JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 6,738,556 $360M 0.18% -330,092 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 5,779,412 $308M 0.01% -475,612 13F-HR Timeline Group GENERAL ATLANTIC, L.P. More: the full row for GENERAL ATLANTIC, L.P. 5,733,989 $306M 8.43% +500,000 13F-HR Timeline RTW INVESTMENTS, LP More: the full row for RTW INVESTMENTS, LP 5,477,561 $292M 4.16% -1,941,779 13F-HR Timeline VANGUARD GROUP INC group of 2 filers holding More: the full row for VANGUARD GROUP INC 4,534,282 $242M +303,638 Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 4,509,325 $241M 0.03% -307,766 13F-HR Timeline Avoro Capital Advisors LLC More: the full row for Avoro Capital Advisors LLC 3,500,000 $187M 3.27% new 13F-HR Timeline WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 3,409,946 $182M 0.03% -2,526,294 13F-HR Timeline Group Deep Track Capital, LP More: the full row for Deep Track Capital, LP 3,042,598 $162M 5.22% -167,672 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 2,745,564 $147M 0.01% +250,821 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 2,710,929 $145M 0.34% +2,202,589 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 2,467,350 $132M 0.7% +1,986,614 13F-HR Timeline UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 2,190,452 $117M -75,863 Timeline Bellevue Group AG in group Bellevue Group AG More: the full row for Bellevue Group AG 1,985,272 $106M 2.33% +734,606 13F-HR Timeline Group ALKEON CAPITAL MANAGEMENT LLC More: the full row for ALKEON CAPITAL MANAGEMENT LLC 1,850,934 $98.8M 0.48% +300,000 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 1,722,405 $91.9M 0.01% -26,789 13F-HR Timeline Group ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 1,536,200 $82M 0.03% +284,831 13F-HR Timeline MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 1,418,215 $75.7M 0.09% -189,627 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 1,320,461 $70.5M 0.01% +1,059,860 13F-HR Timeline Group Logos Global Management LP More: the full row for Logos Global Management LP 1,200,000 $64M 8.55% 0 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 1,169,682 $62.4M 0.05% -739,648 13F-HR Timeline Group Holocene Advisors, LP More: the full row for Holocene Advisors, LP 1,075,642 $57.4M 0.14% new 13F-HR Timeline Pictet Asset Management Holding SA in group Pictet Asset Management Holdi… More: the full row for Pictet Asset Management Holding SA 986,633 $52.8M 0.05% +671,922 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 931,926 $49.7M <0.01% -77,201 13F-HR Timeline Group PERCEPTIVE ADVISORS LLC in group PERCEPTIVE ADVISORS LLC More: the full row for PERCEPTIVE ADVISORS LLC 915,887 $48.9M 1.83% +122,927 13F-HR Timeline Group Redmile Group, LLC in group Redmile Group, LLC More: the full row for Redmile Group, LLC 774,311 $41.3M 4.4% -164,966 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 765,741 $40.9M 0.01% +277,349 13F-HR Timeline Group Long Focus Capital Management, LLC More: the full row for Long Focus Capital Management, LLC 720,000 $38.4M 2.48% -9,504 13F-HR Timeline SILVERARC CAPITAL MANAGEMENT, LLC in group SILVERARC CAPITAL MANAGEMENT,… More: the full row for SILVERARC CAPITAL MANAGEMENT, LLC 713,811 $38.1M 7.8% -6,181 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 693,256 $37M <0.01% -109,598 13F-HR Timeline Group READYSTATE ASSET MANAGEMENT LP More: the full row for READYSTATE ASSET MANAGEMENT LP 640,923 $34.2M 1.42% +540,423 13F-HR Timeline Rock Springs Capital Management LP More: the full row for Rock Springs Capital Management LP 640,526 $34.2M 2.13% -32,233 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 634,326 $33.8M <0.01% -22,407 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 614,266 $32.8M 0.01% +32,012 13F-HR Timeline Group DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 573,688 $30.6M 0.01% +47,046 13F-HR Timeline Group Sofinnova Investments, Inc. More: the full row for