03% 0 13F-HR Timeline ARMISTICE CAPITAL, LLC More: the full row for ARMISTICE CAPITAL, LLC 400,000 $5.26M 0.2% -68,000 13F-HR Timeline RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 384,900 $5.06M 0.01% +206,900 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 381,125 $5.01M <0.01% -18,841 13F-HR Timeline Group Candriam S.C.A. More: the full row for Candriam S.C.A. 347,599 $4.57M 0.03% new 13F-HR Timeline PFM Health Sciences, LP More: the full row for PFM Health Sciences, LP 344,972 $4.53M 0.39% -225,574 13F-HR Timeline MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 343,318 $4.51M 0.01% +207,291 13F-HR Timeline Group Blue Owl Capital Holdings LP More: the full row for Blue Owl Capital Holdings LP 330,600 $4.34M 1.4% +15,600 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 317,574 $4.17M <0.01% +14,928 13F-HR Timeline Group Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 307,880 $4.05M 0.01% +278,446 13F-HR Timeline ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 296,766 $3.9M 0.63% +80,600 13F-HR Timeline Group Ally Bridge Group (NY) LLC More: the full row for Ally Bridge Group (NY) LLC 293,986 $3.86M 3.21% +50,900 13F-HR Timeline PLATINUM INVESTMENT MANAGEMENT LTD More: the full row for PLATINUM INVESTMENT MANAGEMENT LTD 290,836 $3.82M 0.25% +22,949 13F-HR Timeline Cubist Systematic Strategies, LLC More: the full row for Cubist Systematic Strategies, LLC 276,452 $3.63M 0.04% new 13F-HR Timeline DZ BANK AG Deutsche Zentral Genossensch… in group DZ BANK AG Deutsche Zentral G… More: the full row for DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main 257,418 $3.38M <0.01% 0 13F-HR Timeline Group HighMark Wealth Management LLC More: the full row for HighMark Wealth Management LLC 237,285 $3.12M 1.52% +1,500 13F-HR Timeline GREAT POINT PARTNERS LLC More: the full row for GREAT POINT PARTNERS LLC 225,000 $2.96M 1.92% +75,298 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 209,750 $2.76M <0.01% +136,267 13F-HR Timeline Group Exome Asset Management LLC More: the full row for Exome Asset Management LLC 166,944 $2.19M 1.81% +24,200 13F-HR/A Timeline Windmill Hill Asset Management Ltd More: the full row for Windmill Hill Asset Management Ltd 163,768 $2.15M 0.59% +45,855 13F-HR Timeline Trexquant Investment LP More: the full row for Trexquant Investment LP 151,352 $1.99M 0.02% -112,642 13F-HR Timeline WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 149,451 $1.96M <0.01% +10,684 13F-HR Timeline Group Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 140,965 $1.85M <0.01% -86,633 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 135,798 $1.78M <0.01% -71,230 13F-HR Timeline Group LAZARD ASSET MANAGEMENT LLC in group LAZARD ASSET MANAGEMENT LLC More: the full row for LAZARD ASSET MANAGEMENT LLC 131,351 $1.73M <0.01% +57,633 13F-HR Timeline Group FRED ALGER MANAGEMENT, LLC in group FRED ALGER MANAGEMENT, LLC More: the full row for FRED ALGER MANAGEMENT, LLC 123,756 $1.63M 0.01% -22,642 13F-HR Timeline Group Aberdeen Group plc in group Aberdeen Group plc More: the full row for Aberdeen Group plc 119,389 $1.57M <0.01% +28,506 13F-HR Timeline Group Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 118,163 $1.55M 0.01% -159,407 13F-HR Timeline Bollard Group LLC More: the full row for Bollard Group LLC 100,362 $1.32M 0.03% new 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 98,256 $1.29M <0.01% +22,205 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 94,365 $1.24M <0.01% -56,931 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 87,435 $1.15M <0.01% +26,994 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 72,144 $948K <0.01% +56,844 13F-HR Timeline Group OMERS ADMINISTRATION Corp More: the full row for OMERS ADMINISTRATION Corp 55,200 $725K 0.01% new 13F-HR Timeline Allostery Investments LP More: the full row for Allostery Investments LP 52,500 $690K 8.79% -330,024 13F-HR Timeline TUDOR INVESTMENT CORP ET AL More: the full row for TUDOR INVESTMENT CORP ET AL 50,851 $668K 0.01% -55,074 13F-HR Timeline PRELUDE CAPITAL MANAGEMENT, LLC More: the full row for PRELUDE CAPITAL MANAGEMENT, LLC 50,100 $658K 0.06% +14,300 13F-HR Timeline TANG CAPITAL MANAGEMENT LLC in group TANG CAPITAL MANAGEMENT LLC More: the full row for TANG CAPITAL MANAGEMENT LLC 50,000 $657K 0.03% 0 13F-HR Timeline Group Y-Intercept (Hong Kong) Ltd More: the full row for Y-Intercept (Hong Kong) Ltd 46,665 $613K 0.01% new 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 