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Disclosery

UPB UPSTREAM BIO INC

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COMMON STOCK (common), issuer CIK 2022626

133 managers (141 13F filers) reported a position in UPB shares at 2026-03-31, 44,886,514 shares in all. 40 filers opened a position and 38 filers sold out during the quarter.

Managers
133
13F filers
141
New
40
Added
47
Reduced
35
Sold out
38
Shares held by filers
44,886,514

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q1 2026

Filers in the available 13F reports with a share position at 2026-03-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
FMR LLCin group FMR LLC8,101,563$72.9M<0.01%+583,36113F-HRTimelineGroup
ORBIMED ADVISORS LLCin group ORBIMED ADVISORS LLC5,693,589$51.2M1.12%013F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.3,370,689$30.3M<0.01%+26,18513F-HRTimelineGroup
VANGUARD GROUP INCgroup of 6 filers holding2,851,847$25.7MnewTimeline
Decheng Capital LLC2,724,868$24.5M3.71%-418,21013F-HRTimeline
ENAVATE SCIENCES GP, LLC2,459,703$22.1M6.3%013F-HRTimeline
Y-Intercept (Hong Kong) Ltd1,000,631$9.01M0.17%+954,07213F-HRTimeline
FEDERATED HERMES, INC.in group FEDERATED HERMES, INC.979,758$8.82M0.01%+979,27613F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC950,617$8.56M<0.01%+98,70913F-HRTimelineGroup
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC937,323$8.44M0.01%+420,05913F-HRTimelineGroup
SEB Asset Management AB878,473$7.91M0.03%13F-HRTimeline
Bain Capital Life Sciences Investors, L…in group Bain Capital Life Sciences In…867,211$7.8M0.7%-462,33313F-HRTimelineGroup
Woodline Partners LP831,481$7.48M0.03%+71,22913F-HR/ATimeline
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.820,480$7.38M0.01%+793,38913F-HRTimelineGroup
Parkman Healthcare Partners LLC786,783$7.08M0.73%-47,77613F-HRTimeline
SAMSARA BIOCAPITAL, LLC736,047$6.62M0.64%013F-HRTimeline
Pictet Asset Management Holding SAin group Pictet Asset Management Holdi…733,431$6.6M0.01%-39,71713F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP705,350$6.35M<0.01%-613,87613F-HRTimelineGroup
HSBC HOLDINGS PLCin group HSBC HOLDINGS PLC640,326$5.76M<0.01%new13F-HRTimelineGroup
Qube Research & Technologies Ltd619,321$5.57M0.01%new13F-HRTimeline
MORGAN STANLEYin group MORGAN STANLEY552,609$4.97M<0.01%+430,54113F-HRTimelineGroup
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO463,001$4.07M<0.01%+352,72113F-HR/ATimelineGroup
Nantahala Capital Management, LLCin group Nantahala Capital Management,…400,000$3.6M0.22%-94,97113F-HRTimelineGroup
Altshuler Shaham Ltd380,061$3.42M0.06%-961,47913F-HRTimeline
SPHERA FUNDS MANAGEMENT LTD.in group SPHERA FUNDS MANAGEMENT LTD.358,000$3.22M0.55%new13F-HRTimelineGroup
Propel Bio Management, LLC341,779$3.1M1.95%new13F-HRTimeline
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…342,353$3.08M<0.01%-552,38013F-HRTimelineGroup
Jump Financial, LLCin group Jump Financial, LLC319,400$2.87M0.04%new13F-HRTimelineGroup
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC316,587$2.85M<0.01%-16,89413F-HRTimelineGroup
Alyeska Investment Group, L.P.in group Alyeska Investment Group, L.P.298,329$2.68M0.01%013F-HRTimelineGroup
NORTHERN TRUST CORPin group NORTHERN TRUST CORP260,992$2.35M<0.01%+24,19313F-HRTimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co257,729$2.32M<0.01%-27,20213F-HRTimelineGroup
Prosight Management, LP241,123$2.17M0.36%new13F-HRTimeline
UBS Group AGgroup of 2 filers holding231,842$2.09M-1,574,643Timeline
XTX Topco Ltdin group XTX Topco Ltd209,277$1.88M0.03%+194,18613F-HRTimelineGroup
ARROWSTREET CAPITAL, LIMITED PARTNERSHIPin group ARROWSTREET CAPITAL, LIMITED …185,087$1.67M<0.01%new13F-HRTimelineGroup
