UPB UPSTREAM BIO INC

COMMON STOCK (common), issuer CIK 2022626

71 managers (71 13F filers) reported a position in UPB shares at 2024-12-31, 42,074,592 shares in all. 68 filers opened a position and 0 filers sold out during the quarter.

Managers: 71
13F filers: 71
New: 68
Added: 0
Reduced: 0
Sold out: 0
Shares held by filers: 42,074,592

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q4 2024

Filers in the available 13F reports with a share position at 2024-12-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

Holder	Shares	Value	% of portfolio	Change	Source
FMR LLCin group FMR LLC	7,176,187	$118M	0.01%	new	13F-HR Timeline Group
ORBIMED ADVISORS LLCin group ORBIMED ADVISORS LLC	5,693,589	$93.6M	1.94%	new	13F-HR Timeline Group
Decheng Capital LLC	3,285,293	$54M	11.58%	new	13F-HR Timeline
TCG Crossover Management, LLC	2,801,763	$44.9M	4.38%	new	13F-HR Timeline
ENAVATE SCIENCES GP, LLC	2,459,703	$40.4M	29.04%		13F-HR Timeline
Bain Capital Life Sciences Investors, L…in group Bain Capital Life Sciences In…	2,295,322	$37.7M	4.44%	new	13F-HR Timeline Group
Venrock Adviser, LLC	2,295,319	$37.7M	2.59%	new	13F-HR Timeline
SAMSARA BIOCAPITAL, LLC	2,217,146	$36.4M	5%	new	13F-HR Timeline
Omega Fund Management, LLC	2,036,293	$33.5M	21.71%	new	13F-HR Timeline
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…	1,583,154	$25.6M	<0.01%	new	13F-HR Timeline Group
BlackRock, Inc.in group BlackRock, Inc.	1,117,800	$18.4M	<0.01%	new	13F-HR Timeline Group
ALLIANCEBERNSTEIN L.P.	1,111,337	$18.3M	0.01%	new	13F-HR Timeline
NORGES BANK	1,000,000	$16.4M	<0.01%	new	13F-HR Timeline
Deep Track Capital, LP	1,000,000	$16.4M	0.62%	new	13F-HR Timeline
VANGUARD GROUP INCin group VANGUARD GROUP INC	915,021	$15M	<0.01%	new	13F-HR Timeline Group
Siren, L.L.C.in group Siren, L.L.C.	800,000	$13.2M	0.58%	new	13F-HR Timeline Group
Nantahala Capital Management, LLCin group Nantahala Capital Management,…	600,000	$9.86M	0.69%	new	13F-HR Timeline Group
Woodline Partners LP	526,511	$8.66M	0.06%	new	13F-HR Timeline
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC	363,269	$5.97M	<0.01%	new	13F-HR Timeline Group
Balyasny Asset Management L.P.in group Balyasny Asset Management	301,152	$4.95M	0.01%	new	13F-HR Timeline Group
GREAT POINT PARTNERS LLC	300,000	$4.93M	2.32%	new	13F-HR Timeline
MARSHALL WACE, LLPin group MARSHALL WACE, LLP	290,734	$4.78M	0.01%	new	13F-HR Timeline Group
STATE STREET CORPin group STATE STREET CORP	247,187	$4.06M	<0.01%	new	13F-HR Timeline Group
Lynx1 Capital Management LPin group Lynx1 Capital Management LP	240,042	$3.95M	1.48%	new	13F-HR Timeline Group
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC	180,000	$2.96M	<0.01%	new	13F-HR Timeline Group
UBS Group AGin group UBS Group AG	161,512	$2.66M	<0.01%	new	13F-HR Timeline Group
NORTHERN TRUST CORPin group NORTHERN TRUST CORP	143,721	$2.36M	<0.01%	new	13F-HR Timeline Group
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co	135,323	$2.22M	<0.01%	new	13F-HR Timeline Group
Alyeska Investment Group, L.P.in group Alyeska Investment Group, L.P.	85,000	$1.4M	0.01%	new	13F-HR Timeline Group
Moody Aldrich Partners LLC	74,773	$1.23M	0.23%	new	13F-HR Timeline
EcoR1 Capital, LLC	60,000	$986K	0.04%	new	13F-HR Timeline
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO	47,792	$786K	<0.01%	new	13F-HR Timeline Group
SOROS FUND MANAGEMENT LLCin group SOROS FUND MANAGEMENT LLC	46,350	$762K	0.01%	new	13F-HR Timeline Group