45,912 $603K <0.01% -732 13F-HR Timeline Group BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 41,900 $551K 0.02% 0 13F-HR Timeline HighVista Strategies LLC More: the full row for HighVista Strategies LLC 40,684 $535K 0.2% +1,664 13F-HR Timeline Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 39,760 $522K <0.01% -3,102 13F-HR/A Timeline Group VOLORIDGE INVESTMENT MANAGEMENT, LLC More: the full row for VOLORIDGE INVESTMENT MANAGEMENT, LLC 39,379 $517K <0.01% new 13F-HR Timeline Meridian Wealth Partners, LLC More: the full row for Meridian Wealth Partners, LLC 38,101 $501K 0.07% new 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 35,898 $472K 0.02% -5,159 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 34,972 $460K <0.01% +33,854 13F-HR Timeline Group J. Goldman & Co LP More: the full row for J. Goldman & Co LP 33,184 $436K 0.01% -103,490 13F-HR Timeline VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 29,670 $390K <0.01% 0 13F-HR Timeline Group Coastal Bridge Advisors, LLC More: the full row for Coastal Bridge Advisors, LLC 19,653 $258K 0.02% new 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 19,181 $252K 0.02% +870 13F-HR Timeline Campbell & CO Investment Adviser LLC More: the full row for Campbell & CO Investment Adviser LLC 16,619 $218K 0.01% new 13F-HR Timeline Rathbones Group PLC More: the full row for Rathbones Group PLC 16,500 $217K <0.01% 0 13F-HR Timeline D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 15,764 $207K <0.01% new 13F-HR Timeline Group Atria Investments, Inc More: the full row for Atria Investments, Inc 13,929 $183K <0.01% +382 13F-HR Timeline OneAscent Financial Services LLC in group OneAscent Financial Services … More: the full row for OneAscent Financial Services LLC 12,324 $162K 0.01% -892 13F-HR Timeline Group Engineers Gate Manager LP More: the full row for Engineers Gate Manager LP 11,356 $149K <0.01% -734 13F-HR Timeline Quarry LP More: the full row for Quarry LP 8,999 $118K 0.03% new 13F-HR Timeline Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 7,810 $103K 0.03% -1,923 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 7,519 $98.8K <0.01% -30,655 13F-HR/A Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 7,498 $98K <0.01% +743 13F-HR/A Timeline Group SILVERARC CAPITAL MANAGEMENT, LLC in group SILVERARC CAPITAL MANAGEMENT,… More: the full row for SILVERARC CAPITAL MANAGEMENT, LLC 5,000 $65.7K 0.01% -227,758 13F-HR Timeline Group Mirae Asset Global Investments Co., Ltd. in group Mirae Asset Global Investment… More: the full row for Mirae Asset Global Investments Co., Ltd. 3,689 $48.5K <0.01% +634 13F-HR Timeline Group GAMMA Investing LLC More: the full row for GAMMA Investing LLC 3,191 $41.9K <0.01% -1,104 13F-HR Timeline GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 2,283 $30K <0.01% 0 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 1,821 $23.9K <0.01% +491 13F-HR Timeline Group Clearstead Advisors, LLC More: the full row for Clearstead Advisors, LLC 1,638 $21.5K <0.01% new 13F-HR Timeline NATIONAL BANK OF CANADA /FI/ in group NATIONAL BANK OF CANADA /FI/ More: the full row for NATIONAL BANK OF CANADA /FI/ 1,600 $21K <0.01% +1,000 13F-HR/A Timeline Group ADIRONDACK TRUST CO More: the full row for ADIRONDACK TRUST CO 925 $12.2K <0.01% 0 13F-HR Timeline Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 682 $8.96K <0.01% -73 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 479 $6.29K <0.01% -440 13F-HR Timeline Group T. Rowe Price Investment Management, In… More: the full row for T. Rowe Price Investment Management, Inc. 401 $6K <0.01% -1,752,847 13F-HR Timeline Global Retirement Partners, LLC More: the full row for Global Retirement Partners, LLC 350 $4.6K <0.01% 13F-HR Timeline Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 294 $4K <0.01% 0 13F-HR Timeline Group Washington Trust Advisors, Inc. More: the full row for Washington Trust Advisors, Inc. 184 $2.42K <0.01% 0 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 150 $1.97K <0.01% -31,296 13F-HR Timeline Group LANARK FINANCIAL, INC. More: the full row for LANARK FINANCIAL, INC. 138 $1K <0.01% 0 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 20 $263 <0.01% new 13F-HR Timeline Group PRINCIPAL SECURITIES, INC. in group PRINCIPAL FINANCIAL GROUP INC More: the full row for PRINCIPAL SECURITIES, INC. 17 $223 <0.01% new 13F-HR Timeline Group CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.