TCG Crossover Management, LLC181,063$1.63M0.05%-562,82313F-HRTimeline
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\180,889$1.63M<0.01%+53,07413F-HRTimelineGroup
Point72 Asset Management, L.P.in group Point72 Asset Management, L.P.178,168$1.6M<0.01%new13F-HRTimelineGroup
Trexquant Investment LP176,657$1.59M0.01%+145,60813F-HRTimeline
Schonfeld Strategic Advisors LLC161,349$1.45M0.01%+45,54213F-HRTimeline
Boxer Capital Management, LLCin group Boxer Capital Management, LLC150,000$1.35M0.18%013F-HRTimelineGroup
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS126,000$1.13M<0.01%+121,02413F-HRTimelineGroup
ALLIANCEBERNSTEIN L.P.31,010$842K<0.01%013F-HRTimeline
ExodusPoint Capital Management, LP91,431$823K0.01%+16,02913F-HRTimeline
AMERICAN CENTURY COMPANIES INCin group AMERICAN CENTURY COMPANIES INC87,624$789K<0.01%-13213F-HRTimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp81,383$732K<0.01%-3,47013F-HRTimelineGroup
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP80,002$719K<0.01%new13F-HRTimelineGroup
Simplify Asset Management Inc.77,793$700K0.01%new13F-HRTimeline
Nuveen, LLCin group TIAA75,536$680K<0.01%-3,03213F-HRTimelineGroup
EntryPoint Capital, LLC73,568$662K0.19%new13F-HRTimeline
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC72,171$650K<0.01%+41,66813F-HRTimelineGroup
MARSHALL WACE, LLPin group MARSHALL WACE, LLP66,770$601K<0.01%-277,02113F-HRTimelineGroup
RENAISSANCE TECHNOLOGIES LLC62,100$559K<0.01%+45,70013F-HRTimeline
Quantinno Capital Management LP49,389$445K<0.01%+33,97413F-HRTimeline
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/48,460$436K<0.01%-37,92413F-HRTimelineGroup
Swiss National Bank48,100$433K<0.01%+21,50013F-HRTimeline
Squarepoint Ops LLCin group Squarepoint Ops LLC44,626$402K<0.01%new13F-HRTimelineGroup
ALPS ADVISORS INCin group ALPS ADVISORS INC43,992$396K<0.01%-38413F-HRTimelineGroup
STATE OF WISCONSIN INVESTMENT BOARD41,671$375K<0.01%new13F-HRTimeline
RHUMBLINE ADVISERS41,203$371K<0.01%-32013F-HRTimeline
Invesco Ltd.in group Invesco Ltd.40,510$365K<0.01%-122,67613F-HRTimelineGroup
CALIFORNIA STATE TEACHERS RETIREMENT SY…39,661$357K<0.01%+25,00913F-HRTimeline
GSA CAPITAL PARTNERS LLP39,232$353K0.02%new13F-HRTimeline
Stonepine Capital Management, LLC35,000$315K0.28%new13F-HRTimeline
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC35,000$315K0.02%new13F-HRTimelineGroup
Aquatic Capital Management LLC31,484$283K0.01%new13F-HRTimeline
Bleakley Financial Group, LLC28,864$260K<0.01%new13F-HRTimeline
AXQ CAPITAL, LP27,503$248K0.03%new13F-HRTimeline
Mariner, LLCin group Mariner, LLC27,314$246K<0.01%+15,48413F-HRTimelineGroup
PRICE T ROWE ASSOCIATES INC /MD/26,434$238K<0.01%+6,79813F-HRTimeline
TUDOR INVESTMENT CORP ET AL26,412$238K<0.01%new13F-HRTimeline
MARTINGALE ASSET MANAGEMENT L P26,223$236K0.01%new13F-HRTimeline
VICTORY CAPITAL MANAGEMENT INC25,866$233K<0.01%new13F-HRTimeline
BARCLAYS PLCin group BARCLAYS PLC24,720$222K<0.01%-499,77913F-HRTimelineGroup
DNB Asset Management ASin group DNB Asset Management AS23,515$212K<0.01%+10,72213F-HRTimelineGroup
Entropy Technologies, LP23,336$210K0.01%new13F-HRTimeline
DIADEMA PARTNERS LP21,609$194K0.08%+1,10913F-HRTimeline
Man Group plcin group Man Group plc21,154$190K<0.01%new13F-HRTimelineGroup
NISA INVESTMENT ADVISORS, LLC19,558$176K<0.01%+19,15813F-HRTimeline
MetLife Investment Management, LLCin group MetLife Investment Management…19,380$174K<0.01%-29813F-HRTimelineGroup
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding18,427$166K-1,690Timeline
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN18,402$166K<0.01%-18,39213F-HR/ATimelineGroup