Sofinnova Investments, Inc. 548,788 $29.3M 1.99% +38,768 13F-HR Timeline LOOMIS SAYLES & CO L P in group LOOMIS SAYLES & CO L P More: the full row for LOOMIS SAYLES & CO L P 540,788 $28.9M 0.04% +51,850 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 533,416 $28.5M 0.01% +410,253 13F-HR/A Timeline Group EcoR1 Capital, LLC More: the full row for EcoR1 Capital, LLC 440,000 $23.5M 1.39% 0 13F-HR Timeline Vivo Capital, LLC More: the full row for Vivo Capital, LLC 434,689 $23.2M 2.37% +233,521 13F-HR Timeline EMERALD ADVISERS, LLC group of 2 filers holding More: the full row for EMERALD ADVISERS, LLC 427,989 $22.8M -73,448 Timeline VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 417,423 $22.3M 0.02% +334,952 13F-HR Timeline Group Aberdeen Group plc in group Aberdeen Group plc More: the full row for Aberdeen Group plc 391,600 $20.9M 0.04% -15,100 13F-HR Timeline Group PRINCIPAL FINANCIAL GROUP INC in group PRINCIPAL FINANCIAL GROUP INC More: the full row for PRINCIPAL FINANCIAL GROUP INC 390,174 $20.8M 0.01% +133,149 13F-HR Timeline Group Hudson Bay Capital Management LP in group Hudson Bay Capital Management… More: the full row for Hudson Bay Capital Management LP 386,523 $20.6M 0.14% +84,573 13F-HR/A Timeline Group SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT… in group SUMMIT PARTNERS PUBLIC ASSET … More: the full row for SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC 366,997 $19.6M 0.76% -213,003 13F-HR Timeline Group Frazier Life Sciences Management, L.P. More: the full row for Frazier Life Sciences Management, L.P. 366,784 $19.6M 0.78% new 13F-HR Timeline Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 366,769 $19.6M 0.01% +58,443 13F-HR Timeline Group Jain Global LLC More: the full row for Jain Global LLC 345,372 $18.4M 0.29% +222,475 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 341,998 $18.2M 0.01% +107,868 13F-HR Timeline Group University of Wisconsin Foundation More: the full row for University of Wisconsin Foundation 328,504 $17.5M 19.61% 0 13F-HR Timeline BAKER BROS. ADVISORS LP in group BAKER BROS. ADVISORS LP More: the full row for BAKER BROS. ADVISORS LP 324,630 $17.3M 0.17% -224,083 13F-HR Timeline Group Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 318,647 $17M 0.88% new 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 314,989 $16.8M 0.02% +84,125 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 313,493 $16.7M <0.01% -18,890 13F-HR Timeline Group FRED ALGER MANAGEMENT, LLC in group FRED ALGER MANAGEMENT, LLC More: the full row for FRED ALGER MANAGEMENT, LLC 310,569 $16.6M 0.07% -204,755 13F-HR Timeline Group Yiheng Capital Management, L.P. More: the full row for Yiheng Capital Management, L.P. 299,791 $16M 5.79% -60,000 13F-HR Timeline ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 295,000 $15.7M 0.03% +100,000 13F-HR Timeline Group AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 273,445 $14.6M <0.01% +193,978 13F-HR Timeline Group PFM Health Sciences, LP More: the full row for PFM Health Sciences, LP 266,167 $14.2M 1.23% new 13F-HR Timeline Foresite Capital Management VI LLC in group Foresite Capital Management V… More: the full row for Foresite Capital Management VI LLC 244,900 $13.1M 7.35% -120,100 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 237,683 $12.7M <0.01% +25,018 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 3 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 237,590 $12.7M +32,479 Timeline B Group, Inc. More: the full row for B Group, Inc. 232,446 $12.4M 10.71% -10,054 13F-HR Timeline Propel Bio Management, LLC More: the full row for Propel Bio Management, LLC 228,884 $12.2M 14.82% 0 13F-HR Timeline Eagle Health Investments LP More: the full row for Eagle Health Investments LP 226,400 $12.1M 2.98% 0 13F-HR Timeline Ikarian Capital, LLC in group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 220,000 $11.7M 3.88% -25,000 13F-HR Timeline Group ORBIMED ADVISORS