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Disclosery

UPB UPSTREAM BIO INC

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COMMON STOCK (common), issuer CIK 2022626

80 managers (80 13F filers) reported a position in UPB shares at 2025-03-31, 46,279,367 shares in all. 23 filers opened a position and 14 filers sold out during the quarter.

Managers
80
13F filers
80
New
23
Added
11
Reduced
26
Sold out
14
Shares held by filers
46,279,367

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q1 2025

Filers in the available 13F reports with a share position at 2025-03-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
FMR LLCin group FMR LLC7,255,859$44.4M<0.01%+79,67213F-HRTimelineGroup
ORBIMED ADVISORS LLCin group ORBIMED ADVISORS LLC5,693,589$34.8M0.84%013F-HRTimelineGroup
Decheng Capital LLC3,285,293$20.1M5.64%013F-HRTimeline
TCG Crossover Management, LLC2,801,763$17.1M2.34%013F-HRTimeline
ENAVATE SCIENCES GP, LLC2,459,703$15.1M11.34%013F-HRTimeline
Deep Track Capital, LP2,299,567$14.1M0.46%+1,299,56713F-HRTimeline
Bain Capital Life Sciences Investors, L…in group Bain Capital Life Sciences In…2,295,322$14M2.08%013F-HRTimelineGroup
Venrock Adviser, LLC2,295,319$14M1.2%013F-HRTimeline
SAMSARA BIOCAPITAL, LLC2,067,146$12.7M2.26%-150,00013F-HRTimeline
Omega Fund Management, LLC2,036,293$12.5M7.35%013F-HRTimeline
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…1,313,457$8.03M<0.01%-269,69713F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.1,185,768$7.26M<0.01%+67,96813F-HRTimelineGroup
ALLIANCEBERNSTEIN L.P.1,091,186$6.68M<0.01%-20,15113F-HRTimeline
NORGES BANK969,916$5.94M<0.01%-30,08413F-HR/ATimeline
VANGUARD GROUP INCin group VANGUARD GROUP INC907,026$5.55M<0.01%-7,99513F-HRTimelineGroup
Siren, L.L.C.in group Siren, L.L.C.788,450$4.83M0.27%-11,55013F-HR/ATimelineGroup
Nantahala Capital Management, LLCin group Nantahala Capital Management,…594,971$3.64M0.3%-5,02913F-HRTimelineGroup
Altshuler Shaham Ltd3,235,293$3.52M0.09%new13F-HRTimeline
Woodline Partners LP557,063$3.41M0.02%+30,55213F-HRTimeline
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC410,677$2.51M<0.01%+47,40813F-HRTimelineGroup
MARSHALL WACE, LLPin group MARSHALL WACE, LLP304,963$1.87M<0.01%+14,22913F-HRTimelineGroup
GREAT POINT PARTNERS LLC300,000$1.84M1%013F-HRTimeline
STATE STREET CORPin group STATE STREET CORP295,587$1.81M<0.01%+48,40013F-HRTimelineGroup
Parkman Healthcare Partners LLC233,563$1.43M0.17%new13F-HRTimeline
Lynx1 Capital Management LPin group Lynx1 Capital Management LP219,247$1.34M0.48%-20,79513F-HRTimelineGroup
Schonfeld Strategic Advisors LLC177,984$1.09M0.01%new13F-HRTimeline
NORTHERN TRUST CORPin group NORTHERN TRUST CORP137,771$843K<0.01%-5,95013F-HRTimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co132,173$809K<0.01%-3,15013F-HR/ATimelineGroup
UBS Group AGin group UBS Group AG131,551$805K<0.01%-29,96113F-HRTimelineGroup
Velan Capital Investment Management LP107,000$655K0.67%new13F-HRTimeline
Alyeska Investment Group, L.P.in group Alyeska Investment Group, L.P.85,000$520K<0.01%013F-HRTimelineGroup
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC61,796$378K<0.01%new13F-HRTimelineGroup
EcoR1 Capital, LLC60,000$367K0.02%013F-HRTimeline
MORGAN STANLEYin group MORGAN STANLEY51,391$315K<0.01%+8,22813F-HRTimelineGroup
ALPS ADVISORS INCin group ALPS ADVISORS INC39,079$239K<0.01%-4,26113F-HRTimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp36,912$226K<0.01%-113F-HRTimelineGroup
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC32,955$202K<0.01%-11,53513F-HR/ATimelineGroup