SUSQUEHANNA INTERNATIONAL GROUP, LLPin group SUSQUEHANNA INTERNATIONAL GRO…15,961$144K<0.01%-39,88013F-HRTimelineGroup
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …15,338$138K<0.01%+5,19113F-HRTimelineGroup
FRANKLIN RESOURCES INCin group Franklin Resources14,589$131K<0.01%new13F-HRTimelineGroup
Corient Private Wealth LPin group Corient Private Wealth LP12,157$109K<0.01%new13F-HRTimelineGroup
Creative Planningin group Creative Planning10,850$97.7K<0.01%-89913F-HRTimelineGroup
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…10,046$90.4K0.02%+24513F-HRTimelineGroup
Shay Capital LLC10,000$90K0.01%new13F-HRTimeline
STRS OHIO9,800$88.2K<0.01%013F-HRTimeline
Legal & General Group Plcin group Legal & General Group Plc9,609$86.5K<0.01%-4,10013F-HRTimelineGroup
China Universal Asset Management Co., L…9,590$86.3K0.01%+78413F-HRTimeline
Police & Firemen's Retirement System of…9,456$85.1K<0.01%013F-HRTimeline
KLP KAPITALFORVALTNING AS5,900$53.1K<0.01%+3,00013F-HRTimeline
Persistent Asset Partners Ltd5,495$49.5K0.02%-3,41213F-HRTimeline
CITIGROUP INCin group CITIGROUP INC5,055$45.5K<0.01%-1,89413F-HRTimelineGroup
CWM, LLCin group CWM, LLC3,883$34.9K<0.01%+52313F-HRTimelineGroup
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…3,647$32.8K<0.01%+82413F-HRTimelineGroup
Wellington Grp LLC3,000$27K0.01%+1,00013F-HRTimeline
Ameritas Investment Partners, Inc.group of 2 filers holding2,772$24.9K+31Timeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…1,425$12.8K<0.01%+75613F-HRTimelineGroup
GF FUND MANAGEMENT CO. LTD.1,203$10.8K<0.01%+14213F-HRTimeline
Larson Financial Group LLC1,107$9.96K<0.01%+1,09313F-HRTimeline
Sterling Capital Management LLC1,094$9.85K<0.01%-82513F-HRTimeline
Versant Capital Management, Inc762$6.86K<0.01%+20413F-HRTimeline
Rockefeller Capital Management L.P.in group Rockefeller Capital Managemen…738$6.64K<0.01%new13F-HRTimelineGroup
GAMMA Investing LLC715$6.43K<0.01%-18513F-HRTimeline
Quantbot Technologies LP663$5.97K<0.01%new13F-HRTimeline
US BANCORP \DE\in group US BANCORP \DE\590$5.31K<0.01%+4413F-HRTimelineGroup
Zurcher Kantonalbank (Zurich Cantonalba…477$4.29K<0.01%new13F-HRTimeline
Essential Partners LLC402$3.62K<0.01%+30513F-HRTimeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.389$3.5K<0.01%+38413F-HRTimelineGroup
Allworth Financial LP263$2.37K<0.01%+19513F-HRTimeline
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…222$2K<0.01%-6013F-HR/ATimelineGroup
MAI Capital Management171$1.54K<0.01%new13F-HRTimeline
Torren Management, LLC162$1.46K<0.01%-93713F-HRTimeline
NATIXISin group Natixis Investment Managers120$1.08K<0.01%new13F-HRTimelineGroup
N.E.W. Advisory Services LLC120$1.08K<0.01%+6013F-HRTimeline
NEW YORK STATE COMMON RETIREMENT FUND100$900<0.01%-11,60013F-HRTimeline
Wealth Preservation Advisors, LLC86$774<0.01%new13F-HRTimeline
Farther Finance Advisors, LLC81$754<0.01%new13F-HRTimeline
Arax Advisory Partners77$693<0.01%+7513F-HRTimeline
SIGNATUREFD, LLC66$594<0.01%-5113F-HRTimeline
ROTHSCHILD INVESTMENT LLC61$549<0.01%+6013F-HRTimeline
Caitong International Asset Management …23$207<0.01%new13F-HRTimeline
Root Financial Partners, LLC20$180<0.01%new13F-HRTimeline
Parallel Advisors, LLC2$18<0.01%013F-HR/ATimeline
SJS Investment Consulting Inc.2$18<0.01%new13F-HRTimeline
IFP Advisors, Inc1$9<0.01%013F-HRTimeline
Freestone Grove Partners LP1$9<0.01%new13F-HRTimeline
Covestor Ltd4$00%new13F-HRTimelineValue filed as zero, left out of ratios.
NOMURA ASSET MANAGEMENT CO LTDin group NOMURA ASSET MANAGEMENT CO LTD0$00%013F-HRTimelineGroupValue filed as zero, left out of ratios. Amount filed as zero, left out of ratios.