LLC in group ORBIMED ADVISORS LLC More: the full row for ORBIMED ADVISORS LLC 211,300 $11.3M 0.28% +31,400 13F-HR Timeline Group EVENTIDE ASSET MANAGEMENT, LLC More: the full row for EVENTIDE ASSET MANAGEMENT, LLC 200,000 $10.7M 0.19% -534 13F-HR Timeline Rhenman & Partners Asset Management AB More: the full row for Rhenman & Partners Asset Management AB 197,600 $10.5M 1.33% +105,100 13F-HR Timeline TD Asset Management Inc More: the full row for TD Asset Management Inc 191,448 $10.2M 0.01% -17,400 13F-HR Timeline Ensign Peak Advisors, Inc More: the full row for Ensign Peak Advisors, Inc 188,409 $10.1M 0.02% +33,365 13F-HR Timeline Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 167,305 $8.93M <0.01% +50,184 13F-HR Timeline Group SCHRODER INVESTMENT MANAGEMENT GROUP More: the full row for SCHRODER INVESTMENT MANAGEMENT GROUP 149,431 $7.97M 0.01% +32,824 13F-HR Timeline Simplify Asset Management Inc. More: the full row for Simplify Asset Management Inc. 145,609 $7.77M 0.47% 0 13F-HR Timeline Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 141,306 $7.54M 0.06% -172,625 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 138,834 $7.41M 0.01% -12,456 13F-HR Timeline Group Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 134,939 $7.2M 0.01% -23,336 13F-HR Timeline Group Avidity Partners Management LP More: the full row for Avidity Partners Management LP 134,000 $7.15M 1.43% +77,000 13F-HR Timeline STEMPOINT CAPITAL LP More: the full row for STEMPOINT CAPITAL LP 116,779 $6.23M 2.01% -39,406 13F-HR Timeline First Turn Management, LLC More: the full row for First Turn Management, LLC 114,554 $6.11M 1.14% new 13F-HR Timeline NAN FUNG TRINITY (HK) LTD More: the full row for NAN FUNG TRINITY (HK) LTD 110,650 $5.9M 0.71% new 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 107,438 $5.73M <0.01% -3,249 13F-HR Timeline Swiss National Bank More: the full row for Swiss National Bank 106,400 $5.68M <0.01% +11,700 13F-HR Timeline GREAT POINT PARTNERS LLC More: the full row for GREAT POINT PARTNERS LLC 103,848 $5.54M 3.6% new 13F-HR Timeline Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 96,371 $5.14M 0.01% new 13F-HR Timeline Group Rafferty Asset Management, LLC More: the full row for Rafferty Asset Management, LLC 93,128 $4.97M 0.02% +19,047 13F-HR Timeline PRUDENTIAL FINANCIAL INC in group PRUDENTIAL FINANCIAL INC More: the full row for PRUDENTIAL FINANCIAL INC 86,490 $4.62M 0.01% +48,055 13F-HR Timeline Group JENNISON ASSOCIATES LLC More: the full row for JENNISON ASSOCIATES LLC 76,863 $4.1M <0.01% +63,685 13F-HR Timeline Corient Private Wealth LP in group Corient Private Wealth LP More: the full row for Corient Private Wealth LP 73,553 $3.92M 0.01% new 13F-HR/A Timeline Group Soleus Capital Management, L.P. More: the full row for Soleus Capital Management, L.P. 72,000 $3.84M 0.27% -45,000 13F-HR Timeline AXA S.A. in group AXA S.A. More: the full row for AXA S.A. 70,987 $3.79M 0.01% new 13F-HR Timeline Group J. Goldman & Co LP More: the full row for J. Goldman & Co LP 65,628 $3.5M 0.11% +36,302 13F-HR Timeline BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 63,566 $3.39M 0.1% -9,100 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 60,875 $3.25M <0.01% +10,376 13F-HR Timeline Group HighVista Strategies LLC More: the full row for HighVista Strategies LLC 59,993 $3.2M 1.18% +35,926 13F-HR Timeline CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 56,451 $3.01M <0.01% +9,810 13F-HR Timeline PICTON MAHONEY ASSET MANAGEMENT More: the full row for PICTON MAHONEY ASSET MANAGEMENT 56,286 $3M 0.04% +22,675 13F-HR Timeline D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 53,866 $2.87M <0.01% +41,707 13F-HR Timeline Group VICTORY CAPITAL MANAGEMENT INC More: the full row for VICTORY CAPITAL MANAGEMENT INC 51,830 $2.77M <0.01% +16,714 13F-HR Timeline Erste Asset Management GmbH in group Erste Asset Management GmbH More: the full row for Erste Asset Management