BARCLAYS PLCin group BARCLAYS PLC24,993$153K<0.01%-2,02413F-HR/ATimelineGroup
Nuveen, LLCin group TIAA22,586$138K<0.01%13F-HRTimelineGroup
TWO SIGMA INVESTMENTS, LPin group TWO SIGMA INVESTMENTS, LP21,789$133K<0.01%new13F-HRTimelineGroup
SUSQUEHANNA INTERNATIONAL GROUP, LLPin group SUSQUEHANNA INTERNATIONAL GRO…21,264$130K<0.01%new13F-HRTimelineGroup
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC18,822$115K<0.01%new13F-HRTimelineGroup
CITIGROUP INCin group CITIGROUP INC18,178$111K<0.01%-8,32613F-HRTimelineGroup
Invesco Ltd.in group Invesco Ltd.15,315$93.7K<0.01%-28713F-HRTimelineGroup
INTECH INVESTMENT MANAGEMENT LLC15,285$93.5K<0.01%new13F-HRTimeline
Quantinno Capital Management LP15,225$93.2K<0.01%new13F-HRTimeline
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO15,194$93K<0.01%-32,59813F-HRTimelineGroup
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\15,192$93K<0.01%+34113F-HRTimelineGroup
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC15,000$91.8K0.02%new13F-HRTimelineGroup
RHUMBLINE ADVISERS13,327$81.6K<0.01%-3,39413F-HR/ATimeline
XTX Topco Ltdin group XTX Topco Ltd12,731$77.9K<0.01%new13F-HRTimelineGroup
MetLife Investment Management, LLCin group MetLife Investment Management…11,034$67.5K<0.01%013F-HRTimelineGroup
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/10,531$64.5K<0.01%-3,43213F-HRTimelineGroup
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.in group Mirae Asset Global Investment…10,296$63K<0.01%+46813F-HRTimelineGroup
Walleye Capital LLCin group Walleye Capital LLC10,000$61.2K<0.01%013F-HRTimelineGroup
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN9,250$56.6K<0.01%+20313F-HRTimelineGroup
Corebridge Financial, Inc.in group Corebridge Financial, Inc.8,533$52.2K<0.01%-12713F-HRTimelineGroup
NEW YORK STATE COMMON RETIREMENT FUND4,700$28.8K<0.01%new13F-HR/ATimeline
Police & Firemen's Retirement System of…3,350$20.5K<0.01%new13F-HRTimeline
STRS OHIO3,200$19.6K<0.01%013F-HRTimeline
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…1,822$11.2K<0.01%013F-HRTimelineGroup
Legal & General Group Plcin group Legal & General Group Plc1,734$10.6K<0.01%013F-HRTimelineGroup
CWM, LLCin group CWM, LLC1,596$10K<0.01%new13F-HRTimelineGroup
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…1,582$9.68K<0.01%-1,26413F-HRTimelineGroup
CALIFORNIA STATE TEACHERS RETIREMENT SY…1,290$7.89K<0.01%013F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS939$5.75K<0.01%-57213F-HRTimelineGroup
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA832$5K<0.01%-45013F-HR/ATimelineGroup
AMALGAMATED BANK594$4K<0.01%013F-HRTimeline
Versant Capital Management, Inc615$3.76K<0.01%new13F-HRTimeline
GAMMA Investing LLC593$3.63K<0.01%new13F-HR/ATimeline
US BANCORP \DE\in group US BANCORP \DE\562$3.44K<0.01%-1,09813F-HRTimelineGroup
Allworth Financial LP185$1.66K<0.01%new13F-HRTimeline
Sterling Capital Management LLC137$838<0.01%-11213F-HRTimeline
NISA INVESTMENT ADVISORS, LLC136$832<0.01%new13F-HRTimeline
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…135$826<0.01%new13F-HRTimelineGroup
SIGNATUREFD, LLC90$551<0.01%new13F-HRTimeline
Physician Wealth Advisors, Inc.69$423<0.01%new13F-HRTimeline
PRINCIPAL SECURITIES, INC.in group PRINCIPAL FINANCIAL GROUP INC12$197<0.01%013F-HRTimelineGroup
True Wealth Design, LLC16$98<0.01%new13F-HRTimeline
CONCOURSE FINANCIAL GROUP SECURITIES, I…0$0013F-HRTimelineValue filed as zero, left out of ratios. Amount filed as zero, left out of ratios.