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Disclosery

UPB UPSTREAM BIO INC

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COMMON STOCK (common), issuer CIK 2022626

132 managers (134 13F filers) reported a position in UPB shares at 2025-12-31, 51,176,318 shares in all. 42 filers opened a position and 8 filers sold out during the quarter.

Managers
132
13F filers
134
New
42
Added
42
Reduced
33
Sold out
8
Shares held by filers
51,176,318

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q4 2025

Filers in the available 13F reports with a share position at 2025-12-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
FMR LLCin group FMR LLC7,518,202$204M0.01%-568,21113F-HRTimelineGroup
ORBIMED ADVISORS LLCin group ORBIMED ADVISORS LLC5,693,589$155M3.16%013F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.3,344,504$90.8M<0.01%+740,79813F-HRTimelineGroup
Decheng Capital LLC3,143,078$85.3M11.48%-142,21513F-HRTimeline
NORGES BANK2,882,647$78.3M0.01%new13F-HRTimeline
ENAVATE SCIENCES GP, LLC2,459,703$66.8M13.18%013F-HRTimeline
VANGUARD GROUP INCin group VANGUARD GROUP INC2,388,439$64.8M<0.01%-54,11213F-HRTimelineGroup
UBS Group AGgroup of 2 filers holding1,806,485$49M+1,534,214Timeline
JANUS HENDERSON GROUP PLCin group Janus Henderson1,527,958$41.4M0.02%new13F-HRTimelineGroup
Altshuler Shaham Ltd1,341,540$36.4M0.56%-75,28213F-HRTimeline
Bain Capital Life Sciences Investors, L…in group Bain Capital Life Sciences In…1,329,544$36.1M2.76%-1,109,99413F-HRTimelineGroup
Omega Fund Management, LLC1,326,293$36M12.57%-30,00013F-HRTimeline
STATE STREET CORPin group STATE STREET CORP1,319,226$35.8M<0.01%+204,64513F-HRTimelineGroup
Venrock Adviser, LLC1,169,298$31.7M1.57%013F-HRTimeline
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…894,733$24.3M<0.01%-230,66213F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC851,908$23.1M<0.01%+34,79913F-HRTimelineGroup
Parkman Healthcare Partners LLC834,559$22.7M2.16%-8,94313F-HRTimeline
Pictet Asset Management Holding SAin group Pictet Asset Management Holdi…773,148$21M0.02%new13F-HRTimelineGroup
Woodline Partners LP760,252$20.6M0.08%+158,00013F-HRTimeline
Integral Health Asset Management, LLC750,000$20.4M1.03%+175,00013F-HRTimeline
TCG Crossover Management, LLC743,886$20.2M0.67%-1,373,21713F-HRTimeline
SAMSARA BIOCAPITAL, LLC736,047$20M2.06%-226,10713F-HRTimeline
Vestal Point Capital, LP720,000$19.5M0.72%new13F-HRTimeline
Siren, L.L.C.in group Siren, L.L.C.588,450$16M0.48%-200,00013F-HRTimelineGroup
BARCLAYS PLCin group BARCLAYS PLC524,499$14.2M0.01%+439,18413F-HRTimelineGroup
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC517,264$14M0.01%+477,15113F-HRTimelineGroup
Nantahala Capital Management, LLCin group Nantahala Capital Management,…494,971$13.4M0.8%-100,00013F-HRTimelineGroup
MARSHALL WACE, LLPin group MARSHALL WACE, LLP343,791$9.33M0.01%-524,20813F-HRTimelineGroup
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC333,481$9.05M<0.01%+110,26713F-HR/ATimelineGroup
GREAT POINT PARTNERS LLC300,000$8.14M2.64%013F-HRTimeline
Alyeska Investment Group, L.P.in group Alyeska Investment Group, L.P.298,329$8.1M0.02%new13F-HRTimelineGroup
JENNISON ASSOCIATES LLC288,847$7.84M<0.01%new13F-HRTimeline
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co284,931$7.74M<0.01%+10313F-HRTimelineGroup
NORTHERN TRUST CORPin group NORTHERN TRUST CORP236,799$6.43M<0.01%-17,92013F-HRTimelineGroup
Squadron Capital Management LLC230,650$6.26M2.79%13F-HRTimeline