GmbH 47,000 $2.64M 0.02% 0 13F-HR Timeline Group Aquatic Capital Management LLC More: the full row for Aquatic Capital Management LLC 49,393 $2.64M 0.05% -23,381 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 46,536 $2.48M <0.01% -187,636 13F-HR Timeline Group Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 45,940 $2.46M -4,542 Timeline Creative Planning in group Creative Planning More: the full row for Creative Planning 44,333 $2.37M <0.01% +25,643 13F-HR Timeline Group ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 42,929 $2.29M 0.01% -15,376 13F-HR Timeline Group INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 41,887 $2.24M 0.02% -16,635 13F-HR Timeline MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 41,664 $2.22M 0.01% -1,834 13F-HR Timeline Group Connor, Clark & Lunn Investment Managem… More: the full row for Connor, Clark & Lunn Investment Management Ltd. 41,328 $2.21M 0.01% new 13F-HR Timeline Nicholas Investment Partners, LP More: the full row for Nicholas Investment Partners, LP 39,492 $2.11M 0.19% new 13F-HR Timeline MACQUARIE GROUP LTD in group MACQUARIE GROUP LTD More: the full row for MACQUARIE GROUP LTD 39,478 $2.11M <0.01% +9,478 13F-HR Timeline Group Y-Intercept (Hong Kong) Ltd More: the full row for Y-Intercept (Hong Kong) Ltd 39,002 $2.08M 0.05% new 13F-HR Timeline State of New Jersey Common Pension Fund… in group State of New Jersey Common Pe… More: the full row for State of New Jersey Common Pension Fund D 38,461 $2.05M 0.01% -541 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 37,756 $2.01M <0.01% -5,980 13F-HR Timeline Group AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 33,747 $1.8M <0.01% +27,984 13F-HR Timeline Group STATE OF WISCONSIN INVESTMENT BOARD More: the full row for STATE OF WISCONSIN INVESTMENT BOARD 33,546 $1.79M <0.01% -3,594 13F-HR Timeline ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 33,143 $1.77M 0.29% -38,000 13F-HR Timeline Group Caption Management, LLC More: the full row for Caption Management, LLC 31,338 $1.67M 0.15% +26,738 13F-HR Timeline FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 28,573 $1.52M <0.01% +18,176 13F-HR Timeline Group Weiss Asset Management LP in group Weiss Asset Management LP More: the full row for Weiss Asset Management LP 28,526 $1.52M 0.02% new 13F-HR Timeline Group The filing omitted confidential holdings, a later amendment may add them. RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 28,000 $1.49M <0.01% -171,000 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 27,849 $1.49M <0.01% +6,836 13F-HR/A Timeline TWINBEECH CAPITAL LP More: the full row for TWINBEECH CAPITAL LP 26,022 $1.39M 0.03% new 13F-HR Timeline GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 25,717 $1.37M 0.04% -4,063 13F-HR Timeline Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 25,447 $1.36M <0.01% -15,214 13F-HR/A Timeline Group Brevan Howard Capital Management LP in group Brevan Howard Capital Managem… More: the full row for Brevan Howard Capital Management LP 23,426 $1.25M 0.01% new 13F-HR Timeline Group Allostery Investments LP More: the full row for Allostery Investments LP 22,500 $1.2M 15.29% +4,500 13F-HR Timeline ALGERT GLOBAL LLC More: the full row for ALGERT GLOBAL LLC 21,919 $1.17M 0.02% -53,010 13F-HR/A Timeline DekaBank Deutsche Girozentrale More: the full row for DekaBank Deutsche Girozentrale 20,000 $1.14M <0.01% 0 13F-HR Timeline GUGGENHEIM CAPITAL LLC in group GUGGENHEIM CAPITAL LLC More: the full row for GUGGENHEIM CAPITAL LLC 21,147 $1.13M 0.01% +15,204 13F-HR Timeline Group Handelsbanken Fonder AB More: the full row for Handelsbanken Fonder AB 21,000 $1.12M <0.01% 0 13F-HR Timeline Chicago Partners Investment Group LLC More: the full row for Chicago Partners Investment Group LLC 20,658 $1.07M 0.03% -19 13F-HR Timeline PROFUND ADVISORS LLC More: the full row for PROFUND ADVISORS LLC 19,805 $1.06M 0.04% +3,757 13F-HR Timeline ACUTA