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC	45,549	$749K	<0.01%	new	13F-HR Timeline Group
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC	44,490	$731K	<0.01%	new	13F-HR Timeline Group
ALPS ADVISORS INCin group ALPS ADVISORS INC	43,340	$713K	<0.01%	new	13F-HR Timeline Group
MORGAN STANLEYin group MORGAN STANLEY	43,163	$710K	<0.01%	new	13F-HR/A Timeline Group
Verition Fund Management LLC	37,379	$615K	<0.01%	new	13F-HR Timeline
Bank of New York Mellon Corpin group Bank of New York Mellon Corp	36,913	$607K	<0.01%	new	13F-HR Timeline Group
BARCLAYS PLCin group BARCLAYS PLC	27,017	$444K	<0.01%	new	13F-HR/A Timeline Group
CITIGROUP INCin group CITIGROUP INC	26,504	$436K	<0.01%	new	13F-HR Timeline Group
Nuveen Asset Management, LLCin group TIAA	22,586	$371K	<0.01%	new	13F-HR Timeline Group
RHUMBLINE ADVISERS	16,721	$275K	<0.01%	new	13F-HR/A Timeline
Invesco Ltd.in group Invesco Ltd.	15,602	$256K	<0.01%	new	13F-HR Timeline Group
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\	14,851	$244K	<0.01%	new	13F-HR/A Timeline Group
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/	13,963	$230K	<0.01%	new	13F-HR Timeline Group
Davidson Kempner Capital Management LP	12,500	$205K	<0.01%	new	13F-HR TimelineThe filing omitted confidential holdings, a later amendment may add them.
MetLife Investment Management, LLCin group MetLife Investment Management…	11,034	$181K	<0.01%	new	13F-HR Timeline Group
Walleye Capital LLCin group Walleye Capital LLC	10,000	$164K	<0.01%	new	13F-HR Timeline Group
Sandia Investment Management LP	10,000	$164K	0.31%	new	13F-HR Timeline
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.in group Mirae Asset Global Investment…	9,828	$162K	<0.01%	new	13F-HR Timeline Group
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN	9,047	$149K	<0.01%	new	13F-HR Timeline Group
Corebridge Financial, Inc.in group Corebridge Financial, Inc.	8,660	$142K	<0.01%	new	13F-HR Timeline Group
SG Americas Securities, LLC	7,590	$125K	<0.01%	new	13F-HR Timeline
STRS OHIO	3,200	$52.6K	<0.01%	new	13F-HR Timeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…	2,846	$46.8K	<0.01%	new	13F-HR Timeline Group
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…	1,822	$30K	<0.01%	new	13F-HR Timeline Group
Legal & General Group Plcin group Legal & General Group Plc	1,734	$28.5K	<0.01%	new	13F-HR Timeline Group
US BANCORP \DE\in group US BANCORP \DE\	1,660	$27.3K	<0.01%	new	13F-HR Timeline Group
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS	1,511	$24.8K	<0.01%	new	13F-HR Timeline Group
CALIFORNIA STATE TEACHERS RETIREMENT SY…	1,290	$21.2K	<0.01%	new	13F-HR/A Timeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA	1,282	$21K	<0.01%	new	13F-HR Timeline Group
AMALGAMATED BANK	594	$10K	<0.01%	new	13F-HR Timeline
Sterling Capital Management LLC	249	$4.09K	<0.01%	new	13F-HR Timeline
R Squared Ltd	160	$2.63K	<0.01%		13F-HR Timeline
Aster Capital Management (DIFC) Ltd	134	$2.2K	<0.01%	new	13F-HR Timeline
Caitong International Asset Management …	44	$723	<0.01%		13F-HR/A Timeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.	17	$279	<0.01%	new	13F-HR/A Timeline Group
PRINCIPAL SECURITIES, INC.in group PRINCIPAL FINANCIAL GROUP INC	12	$197	<0.01%	new	13F-HR Timeline Group
NATIONAL BANK OF CANADA /FI/in group NATIONAL BANK OF CANADA /FI/	7	$115	<0.01%	new	13F-HR Timeline Group
CONCOURSE FINANCIAL GROUP SECURITIES, I…	0	$0	0%	new	13F-HR TimelineValue filed as zero, left out of ratios. Amount filed as zero, left out of ratios.