Invesco Ltd.in group Invesco Ltd.163,186$4.43M<0.01%+145,99613F-HRTimelineGroup
Boxer Capital Management, LLCin group Boxer Capital Management, LLC150,000$4.07M0.89%new13F-HRTimelineGroup
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\127,815$3.47M<0.01%+101,07813F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY122,068$3.31M<0.01%+34,53313F-HR/ATimelineGroup
SummitTX Capital, L.P.116,724$3.17M0.1%+4,32013F-HRTimeline
Schonfeld Strategic Advisors LLC115,807$3.14M0.02%-74,43713F-HRTimeline
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO110,280$2.99M<0.01%+80,33313F-HRTimelineGroup
AMERICAN CENTURY COMPANIES INCin group AMERICAN CENTURY COMPANIES INC87,756$2.38M<0.01%+16,21613F-HRTimelineGroup
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/86,384$2.35M<0.01%+30,91113F-HRTimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp84,853$2.3M<0.01%-6,66813F-HRTimelineGroup
Nuveen, LLCin group TIAA78,568$2.13M<0.01%+8,68613F-HRTimelineGroup
ExodusPoint Capital Management, LP75,402$2.05M0.02%new13F-HRTimeline
Artia Global Partners LP68,653$1.86M0.3%new13F-HRTimeline
Exome Asset Management LLC64,845$1.76M0.87%+12,88513F-HRTimeline
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC56,557$1.54M<0.01%new13F-HRTimelineGroup
SUSQUEHANNA INTERNATIONAL GROUP, LLPin group SUSQUEHANNA INTERNATIONAL GRO…55,841$1.52M<0.01%new13F-HRTimelineGroup
SEVEN GRAND MANAGERS, LLC50,000$1.36M0.1%new13F-HRTimeline
Y-Intercept (Hong Kong) Ltd46,559$1.26M0.03%new13F-HRTimeline
ALPS ADVISORS INCin group ALPS ADVISORS INC44,376$1.2M0.01%+18,41413F-HRTimelineGroup
RHUMBLINE ADVISERS41,523$1.13M<0.01%-7,88313F-HRTimeline
Rafferty Asset Management, LLC38,683$1.05M<0.01%+4,16213F-HRTimeline
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN36,794$999K<0.01%+11,63413F-HRTimelineGroup
Trexquant Investment LP31,049$843K0.01%new13F-HRTimeline
ALLIANCEBERNSTEIN L.P.31,010$842K<0.01%+11,16013F-HRTimeline
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC30,503$828K<0.01%+54913F-HRTimelineGroup
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.27,091$736K<0.01%new13F-HRTimelineGroup
Swiss National Bank26,600$722K<0.01%new13F-HRTimeline
DIADEMA PARTNERS LP20,500$557K0.33%new13F-HRTimeline
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding20,117$547K+3,254Timeline
MetLife Investment Management, LLCin group MetLife Investment Management…19,678$534K<0.01%-2,01313F-HRTimelineGroup
PRICE T ROWE ASSOCIATES INC /MD/19,636$534K<0.01%+1,13513F-HRTimeline
PSP Research LLC17,634$479K0.42%13F-HRTimeline
PRELUDE CAPITAL MANAGEMENT, LLC16,560$450K0.03%+82513F-HRTimeline
RENAISSANCE TECHNOLOGIES LLC16,400$445K<0.01%new13F-HRTimeline
Quantinno Capital Management LP15,415$419K<0.01%+52613F-HRTimeline
XTX Topco Ltdin group XTX Topco Ltd15,091$410K0.01%new13F-HRTimelineGroup
CALIFORNIA STATE TEACHERS RETIREMENT SY…14,652$398K<0.01%+12,47613F-HRTimeline
PROFUND ADVISORS LLC14,582$396K0.01%new13F-HRTimeline
Graham Capital Management, L.P.13,712$372K0.01%new13F-HRTimeline
Legal & General Group Plcin group Legal & General Group Plc13,709$372K<0.01%+10,78513F-HRTimelineGroup
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC13,420$364K<0.01%new13F-HRTimelineGroup
DNB Asset Management ASin group DNB Asset Management AS12,793$347K<0.01%new13F-HRTimelineGroup
Virtu Financial LLCin group Virtu Financial LLC12,246$332K0.01%new13F-HRTimelineGroup
Verition Fund Management LLC12,020$326K<0.01%-34,98113F-HRTimeline
Mariner, LLCin group Mariner, LLC11,830$321K<0.01%+89713F-HRTimelineGroup