CAPITAL PARTNERS, LLC More: the full row for ACUTA CAPITAL PARTNERS, LLC 19,772 $1.06M 1.47% new 13F-HR Timeline PRELUDE CAPITAL MANAGEMENT, LLC More: the full row for PRELUDE CAPITAL MANAGEMENT, LLC 19,072 $1.02M 0.1% -4,918 13F-HR Timeline SummitTX Capital, L.P. More: the full row for SummitTX Capital, L.P. 18,472 $986K 0.04% -12,086 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 18,369 $980K 0.03% +16,727 13F-HR Timeline Group Graham Capital Management, L.P. More: the full row for Graham Capital Management, L.P. 18,303 $977K 0.03% new 13F-HR Timeline STATE BOARD OF ADMINISTRATION OF FLORID… More: the full row for STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 18,171 $970K <0.01% +3,521 13F-HR Timeline F/m Investments LLC More: the full row for F/m Investments LLC 17,984 $960K 0.03% -10,606 13F-HR Timeline TEACHERS RETIREMENT SYSTEM OF THE STATE… More: the full row for TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY 17,497 $934K 0.01% -1,768 13F-HR Timeline ProShare Advisors LLC More: the full row for ProShare Advisors LLC 17,309 $924K <0.01% -2,420 13F-HR Timeline Allianz Asset Management GmbH in group Allianz SE More: the full row for Allianz Asset Management GmbH 17,000 $907K <0.01% +4,200 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 16,720 $893K <0.01% -9,882 13F-HR/A Timeline Group ARIZONA STATE RETIREMENT SYSTEM More: the full row for ARIZONA STATE RETIREMENT SYSTEM 16,246 $867K <0.01% +2,257 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 16,011 $854K 0.08% +41 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 15,874 $847K 0.01% -150 13F-HR Timeline TEACHER RETIREMENT SYSTEM OF TEXAS More: the full row for TEACHER RETIREMENT SYSTEM OF TEXAS 14,977 $799K <0.01% +1,828 13F-HR Timeline Nebula Research & Development LLC More: the full row for Nebula Research & Development LLC 14,793 $789K 0.07% new 13F-HR Timeline Atom Investors LP More: the full row for Atom Investors LP 14,181 $757K 0.07% -29,970 13F-HR Timeline Kennondale Capital Management LLC More: the full row for Kennondale Capital Management LLC 14,108 $753K 0.77% 0 13F-HR Timeline STRS OHIO More: the full row for STRS OHIO 14,000 $747K <0.01% +1,400 13F-HR Timeline Universal- Beteiligungs- und Serviceges… in group Universal- Beteiligungs- und … More: the full row for Universal- Beteiligungs- und Servicegesellschaft mbH 12,228 $652K <0.01% +792 13F-HR Timeline Group KLP KAPITALFORVALTNING AS More: the full row for KLP KAPITALFORVALTNING AS 11,800 $630K <0.01% +2,200 13F-HR Timeline SEI INVESTMENTS CO in group SEI INVESTMENTS CO More: the full row for SEI INVESTMENTS CO 11,602 $619K <0.01% -5,177 13F-HR Timeline Group Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 11,107 $593K <0.01% +3,262 13F-HR Timeline Symmetry Investments LP in group Symmetry Investments LP More: the full row for Symmetry Investments LP 10,500 $560K 0.05% new 13F-HR Timeline Group E Fund Management Co., Ltd. More: the full row for E Fund Management Co., Ltd. 10,395 $555K 0.03% +3,471 13F-HR Timeline Hunting Hill Global Capital, LLC More: the full row for Hunting Hill Global Capital, LLC 10,301 $550K 0.3% new 13F-HR Timeline NEOS Investment Management LLC More: the full row for NEOS Investment Management LLC 10,239 $546K 0.01% -1,539 13F-HR Timeline Tema ETFs LLC More: the full row for Tema ETFs LLC 10,239 $546K 0.15% -1,539 13F-HR Timeline ENVESTNET ASSET MANAGEMENT INC in group ENVESTNET ASSET MANAGEMENT INC More: the full row for ENVESTNET ASSET MANAGEMENT INC 9,605 $513K <0.01% -3,729 13F-HR Timeline Group OP Asset Management Ltd More: the full row for OP Asset Management Ltd 8,761 $467K 0.01% new 13F-HR/A Timeline CIBC WORLD MARKETS CORP More: the full row for CIBC WORLD MARKETS CORP 8,612 $460K <0.01% -7,930 13F-HR Timeline HighTower Advisors, LLC More: the full row for HighTower Advisors, LLC 8,450 $451K <0.01% +1,229 13F-HR Timeline Headlands Technologies LLC More: the full row for Headlands