Creative Planningin group Creative Planning11,749$319K<0.01%-2,51713F-HRTimelineGroup
NEW YORK STATE COMMON RETIREMENT FUND11,700$318K<0.01%+5,40013F-HRTimeline
TWO SIGMA INVESTMENTS, LPin group TWO SIGMA INVESTMENTS, LP10,500$285K<0.01%013F-HRTimelineGroup
INTECH INVESTMENT MANAGEMENT LLC10,396$282K<0.01%013F-HRTimeline
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …10,147$275K<0.01%-1,94513F-HRTimelineGroup
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…9,801$266K0.07%-4213F-HRTimelineGroup
STRS OHIO9,800$266K<0.01%new13F-HRTimeline
VARCOV Co.9,619$261K0.1%13F-HRTimeline
Police & Firemen's Retirement System of…9,456$257K<0.01%+913F-HRTimeline
Persistent Asset Partners Ltd8,907$242K0.12%new13F-HRTimeline
China Universal Asset Management Co., L…8,806$239K0.02%new13F-HRTimeline
ProShare Advisors LLC8,354$227K<0.01%new13F-HRTimeline
SEI INVESTMENTS COin group SEI INVESTMENTS CO8,087$220K<0.01%new13F-HRTimelineGroup
CITIGROUP INCin group CITIGROUP INC6,949$189K<0.01%-35,08813F-HRTimelineGroup
SG Americas Securities, LLC5,518$150K<0.01%new13F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS4,976$135K<0.01%-1,55113F-HRTimelineGroup
CWM, LLCin group CWM, LLC3,360$91K<0.01%+1913F-HRTimelineGroup
KLP KAPITALFORVALTNING AS2,900$78.7K<0.01%new13F-HRTimeline
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…2,823$76.6K<0.01%-21113F-HRTimelineGroup
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…2,741$74.4K<0.01%013F-HRTimelineGroup
Wellington Grp LLC2,000$54.3K0.02%13F-HR/ATimeline
Sterling Capital Management LLC1,919$52.1K<0.01%-34513F-HRTimeline
Torren Management, LLC1,099$29.8K0.02%13F-HRTimeline
GF FUND MANAGEMENT CO. LTD.1,061$28.8K<0.01%new13F-HRTimeline
AMALGAMATED BANK1,031$28K<0.01%+43713F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA969$26K<0.01%+13713F-HRTimelineGroup
GAMMA Investing LLC900$24.4K<0.01%+1013F-HRTimeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…669$18.2K<0.01%-1,19913F-HRTimelineGroup
Versant Capital Management, Inc558$15.2K<0.01%+1013F-HRTimeline
US BANCORP \DE\in group US BANCORP \DE\546$14.8K<0.01%+1513F-HRTimelineGroup
FEDERATED HERMES, INC.in group FEDERATED HERMES, INC.482$13.1K<0.01%new13F-HRTimelineGroup
SIMPLEX TRADING, LLC466$12.7K<0.01%new13F-HRTimeline
NISA INVESTMENT ADVISORS, LLC400$10.9K<0.01%+30413F-HRTimeline
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…282$7.66K<0.01%-2813F-HRTimelineGroup
Global Retirement Partners, LLC273$7.41K<0.01%-5913F-HRTimeline
Aster Capital Management (DIFC) Ltd271$7.36K<0.01%-87013F-HRTimeline
Daiwa Securities Group Inc.in group Daiwa Securities Group Inc.180$5K<0.01%new13F-HRTimelineGroup
J.Safra Asset Management Corp128$3.48K<0.01%013F-HRTimeline
SIGNATUREFD, LLC117$3.18K<0.01%+6613F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…106$2.88K<0.01%-2413F-HRTimelineGroup
Essential Partners LLC97$2.63K<0.01%013F-HRTimeline
Allworth Financial LP68$1.85K<0.01%+113F-HRTimeline
N.E.W. Advisory Services LLC60$1.63K<0.01%013F-HRTimeline
SageView Advisory Group, LLC30$815<0.01%new13F-HRTimeline
Sunbelt Securities, Inc.19$516<0.01%013F-HRTimeline
Larson Financial Group LLC14$380<0.01%new13F-HRTimeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.5$136<0.01%new13F-HRTimelineGroup
Arax Advisory Partners2$54<0.01%-14713F-HRTimeline
Parallel Advisors, LLC2$54<0.01%013F-HRTimeline
ROTHSCHILD INVESTMENT LLC1$27<0.01%new13F-HRTimeline
IFP Advisors, Inc1$27<0.01%-113F-HRTimeline
NOMURA ASSET MANAGEMENT CO LTDgroup of 2 filers holding0$0-28,290Timeline