Technologies LLC 8,329 $444K 0.05% +8,208 13F-HR Timeline PUBLIC EMPLOYEES RETIREMENT ASSOCIATION… More: the full row for PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO 8,148 $435K <0.01% new 13F-HR Timeline Skandinaviska Enskilda Banken AB (publ) More: the full row for Skandinaviska Enskilda Banken AB (publ) 7,676 $410K <0.01% 0 13F-HR Timeline HARVEST MANAGEMENT LLC More: the full row for HARVEST MANAGEMENT LLC 7,500 $400K 0.19% new 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 7,475 $399K <0.01% +2,389 13F-HR Timeline Group Engineers Gate Manager LP More: the full row for Engineers Gate Manager LP 7,474 $399K <0.01% new 13F-HR Timeline AlphaQuest LLC More: the full row for AlphaQuest LLC 7,174 $383K 0.04% -2,442 13F-HR Timeline Summit Financial Wealth Advisors, LLC More: the full row for Summit Financial Wealth Advisors, LLC 7,155 $382K 0.07% 0 13F-HR Timeline Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 7,136 $381K 0.01% -406 13F-HR Timeline Group DLD Asset Management, LP More: the full row for DLD Asset Management, LP 7,107 $379K 0.05% new 13F-HR/A Timeline Trexquant Investment LP More: the full row for Trexquant Investment LP 6,383 $341K <0.01% new 13F-HR Timeline LOS ANGELES CAPITAL MANAGEMENT LLC More: the full row for LOS ANGELES CAPITAL MANAGEMENT LLC 6,335 $338K <0.01% -1,155 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 6,300 $336K <0.01% -160 13F-HR/A Timeline Group CANADA LIFE ASSURANCE Co in group CANADA LIFE ASSURANCE Co More: the full row for CANADA LIFE ASSURANCE Co 6,242 $334K <0.01% +2,192 13F-HR Timeline Group NORTH STAR ASSET MANAGEMENT INC More: the full row for NORTH STAR ASSET MANAGEMENT INC 5,700 $304K 0.01% new 13F-HR Timeline XPONANCE LLC More: the full row for XPONANCE LLC 5,464 $292K <0.01% -101 13F-HR Timeline SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 5,345 $285K <0.01% -1,150,442 13F-HR Timeline Legato Capital Management LLC More: the full row for Legato Capital Management LLC 5,322 $284K 0.03% new 13F-HR Timeline Parallel Advisors, LLC More: the full row for Parallel Advisors, LLC 5,166 $276K 0.01% -3 13F-HR Timeline Palumbo Wealth Management LLC More: the full row for Palumbo Wealth Management LLC 4,910 $262K 0.08% new 13F-HR Timeline MACKENZIE FINANCIAL CORP More: the full row for MACKENZIE FINANCIAL CORP 4,798 $256K <0.01% new 13F-HR Timeline LPL Financial LLC More: the full row for LPL Financial LLC 4,791 $256K <0.01% -1,434 13F-HR Timeline TUDOR INVESTMENT CORP ET AL More: the full row for TUDOR INVESTMENT CORP ET AL 4,674 $249K <0.01% -40,327 13F-HR Timeline CHOREO, LLC More: the full row for CHOREO, LLC 4,246 $227K <0.01% new 13F-HR Timeline NEUBERGER BERMAN GROUP LLC in group NEUBERGER BERMAN GROUP LLC More: the full row for NEUBERGER BERMAN GROUP LLC 4,112 $219K <0.01% new 13F-HR/A Timeline Group FARALLON CAPITAL MANAGEMENT, L.L.C. More: the full row for FARALLON CAPITAL MANAGEMENT, L.L.C. 4,000 $213K <0.01% new 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. OPTIMIZE FINANCIAL INC. More: the full row for OPTIMIZE FINANCIAL INC. 3,920 $209K 0.13% new 13F-HR Timeline Northwest & Ethical Investments L.P. More: the full row for Northwest & Ethical Investments L.P. 3,700 $208K 0.01% +2,900 13F-HR Timeline Janney Montgomery Scott LLC More: the full row for Janney Montgomery Scott LLC 3,810 $203K <0.01% new 13F-HR Timeline EASTERN BANK More: the full row for EASTERN BANK 3,500 $187K <0.01% 0 13F-HR Timeline Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 3,323 $177K <0.01% -69,661 13F-HR Timeline Group US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 3,065 $164K <0.01% +1,300 13F-HR Timeline Group AMALGAMATED BANK More: the full row for AMALGAMATED BANK 2,570 $137K <0.01% 0 13F-HR Timeline NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 2,391 $128K <0.01% +1,429 13F-HR Timeline PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 1,952 $104K <0.01% +294 13F-HR Timeline Group